| 肢体远隔缺血后适应对SD大鼠脑缺血再灌注损伤的影响 |
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| 引用本文： | 蒲举,;姚声涛.肢体远隔缺血后适应对SD大鼠脑缺血再灌注损伤的影响[J].河北北方学院学报(医学版),2014(4):10-14. |
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| 作者姓名： | 蒲举 ;姚声涛 |
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| 作者单位： | [1]南充市中心医院,中国南充637100; [2]遵义医学院附属医院脑血管病科,中国遵义563000 |
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| 基金项目： | 遵义市科技局与遵艾医院科技合作项目（No.2010017） |
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| 摘 要： | 目的：研究肢体远隔缺血后适应（limbremoteisehemiepostconditioning，RIP）对脑缺血再灌注损伤的影响。方法：建造大脑中动脉闭塞模型，予以双下肢远隔缺血后适应，采用Bederson评分法对雄性SD大鼠脑缺血后12、24、72h进行评分，运用磁共振T2加权像（T2-WeightedImaging，T2WI）计算梗死体积。结果：RIP组大鼠24h后Bederson评分较再灌注模型组评分减少，差异有统计学意义（P〈0．05），据T2WI算得RIP组脑梗死体积在12、24、72h均较再灌注模型组减少，差异有统计学意义（P〈0．05）。结论：RIP减少缺血后24h神经功能评分，减少梗死体积，具有减轻再灌注损伤作用。
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| 关 键 词： | 远隔缺血后适应 再灌注损伤 神经功能评分 |
Effects of Limb Remote Ischemic Postconditioning on Cerebral Ischemia-Reperfusion Injury |
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| Institution: | PU Ju, YAO Sheng-tao( 1. Nanchong Central Hospital, Nanchong, 637100, China 2. Department of Cerebral Vascular Diseases, Affiliated Hospital of Zunyi Medical College, Zunyi, 563000, China) |
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| Abstract: | Objective：To study the effects of limb remote ischemic postconditioning （RIP） on reducing brain damage in cerebral ischemia-reperfusion （I-R）. Methods：Ischemia-reperfusion injury and remote ischemic postconditioning models were established in rats. The neurological deficit scores were assessed （Bederson score） at 12,24 and 72 h post-surgeries. T2-Weighted Imaging of magnetic resonance imaging （MRI） was used to determine the infarct volume at 12,24,72 h. Results：Compared with the model groups,the neurological deficit scores were decreased in 24 h groups （P〈0.05）.The volume of infraction in RIP groups was significantly smaller than those in the model groups after ischemia at each time point. Conclusion：RIP reduces the neurological deficit scores at 24 h after ischemia, alleviates the volume of cerebral infraction from 12 h to 72 h after ischemia, suggesting that RIP can decrease cerebral ischemia reoerfusion injury. |
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| Keywords: | remote ischemic postconditioning ischemia-reperfusion neurological deficitscores |
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