共查询到20条相似文献，搜索用时 15 毫秒
1.
S. B. Sharma S. Dwivedi K. M. Prabhu Narendra Kumar M. C. Baruah 《Indian journal of clinical biochemistry : IJCB》1999,14(2):245-248
Serum lipid profile, apolipoprotein-B (apo-B), malondialdehyde levels(MDA) and superoxide dismutase (SOD) activity were assessed
in 12 cases of xanthelasma with and without coronary artery disease (CAD)/hypertension (HTN) and results are compared with
healthy controls. Dyslipidemia was found in 65% cases of xanthelasma as compared to 20% healthy controls. Xanthelasma patients
had significantly high malondialdehyde (MDA) levels (p<0.01) and significantly decreased (p<0.05) SOD activity as compared
to controls. Among xanthelasma patients, xanthelasma with CAD/HTN showed higher total cholesterol (236±32.7 vs 188±24.7 mg/dl),
low density lipoprotein cholesterol (157±35.5 vs 113±16 mg/dl) and Apo-B (120.5±9.4 vs 114±19.2 mg/dl) levels as compared
to xanthelasma without CAD/HTN. Results of our study indicate that xanthelasma patients with increased apo-B, MDA and decreased
SOD need cardiovascular monitoring. 相似文献
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Bina R. Baxi Prabhudas S. Patel Siddharth G. Adhvaryu 《Indian journal of clinical biochemistry : IJCB》1990,5(2):139-144
For evolving a potential Biochemical index for early diagnosis of oral cancer, serum levels of total sialic acid (TSA), lipid
bound sialic acid (LSA), mucoid proteins and hexoses (galactose and mannose) were determined in 30 patients with oral cancer.
The results were compared with similar values obtained for 30 patients with oral precancerous conditions, 24 healthy controls
and 15 normal individuals with a habit of tobacco chewing. All the biomarkers were significantly elevated in oral cancer patients
compared to the controls, the normal chewers and precancer patients. The levels of glycoconjugates showed significant increase
in patients with oral precancerous conditions compared to the controls. Only LSA and hexoses showed significantly elevated
levels in oral precancer patients compared to the normal chewers. The levels of glycoconjugates were more or less comparable
between normal chewers and the controls. The parameters evaluated in the oral cancer patients also showed a progressive rise
with the clinical stage of the malignant disease. The levels of the four glycoconjugates were also higher in patients with
metastasis compared to those with only primary disease. The present findings suggest that the glycoconjugates have clinical
utility in diagnosis of the patients with cancer of the oral cavity as well as in staging the disease. 相似文献
5.
Sharmila Upadhya Subramanya Upadhya K. S. Prabhu 《Indian journal of clinical biochemistry : IJCB》2002,17(1):20-24
The present study was done to assess the levels of glycoconjugates and ceruloplasmin in sera of patients with cervical cancer.
Serum hexoses, hexosamines, sialic acid and fucose are elevated in a variety of inflammatory and neoplastic conditions. All
the glycoconjugates, except fucose were increased in serum of patients compared to controls. Also, hexoses and sialic acid
levels were high in patients with later stages of cancer compared to patients with early stage disease (P=<0.0001, P=0.03).
Serum ceruloplasmin was increased in patients with early stage cancer (51.5mg/dl) and with late stage cancer (61mg/dl) compared
to controls (38mg/dl). The elevated glycoconjugates may be the result of inflammatory reaction associated with neoplasia,
as serum ceruloplasmin (an acute phase reactant) is also increased in these patients. 相似文献
6.
目的:探讨慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机的临床护理方法及其疗效。方法:随机选择2012年1月~2014年2月广西中医药大学第一附属医院收治的100例慢性阻塞性肺疾病合并呼吸衰竭使用无创呼吸机进行治疗的患者,将所有患者随机分为研究组与对照组,每组50例患者。研究组患者给予舒适护理治疗,对照组患者给予常规护理治疗,分析两组的最终护理效果。结果:研究组患者在治疗积极配合率、并发症发生率以及不良情绪发生率上明显优于对照组,研究组患者的PaO2、PH与对照组对比,都明显高于对照组,PaCO2明显低于对照组,两组对比差异有统计学意义(P0.05)。结论:对慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机患者给予舒适护理治疗,可有效改善症状,提高临床疗效,值得推广。 相似文献
7.
Serum glycoproteins were evaluated in oral squamous cell carcinoma patients treated with radiotherapy and also the effect
of vitamin E was studied. Cell surface glycoconjugates are important parameters in the detection of malignancy. Thus, the
objective of the present study is to evaluate the efficacy of vitamin E on glycoproteins in oral cavity cancer patients treated
with radiotherapy. The study includes 26 age and sex matched normal healthy individuals and 26 patients with squamous cell
carcinoma of oral cavity. These patients were divided into two groups, one for radiotherapy alone (at a dosage of 6000 cGy
in five fractions per week for a period of six weeks) and the other for radiotherapy plus vitamin E supplementation (at a
dosage of 400 IU / day of vitamin E) for the entire period of radiotherapy. Levels of hexose, hexosamine, fucose and sialic
acid were increased in oral squamous cell carcinoma patients and a significant decrease was observed in radiation treated
patients when compared to control. The levels of glycoconjugates were significantly decreased in radiation treated patients
supplemented with vitamin E. This measurement may be useful in assessing disease progression and identifying patients resistant
to therapy and a possible role of vitamin E on reduction in glycoconjugate levels of radiation treated oral squamous cell
carcinoma patients. 相似文献
8.
Walid E. Zahran Kholoud A. Salah El-Dien Philip G. Kamel Ahmed Shawky El-Sawaby 《Indian journal of clinical biochemistry : IJCB》2013,28(2):141-146
Tumor necrosis factor (TNF-α) is a cytokine involved in systemic inflammation during acute phase reactions. The current study was designed to investigate the levels of pro-inflammatory cytokine (TNF-α) along with the anti-inflammatory cytokine (IL-10) during progression of non-alcoholic fatty liver disease (NAFLD) from simple steatosis to non-alcoholic steatohepatitis (NASH) and fibrosis in diabetic patients, and correlate the levels of cytokines with the progression of NAFLD. Fifty-two diabetic patients compared to 18 healthy controls were participated in this study. Based on clinical diagnosis, patients were divided into three groups: simple steatosis, NASH and fibrosis. Serum liver function tests, fasting blood glucose, bilirubin, ALT, AST, TNF-α, IL-10 and lipid profile were measured. TNF-α levels were significantly higher in NAFLD patients compared to control subjects with a significant positive correlation with body mass index and fasting blood glucose (FBG) but with negative correlation with IL-10. Serum IL-10 levels were significantly lower in NAFLD patients compared with controls. A positive correlation between IL-10 and HDL-C with concomitant negative correlation between IL-10 and FBG and triacylglycerides was found. Cytokine analyses showed that there was a prominent imbalance between TNF-α and IL-10 in patients with NAFLD, and this imbalance increase by increasing the progression of NAFLD especially in obese diabetic patients. TNF-α and IL-10 could be used in diagnosis and follow-up of NAFLD stages in a way to avoid liver biopsies in greater proportion of patients. 相似文献
9.
Serum CRP and uric acid levels were estimated in twenty-five patients with psoriasis (group III) before and after 12 weeks
of treatment. Results were compared with a group of 25 normal subjects (group I) and a group of 25 patients of various skin
diseases other than psoriatic lesion (group II). Mean value for CRP was found to be increased by more than 20 folds in patients
with psoriasis, which was subsequently reduced to nearly 50% of the initial value after 12 weeks of treatment. These patients
also showed hyperuricemia. Nearly 25% of these patients also exhibited arthritis. It is thus suggested that both CRP and uric
acid levels should be monitored in patients with psoriasis. 相似文献
10.
Lakshmi Krishnamoorthy Elizabeth Zachariah P. G. Ramaswamy N. Anantha 《Indian journal of clinical biochemistry : IJCB》1994,9(1):37-39
Circulating levels of gonadotropins (FSH,LH), prolactin (PRL), estradiol and progesterone were measured by radioimmunoassay
in the sera of 60 patients with histopathologically proven breast cancer. 30 patients belonged to the post and 30 to the premenopausal
group. 30 healthy women, 15 each in the pre and post menopausal groups served as controls for the study.
Prolactin was elevated in 33% and 26% of pre and post menopausal breast cancer patients respectively. Lower levels of estradiol
and progesterone were observed during the luteal phase of the menstrual cycle in premenopausal breast cancer patients. Among
postmenopausal patients with breast cancer, LH was elevated in 32%, FSH in 15% and estradiol in 30% of the patients studied. 相似文献
11.
R. D. Ankush A. N. Suryakar N. R. Ankush 《Indian journal of clinical biochemistry : IJCB》2009,24(2):184-189
This study was undertaken to evaluate the levels of plasma magnesium, lipid peroxides, nitric oxide end products, erythrocyte
membrane lipid peroxides, erythrocyte reduced glutathione and erythrocyte superoxide dismutase activity in type-2 diabetes
mellitus patients. 60 patients with type-2 diabetes mellitus and 30 healthy control subjects were included in this study.
Among 60 type-2 diabetic patients, 30 patients were without complication and 30 patients were with various complications.
Decreased levels of plasma magnesium, erythrocyte reduced glutathione and erythrocyte superoxide dismutase activity while
increased levels of plasma lipid peroxides, nitric oxide end products and erythrocyte membrane lipid peroxides were observed
in patients with type-2 diabetes mellitus. We propose that, under the shadow of hypomagnesaemia, there is excessive production
of reactive oxygen species and reactive nitrogen species as reflected by elevated lipid peroxides and nitric oxide end products
concomitant with dwindled antioxidants and suggest their association with late complications in type-2 diabetes mellitus. 相似文献
12.
G. N. Raval L. J. Parekh D. D. Patel F. P. Jha R. N. Sainger P. S. Patel 《Indian journal of clinical biochemistry : IJCB》2004,19(2):60-71
Sialic acid, the end moieties of the carbohydrate chains are biologically important and essential for functions of glycoconjugates
and are reported to be altered in cancer patients. Two hundred and twenty five breast cancer (BC) patients, 100 patients with
benign breast disease (BBD) and 100 healthy females (controls) were enrolled for the study. Eight hundred and twenty four
follow-up samples of 225 breast carcinoma patients were also evaluated. The association of sialic acid forms, sialyltransferase
and α-2–6 sialoproteins levels with presence and extent as well as prognosis of breast carcinoma was studied. Serum sialic
acid forms and sialyltransferase revealed significantly elevated levels among untreated breast cancer patients as compared
to the controls, patients with BBD as well as cancer patients in remission. Non-responders showed comparable levels of the
markers with those found in breast cancer patients at the time of diagnosis. Higher levels of sialic acid forms at diagnosis
were associated with poor prognosis. A positive correlation between serum levels of different forms of sialic acids and extent
of malignant disease was observed. The changes in serum proteins with terminal α-2–6 sialic acid correlated well with alterations
in the levels of sialic acid forms and sialyltransferase. Malignant tissues showed elevated levels of sialic acid and sialyltransferase
as compared to surrounding normal tissues.
The results suggested potential utility of these markers in evaluation of clinical outcome. 相似文献
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J. J. Fleming S. Rajaratnam M. S. Seshadri A. S. Kanagasabapathy 《Indian journal of clinical biochemistry : IJCB》2001,16(1):95-100
An audit of 2509 patient specimens analyzed for both total thyroxine (TT4) and free thyroxine (FT4) by the ACS-180 automated
chemiluminescence immunoassay analyzer revealed that there were 219 discrepancies (8.7% of the total). A discrepancy was defined
as one analyte within its reference range and the other outside. The discrepant results were divided into 4 groups: group
A: normal TT4, but decreased FT4, 101 patients (4.0%); group B: increased TT4, normal FT4, 78 patients (3.1%); group C: decreased
TT4, normal FT4, 34 patients (1.4%); and group D: normal TT4, increased FT4, 6 patients (0.2%). TSH measurements were available,
by a 3rd generation chemiluminescent assay, in 142 of these patients, and were consistent with the FT4 result in 72 patients, with
TT4 in 61 cases and with neither in 9 patients. The clinical diagnosis was investigated in a subgroup of 43 endocrine patients.
Thirteen of the 20 endocrine patients in group A were diagnosed as hypothyroid, with a measured serum TSH, in 11 of them,
of median 14.6, range 1.2 to 46.2 μlU/ml. Eleven of the 19 endocrine patients in group B were on thyroid replacement, with
a measured serum TSH, in 7 of them of <0.01 μlU/ml. The audit of current laboratory practice led to a suggestion to replace
the current thyroid function screening strategy of measuring both TT4 and FT4 by the combination of FT4 and TSH. The reasons
for the discrepancies and the alternative strategies for screening of thyroid function are discussed. 相似文献
15.
观察心理干预对糖尿病勃起功能障碍患者心理状态的影响。将30例勃起功能障碍的糖尿病患者进行心理干预,干预前后根据自评抑郁量表(SDS)、自评焦虑量表(SAS)以及国际勃起功能指数-5表(IIEF-5)进行评分。患者在接受一系列的心理干预后,SDS和SAS评分均显著低于干预前(p<0.01),规范治疗一周后,勃起功能指数却较前增高。心理干预能改善糖尿病勃起功能障碍患者的心理状态。 相似文献
16.
Svjetlana Karabuva Vedran Carevi? Mislav Radi? Damir Fabijani? 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2013,23(3):351-359
Aim:
The aim of study was to: 1) examine the relationship between ABO blood groups and extent of coronary atherosclerosis in patients with chronic coronary artery disease (CAD), 2) compare ABO blood groups distribution in CAD patients and general population, 3) examine possible differences in traditional risk factors frequency in CAD patients with different ABO blood groups.Materials and methods:
In the 646 chronic CAD patients (72.4% males) coronary angiograms were scored by quantitative assessment using multiple angiographic scoring system, Traditional risk factors were self reported or measured by standard methods. ABO blood distribution of patients was compared with group of 651 healthy blood donors (74.6% males).Results:
Among all ABO blood group patients there was no significant difference between the extent of coronary atherosclerosis with regard to all the three scoring systems: number of affected coronary arteries (P = 0.857), Gensini score (P = 0.818), and number of segments narrowed > 50% (P = 0.781). There was no significant difference in ABO blood group distribution between CAD patients and healthy blood donors. Among CAD patients, men with blood group AB were significantly younger than their pairs with non-AB blood groups (P = 0.008). Among CAD patients with AB blood group, males < 50 yrs were significantly overrepresented when compared with the non-AB groups (P = 0.003).Conclusions:
No association between ABO blood groups and the extent of coronary atherosclerosis in Croatian CAD patients is observed. Observation that AB blood group might possibly identify Croatian males at risk to develop the premature CAD has to be tested in larger cohort of patients. 相似文献17.
颅脑损伤患者病死通常由其脑神经损伤引起,脑外器官功能障碍亦常见,其中最常见的并发症是呼吸功能障碍。颅脑损伤(traumatic brain injury,TBI)患者在全身麻醉手术后,多数仍需呼吸支持。颅脑损伤患者术后拔管时机一直是临床研究的热点和难点。该文从急诊颅脑损伤患者麻醉评估、拔管条件、拔管时机等方面入手,对麻醉专业住院医师规范化培训的教学进行系统总结。 相似文献
18.
Walid E. Zahran Magda I. Mahmoud Kamal A. Shalaby Manal H. Abbas 《Indian journal of clinical biochemistry : IJCB》2013,28(3):272-276
Rheumatoid arthritis (RA) is the most common inflammatory systemic autoimmune disease, primarily affecting the peripheral joints. Anti-mutated citrullinated vimentin autoantibodies (anti-MCV) of IgG isotype were shown to be a useful diagnostic marker of RA especially in RA patients who were anti-cyclic citrullinated protein autoantibodies (anti-CCP) negative. Nevertheless, published data correlates rheumatoid factor (RF), anti-CCP or anti-MCV antibodies with either erythrocyte sedimentation rate (ESR) or serum C-reactive protein (CRP) as markers of disease activity, not investigated the possible correlations of RA autoantibodies towards ESR and CRP in comparison. Herein, we aim to evaluate the usefulness of anti-MCV as a dependable marker in established RA compared with anti-CCP and RF antibodies and to examine correlations between RF, anti-CCP and anti-MCV antibodies towards ESR and serum CRP. Serum RF-IgA, RF-IgM, anti-CCP and anti-MCV levels were measured in 30 patients with RA and 40 patients with other autoimmune diseases (non-RA) compared with 20 normal subjects. Specificity, sensitivity and AUC for RF antibodies, anti-CCP and anti-MCV were calculated towards RA diagnosis. Our results showed that ESR and CRP had significantly higher values in both RA and non-RA patients compared with our healthy controls with observed significant increment in RA patients compared with non-RA patients. An important finding from our study is that 33.3 % of RA patients were anti-CCP negative but being positive towards anti-MCV. Also, in-between 36.7 up to 40 % of RA patients were RF-IgA and RF-IgM negative while being anti-MCV positive. Anti-MCV antibodies showed the highest specificity and sensitivity (97.5 and 86.6 %, respectively) towards RA diagnosis with the highest AUC value (0.920) compared with anti-CCP and RF antibodies. Correlation analyses revealed that there was no significant correlation between ESR along with CRP towards RF-IgA, RF-IgM and anti-CCP while profound highly significant correlation exhibited between ESR and CRP towards anti-MCV data (r = 0.879 and 0.994, respectively). Thus, our data suggest that the assessment of serum anti-MCV autoantibodies along with ESR and CRP considered as a simple laboratory regime for monitoring RA patients to assess and follow-up disease activity. The addition of anti-MCV autoantibodies to serologic markers in the ACR/EULAR classification criteria for RA will add points for patients with negative anti-CCP and RF antibodies. 相似文献
19.
C. Rekha Srinivasa Phanidhar A. Vidya Sagar A. Revathi W. A. Asra 《Indian journal of clinical biochemistry : IJCB》2007,22(2):136-139
In a prospective study of 47 patients of subclinical hepatic encephalopathy in cirrhosis of liver, aged between 23 and 60
years, 49% showed Helicobacter pylori positivity by rapid urease test. The baseline characters of patients (mean age, serum
creatinine, sereum albumin, serum bilirubin, prothrombin time) were similar among patients with and without Helicobacter infection
in all the patients. There was no statistically significant difference in blood ammonia levels in either group of patients.
Blood ammonia values showed good correlation with the functional state of liver function but they did not show statistically
significant difference between two groups of patients in any of Child Pugh classes. It is concluded that Helicobacter pylori
does not contribute significantly to blood ammonia levels and the severity of hepatic encephalopathy. 相似文献
20.
The present study was undertaken to investigate the relation of retinol with lipid profile of patients with cancers of breast,
stomach, oesophagus, colon, gallbladder, pancreas, lung and cervix. Serum retinol was assayed in 120 patients and 40 healthy
normal control by reverse phase HPLC using CLC-ODS C-18 columns and retinyl acetate as an internal standard.
Significant decease in serum cholesterol and LDL was observed in patients with cancers of esophagus, colon, stomach, pancreas
and gallbladder respectively.
Retinol was reduced in all forms of cancers but pronounced decrease was observed in oesophagus, gallbladder, pancreas, stomach
and colon. Serum Retinol in all patients was directly correlated with total cholesterol and LDL. These findings suggest that
therapeutic modalities of this vitamin could be planned for these patients, as vitamin A is known to act as an antioxidant
for prevention of certain cancers. 相似文献