| 灭活的双歧杆菌抗免疫功能低下致小鼠肠源性感染的研究 |
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| 引用本文： | 伦永志,胡捷,罗学娅,黄敏,孙慎侠,刘亚力.灭活的双歧杆菌抗免疫功能低下致小鼠肠源性感染的研究[J].大连大学学报,2006,27(2):78-80,90. |
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| 作者姓名： | 伦永志 胡捷 罗学娅 黄敏 孙慎侠 刘亚力 |
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| 作者单位： | 1. 大连大学,医学院,辽宁,大连,116622
2. 大连医科大学,辽宁,大连,116023 |
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| 摘 要： | 目的:观察灭活的双歧杆菌对免疫功能低下致小鼠肠源性感染的治疗作用.方法:采用腹腔注射环磷酰胺造成免疫功能低下小鼠动物模型,分别以双歧杆菌灭活菌液、活菌液对小鼠进行灌胃治疗后,检测临床血清学指标与组织匀浆内示踪菌.结果:活菌组、死菌组同自然恢复组相比,临床血清学指标水平与组织匀浆内示踪菌数量恢复至正常对照组水平.结论:双歧杆菌灭活菌液具有与活菌液相同的抗免疫功能低下致小鼠肠源性感染作用.
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| 关 键 词： | 双歧杆菌 免疫功能低下 肠源性感染 血清学 示踪菌 |
| 文章编号： | 1008-2395（2006）02-0078-04 |
| 收稿时间： | 2004-11-03 |
| 修稿时间： | 2004年11月3日 |
Study on heat-killed bifidobacterium curing mice with enterogenic infection caused by immunocompromise |
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| LUN Yong-zhi,HU Jie,LUO Xue-ya,HUANG Min,SUN Shen-xia,LIU Ya-li.Study on heat-killed bifidobacterium curing mice with enterogenic infection caused by immunocompromise[J].Journal of Dalian University,2006,27(2):78-80,90. |
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| Authors: | LUN Yong-zhi HU Jie LUO Xue-ya HUANG Min SUN Shen-xia LIU Ya-li |
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| Abstract: | Objective]To observe the curing effect of heat-killed bifidobacterium to mice with enterogenic infection caused by immunocompromise.Methods] The animal model of mice with enterogenic infection caused by immunocompromise was made by means of injecting cyclophosphamide into mice adoment,and given by intragastric administration therapy including live bifidobacterial suspension and heat-killed bifidobacterial suspension.Clinical serology indexes and tissue bomogenate tagging bacterium of mice were detected.Results] Versus spontaneous recovery group,all indexes of live strains group and heat-killed strains group recuperated to normal control level.Conclusions]Heat-killed bifidobacterium has curing effect to mice with enterogenic infection caused by immunocompromise same as live bifidobacterium. |
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| Keywords: | bifidobacterium immunocompromise enterogenic infection serology tagging bacterium |
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