| 三七总皂甙对大鼠脑出血灶周围神经元Bcl-2/Bax及脑含水量变化的影响 |
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| 引用本文： | 朱继红,王登科,戴新文,董克勤,贺岭风.三七总皂甙对大鼠脑出血灶周围神经元Bcl-2/Bax及脑含水量变化的影响[J].宁夏师范学院学报,2013(6):112-115. |
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| 作者姓名： | 朱继红 王登科 戴新文 董克勤 贺岭风 |
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| 作者单位： | 宁夏师范学院医学院,宁夏固原756000 |
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| 基金项目： | 宁夏师范学院科研项目资助（YB201346）. |
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| 摘 要： | 研究大鼠脑出血给予三七总皂甙治疗后,神经元Bcl-2和Bax的表达有无变化,并观察脑出血大鼠在不同时间点相干/湿重法测定脑含水量的变化.神经行为学检测结果表明,脑出血组大鼠的神经功能评分分值升高；2d后治疗组大鼠与脑出血组相比分值下降（P＜0.01）.免疫组织化学结果显示,治疗组Bcl-2的阳性表达较脑出血组高（P＜0.01）、Bax的阳性表达较脑出血组低（P＜0.01）,Bcl-2/Bax蛋白比值增高；脑含水量即12 h开始增加,24 h后比较明显,48 h达高峰,7d之后与正常组无明显差异.三七总皂甙治疗组48 h ～72h干预后,脑含水量明显低于其脑出血组（P＜0.05）.
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| 关 键 词： | 三七总皂甙 脑出血 神经元 脑含水量 |
Effect of Total Panax Notoginseng Saponins on Variation of Bcl-2/Bax in the Adjacent Neurons and Cerebral Water Content of Intracerebral Hemorrhage in Rats |
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| ZHU Jihong,WANG Dengke,DAI Xinwen,DONG Keqin,HE Lingfeng.Effect of Total Panax Notoginseng Saponins on Variation of Bcl-2/Bax in the Adjacent Neurons and Cerebral Water Content of Intracerebral Hemorrhage in Rats[J].Journal of Ningxia Teachers College,2013(6):112-115. |
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| Authors: | ZHU Jihong WANG Dengke DAI Xinwen DONG Keqin HE Lingfeng |
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| Institution: | ( Department of Medical, Ningxia Normal University, Guyuan, Ningxia 756000 ) |
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| Abstract: | Through studying the therapeutic effect of Total Panax Notoginseng Saponins on variation of Bcl - 2/Bax in the ad- jacent neurons, observing and measuring the cerebral water content of intracerebral hemorrhage in rats by dry/wet weight method, the results showed that, in neurological testing, neurological function score of intracerebral hemorrhage rats increased. In contrast, the score of 2d treated rats decreased （P 〈 0.01 ）. The immuno - histochemistry results showed that the expression of Bcl - 2 in treatment group is higher than that in ICH group （P 〈 0.01）. However, the expression of Bax （P 〈 0.01 ） degraded prominently and the protein ratio of Bcl -2/Bax increased in the treated group. Cerebral water content began to increase afterl2 hours and be- came obvious after 24 hours. It reached the peak in 48 hours and had no significant difference from the normal group after 7 days. After 48 - 72 hours of the intervention, cerebral water content of the PNS treatment group was significantly lower than the cerebral hemorrhage group （P 〈 0.05 ） , which has statistical significance. |
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| Keywords: | Total Panax Notoginseng Saponins Intracerebral hemorrhage Neurons Cerebral water content |
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