| 盐酸甲氧氯普胺海藻酸钙微球的制备和释药研究 |
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| 引用本文： | 范晋勇,高俊苹.盐酸甲氧氯普胺海藻酸钙微球的制备和释药研究[J].德州学院学报,2012,28(2):40-42,62. |
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| 作者姓名： | 范晋勇 高俊苹 |
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| 作者单位： | 1. 德州学院化学系,山东德州,253023
2. 德州聚安特安全服务有限公司,山东德州,253000 |
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| 摘 要： | 制备盐酸甲氧氯普胺海藻酸钙凝胶微球并考察不同因素影响下的释药性.采用滴制法制备盐酸甲氧氯普胺海藻酸钙凝胶微球,海藻酸浓度为2%,氯化钙浓度为1%,载药微球在酸性环境中具有良好的缓释效果,缓释时间能持续8h.盐酸甲氧氯普胺海藻酸钙缓释凝胶微球具有良好的应用前景.
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| 关 键 词： | 盐酸甲氧氯普胺 海藻酸钙 微球 缓释 |
Preparation and Release Characteristics of Ca-alginate Gel Beads Loading Metoclopramide |
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| FAN Jin-yong,GAO Jun-ping.Preparation and Release Characteristics of Ca-alginate Gel Beads Loading Metoclopramide[J].Journal of Dezhou University,2012,28(2):40-42,62. |
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| Authors: | FAN Jin-yong GAO Jun-ping |
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| Institution: | 1.Department of Chemistry,Dezhou University,Dezhou Shandong 253023,China; 2.Dezhou Ju,anTe Security Service Co.,LTD,Dezhou Shandong 253000,China) |
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| Abstract: | The purpose of this research is to study the Ca-alginate Gel Beads loading Metoclopramide with time in drug release.The drug-loading microspheres was prepared by dipping method.The alginate concentration was 2% and calcium chloride was 1%.The medicine-microsphere in acidic environment has good effect,slow release time can continue 8 h.the Ca-alginate Gel Beads loading Metoclopramide has good application prospect. |
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| Keywords: | Metoclopramide alginate microsphere slow release |
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