| 烟酰胺超载对大鼠血浆内甲基化反应水平的影响 |
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| 引用本文： | 伦永志,孙杰,骆宁,姚晓坤,周士胜.烟酰胺超载对大鼠血浆内甲基化反应水平的影响[J].大连大学学报,2014(6):76-78,103. |
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| 作者姓名： | 伦永志 孙杰 骆宁 姚晓坤 周士胜 |
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| 作者单位： | 1. 大连大学 医学院 辽宁省高校生物物理学重点实验室,辽宁 大连,116622
2. 大连港医院 检验科,辽宁 大连,116013 |
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| 基金项目： | 辽宁省教育厅科学技术研究项目(L2012441)。 |
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| 摘 要： | 利用长期大鼠高烟酰胺喂养模型,观察烟酰胺超载对血浆内甲基化反应指标的影响。结果发现,高烟酰胺摄入将伴随高甲基供体消耗,并引起血中甜菜碱水平明显降低,直接证明过量烟酰胺会导致甲基库耗竭。这表明过量的烟酰胺可能通过甲基耗竭诱导氧化性线粒体和DNA损伤及DNA甲基化样式的改变。
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| 关 键 词： | 烟酰胺 代谢综合征 甲基化 |
Effect of Excess Nicotinamide on Plasma Methylation Reaction Levels in Rat |
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| LUN Yong-zhi,SUN Jie,LUO Ning,YAO Xiao-kun,ZHOU Shi-sheng.Effect of Excess Nicotinamide on Plasma Methylation Reaction Levels in Rat[J].Journal of Dalian University,2014(6):76-78,103. |
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| Authors: | LUN Yong-zhi SUN Jie LUO Ning YAO Xiao-kun ZHOU Shi-sheng |
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| Institution: | LUN Yong-zhi;SUN Jie;LUO Ning;YAO Xiao-kun;ZHOU Shi-sheng;Liaoning Provincial University Key Laboratory of Biophysics, Medical College, Dalian University;Department of Clinical Laboratory, Dalian Port Hospital; |
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| Abstract: | Long-term high nicotinamide feeding test was performed to investigate the effect of excess nicotinamide on plasma methylation reaction levels. The results shown high nicotinamide intake may lead to a depletion of labile methyl groups. Nicotinamide overload significantly lower plasma betaine levels which suggested the deletion of methyl groups. Therefore, the present study demonstrated that excess nicotinamide may trigger oxidative damage and abnormal DNA methylation patterns due to promote the generation of ROS and its depletion of the methyl donor pool. |
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| Keywords: | nicotinamide metabolic syndrome methylation |
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