首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献，搜索用时 156 毫秒
1.
肿瘤的生长需要依靠自身血管供氧和营养物质,血管内皮生长因子(VEGF)在调节血管生成中起着非常重要的作用,是内皮细胞的增殖以及迁移等重要的影响因子.目前,血管内皮生长因子抑制剂作为一类新型的小分子抗肿瘤药物,已经在临床治疗上得到了成功的应用.近年,已研究出多种对VEGF及其受体具有高选择性的抑制剂.本文从不同血管内皮生长因子抑制剂出发,综述了以VEGF/VEGFR为靶点的抗肿瘤药物的研究进展,为癌症的治疗提供有效的临床策略.  相似文献   

2.
目的 :检测鼻咽癌中血管内皮生长因子 (Vascularendothelialgrowthfactor ,VEGF)的表达和微血管计数 (Microvesselcount ,MVC) ,以探讨其相互关系及临床意义 .方法 :采用免疫组织化学S -P法 ,检测 6 8例鼻咽癌NPC和 12例鼻咽部粘膜慢性炎症的石蜡标本组织中血管内应生长因子 (VEGF)的表达 ,并根据Ⅷ因子相关抗原标记的内皮细胞对微血管进行计数 .结果 :1) 6 8例鼻咽癌标本中 4 1例VEGF检测阳性 (6 0 3% ) ,对照组 12例鼻咽部粘膜慢性炎症标本组织均未见阳性着色 . 2 )鼻咽癌组织中的MVC显著高于鼻咽部粘膜慢性炎症组 ,鼻咽癌组织中VEGF表达和MVC转移组均高于非转移组 ,差异有显著意义 (P <0 . 0 1) . 3)鼻咽癌组织中的VEGF表达和MVC随着临床分期上升而升高 . 4 )在鼻咽癌中VEGF表达与MVC呈正相关 (r=0 . 75 5 5 9) ,相关有显著性 (P <0 0 0 1) .结论 :鼻咽癌组织中VEGF表达和微血管计数与癌生物学行为密切相关 ,有可能作为判断肿瘤生物学行为 ,转移潜能及预后指标 .对采用血管生成抑制剂防止鼻咽癌转移有参考价值  相似文献   

3.
本研究通过比较间歇性跛行(IC)和严重肢体缺血(CLI)患者的血液参数,选择合适的临床和生化特指标,以评估促血管生成的潜力和抑制血管生成的作用.结果表明,通过刺激下肢动脉疾病(LEAD)病人血浆中的血管生成,内皮生长因子A(VEGF-A)浓度会显著增加,同时依赖于循环受体sVEGFR-1和sVEGFR-2的抑制也会显著减少.与IC病人相比,CLI病人具有较高的VEGF-A、金属蛋白酶9(MMP-9)、金属蛋白酶组织抑制因子1(TIMP-1)和TIMP-2浓度.  相似文献   

4.
为了提高血管内皮生长因子(VEGF)121的免疫原型,文章用戊二醛一步偶联法将VEGF121与HSP65偶联形成HSP65-VEGF121复合物,并研究其免疫学效果,结果发现HSP65可以提高VEGF121的免疫原性,但抗肿瘤效果并未显著增强.  相似文献   

5.
研究目的:探讨血糖控制良好的2型糖尿病患者血管内皮生长因子-A(VEGF-A)及其受体VEGFR1和VEGFR2含量及其临床意义。研究方法:本文以31例血糖得到良好控制且没有明显大血管或微血管病变的2型糖尿病患者作为研究对象(实验组),30位健康志愿者为对照组,同期检测患者及健康志愿者的空腹血糖、血脂、糖化血红蛋白水平,及血清VEGF-A、VEGFR1和VEGFR2含量,并加以比较和统计学分析。重要结论:研究结果表明,血糖控制良好的2型糖尿病患者血清中的VEGF-A及其受体VEGFR1和VEGFR2的含量和健康志愿者基本一致,两者无统计学意义,这可能显示血糖水平的合理控制能延缓血管并发症的产生。同时,2型糖尿病患者的血清VEGFR2含量和高密度脂蛋白胆固醇水平之间存在负相关,而血清VEGF-A、VEGFR2含量和甘油三脂水平之间存在正相关,这也表明糖尿病患者的血脂紊乱可能参与了血管生成的调节。  相似文献   

6.
VEGF在胃癌中的表达及意义   总被引：1，自引：0，他引：1  
胃癌是人体中最常见、多发、危害最大的恶性肿瘤之一。胃癌的发生、发展及其侵袭转移是一个多因素、多阶段的复杂过程,而新血管生成是其重要的前提条件之一,是影响肿瘤发生与否的关键环节。血管内皮生长因子(Vascu-lar endothelial growth factor,VEGF)是促进内皮细胞分裂和血管生成的重要因子,在胃癌的生长、转移过程中,VEGF扮演者重要的角色,它在血管内皮细胞、淋巴管内皮细胞的分裂增殖过程中起关键作用,它与血管、淋巴管的发生、发展密切相关。一、VEGF和VEGF受体家族VEGF家族是内皮细胞的特异有丝分裂原,是一种多肽生长因子,能增强内皮细胞的生存能力,促进有丝分裂,增强趋化性和血管渗透性。VEGF家族包括VEGF-A、VEGF-B、VEGF-C、VEGF-D、VEGF-E和胎盘生长因子(PLGF)。VEGF-A主要调节血管的生成;VEGF-C和VEGF-D主要调节淋巴管的生成;VEGF-B在结构上类似VEGF-A和PLGF,它在结直肠癌的转移淋巴结中有高水平表达,但它的具体功能还没完全明了;VEGF-E结构类似VEGF-A,能够有效促进血管的生成。VEGF-A基因定位于6P21.3染色...  相似文献   

7.
目的探讨介入化疗对直肠癌血管内皮生长因子表达(VEGF)及微血管计数(MVD)的影响.方法对34例直肠癌患者介入化疗前后的肿瘤组织,用CD34对VEGF表达进行测定,并进行MVD计数.结果本组患者介入化疗前及后4至5周VEGF阳性表达率分别为61.7%(21/34)、32.4%(11/34),MVD计数明显降低,差异均有显著性意义(P＜0.01);结论介入化疗能降低直肠癌组织VEGF的表达,减少MVD计数,提示介入化疗可能调节直肠癌的分化程度,减少术后转移.  相似文献   

8.
目的:探讨保心汤对稳定型心绞痛患者血管内皮生长因子(VEGF)和心率变异性(heart rate variability,HRV)的影响.方法:82例冠心病稳定型心绞痛患者随机分为 2组,中药组服用常规西药加中药保心汤,常规组服用常规西药.治疗前和治疗 4周后分别检测 2组血浆 VEGF和24h动态心电图HRV的变化.结果:血浆 VEGF和 HRV治疗前 2组比较差异无显著性;治疗后中药组VEGF明显增加(P<0.05),常规组无明显变化;两组均能改善HRV,但中药组改善更加明显 (P<0.005).结论:保心汤能提高血浆VEGF和改善心率变异性,通过促进冠脉侧支循环的建立而达到治疗冠心病及改善预后的目的.  相似文献   

9.
目的：探讨血管内皮生长因子（VEGF）在膀胱移行细胞癌中的表达及临床意义。方法：采用免疫组化、ELISA方法对45例膀胱移行细胞癌组织、血浆和10例正常膀胱黏膜组织、30例正常成人血浆中VEGF进行检测分析。结果：VEGF在膀胱移行细胞癌患者中呈高表达，且随分期、分级的增高而增高；膀胱癌手术前患者血浆中VEGF的浓度高于手术后。结论：1．VEGF的表达与膀胱移行细胞癌的病理分级、临床分期及生物学行为有密切关系；2．血浆中VEGF水平可有助于预测膀胱癌患者手术疗效。  相似文献   

10.
目的:探讨肺癌血管内皮生长因子(VEGF)的表达与非小细胞肺癌临床病理特征的关系及其临床意义。方法:用免疫组化SP法检测87例非小细胞肺癌(non small cell lung cancer,NSCLC)组织、17例良性肺疾病和6例正常肺组织中VEGF的表达。结果:在NSCLC组织中血管内皮细胞VEGF的高表达率62.69%(54/87),良性肺疾病和正常肺组织中的高表达率4.35%(1/23),两者比较有显著性差异,P<0.01;低分化NSCLC细胞胞质VEGF的高表达率90.63%(29/32)明显高于高、中分化NSCLC细胞胞质的高表达率45.45%(25/55),P<0.01;在有淋巴结转移的NSCLC细胞胞质中VEGF高表达率90.20%(46/51),明显高于无淋巴结转移组的高表达率22.22%(8/36),P<0.01;NSCLC胞质中VEGF蛋白高表达率与临床分期密切相关,Ⅲ、Ⅳ期高于Ⅰ、Ⅱ期,分别是87.50%(49/56),16.13%(5/31),P<0.01。结论:VEGF高表达与NSCLC的生物学行为密切相关,它的高表达提示NSCLC患者预后不良。  相似文献   

11.
Plexiform lesions (PLs), which are often accompanied by perivascular infiltrates of mononuclear cells, represent the hallmark lesions of pulmonary arteries in humans suffering from severe pulmonary arterial hypertension (PAH). Endothelial progenitor cells (EPCs) have been recently implicated in the formation of PLs in human patients. PLs rarely develop in rodent animal models of PAH but can develop spontaneously in broiler chickens. The aim of the present study was to confirm the presence of EPCs in the PLs in broilers. The immune mechanisms involved in EPC dysfunction were also evaluated. Lungs were collected from commercial broilers at 1 to 4 weeks of age. The right/total ventricle ratios indicated normal pulmonary arterial pressures for all sampled birds. Immunohistochemistry was performed to determine the expressions of EPC markers (CD133 and VEGFR-2) and proangiogenic molecule hepatocyte growth factor (HGF) in the lung samples. An EPC/lymphocyte co-culture system was used to investigate the functional changes of EPCs under the challenge of immune cells. PLs with different cellular composition were detected in the lungs of broilers regardless of age, and they were commonly surrounded by moderate to dense perivascular mononuclear cell infiltrates. Immunohistochemical analyses revealed the presence of CD133+ and VEGFR-2+ cells in PLs. These structures also exhibited a strong expression of HGF. Lymphocyte co-culture enhanced EPC apoptosis and completely blocked HGF-stimulated EPC survival and in vitro tube formation. Taken together, this work provides evidence for the involvement of EPCs in the development of PLs in broilers. It is suggested that the local immune cell infiltrate might serve as a contributor to EPC dysfunction by inducing EPC death and limiting their response to angiogenic stimuli. Broiler chickens may be valuable for investigating reversibility of plexogenic arteriopathy using genemodified inflammation-resistant EPCs.  相似文献   

12.
Extracellular signal-regulated protein kinase 5 (ERK5), also known as big mitogen-activated protein kinase 1 (MAPK1), is an important member of ERK family, which is a subfamily of the large MAPK family. ERK5 is expressed in many tissues, including the dorsal root ganglion (DRG) neurons and the spinal cord. In this review, we focus on elaborating ERK5-associated pathway in pathological pain, in which the ERK5/CREB (cyclic adenosine monophosphate (cAMP)-response element-binding protein) pathway plays a crucial role in the transduction of pain signal and contributes to pain hypersensitivity. ERK5 activation in the spinal dorsal horn occurs mainly in microglia. The activation of ERK5 can be mediated by N-methyl-d-aspartate (NMDA) receptors. We also elaborate the relationship between ERK5 activation and nerve growth factor-tyrosine kinase A (NGF-TrkA), and the connection between ERK5 activation and brain-derived neurotrophic factor (BDNF) in pathological pain in detail.  相似文献   

13.
280 Colombian infants at risk of malnutrition were randomly assigned to 1 of 4 experimental groups formed by the presence/absence of 2 interventions: (1) food supplementation for the entire family, from mid-pregnancy until the target child was 3 years old, and (2) a twice-weekly home-visiting program to promote cognitive development, from birth until age 3. All families received free medical care and were studied prospectively. At 3 years of age, children who had received food supplementation averaged 2.6 cm and 642 grams larger than controls. Home visiting and supplementation together reduced the number of children with severe growth retardation. 3 years after intervention (age 6), supplementation effects remained. Children in the home visit condition had become larger than controls, by 1.7 cm and 448 grams. The interactive effect to reduce stunting was marginally significant at this age, and the overall distribution of scores was improved. Other results suggest that changes in family functioning as well as biological mechanisms account for the observed pattern of results.  相似文献   

14.
We examined models of individual change and correlates of change in the growth of reading skills in a sample of 40 children from kindergarten through third grade. A broad range of correlates was examined and included family literacy, oral language, emergent reading, intelligence, spelling, and demographic variables. Individual growth curve analysis was used to model change in Letter Word Identification (LWID), Word Attack (WA), and Passage Comprehension (PC) subtests of the Woodcock–Johnson Psychoeducational Battery – Revised. Third grade LWID was predicted uniquely by family literacy, phonological awareness, and emergent reading skills. Growth in LWID was predicted uniquely by emergent reading skills. Phonological awareness, spelling, and emergent reading were unique predictors of third grade WA, whereas family literacy and emergent reading skills uniquely predicted third grade PC. The general oral language factor defined by semantic and syntactic variables did not contribute significant unique variance in any of the models. Thus, the pattern of results extends the model of emergent-to-conventional literacy proposed by Whitehurst and Lonigan (1998) to third grade and suggests that early contextual understandings necessary for competent reading (family literacy and emergent reading) become more influential as reading skills develop.  相似文献   

15.
The analysis of the association between educational status and fertility decline is performed 1) by examining the rates of enrollment in primary and secondary schools by gender and 2) by assessing the effects of the change/spread in rates of enrollment between 1965 and 1986. 59 countries were involved in the cross-sectional analysis. Variables included the logged crude birth rate, total enrollment rates, enrollment rates by gender, male-female ratios, the growth rate for each educational measure by world system status (core, peripheral, and semiperipheral countries), control variables (economic growth, family planning, multinational corporate penetration, women's labor force participation, child mortality rate, social insurance programs), and enrollment changes. The evidence reflects a strong association between levels of enrollment of girls in primary and secondary school and gender inequality and fertility declines. Caldwell's theory of the flows of wealth and the spread of education effect was found to have little support. High levels of female enrollment and low levels of gender inequality in access to schooling are associated with fertility declines. Caldwell's theory is that this indicates a decline in patriarchy, change in women's familial roles and a shift to a more egalitarian family structure. Increases in female education mean higher status and more power for women.  相似文献   

16.
近年来 ,连锁和关联分析最流行的方法要属传递不平衡检验 (TDT) 而评估TDT的功效和样本大小至关重要 许多文章已讨论此问题 但以前的方法既不精确也不一般化 他们都作了一个简单的假设 ,即每个家庭仅有一个受累子代或两个受累同胞对或非受累同胞对 一个例外是Chen和Deng发展的方法 但他们并没有考虑不同比例的这些家庭对TDT功效和样本大小的影响 本文应用“PC”软件 ,调查了在四个遗传模式下不同的家庭结构对TDT功效的影响 ,考虑以下三种情形 :(1)不同家庭结构的不同比例 ,(2 )标记和易感基因间的不同重组率 ,(3)父母的不同致病状态 调查具有实践意义 因为在实际中 ,更多的是征集到不同结构的家庭 如何设计不同家庭的比例相当重要  相似文献   

17.
This study evaluated a 4-week program to increase the time families spent engaging in outdoor activity. Parents were provided strategies to increase family outdoor activity and locations to be active. Sixteen families completed the program. Duration and number of family outdoor activity bouts per week, type of activities, locations, and family member attendance were measured using logs. Pre/post surveys were conducted to determine the usefulness of providing educational resources and maps. Compared to baseline (216.1±127.3 min/week), family outdoor activity for weeks 1 (316.1±180.2 min/week), 2 (351.1±209.1 min/week), and 4 (317.5±186.8 min/week) were significantly greater at follow-up. At follow-up, parents reported increased regular exercise and encouragement for their child to be active. Children reported adults engaged in physical activity with them and increased transportation to places to be active. This novel program increased family outdoor activity levels and contributes to limited research on strategies to increase outdoor activity in youth.  相似文献   

18.
The present study concurrently examined protective factors associated with the adaptive outcomes of resilience and posttraumatic growth (PTG; defined as positive psychological change resulting from a life crisis or trauma), after accounting for relevant demographic factors and the impact of circumstances surrounding childhood victimization (i.e., age of first trauma, frequency of victimization, and perception of trauma severity). The protective factors examined in the present study included social support from friends and family, optimism, positive religious coping (i.e., looking to God for support and guidance; forgiveness), and negative religious coping (i.e., feeling abandoned by God; anger towards God). Participants included 161 college students from the US MidSouth, aged 18–24 (Mage = 19.97, SD = 1.86). All participants reported experiencing physical violence and/or sexual abuse during their childhood. Hierarchical multiple regression analyses indicated that after accounting for demographics and circumstances surrounding the childhood victimization, higher resilience was associated with greater family support, optimism, and positive religious coping, while higher posttraumatic growth was associated with greater optimism and positive religious coping. These findings underscore the protective role of optimism with respect to both resilience and posttraumatic growth. Additionally, results highlight the importance of examining cognitions related to religious coping rather than simply assessing broadband religiosity, as only positive religious coping was associated with adaptive outcomes. Findings suggest the importance of early intervention to bolster protective factors (i.e., family support, positive thinking, gratitude, and positive religious coping skills) among youth exposed to childhood physical and sexual victimization.  相似文献   

19.
This study examined growth trajectories of texting (and other media) over a 6‐year time period. Participants were 425 adolescents from Washington, USA (age 13 at Time 1, age 18 at Time 6; 48% male, 68% European American). Analyses suggested a curvilinear pattern for texting and social media use, with rates peaking during midadolescence. There was also considerable heterogeneity in trajectories of texting. A growth mixture model revealed four distinct classes of individuals: perpetuals (14%), decreasers (7%), moderates (68%), and increasers (11%). Higher levels of depression, being a male, and coming from a single‐parent family predicted being a “perpetual” texter. Perpetuals had the most problematic outcomes compared to other classes, including higher depression, anxiety, aggression, and poor relationships with fathers.  相似文献   

20.
应用多目标决策的综合评价方法,对马尾松实生种子园子代测定林进行综合评选,依据对白砂国有林场11年生马尾松实生种子园的调查结果进行多性状综合优化选择,初步筛选出与永定对照(CK1)相比较生长量好且结实量高的家系70个,生长量最好且结实量最高的家系38个,这38个优良家系可以作为下一代种子园优先选择的建园材料。  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号