| 基于序列及结构特征的固有无序蛋白—核酸相互作用位点预测分析 |
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| 引用本文： | 王洪波,郭珍珍,于家峰等.基于序列及结构特征的固有无序蛋白—核酸相互作用位点预测分析[J].德州学院学报,2014(2):6-10. |
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| 作者姓名： | 王洪波 郭珍珍 于家峰等 |
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| 作者单位： | [1]山东省功能大分子生物物理重点实验室,德州学院生物物理研究所,山东德州253023 [2]德州学院物理与电子信息学院,山东德州253002 [3]山东师范大学生命科学学院,济南250014 |
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| 基金项目： | 国家自然科学基金资助项目（61271378） |
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| 摘 要： | 固有无序蛋白是一类具有柔性结构的蛋白质,许多情况下通过与其它物质相互作用形成稳定结构来发挥重要生物功能.本文分别利用基于序列特征和结构特征的蛋白质结合位点预测程序对固有无序蛋白有序区和无序区与核酸分子的结合位点进行了预测分析.结果发现,基于结构特征的结合位点预测方法整体上要优于基于序列特征的预测方法,表明无序区尽管缺少稳定空间结构,结构特征依然在固有无序蛋白结合位点中发挥了重要作用.因此,可以为今后固有无序蛋白序列特征及结构特征的提取提供可靠依据.
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| 关 键 词： | 固有无序蛋白 序列特征 结构特征 结合位点预测 |
Prediction of Binding Sites Intrinsically Disordered Proteins- nucleic Acids Complexes by Sequence and Structure |
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| WANG Hong-bo,GUO Zhen-zhen,YU Jia-feng,WANG Ji-hua.Prediction of Binding Sites Intrinsically Disordered Proteins- nucleic Acids Complexes by Sequence and Structure[J].Journal of Dezhou University,2014(2):6-10. |
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| Authors: | WANG Hong-bo GUO Zhen-zhen YU Jia-feng WANG Ji-hua |
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| Institution: | 1. Shandong Provincial Key Laboratory of Functional Macromolecular Biophysics, Institute of Biophysics, Dezhou University, Dezhou Shandong 253023, China; 2. School of Physics and Electronic Information, Dezhou University, Dezhou Shandong 253023,China; 3. School of Life Science, Shangdong Normal University, Jinan 250014, China) |
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| Abstract: | Intrinsically disordered protein is a class of proteins with flexible structure, which perfom important biological function via interacting with other substances. In this paper, the binding sites of IDPs are predicted using sequence and structure based methods, resectively. The results show that structure based binding sites predictor is better than the sequence based methods in most cases. Then, although lack of stable spatial structure, information of structure plays important role in the interaction of intrinsically disordered proteins. |
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| Keywords: | intrinsically disordered proteins sequence features structural features binding sites prediction |
| 本文献已被 CNKI 维普 等数据库收录！ |
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