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1.
目的:探讨5-Fu肠腔化疗辅助结直肠癌根治术的应用及其机制。方法:总结我院1995年2月~2005年5月125例结直肠癌在根治术中辅助应用5-Fu肠腔化疗的临床资料。结果:本组125例无一例死亡,2例术后吻合口漏。经再次手术后治愈;96例随诊1~5年,失访29例,5年存活82例,其中并存肝转移者3例,骨转移者2例。5年生存率65.6%。结论:直肠癌根治术中辅助5-Fu肠腔化疗方法简便,效果明显,值得临床推广应用。  相似文献   

2.
目的探讨15例乳癌术后局部复发患者的治疗方法.方法15例乳癌患者中行单纯乳房切除加腋窝淋巴结清扫2例,乳癌根治术9例,改良根治4例.结果随访15例中,一年内死亡1例,生存2年3例,生存3年5例,生存5年以上6例.初步探讨了乳癌术后局部复发的手术治疗,提出了局部复发的特点、机制、手术治疗的原则及意义.结论笔者认为再手术对局部复发的控制优于其它的治疗方法.  相似文献   

3.
研究背景与目的:近50年来,尽管外科技术有迅猛发展,但直肠癌的手术治愈率、5年生存率始终徘徊在50%左右,治疗失败原因主要为局部复发率较高,特别是在低位直肠癌保肛术后的病人尤其突出。本研究的目的是:为了最大限度地减少直肠癌病人术后的局部复发及提高低位直肠癌手术的保肛率,从而延长直肠癌病人的生存期和改善其生存质量。方法:选取62例可行根治术的直肠癌患者为研究对象,随机分为两组各31例,实验组进行术前联合放化疗。放疗每周5d,每次200cGy,共5周23次,总剂量4600cGy。化疗的给药方式以放疗期间口服希罗达胶囊1.5克,每天两次。休息4~6周进行手术。对照组直接手术治疗。结果:术前放疗组病例术后病理见周围炎性细胞浸润和纤维组织增生,肿瘤供应血管明显变细,部分血管纤维化闭塞。肿瘤细胞水肿变形、核固缩及细胞崩解等,肿瘤组织血管出现栓塞,部分肿瘤组织出现液化、坏死。实验组保肛率达74.2%,3年局部复发率3.2%,对照组保肛率32.3%,3年局部复发率19.4%。两组比较差异有显著性有意义.进展期低位直肠癌的患者在接受新辅助治疗后,能使肿瘤降期,切除率增加,提高保肛率,降低局部复发率,同时副反应轻,患者依顺性较好。  相似文献   

4.
目的 :通过临床病理分析 ,为临床治疗提供依据。方法 :对本院 10年间收治的经病理诊断为良性肿块的 171例患者进行临床、病理特点、预后分析及随访。结果 :171例中 ,119例经中西药治疗无显著疗效。手术行肿块切除 76例 ,区段切除 88例 ,单纯乳房切除 3例。有 1例 6年后转变为乳癌而行乳癌根治术。结论 :乳腺良性肿块中以囊性增生多见 ,其中乳管上皮增生和乳头状瘤病与乳癌关系密切。临床治疗应进行必要和区段切除 ,重度非典型增生必要时行全乳房切除术。  相似文献   

5.
目的:探讨不同治疗方法对鼻腔非翟奇金淋巴瘤(NHL)患者的预后影响。方法:在59例原发于鼻腔NHL IE期患者中,化疗+放疗33例。放疗+化疗8例,单纯化疗10例,单纯放疗8例,化疗方案为CHOP。结果:全组患者的1,3.5年生存率分别为71.2%,42.0%和38.5%,不同治疗方法的生存率差异无显著性(P=0.3943),但生存曲线显示,放化组优于其他组。临床分期显示,IE局限组患者1,3,5年生存率为84.2%、67.7%和62.0%,IE超腔组患者为50.0%、14.3%和14.3%,差异有显著性(P=0.0012)。首程化疗≥3个周期24例,首程放疗≥40G,16例,完全缓懈率(CR率)分别为25.0%和75.0%,差异无显著性(P=0.002)。首程化疗2,3~4,5~6个周期的CR率分别为10.5%、25.0%和25.0%,差异无显著性(P=0.48),并发症发生率及治疗相关死亡率均以化放组为高(39.4%,15.2%),但差异无显著性(P=0.202,P=0.693)。结论:Ⅰ期鼻腔NHL患者首选放疗,以尽早达到局部控制.再根据临床分期及恶性程度或国际预后指数(IPI)酌情给予更有效的化疗方案。  相似文献   

6.
顺铂联合放疗治疗晚期子宫颈癌的临床分析   总被引:2,自引:0,他引:2  
目的:评价顺铂辅助化疗联合放射治疗晚期子宫颈癌的疗效。方法:同期对比分析经放疗加顺铂化疗(放化组)60例和单纯放疗(单放组)60例Ⅲ期子宫颈癌患者5年生存率、局部控制率、远处转移率和并发症。结果:5年生存率放化组63.33%,单放组43.33%(P〈0.05)。局部控制率放化组80%,单放组60%(P〈0.05)。远处转移率放化组43.33%,单放组41.66%(P〉0.05)。放射性直肠炎:放化组13.33%,单放组10.00%(P〉0.05)。放射性膀胱炎放化组8.33%,单放组10.00%(P〉0.05)。无因治疗而引起的死亡发生。结论:放射治疗联合顺铂化疗能提高Ⅲ期子宫颈癌患者局部控制率和5年生存率,未改善远处转移率,副作用能耐受。  相似文献   

7.
目的 :探讨如何降低乳腺癌术后皮下积液的发生率。方法 :对 5 4例应用新方法的乳癌根治术病例与过去实施的 12 8例乳癌根治术进行了对比研究。结果 :乳腺癌根治术后皮下积液发生率由 2 4 .2 %降至现在的 9.3% ,经统计学处理二组间有显著性差异。结论 :预防乳癌术后皮下积液的要点是 :防止腋下淋巴管瘘 ;腋下及胸骨旁置双管引流 ;将皮瓣与胸壁做广泛缝合 ,促进二者早日愈合 ;胸带加压包扎要适度 ;保持引流通畅。  相似文献   

8.
目的探讨保留胸大小肌乳腺癌改良根治术(改良根治术)的效果。方法将100例女性乳腺癌患者随机分为观察组和对照组,各50例。对照组患者接受传统根治术,观察组患者采用改良根治术。对比2组患者住院时间、并发症发生情况及3 a生存率等。结果观察组住院时间、不良反应均低于对照组,2组比较,差异有统计学意义(P<0.01)。2组患者3 a生存率及复发情况对比差异无统计学意义(P>0.05)。结论乳腺癌改良根治术创伤小、住院时间短、并发症少,患者生活质量高。  相似文献   

9.
探讨胃癌根治术后腹腔感染对患者远期预后的影响。收集莆田学院附属医院胃肠外科2007年1月至2011年12月入组的胃癌根治患者的临床病理资料,分析胃癌根治术后腹腔感染与预后的关系。结果显示,全组342例患者中,发生腹腔感染患者26例,发生率为7. 6%;腹腔感染死亡患者1例,死亡比率为3. 8%。腹腔感染患者和无感染患者术后5年总体生存率分别为60. 2%和58. 1%(P=0. 089),差异无统计学意义。进一步根据TNM分期,Ⅰ、Ⅱ、Ⅲ期腹腔感染患者的5年总体生存率分别为92. 2%、62. 9%、45. 8%,与无感染组差异均无统计学意义(P>0. 05)。结果表明:胃癌根治术后腹腔感染的发生与术前合并症和长时间手术密切相关,但是腹腔感染并不会降低患者的长期生存率。  相似文献   

10.
目的:比较分析局部晚期非小细胞肺癌同步放化疗与序贯放化疗的疗效和毒副反应.方法:30例Ⅲ-Ⅳ期非小细胞肺癌患者接受放疗同步联合PC(PTX+PDD)方案化疗:患者于前三周期给予PC方案化疗,从第四周期开始实施同步放化疗,放化疗结束后再巩固2-4周期.其余20例患者接受放疗序贯化疗(序贯组):应用PC方案化疗3周期,再行放疗,放疗后巩固化疗4周期.结果:同步组和序贯组总有效率分别为91.5%和80.0%,同步组疗效优于序贯组(P=0.035);两组生存率无显著性差异(P〉0.05).结论:放疗同步化疗较序贯化放疗治疗局部晚期非小细胞肺癌能够提高治疗的有效率.  相似文献   

11.
INTRODUCTION With the enormous progress in tumor immu-nology,immunotherapy has reached an exciting phase in its evolution for the treatment of cancer(Hart,2005;Onji and Akbar,2005).Although an effective immunotherapeutic regimen has yet not been dem-onstrated in the clinical setting and the ultimate role of immunotherapy in the treatment of glioma is still unknown,the potential for immunotherapy as an adjunct to the current treatment of gliomas is now based on solid evidence(Yu et al.,20…  相似文献   

12.
Malignant gliomas are the most devastating tumors in clinical practice and nave poorest survival, Immunological treatment of such patients may likely increase the survival and quality of life. Dendritic cells (DCs), most potent antigen presenting cells in combination with oral chemotherapeutic agents may be tried for patients giving consent to such treatment. We have successfully combined the two therapies in an adult male patient who was on downhill course after being operated on once with post operation chemotherapy and radiotherapy for glioma in the left parietal area. He received five dendritic cell therapy vaccines in combination with oral chemotherapy and responded dramatically having near normal quality of life for an additional five months with this regime, increasing the survival after operation to 11 months. This therapy is continuing with radiological betterment of the lesion. The DCs are matured with antigen extracted from wax embedded tissue at 6th day of culture. We feel that the treatment can be given to more number of patients to establish its efficacy for the dreaded cancer glioblastoma multiforme.  相似文献   

13.
Surgical management of gastric stump cancer: a report of 37 cases   总被引:3,自引:0,他引:3  
Objective: To observe the clinicopathological characteristics of gastric stump cancer (GSC) and evaluate the benefits of radical surgery of GSC. Methods: The clinicopathological characteristics and postoperative survival time of 37 GSC patients who underwent surgery were investigated retrospectively. The survival time was compared according to the type of surgical pTMN stage. Survival curves were traced by using Kaplan-Meier methods. Results: Most GSC (32/37) was detected in patients who had received Billroth Ⅱ reconstruction after partial gastrectomy for benign gastric disease. The lesser curvature side and the suture line of anastomosis were the most frequent sites where GSC occurred (27/37). Differentiated adenocarcinoma was the dominant histopathological type (24/37). The postoperative 5-year survival rate of early stage GSC patients (n=9) was significantly higher than advanced stage GSC (n=12) (55.6% vs 16.5%, xL2=1 1.48, P<0.01). Five-year survival rate of 21 GSC patients with radical resection were 75% (3/4) for stage Ⅰ, 60% (3/5) for stage Ⅱ, 14.2% (1/7) for stage Ⅲ, and 0% (0/5) for stage Ⅳ respectively.The median survival time of 21 GSC patients who underwent radical resection was longer than those undergoing palliative operation (43.0m vs 13.0m, xL2=36.31, P<0.01), the median survival time of stage Ⅳ patients with radical resection was 23.8months. Conclusions: Without remote metastasis, radical resection for GSC is possible, and is an effective way to improve the prognosis of GSC. Even in stage Ⅳ GSC, radical resection can still prolong the survival time. It is necessary for the patients with benign gastric diseases who received partial gastrectomy to carry out the endoscopy follow-up, especially in patients with Billroth Ⅱ reconstruction procedure at 15-20 years.  相似文献   

14.
目的:探讨咪达唑仑硬膜外麻醉的临床应用。方法:将2011年襄樊职业技术学院附属医院硬膜外麻醉下行下腹部或下肢手术的病例60例,随机平分2组。硬膜外麻醉阻滞完善后,Ⅰ组病人静脉注射咪达唑仑0.1-0.2 mg/kg,Ⅱ组病人未给予任何镇静药物,同时监测血压、心率、血氧饱和度、呼吸变化、焦虑程度,术后24 h随访病人的术中记忆。结果:Ⅰ组病人应用咪达唑仑后血压、心率轻度下降,焦虑程度明显下降;Ⅱ组病人术中血压、心率升高,相对Ⅰ组病人明显焦虑紧张(P〈0.01)。术后24 h随访对术中记忆的遗忘率,Ⅰ组病人明显高于Ⅱ组病人(P〈0.01)。结论:咪达唑仑用于硬膜外麻醉,可以消除病人在手术中的不良记忆,是一种方便、安全、疗效高的麻醉辅助方法。  相似文献   

15.
目的:研究CHOP及GRP78与复发性GBM的相关性。方法:采用Western blot检测CHOP及GRP78在初发及复发GBM组织中的表达;Real-time PCR检测GRP78在初发以及复发GBM组织中的表达。结果:CHOP及GRP78在初发GBM中表达上调,而在经过原发性肿瘤切除后接受放疗和替莫唑胺化疗的复发性GBM中增加尤为显著。结论:CHOP及GRP78在GBM发病机制中起重要作用,该分子有望成为GMB潜在的诊断及预后评估标志物。  相似文献   

16.
目的比较生物羊膜移植术和自体角膜缘干细胞移植术治疗复发性翼状胬肉的临床疗效。方法将115例168眼复发性翼状胬肉随机分为A(56例82只眼)、B(59例86只眼)两组,两组于显微镜下切除胬肉组织后,A组采用生物羊膜移植术,B纽采用自体角膜缘干细胞移植术,术后随访6个月-12个月。观察两组疗效并进行分析比较。结果角膜创面上皮平均愈合时间A组为4—8(5.9±2.1)d,B组为2-5(3.2±2.2)d。两组比较差异有统计学意义(P〈0.05)。复发率A组为28.05%(23眼),B组为9.30%(8眼),两组比较差异有统计学意义(P〈0.05)。结论自体角膜缘干细胞移植术治疗复发性翼状胬肉的疗效好于生物羊膜移植术,其角膜创面修复快,复发率低,是一种理想的手术方法。  相似文献   

17.
INTRODUCTION In cancer patients, tumor immunity is generally impaired. However, tumor immunity may occur in-vivo as circulating tumor-specific antibodies, with cytotoxic T lymphocytes (CTLs) having been identi- fied in cancer patients (Disis et al., 1997; Albert et al., 1998) suggesting that effective anti-tumor responses may be elicited through immunotherapeutic strategies. In recent years, a number of clinical trials have proved the safety and feasibility of using human dendritic cell…  相似文献   

18.
Gallbladder cancer has a poor outcome because of its anatomy and location. Often, the diagnosis is made very late due to its silent course. Post-operated cases do respond to chemotherapy but the survival is counted in months and the quality of life is further hampered due to toxicity of drugs. Immunotherapy holds good promise in non-responding cancers treated by conventional chemotherapeutic agents. Among various therapies, dendritic cell therapy is growing at rapid pace due to its acceptable rationale. It has been utilized in treating successfully resected stage Ill (T2, N1, M0) gallbladder cancer in one of our patients. A 48 years old lady treated with this therapy is free of metastasis with ten doses of autologous dendritic cell vaccine constructed by utilizing resected tumor lysate antigen. She has received ten doses of therapy in 14 months of her treatment. This therapy has proven to be safe and without apparent side effects. The positive clinical response obtained supports that autologous dendritic cell-based immunotherapy is a promising therapeutic approach for refractory gallbladder cancers.  相似文献   

19.
目的 总结26例肾移植的临床经验和教训。方法 回顾26例肾移植的临床资料,分析供受的状况,组织配型,移植手术,术后并发症及免疫抑制治疗方案对移植效果的影响。结果 70年代有80年代一年人/肾存活率均为33.3%/33.3%,90年代一年,三年人/肾存活率分别为90%/85%,80%/75%,超急性排斥反应发生率3.9%,急性及慢性排斥反应发生率均为11.5%,药物中毒发生率7.8%。结论 合理应用免疫抑制剂,提高外科手术,加强组织配型是提高肾移植受存活率的关键因素。  相似文献   

20.
炎性乳腺癌的诊断和治疗   总被引:1,自引:0,他引:1  
[目的]:探索炎性乳腺癌的诊断和治疗.[方法]:10例经病理或细胞学检查确诊的炎性乳腺癌先给2~3个周期的CAF(阿霉素+环磷先胺+氟尿嘧啶)方案化疗,然后行总量的2/3量的乳腺及同侧腋窝的放射治疗,放疗结束后休息2周即行乳癌根治切除术,术后切口愈合后再给剩余1/3量的放射治疗,照射胸壁及同侧腋窝和锁骨上使放射总量达到60~70 Gy/野,在放疗前后穿插化疗(CAF)4个周期.[结果]:1例患者未完成治疗出院后1个月死亡.9例患者完成上述序惯治疗,全部病例乳腺红肿、高张消退,乳腺内肿块及同侧腋窝淋巴结明显缩小.手术切除标本检查有5例乳腺内找到癌灶,其中典型炎性癌1例、单纯癌2例、硬癌2例,4例乳腺组织内未找到癌灶.同侧腋窝淋巴结见癌转移7例,同侧锁骨上淋巴结见癌转移2例.生存时间1~28个月,中位生存时间12个月.[结论]:炎性乳腺癌通过序惯治疗可以提高治疗的有效性、延长生命,提高生存质量.  相似文献   

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