| 调整工艺路线改革天然药物化学实验 |
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| 引用本文： | 徐娟华,姚爱平,黄亦佳,卢启洪,董兆怿.调整工艺路线改革天然药物化学实验[J].实验室研究与探索,2004,23(4):24-25,30. |
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| 作者姓名： | 徐娟华 姚爱平 黄亦佳 卢启洪 董兆怿 |
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| 作者单位： | 浙江大学,药学院,浙江,杭州,310031 |
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| 摘 要： | 对粉防己生物碱的提取分离工艺路线进行调整设计,改革天然药物化学实验,使有机整体化和降低成本、毒性等;采用酸水—有机溶剂法提取生物碱,柱层析、制备层析分离汉防己甲素和汉防己乙素;柱层析分离成功率约82%,制备层析成功率100%。找到了适合学生实验室的工艺和条件,提高了学生的实验兴趣和实验效果。
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| 关 键 词： | 提取分离 柱层析 制备层析 实验改革 |
| 文章编号： | 1006-7167(2004)04-0024-03 |
Adjusting Technical Route to Reform the Experimentation on Chemistry of Nature Drugs |
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| XU Juan-hua,YAO Ai-ping,HUANG Yi-jia,LU Qi-hong,DONG Zhao-yi.Adjusting Technical Route to Reform the Experimentation on Chemistry of Nature Drugs[J].Laboratory Research and Exploration,2004,23(4):24-25,30. |
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| Authors: | XU Juan-hua YAO Ai-ping HUANG Yi-jia LU Qi-hong DONG Zhao-yi |
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| Abstract: | By adjusting and designing technical route about extraction and isolation of alkaloids from Stephania tetrandra S. Moore, in order to reform experimentation on medicinal chemistry of Nature Products , to connect experiments , reduce the cost and toxicity and so on. To extract the alkaloids with acidic solution and organic solvent ,and to isolate tetrandrine and fanchineline with column chromatograph and thick-layer chromatograph. Result: The succeed of column chromatograph is about 82% , thick-layer chromatograph is about 100%. It is found the suitable technical route for the experiment of students, which raises their interesting and improves the effect of experiment. |
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| Keywords: | extraction and isolation column chromatograph thick-layer chromatograph experiment reformation |
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