| 小分子抗癌新药nutlin-3的合成新法研究 |
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| 引用本文： | 陈芬,覃宇,丁四海.小分子抗癌新药nutlin-3的合成新法研究[J].武汉职业技术学院学报,2011,10(1):75-78. |
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| 作者姓名： | 陈芬 覃宇 丁四海 |
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| 作者单位： | 武汉职业技术学院生物工程学院,湖北,武汉,430074 |
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| 摘 要： | 以4-甲氧基-2-羟基苯甲醛和对氯苯甲醛为原料,采用7步反应初步合成了小分子抗肿瘤药物nutlin-3,TLC检测每一步反应,总收率40%。对中间体和目标产物的结构和纯度进行了IR和1H NMR表征。
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| 关 键 词： | Nutlins 咪唑啉类似物 抗肿瘤 合成 表征 |
Research of Synthetic Methods to Nutlin-3,a Small Molecules Anticancer Drug |
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| CHEN Fen,QIN Yu,DING Si-hai.Research of Synthetic Methods to Nutlin-3,a Small Molecules Anticancer Drug[J].Journal of Wuhan Institute of Technology,2011,10(1):75-78. |
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| Authors: | CHEN Fen QIN Yu DING Si-hai |
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| Institution: | CHEN Fen,QIN Yu,DING Si-hai(Biology Engineering Department,Wuhan Polytechnic,Wuhan 430074,China) |
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| Abstract: | Nutlin-3 is A small molecules anticancer drug,synthesized from the starting materials 4-methoxy-2-hydroxybenzaldehyde and its seven steps in chlorobenzaldehyde is listed in this paper.Every step of the reaction was tested by TLC and the total yield was 40%.The structure and purity of intermediate products was characterized by IR and 1H NMR spectra. |
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| Keywords: | nutlins imidazoline analogues anticancer synthesis indicate |
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