| 冷冻干燥法制备隐丹参酮纳米脂质体 |
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| 引用本文： | 张晓伟.冷冻干燥法制备隐丹参酮纳米脂质体[J].忻州师范学院学报,2008,24(5). |
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| 作者姓名： | 张晓伟 |
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| 作者单位： | 山西机电职业技术学院,山西长治,046000 |
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| 摘 要： | 目的：用大豆卵磷脂作为载体，以隐丹参酮作为模型药。制备隐丹参酮纳米脂质体。方法：用超声一匀浆一冷冻干燥法制备隐丹参酮纳米脂质体。采用透射电镜测试隐丹参酮脂质体的粒径，用激光粒度分布仪测试平均粒径及粒度分布。结果：冷冻干燥法制备隐丹参酮纳米脂质体的粒径20—80nm之间。随着大豆卵磷脂与隐丹参酮配比的减小，粒径逐渐减小，包封率逐渐减小。体外释药表现为零级动力学释药特征。结论：用超声一匀浆一冷冻干燥法制备隐丹参酮纳米脂质体的方法可行。
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| 关 键 词： | 隐丹参酮 脂质体 包封率 |
To Prepare Cryptotanshione Liposomes by Freeze-drying |
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| ZHANG Xiao-Wei.To Prepare Cryptotanshione Liposomes by Freeze-drying[J].Journal of Xinzhou Teachers University,2008,24(5). |
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| Authors: | ZHANG Xiao-Wei |
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| Abstract: | Objective:To prepare cryptotanshinone Nano-liposomes using the Soya lecithin as the carries and using the cryptotanshinone as a model drug.Methods:Cryptotanshinone Nano-liposomes were prepared by ultrasonic bath-refining-freeze-drying.The mean diameter and its distribution were measured by means of Zetasizer.The diameter were observed by transmission electron microscope .Results:The diameter of cryptotanshinone Nano-liposomes which were prepared by freeze-drying is an a range of 20-80nm.With the drug loading of cryptotanshinone increasing,the diameter of cryptotanshinone Nano-liposomes were less and entrapment efficiency were bigger.The drug release behavior in vitro appeared zero level dynamics.Conclusion:The preparation method of cryptotanshinone is simple. |
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| Keywords: | cryptotanshinone liposomes entrapment efficiency |
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