| 奥丁尼酮洛芬缓释胶囊中酮洛芬的手性拆分 |
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| 引用本文： | 侯冬岩,回瑞华,刁全平,李铁纯,刘晓媛.奥丁尼酮洛芬缓释胶囊中酮洛芬的手性拆分[J].鞍山师范学院学报,2009,11(2):24-27. |
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| 作者姓名： | 侯冬岩 回瑞华 刁全平 李铁纯 刘晓媛 |
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| 作者单位： | 鞍山师范学院,化学系,辽宁,鞍山,114007 |
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| 基金项目： | 辽宁省教育厅科学技术基金 |
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| 摘 要： | 采用高效液相色谱法,以β-环糊精为手性固定相拆分奥丁尼酮洛芬缓释胶囊中酮洛芬对映体,并对流动相中甲醇的含量、流动相的pH值、缓冲盐的浓度等色谱条件对拆分结果的影响进行了探讨.结果表明,在柱温为25℃,pH值为4.0,采用0.01 mol/L的磷酸二氢钾缓冲溶液,甲醇40%（V/V）作流动相时,奥丁尼酮洛芬缓释胶囊中的酮洛芬对映体能达到较好分离.
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| 关 键 词： | 奥丁尼酮洛芬 手性固定相 分离 |
Enantiomers Separation of Ketoprofen Sustained Release Capsules |
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| HOU Dong-yan,HUI Rui-hua,DIAO Quan-ping,LI Tie-chun,LIU Xiao-yuan.Enantiomers Separation of Ketoprofen Sustained Release Capsules[J].Journal of Anshan Teachers College,2009,11(2):24-27. |
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| Authors: | HOU Dong-yan HUI Rui-hua DIAO Quan-ping LI Tie-chun LIU Xiao-yuan |
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| Institution: | Department of Chemistry;Anshan Normal University;Anshan Liaoning 114007;China |
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| Abstract: | The method HPLC was developed for the separation of ketoprofen sustained release capsules by β-cyclodextrin chiral stationary phase. The effects of the concentration of methanol for mobile phase,pH and the concentration of salt on chiral separation were studied. The results show that the column temperature 25 ℃ ,0. 01 mol/L potassium dihydrogen phosphate pH = 4.0, containing 40% （V/V） methanol as eluant, ketoprofen sustained release capsules enantiomers were separated. |
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| Keywords: | Ketoprofen sustained release capsules Chiral stationary phase Separation |
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