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| 当归、川芎嗪注射液对失血性休克大鼠血液动力学的影响 | |
| 引用本文： | 魏会平,刘圣君,刘艳凯,姜华.当归、川芎嗪注射液对失血性休克大鼠血液动力学的影响[J].河北北方学院学报(医学版),2008,25(1):20-22. |
| 作者姓名： | 魏会平 刘圣君 刘艳凯 姜华 |
| 作者单位： | 1. 河北北方学院医学院生物教研室,河北,张家口,075000 2. 河北北方学院附属第一医院肾内科,河北,张家口,075000 3. 河北北方学院医学院病理生理教研室,河北,张家口,075000 |
| 基金项目： | 河北省中医药科学研究计划(编号:200002) |
| 摘 要： | 目的:探讨川芎嗪、当归注射液对失血性休克大鼠血液动力学的影响。方法:颈动脉放血复制大鼠失血性休克模型,通过微循环观察、器官血流和血液流变学测定方法,观察川芎嗪、当归注射液对失血性休克大鼠血液动力学的影响。结果:失血性休克时,微循环明显障碍,主要表现为微血流变慢和血细胞聚集;经川芎嗪、当归注射液治疗后,微循环改善,血粘度、血小板粘附率和聚集率降低,器官微区血流量增加,与NS组比较有显著性差异(P<0.05)。结论:川芎嗪、当归注射液能明显改善失血性休克大鼠微循环障碍,降低血小板聚集率,增加器官血液灌流量。 |
| 关 键 词： | 川芎嗪 当归 休克/出血性 血小板 |
| 文章编号： | 1673-1484（2008）01-0020-03 |
Effects of Tetramethylpyrazine and Angelica Parenteral Solution on Hemodynamics in Rats with Hemorrhagic Shock |
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| WEI Hui-ping, LIU Sheng-jun,LIU Yan-kai, et al.Effects of Tetramethylpyrazine and Angelica Parenteral Solution on Hemodynamics in Rats with Hemorrhagic Shock[J].Journal of Hebei North University:Medical Edition,2008,25(1):20-22. | |
| Authors: | WEI Hui-ping LIU Sheng-jun LIU Yan-kai |
| Abstract: | Objective:To investigate effects of Tetramethylpyrazine and angelica parenteral solution on hemodynamics in rats with hemorrhagic shock.Methods:A model of hemorrhagic shock was made in rats by blood loss from carotid,and effects of Tetramethylpyrazine and angelica parenteral solution on hemodynamics were observed in these rats by observation of mesenteric microcirculation,determination of hemorheology and blood flow volume.Results:The microcirculation disturbance was mainly slow micro-blood flow and blood cells aggregation in hemorrhagic shock rats,after treatment with Tetramethylpyrazine and angelica parenteral solution,the microcirculation was improved,rate of platelet aggregation and blood viscosity were low,but the micro-area blood flow volume of organs was evidently increased,there was significant difference compared with that of normal saline(NS) group(P<0.05).Conclusion:Tetramethylpyrazine and angelica parenteral solution can improve microcirculation,increase blood flow volume of organs and reduce platelet aggregation in rats with hemorrhagic shock. |
| Keywords: | Tetramethylpyrazine Angelica sinensis Shock/Hemorrhagic Platelets |
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