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1.
用单光子吸收法（ＳＰＡ）对杭州市汉族５０岁以上的８０例非胰岛素依赖性糖尿病（ＮＩＤＤＭ）患者和年龄、性别与ＮＩＤＤＭ患者相配对的４３１名正常人的前臂尺、桡骨骨密度（ＢＭＤ）进行测定，发现女性轻中型和重型组、男性重型组ＮＩＤＤＩＭ患者的尺桡骨平均ＢＭＤ显著地低于正常人（Ｐ＜０．０１）；本组ＮＩＤＤＭ患者（男女合计）的一般性骨质疏松症（ＧＯＰ）和进行性骨质疏松症（ＰＯＰ）的发病率分别为６３．７５％和８．７５％，与正常人组相比较差异非常显著（Ｐ＜０．０１）；不同病程ＮＩＤＤＭ患者组别间尺桡骨平均ＢＭＤ的差异不显著（Ｐ＞０．０５），提示ＮＩＤＤＭ的病程与ＢＭＤ的相关程度不密切。 相似文献
2.
应用症状自评量表（Ｓｃｌ－９０）对我院九六级新生进行问卷调查．结果发现Ｓｃｌ－９０各因子总均分为１．３６～１．７１．阳均分为２．２８～２．５３，阳性项目数为２７．９１～４０．３４，均高于国内正常青年组．心理问题较多的项目是强迫、人际敏感、偏执和敌对，其中达中等严重程度的占４．４％以上．财经类大学生的心理问题各因子分比例不尽相同，财政专业学生发生的心理异常现象显著多于其它专业（Ｐ＜０．０５或Ｐ＜０．０１）． 相似文献
3.
报告１０８例病毒性肝炎患者血清总补体（ＣＨ＿（５０））和Ｃ＿３值的检测结果：急性肝炎的ＣＨ＿（５０）为６８．４±６．１３单位／ｍｌ，Ｃ＿３为１３０．２±６．６７ｍｇ％，均高于正常组（ＣＨ＿（５０）为４８．５±５．７５单位／ｍｌ，Ｃ＿３为１０２±５ｍｇ％），Ｐ＜０．０１；其他类型的肝炎患者组的补体均低于正常组，Ｐ＜０．０１．补体的含量与Ｔ细胞花环（Ｅｔ花环）呈中度相关，与ＧＰＴ呈高度相关，因此测定ＣＨ＿（５０）和Ｃ＿３可作为衡量患者机体免疫功能和判断病毒性肝炎预后的指标之一。 相似文献
4.
本文对夏秋季节≤３１００，≤３８００和≤４５００ｍ三种海拔高度污水进行细菌总及种类的调查，经ｔ和ｘ＾２检验，三种海拔高度之间细菌总数相差不显著，（Ｐ〉０．０５）；三种海拔检出的细菌除≤３８００ｍ的绿脓杆菌与另两组相差特别显著外（ｐ〈０．０１）其它细菌与海拔高度无关；三种海拔高度之间细菌总阳性检出率相差不显著（Ｐ〉０．０５），说明夏秋季节在≤４５００ｍ海拔高度的污水，除绿脓杆菌外，海拔高度对细菌生长 相似文献
5.
牙周病患者唾液中一氧化氮含量的研究 总被引：2，自引：0，他引：2
通过检测牙周病患者唾液亚硝酸盐的含量来代表一氧化氮的含量,对１５例牙龈炎患者、１７例牙周炎患者和２７例正常对照唾液一氧化氮的含量进行了检测．结果表明,正常对照唾液一氧化氮的含量为２８．８０６±６．６０４μｍｏｌ／Ｌ,男女间无显著性差异（Ｐ＞０．０５）,牙龈炎和牙周炎患者唾液一氧化氮的含量分别为３４．３６５±７．１４８μｍｏｌ／Ｌ、５６．２１４±１３．５３７μｍｏｌ／Ｌ,均明显高于正常对照（Ｐ＜０．０２,Ｐ＜０．０１）,牙周炎患者唾液一氧化氮的含量明显高于牙龈炎（Ｐ＜０．０１）．提示唾液一氧化氮含量的变化与牙周病有密切关系． 相似文献
6.
５９例诊断为耳部化脓性感染的门诊病人按随机分组，双盲法给药，分别接受氟嗪酸滴耳剂和氯霉素眼液滴耳治疗，显效率分别为７１．１％和３８．１％，有显著差异（Ｐ＜０．０１），包括两名儿童在内的所有病人均示出现头晕、耳鸣、耳聋加重等副反应，２９例细菌学结果显示，氟嗪酸组细菌阴转率为９４．７％，远高于氯霉素组（５５．６％）。 相似文献
7.
慢性肺心病患者血清TNF-α及IL-8改变及意义 总被引：3，自引：0，他引：3
探讨了慢性肺心病（ＣＰＨＤ）急性加重期及经治疗缓解后血清白细胞介素－８（ＩＬ－８）和肿瘤坏死因子－α（ＴＮＦ－α）水平的变化．用双抗体夹心ＥＬＩＳＡ法检测了３０例ＣＰＨＤ患者急性加重期及治疗缓解后血清ＩＬ－８和ＴＮＦ－α,并与相应年龄的健康对照组比较．结果发现ＣＰＨＤ患者急性加重期血清ＩＬ－８及ＴＮＦ－α水平显著高于正常对照组（Ｐ＜０．０５）,且治疗缓解后血清ＴＮＦ－α水平显著降低（Ｐ＜０．０５）,而血清ＩＬ－８水平则基本不变（Ｐ＞０．０５）．说明ＩＬ－８、ＴＮＦ－α参与了ＣＰＨＤ的发生和发展,这为探求治疗新途径提供了依据． 相似文献
8.
用脑电地形图（ＢＥＡＭ）技术观察了３０例急性脑血管意外患者．并同时进行了脑电图（ＥＥＧ）检查，其中２３例作了ＣＴ扫描．结果表明，ＢＥＡＭ对急性脑血管意外的阳性率、定侧率与ＥＥＧ比较均有显著差异（Ｐ＜０．０５）；与ＣＴ比较总阳性率无明显差异（Ｐ＞０．０５）；但三无内检查阳性率有显著差异（Ｐ＜０．０５）． 相似文献
9.
高原健康老人红细胞免疫功能及其调节因子的变化研究 总被引：1，自引：0，他引：1
目的：了解高原健康老人细胞免疫功能的变化状况。方法：采用红细胞酵母菌花环法,检测了生活居住在拉萨的健康老人３７人的红细胞免疫粘附功能及血清中红细胞免疫粘附调节因子活性,与生活居住在同地的青壮年４４人进行了比较。结果：老年组红细胞Ｃ３ｂ受体花不率及红细胞Ｃ３ｂ花环促进率明显低于青壮年组（Ｐ〈０．０１）,而红细胞免疫复合物花环率及红细胞Ｃ３ｂ受体花环抑制率明显高于青壮年组（Ｐ〈０．０１和〈０．０５）, 相似文献
10.
同步辐射对直肠癌组织微量元素测定的意义探讨 总被引：2，自引：0，他引：2
采用同步辐射荧光分析光谱法（ＳＲＸＦＳ）对９例直肠癌及癌旁移行粘膜和正常粘膜中微量元素的含量进行分析，结果显示，癌组织中Ｃｕ、Ｚｎ、Ｍｎ三种微量元素相对含量分别为３８１９９．１６、１５５５７．０４和２０９．８６，显著低于正常粘膜组织（Ｐ＜０．０５，或Ｐ＜０．００１）；而宏量元素Ｃｌ含量为３４３８．１６，显著高于正常粘膜（Ｐ＜０．０５）。癌旁移行粘膜中Ｃｕ、Ｚｎ、Ｍｎ、Ｃｌ、Ｔｉ、Ｓｅ元素含量介于癌组织和正常粘膜之间，作者认为，微量元素Ｃｕ、Ｚｎ、Ｍｎ可能是直肠癌的相关性元素，癌旁移行粘膜多种元素含量变化趋势，提示癌旁移行粘膜可能是一类潜在性交界性瘤变。 相似文献
11.
Bibhas Roy Gautam Chattopadhyay Debasish Mishra Tamal Das Suman Chakraborty Tapas K. Maiti 《Biomicrofluidics》2014,8(3)
An on-chip lectin microarray based glycomic approach is employed to identify glyco markers for different gastritis and gastric cancer. Changes in protein glycosylation have impact on biological function and carcinogenesis. These altered glycosylation patterns in serum proteins and membrane proteins of tumor cells can be unique markers of cancer progression and hence have been exploited to diagnose various stages of cancer through lectin microarray technology. In the present work, we aimed to study the alteration of glycan structure itself in different stages of gastritis and gastric cancer thoroughly. In order to perform the study from both serum and tissue glycoproteins in an efficient and high-throughput manner, we indigenously developed and employed lectin microarray integrated on a microfluidic lab-on-a-chip platform. We analyzed serum and gastric biopsy samples from 8 normal, 15 chronic Type-B gastritis, 10 chronic Type-C gastritis, and 6 gastric adenocarcinoma patients and found that the glycoprofile obtained from tissue samples was more distinctive than that of the sera samples. We were able to establish signature glycoprofile for the three disease groups, that were absent in healthy normal individuals. In addition, our findings elucidated certain novel signature glycan expression in chronic gastritis and gastric cancer. In silico analysis showed that glycoprofile of chronic gastritis and gastric adenocarcinoma formed close clusters, confirming the previously hypothesized linkage between them. This signature can be explored further as gastric cancer marker to develop novel analytical tools and obtain in-depth understanding of the disease prognosis. 相似文献
12.
Saroj Kant Sinha Satya Vati Rana Deepak Kumar Bhasin Kusum Joshi 《Indian journal of clinical biochemistry : IJCB》2005,20(1):169-172
Duodenal ulcer is a common disease and is considered acid-peptic disease. Duodenal ulcer patients are known to have higher
incidence of antral gastritis and duodentitis than general population. Thus one can expect some alteration in the enzyme products
of mucosal cells of antrum and duodenum in this condition. The present study was planned in 30 patients of duodenal ulcer
and 30 of non-ulcer dyspepsia. After overnight fast, upper gastrointestinal endoscopy was done using forward viewing fibreoptic
endoscope. Two pairs of biopsies were taken from the antrum and two from the descending duodenum using standard biopsy forceps.
One pair of biopsy from each site was taken in 10% formal saline for histopathological examination. One pair of biopsies from
each site was collected in saline for the measurement of disaccharidases by Dahlquist method. Activities of lactase, sucrase
and maltase were significantly higher in descending duodenum mucosa as compared to antral mucosa in both groups. Activities
of these enzymes in antrum and duodenum of both groups did not differ significantly. No significant difference was found in
disaccharidases in antrum and descending duodenum in patients with or without histological gastritis. This study suggests
that the disaccharidases do not change in antrum and duodenum of ulcer patients as compared to the patients with non-ulcer
dyspepsia. 相似文献
13.
Ragini Srivastava Antara Kashyap Mohan Kumar Gopal Nath Ashok Kumar Jain 《Indian journal of clinical biochemistry : IJCB》2013,28(1):19-23
Helicobacter pylori infection stimulates strong local inflammatory and specific IgA antibody production. The influence of antibodies on the bacterial colonization is not clear. Here, we have analysed the association between the mucosal IgA level and IL-1β in various manifestations of the infection seen endoscopically. Antral biopsies of 57 dyspeptic patients were taken for culture, histology and estimation of mucosal levels of anti-H. pylori IgA and IL-1β. Mean mucosal IgA level was higher in patients with normal mucosa compared to all other groups and lower IgA level was associated with higher bacterial density. IL-1β was higher in ulcer patients and suspicious malignancy group as compared to normal group and higher level of IL-1β was associated with higher grades of metaplasia. Present study indicates that local immunity seems to have a protective role against H. pylori infection and higher level of IL-1β induced by the pathogen may be associated with metaplasia and carcinogenesis. 相似文献
14.
BackgroundIn order to study the influence of long-term growth process and evolution environment on intestinal bacteria of different breeds, the intestinal bacteria and volatile fatty acids among the faeces of Min, Landrace and Yorkshire pigs were analysed by Illumina high-throughput sequencing of the 16S-rDNA and gas chromatography.ResultsThe shared core microbiota of Landrace, Yorkshire and Min pig were 1273, accounting for 69.56% of total abundance of organisms. The proportion of Firmicutes in Min pig faeces (57.89%) was significantly higher than that in Landrace and Yorkshire pig faeces (47.01% and 46.40%, respectively) (P < 0.05), but that of Bacteroidetes was exactly opposite. Moreover, Min pig presented more highly efficient membrane transport, environmental adaptation, carbohydrate transport, and metabolism than Yorkshire pig (P < 0.05). The acetic acid/total volatile fatty acid ratio in Min pig was significantly higher than that in Landrace pig (P < 0.05), and the isobutyric acid/ total volatile fatty acid ratio in Min pig was significantly larger than that in Yorkshire pig (P < 0.05). Furthermore, the content of branched chain volatile fatty acids in Min pig was significantly higher than that in Yorkshire pig (P < 0.05).ConclusionsThis study demonstrated that Min pig, as an excellent breed in the cold area of China, possessed special intestinal floral structure compared to the imported pigs in order to satisfy their physiological and metabolic demands, which may influence their characteristics such as resistance to cold, diseases, and crude feeding, and the ability to deposit intramuscular fat.How to cite: Yang Y, Sun C, Li F, et al. Characteristics of faecal bacterial flora and volatile fatty acids in Min pig, Landrace pig, and Yorkshire pig. Electron J Biotechnol 2021;53. https://doi.org/10.1016/j.ejbt.2021.05.002 相似文献
15.
目的:观察逍遥散治疗慢性乙型病毒性肝炎的临床疗效。方法:100例慢性乙型病毒性肝炎患者随机分为两组,观察组50例在对照组基础上口服逍遥散,150ml/次,3次/d;对照组50例口服恩替卡韦分散片,0.5mg/次,1次/d。两组患者均治疗3个疗程共12周,观察两组患者治疗前后的临床症状、体征、HBV-DNA、肝功能的变化程度。结果:观察组患者临床疗效总有效率显著高于对照组(98%vs 84%),两组间比较差异有显著性意义(P0.05)。结论:加服逍遥散治疗慢性乙型病毒性肝炎有较好的疗效,值得临床进一步研究应用。 相似文献
16.
目的：探讨影响儿童过敏性紫癜（Henoch-Schonlein Purpura,HSP）复发的相关因素,以及采取的预防措施。方法：选取2012年01月至2013年12月在某市级儿童医院住院确诊为HSP,初发病例的患儿作为研究对象,进行回顾性分析。共收集364例患儿,其中失访16例,选择符合诊断标准的患儿348例为研究对象。结果：复发组年龄≥7岁构成比、感染发生率、食物过敏发生率、肾脏受累发生率明显高于未复发组,差异显著（P〈0.05）;复发组男女比例为1.77∶1,未复发组男女比例为1.05∶1,两组男女构成比差异具有统计学意义（P〈0.05）;两组在地区（生活农村、城镇）、发病季节、关节症状、消化道症状、皮疹发生率差异无统计学意义（P〉0.05）。结论：对有上述异常指标患儿应加强随访观察,积极寻找、消除诱因,避免疾病复发与恶化。 相似文献
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目的了解高职院校大学生焦虑、心理压力特．点及相互关系,为增进高职生身心健康提供依据。方法采用《中国大学生心理应激量表》（CCSPSS）,《状态特质焦虑问卷》（STAI）对石家庄市763名高职生进行测查。结果高职生状态焦虑水平高于一般人群常模,与心理压力呈正相关,特质焦虑水平无明显差异,与心理压力不存在相关关系。状态、特质焦虑在性别、年级、城乡变量上差异无统计学意义。高职生学习、生活、发展、社交、家庭压力及压力总分低于大学生常模群体,差异均有统计学意义（P〈0．01）。女生社交压力高于男生,差异有统计学意义（P〈O05）。农村来源的学生学习压力高于城市来源学生,（P〈0．05）。不同年级在学习、生活、发展、社交及心理压力总分方面差异有统计学意义（P〈0．01）,一年级学习压力最高,二年级总的心理压力和发展压力最高,三年级总的心理压力及各方面压力最低。结论心理压力是状态焦虑的重要相关因素,应针对不同情况,加强高职生学习、社交、生活适应教育,从而缓解心理压力,减轻焦虑。 相似文献
19.
Anurag Srivastava L. D. Joshi S. P. Singh 《Indian journal of clinical biochemistry : IJCB》1989,4(1):50-57
Normal and alloxan induced diabetic guinea pigs were kept on whole seed diet of green gram for 4 weeks. Serum total lipids
were found to be significantly decreased in both normal and diabetic guinea pigs (P <0.001)—Both free and esterified fractions
of cholesterol were found to be lowered significantly in diabetic animals (P<0.05; <0.01, respectively), whereas only esterified
fraction was reduced significantly in case of normals (P<0.05). Significant lowering of triglyceride levels (P<0.01) was also
noticed in both normal as well as diabetic guinea pigs while phospholipids remained almost unaffected. Green gram feeding
decreased the total cholesterol / phospholipid ratio from 0.630 to 0.625 in normal and from 1.039 to 0.850 in diabetic guinea
pigs indicating its antiatherogenic nature. 相似文献