共查询到20条相似文献，搜索用时 15 毫秒
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K. Usha G. Mary Kasturi P. Hemalatha 《Indian journal of clinical biochemistry : IJCB》2007,22(2):132-135
The present study was undertaken to analyze the levels of some known antioxidant (both enzymic and non enzymic) activities
in the rootsof Hygrophila spinosa andCassia occidentalis also to find out the hepatoprotective effect of the same in carbon tetrachloride induced liver damage in albino rats. The
roots were found to be rich in antioxidants. Liver damage in rats were induced by carbon tetrachloride. To find out the hepatoprotective
activity, the aqueous extract of the plant root samples were administrated to rats for 15 days. The serum marker enzymes Aspartate
transaminase, Alanine transaminase and Gama Glutamyl were measured in experimental animals. The increased enzyme levels after
liver damage with carbon tetrachloride were nearing to normal value when treated with aqueous extract of the root samples.
Histopathological observation also proved the hepatoprotectivity of the root samples. 相似文献
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Winston Costa Pereira Muddanna S. Rao D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2003,18(2):161-168
Immunization with a proper dose of an antigenic stimulus leads to cell proliferation and antibody response of circulating
lymphocytes. We have previously observed that Secondary immunized spleenocytes resist ceramide-mediated apoptosisin vitro. Our present study is aimed at investigating thein vivo effect of immunization on apoptosis. Mice were subjected to either Primary or Secondary dose with Tetanus Toxoid. Unimmunized
spleenocytes served as controls. Unimmunized, Primary and Secondary immunized mice were later exposed to chemotherapeutic
drugs such as Etoposide/Methotrexate/Vincristine to induce apoptosis. Apoptosis was studied by using the Feulgen reaction
on 5μ thin parafin sections of spleen. It was observed that Secondary immunized mice showed a lower percentage of apoptosis
as compared to Primary or Unimmunized mice that was subjected to either of the chemotherapeutic drugs. It was thus concluded
that Secondary immunization inhibits the process of chemotherapeutic drug induced apoptosis in vivo. 相似文献
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Summary In order to understand the mechanism of fauling of electrode surfaces ofin vivo electrochemical sensors used for monitoring whole blood, the investigations on protein adsorption on the membrane surfaces
were undertaken. Using an oxygen sensor, the protein adsorption studies were carried out on two different polymeric surfaces-teflon
(PTFE) and polyurethane (PU)-using Scanning Electron Microscopy and Fourier Transform Infrared Spectrophotometry. Investigations
reveal that even a single protein like albumin or fibrinogen tend to adhere to the sensor membrane surface and influences
the electrochemical characteristics of the sensor. The influence is more significant, in the case of PTFE membrane. 相似文献
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Jyoti Sethi Sushma Sood Shashi Seth Anjana Talwar 《Indian journal of clinical biochemistry : IJCB》2004,19(2):152-155
Ocimum sanctum leaves have been traditionally used in treatment of diabetes mellitus. Dietary supplementation of fresh tulsi leaves in a
dose of 2 gm/kg BW for 30 days led to significant lowering of blood glucose levels in test group. Intake ofOcimum sanctum also led to significant increase in levels of superoxide dismutase, reduced glutathione and total thiols, but marked reduction
in peroxiodised lipid levels as compared to untreated control group. The leaves were found to possess both superoxide and
hydroxyl free radical scavenging action. The present observations establish the efficacy ofOcimum sanctum leaves in lowering blood glucose levels and antioxidant property appears to be predominantly responsible for hypoglycemic
effect. 相似文献
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P Renuka Devi S Krishna Kumari C Kokilavani 《Indian journal of clinical biochemistry : IJCB》2007,22(1):143-147
The effect of the oral administration ofVitex negundo leaf extract on the levels of enzymic and non-enzymic antioxidants were studied in the adjuvant induced arthritic (AIA) rats
The levels of antioxidant enzymes such as SOD, CAT, GPx, G6PD, GSH and Vit-C were estimated in various groups of the experimental
rats. It was observed that the antioxidant enzyme levels in the AIA were significantly low when compared to normal rats. A
significant decrease in enzymic antioxidant—SOD, CAT, GPx, G6PD and non-enzymic antioxidant—GSH, Vit-C were observed in the
liver of AIA rats compared to the normal rats. These results suggest that the leaf extract ofVitex negundo possesses antioxidant activity. 相似文献
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Present study aimed to evaluate the protective role of the aqueous extract of Phyllanthus niruri (P. niruri) against nimesulide-induced
hepatic disoder in mice by determining levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase
(GPT) and alkaline phosphatase (ALP) in serum and also by measuring the hepatic content of the antioxidant enzymes, superoxide
dismitase (SOD) and catalase (CAT); the free radical scavenger, reduced glutathione (GSH) and thiobarbituric acid reacting
substances (TBARS). Aqueous extract of P. niruri was administered either orally or intraperitoneally in different doses and
times as needed for the experiments. Intraperitoneal of the extract (100 mg/kg body weight for seven days) reduced nimesulide
(750 mg/kg body weight for 3 days) induced increased levels of GOT (37.0±1.8 units/ml in control group vs. 91.8±2.0 units/ml
in nimesulide treated group vs. 35.0±1.0 units/ml in extract treated group), GPT (30.0±2.1 units/ml in control group vs. 88.4±2.9
units/ml in nimesulide treated group vs. 34.1±1.8 units/ml in extract treated group), and ALP (7.86±0.47 KA units/ml in control
group vs. 23.80±0.60 KA units/ml in nimesulide treated group vs. 7.30±0.40 KA units/ml, in extract treated group) to almost
nomal. In addition, P. niruri restored the nimesulide induced alterations of hepatic SOD (550±20 units/mg total protein in
control group vs. 310±13 units/mg total protein in nimesulide treated group vs. 515±10 units/mg total protein in extract treated
group), CAT (99.5±2 units/mg total protein in control group vs. 25.0±1.5 units/mg total protein in nimesulide treated group
vs. 81.0±0.8 units/mg total protein in extract treated group), GSH (90±3 nmoles/mg total protein in control group vs. 17±4.2
nmoles/mg total protein in nimesulide treated group vs. 81±1 nmoles/mg total protein in extract treated group) and TBARS (measured
as MDA, 36.6±3.0 nmoles/g liver tissue in control group vs. 96.3±5.2 nmoles/g liver tissue in nimesulide treated group vs.
41.2±1.7 nmoles/g liver tissue in extract treated group) contents. Dose-dependent studies showed that the herb could protect
liver even if the nimesulide-induced injury is severe. Intraperitoneal administration of the extract showed better protective
effect than oral administration. Combining all, the data suggest that P. niruri possesses hepatoprotective activity against
nimesulide-induced liver toxicity and probably acts via an antioxidant defense mechanism. To the best of our knowledge, this
is the first report of the hepatoprotective action of P. niruri against nimesulide induced liver damage. 相似文献
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R. Kaleysa Raj C. G. Pradeep C. Maya Devi Linda John M. R. Rekha Sheeba K. Oommen 《Indian journal of clinical biochemistry : IJCB》1997,12(1):32-34
ES materials released along with the release of mf showed immunosuppression as evidenced by a decrease in T lymphocyte levels in the immunised animals. Lipid fractions of the mf associated ES materials and protein fractions of the detergent soluble materials were found to cause suppression of immune response in the host. Further study revealed that the suppression associated with the lipid fractions is actually the end result and that mf associated ES materials is actually a mixture of immunosuppressive and immunopotentiating components and the release of the components is most likely regulated. 相似文献
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Santosh Kumar Singh Achyut Narayan Kesari Prashant Kumar Rai Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2007,22(2):48-52
The present study reveals the effect of Musa paradisiaca stem juice on blood glucose level (BGL) of normal & diabetic rats.
The dose of 500 mg/kg bodyweight produces a significant rise of 28.3% in blood glucose level after 6h of oral administration
in normal rats. Whereas, in sub diabetic rats the same dose produces a rise of 16.4% in blood glucose levels within 1h during
glucose tolerance test (GTT) and a rise of 16% after 4 h in fasting blood glucose levels of severe diabetic cases. These results
were unexpected and important to report as other species of Musa like Musa sapientum has been reported for its hypoglycemic
effect. 相似文献
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The antiulcerogenic effects of the methanolic extract ofSolanum nigrum berries (SBE) on aspirin induced ulceration in rats with respect to antioxidant status in the gastric mucosa have been investigated.
Oxygen free radicals are considered to be important factors in the pathogenesis of gastric ulcer. The level of lipid peroxides,
which were elevated highly in rats with acute gastric mucosal injury was taken as an index of oxidative stress. The activities
of antioxidant defense enzymes were also decreased considerably by oral gastric administration of aspirin. The decreased levels
of antioxidant enzymes and increased mucosal injury were altered to near normal status upon pretreatment with (SBE) when compared
to the ulcer induced rats. The results indicate that (SBE) may exert its gastroprotective effect by a free radical scavenging
action. Our observations suggest that (SBE) may have considerable therapeutic potential in the treatment of gastric diseases. 相似文献
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K. A. Faseehuddin Shakir Basavaraj Madhusudhan 《Indian journal of clinical biochemistry : IJCB》2007,22(2):129-131
Antioxidant property of flaxseed chutney was evident by decreasing lipid peroxidation (TBARS) and predictor enzyme γ-glutamyl
transpeptidase profile and micronuclei formation in azoxymethane treated rats. After 10 weeks, rats fed with either fiber-free
basal diet or Antioxidant diet exhibited over sevenfold increase in γ-glutamyl transpeptidase activity and nearly fourfold
increase in micronuclei load in comparison to controls (p<0.001). A significant reduction in both γ-glutamyl transpeptidase
level (52%) and micronuclei formation (47%) was observed in fiber-free basal diet/Antioxidant diet/flaxseed chutney diet fed
rats. Relative to rats fed fiber-free basal diet, the profile of γ-glutamyl transpeptidase and micronuclei load was not significantly
altered. 相似文献
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P. Pavana S. Sethupathy S. Manoharan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):77-83
The aim of the present study was to evaluate the antihyperglycemic and antilipidperoxidative effects of ethanolic seed extract
ofTephrosia purpurea (TpEt) in streptozotocin induced diabetic rats. Hyperglycemia associated with an altered hexokinase and glucose 6 phosphatase
activities, elevated lipid peroxidation, disturbed enzymatic and non-enzymatic antioxidants status were observed in streptozotocin
induced diabetic rats. Oral administration of “TpEt” at a dose of 300mg/kg bw showed significant antihyperglcemic and antilipidperoxidative
effects as well as increased the activities of enzymatic antioxidants and levels of non enzymatic antioxidants. We also noticed
that the antihyperglycemic effect of plant drug (TpEt) was comparable to that of the reference drug glibenclamide. Our results
clearly indicate that “TpEt” has potent antihyperglycemic and antilipidperoxidative effects in streptozotocin induced diabetic
rats and therefore further studies are warranted to isolate and characterize the bioactive antidiabetic principles from “TpEt”. 相似文献
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Y. K. Murali Ramesh Chandra P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2004,19(2):202-204
Water extract of dry fruits ofTerminalia chebula (Hindi-Harda, Telugu-Karakkaya) at a dose of 200 mg/kg body weight improved the glucose tolerance as indicated by 44% of
reduction in the peak blood glucose at 2nd hour in glucose tolerance test in diabetic (streptozotocin induced) rats. Treatment of diabetic rats with an initial fasting
blood glucose of 253±9.4 mg/dl daily once with the water extract (200 mg/kg) for two weeks brought down the fasting blood
glucose to 123±8.4 mg/dl which is only slightly above the normal value. These results indicate that water extract of Terminalia
chebula improves glucose tolerance and brings down fasting blood glucose in diabetic rats. 相似文献