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1.
Dietary spice components ofCurcuma longa andAbroma augusta have been screened for their protective effect against reactive oxygen species induced lipid peroxidation. They have been
found to be efficient antioxidant when administered in combination. The purpose of the study was to investigate the effect
of oral administration (300mg/Kg) of the aqueous extract of turmeric whose active ingredient isCurcumin andAbromine powder as a hypoglycemic agent mixed with diet. The effect of this aqueous extract on blood glucose, lipid peroxidation (LPO)
and the antioxidant defense system in rat tissues like liver, lung, kidney and brain was studied for 8 weeks in streptozotocin
induced diabetic rats. The administration of an aqueous extract of turmeric and abromine powder resulted in a significant
reduction in blood glucose and an increase in total haemoglobin. The aqueous extract also resulted in decreased free radical
formation in the tissues studied.
The decrease in thiobarbituric acid reactive substances (TBARS) and increase in reduced glutathione (GSH), superoxide dismutase
(SOD) and catalase (CAT) clearly showed the antioxidant property of the mixture. It is suggested that these changes initially
counteract the oxidative stress in diabetes however, a gradual decrease in the antioxidative process may be one of the factors
which results in chronic diabetes. These results indicate that the mixture of the two plants have shown antidiabetic activity
and also reduced oxidative stress in diabetes. A combination ofAbroma augusta and Curcuma longa also restored the other general parameters in diabetic animals. The results were statistically analyzed and indicated that
combination of herbal extracts showed better efficacy as compared to individual herbal plant extracts used. 相似文献
2.
This paper deals with intercultural aspects of privacy, particularly with regard to differences between Japanese and Western
conceptions. It starts with a reconstruction of the genealogy of Western subjectivity and human dignity as the basic assumptions
underlying Western views on privacy. An analysis of the Western concept of informational privacy is presented. The Japanese
topic of ‘‘denial of self” (Musi) as well as the concepts of Seken, Shakai and Ikai (as analyzed by the authors of the companion piece on privacy in Japan) give rise to intercultural comparisons. The paper
addresses the question of privacy in cyberspace and mass media. Finally the question of freedom of speech is related to the
Japanese concepts of Ohyake and Watakusi. 相似文献
3.
[目的]为丰富期刊学术影响力评价指标体系,提出了一种新的期刊学术影响力评价指标-f(x)指数。[方法]以《中国科技期刊引证报告》2012年期刊目录中的34种图书情报学期刊为例,通过CNKI获取各期刊2012年的载文量、篇被引频次,利用excel、c++计算相应评价指标的得分,并根据f(x)指数的得分对期刊进行排名。[结果]与当年遴选出的CSSCI核心期刊相比,评价结果准确率达94.12%;对各指标进行相关分析,发现f(x)指数与包括影响因子在内的多种期刊评价指标存在较强的正相关。[结论]f(x)指数利用对数函数的性质,考虑了期刊的载文量、总被引、篇均被引等因素,考虑了低被引和高被引论文的差异性,可作为期刊学术影响力评价的指标。 相似文献
4.
基于MODIS数据的泰国林地资源提取 总被引：1，自引：1，他引：0
遥感技术的发展为我们对世界资源的研究提供了新的手段,克服了世界资源研究过程中数据缺乏的困难。泰国曾经是林地资源丰富的国家,尤其是热带林地资源,但是近几十年来林地面积在不断减少,带来了一系列生态问题。选用MOD09Q1的1、2波段,MOD09A1的第6波段以及MOD11A2数据产品提取了泰国林地分布情况。由于泰国地处热带地区云雾噪音为林地的提取造成了很大的不确定性,为了有效去除云雾噪音影响,结合NDVI、NDSI、LST多参数在林地提取中的优势对泰国林地进行提取。采用泰国2003年统计年鉴提供的分省林地面积以及2003年p131r47和p131r48共2景ETM影像进行了精度验证。结果表明,利用多参数综合分类方法对林地提取精度较高,通过与2003年统计年鉴数据进行回归分析发现二者存在明显的线性关系,决定系数达到0.9264。 相似文献
5.
Poonam Gautam Taruna Madan W. N. Gade P. Usha Sarma 《Indian journal of clinical biochemistry : IJCB》2006,21(2):12-19
Allergenic/antigenic proteins are known to induce Type I and Type III hypersensitivity reactions leading to allergic bronchopulmonary
aspergillosis (ABPA) in immunocompetent host. The common structural features or intrinsic properties of the allergens/antigens
leading to allergenicity in a host are not well understood. In the current report, comparative analysis of proteins on two
dimensional gel electrophoresis (2D-3) and specific IgE immunoblots ofA. fumigatus secretory proteins (1st, 2nd and 3rd week culture filtrate proteins) was carried out. We observed a total of 159 proteins in 1st, 2nd and 3rd week culture filtrates ofA. fumigatus. Specific IgE immunoreactivity was observed in 75 proteins with different intensity. Third week culture filtrate showed maximum
number of proteins, 142, and specific IgE immunoreactive proteins, 65. MALDI-TOF analysis resulted in putative identification
of two allergens as hypothetical protein YBL057c fromSaccharomyces cereviseae and unnamed protein product fromDebaryomyces hansenii (similar to IPF14568 ofCandida albicans). Identification of a repertoire of specific IgE immunoreactive proteins will facilitate the studies on structure-function
relationship of these proteins relevant for diagnosis and pathogenesis. 相似文献
6.
Anubha Paliwal Nivedita Bir Sowmya Raghuraman T. L. P. Reddy P. Usha Sarma 《Indian journal of clinical biochemistry : IJCB》1999,14(2):129-134
Oligonucleotide primers were synthesised based on the gene sequence of an 18 kDa allergen/antigen ofA. fumigatus isolated from a pathogenic strain. Polymerase chain reaction (PCR) was carried out using the forward and reverse primers
and genomic DNA ofA. fumigatus, A. flavus andA. niger as template. This resulted in a PCR product of 480 bp with onlyA. fumigatus. The absence of PCR product inA. flavus andA. niger with the primers of Asp fl facilitated use of these primers for detection ofA. fumigatus in clinical specimens of patients. The results were compared with microscopy, culture and serology. Application of PCR test
to clinical samples of aspergillosis patients is discussed. 相似文献
7.
长期以来,国际科学界在体外人胚胎研究领域所遵循的“14天规则”,将人胚胎体外研究时间限制在受精后的14天内,这是该研究领域最重要的伦理规则。随着胚胎培养技术的发展,这一伦理规则受到前所未有的挑战。2021年,国际干细胞研究学会（ISSCR）在《干细胞研究和临床转化指南》中建议有条件地放宽这一限制,科学界重启关于“14天规则”的讨论。文章以“14天规则”为切入点,系统梳理人胚胎研究伦理规制的历史背景和现实挑战,围绕人胚胎的道德地位、尊严和法律地位等关键伦理问题进行分析,全面分析各界利益相关者的观点和态度,从而结合实际做出评估,明确提出审慎、适当延长“14天规则”的政策建议和具体措施。 相似文献
8.
R. L. Gupta Sundeep Jain V. Talwar H. C. Gupta P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》1999,14(1):12-18
Based on our demonstration earlier that ethanol extract, water extract and a compound purified from garlic possessedin vitro antitubercular activity against drug resistant and susceptibleMycobacterium tuberculosis, we tried the effect of garlic extract in 30 patients of tubercular lymphadenitis. For ethical considerations, two groups
of patients, 30 each, were given antitubercular therapy (ATT) consisting of isoniazid, rifampicin, ethambutol and pyrazinamide
for 30 days. For the next 15 days (31 to 45 days) group 1 patients received 3–6 garlic pearls per day in addition to ATT while
group 2 patients received ATT only. From 46th day onwards both the groups received ATT only for 6–8 months. Antitubercular
activity of the serum samples collected on 45th day was assessed by its effect on the growth ofM. tuberculois. The serum of group 1 patients showed significantly much higher antitubercular activity than that of group 2 patients. Further,
there was relief of dyspeptic symptoms caused by ATT therapy in patients of group 1 with garlic plus ATT therapy but no change
in group 2 patients with ATT only. Liver function and hematological tests were normal in both the groups after 6 months of
therapy. Garlic extracts or compounds have a good potential as antitubercular(s) drug if given as a supplement to ATT. 相似文献
9.
P Renuka Devi S Krishna Kumari C Kokilavani 《Indian journal of clinical biochemistry : IJCB》2007,22(1):143-147
The effect of the oral administration ofVitex negundo leaf extract on the levels of enzymic and non-enzymic antioxidants were studied in the adjuvant induced arthritic (AIA) rats
The levels of antioxidant enzymes such as SOD, CAT, GPx, G6PD, GSH and Vit-C were estimated in various groups of the experimental
rats. It was observed that the antioxidant enzyme levels in the AIA were significantly low when compared to normal rats. A
significant decrease in enzymic antioxidant—SOD, CAT, GPx, G6PD and non-enzymic antioxidant—GSH, Vit-C were observed in the
liver of AIA rats compared to the normal rats. These results suggest that the leaf extract ofVitex negundo possesses antioxidant activity. 相似文献
10.
K. A. Faseehuddin Shakir Basavaraj Madhusudhan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):117-121
Rats fed with hypercholesterolemic diet showed a significant increase in serum total—cholesterol, liver homogenate total-cholesterol,
HDL-cholesterol and changed LDL-cholesterol, and HDL/LDL ratio in comparison to control. Flaxseedchutney (FC) supplemented diet (15%, w/w) was found to be more effective in restoring lipid profile changes in rats fed with cholesterol,
(1.0%). The activities of serum marker enzymes glutamate oxaloacetate transminase (GOT), glutamate pyruvate transaminase (GPT)
and alkaline phosphatase (ALP) were elevated significantly in carbon tetrachloride induced rats. Administration of flaxseedchutney (15%, w/w) resulted in depletion of serum marker enzymes and exhibited recoupment thus showing significant hepatoprotective
effect. It was observed that flaxseedchutney supplemented diet could lower the serum cholesterol and as a potential source of antioxidants it could exert protection against
hepatotoxic damage induced by carbon tetrachloride (CCl4) in rats. 相似文献
11.
Manjusha Dixit Anvesha Srivastava Gourdas Choudhuri Balraj Mittal 《Indian journal of clinical biochemistry : IJCB》2008,23(2):123-129
Background: Imbalance in cholesterol homeostasis may lead to gallstone disease. Apolipoprotein B is sole component of low-density
lipoprotein and plays an important role in cholesterol metabolism. The present study was carried out to explore the association
of APOB 3′ VNTR, exon 26 XbaI and signal peptide insertion/ deletion polymorphisms with gallstone disease. 214 ultrasonographically proven gallstone patients
and 322 healthy, age and sex matched controls were taken for the study. Genotyping was done using PCR followed by polyacrylamide
gel electrophoresis for VNTR and insertion/ deletion analysis. For APOB XbaI polymorphism PCR product was digested with XbaI restriction enzyme, followed by agarose gel electrophoresis. All statistical analyses were done using SPSS v11.5. Higher
repeat alleles of APOB 3′ VNTR polymorphism were more frequent in gallstone patients than in controls. Alleles with more than 57 repeats were present
only in patient group. Long (L) alleles with repeat higher than 49, were significantly higher (P=0.000; OR=3.705, 95% CI 2.577–5.326) and medium (M) alleles were lower (P=0.000; OR=0.406, 95% CI 0.304–0.542) in patients than in controls. To nullify the effect of gender, data was further stratified
into male and female population. APOB 3′ VNTR, L alleles were imposing risk and M alleles were protective in both male and female population. APOB
XbaI and insertion/deletion polymorphisms were not found to be associated with the gallstone disease. Longer alleles of APOB 3′ VNTR occur more frequently in gallstone patients, and may be an important risk factor for the development of gallstone
disease. APOB XbaI and signal peptide insertion/deletion polymorphisms may not be contributing to the risk for gallstone disease. 相似文献
12.
Researchers in indexing and retrieval systems have been advocating the inclusion of more contextual information to improve results. The proliferation of full-text databases and advances in computer storage capacity have made it possible to carry out text analysis by means of linguistic and extra-linguistic knowledge. Since the mid 80s, research has tended to pay more attention to context, giving discourse analysis a more central role. The research presented in this paper aims to check whether discourse variables have an impact on modern information retrieval and classification algorithms. In order to evaluate this hypothesis, a functional framework for information analysis in an automated environment has been proposed, where the n-grams (filtering) and the k-means and Chen’s classification algorithms have been tested against sub-collections of documents based on the following discourse variables: “Genre”, “Register”, “Domain terminology”, and “Document structure”. The results obtained with the algorithms for the different sub-collections were compared to the MeSH information structure. These demonstrate that n-grams does not appear to have a clear dependence on discourse variables, though the k-means classification algorithm does, but only on domain terminology and document structure, and finally Chen’s algorithm has a clear dependence on all of the discourse variables. This information could be used to design better classification algorithms, where discourse variables should be taken into account. Other minor conclusions drawn from these results are also presented. 相似文献
13.
Jyoti Sethi Sushma Sood Shashi Seth Anjana Talwar 《Indian journal of clinical biochemistry : IJCB》2004,19(2):152-155
Ocimum sanctum leaves have been traditionally used in treatment of diabetes mellitus. Dietary supplementation of fresh tulsi leaves in a
dose of 2 gm/kg BW for 30 days led to significant lowering of blood glucose levels in test group. Intake ofOcimum sanctum also led to significant increase in levels of superoxide dismutase, reduced glutathione and total thiols, but marked reduction
in peroxiodised lipid levels as compared to untreated control group. The leaves were found to possess both superoxide and
hydroxyl free radical scavenging action. The present observations establish the efficacy ofOcimum sanctum leaves in lowering blood glucose levels and antioxidant property appears to be predominantly responsible for hypoglycemic
effect. 相似文献
14.
M. I. Akpanabiatu I. B. Umoh E. O. Udosen A. E. Udoh E. E. Edet 《Indian journal of clinical biochemistry : IJCB》2005,20(2):29-34
Aqueous extract of the leaf and root ofNauclea latifolia Sm. (Rubiaceae) is used in Nigerian folk medicine for the treatment of hypertension. This work is carried out to investigate
the effect ofNauclea latifolia leaf extract on lipid profile and cardiovascular activity of rats. Normal and 10% coconut oil fed rats were treated with
the water-soluble fraction of the ethanol extract ofNauclea latifolia leaf for 2 weeks. Forty-eight mature male albino rats of the Wistar strain were divided into two experiments of four groups,
each group having 6 animals. Experiment I animals were treated with the water-soluble fraction of the ethanol extract whilst
experiment II animals were fed 10% coconut oil meal before treatment with the water-soluble fraction of the ethanol extract.
A single oral dose ofNauclea latifolia was 170, 340 and 510 mg/kg body wt/day of the extracts respectively for 2 wks. There was no significant change in the lipid
profile of the experimental animals as compared with the controls. There was about 40% relaxation on contracted thoracic aorta
that was pre-contracted with 2 μM phenylephrine. The viability of the tissue was tested against 10 μM of acetylcholine. There
was no significant (P>0.05) change in Na+ concentration in the serum. However, the K+ concentration in the serum of the experimental animals showed a significant increase. The study shows that ethanol extract
ofNauclea latifolia has vasodilator action on the aorta and that lipid profiles of experimental rats were not affected. Furthermore, the increase
in the K+ may be contributing to the vasodilator effect ofNauclea latifolia. 相似文献
15.
Halim Eshrat M. Ali Hussain Kaiser Jamil Mala Rao 《Indian journal of clinical biochemistry : IJCB》2001,16(1):77-80
The hypoglycemic effect of the aqueous extract ofAbroma augusta (Family: Steculiceae) was studied in normal as well as alloxan diabetic rats. Treatement of diabetic rats with 4 ml (4gm
dry weight) of agueous extract ofA. augusta for 16 weeks resulted in gradual but significant fall in fasting blood glucose and improvement in glucose tolerance. Serum
total and LDL cholesterol and triacylglycerol which increased in diabetic rats showed improvement. These results show that
the water extract ofA. augusta has both hypoglycemic and hypocholesterolemic effects. 相似文献
16.
Bonny Bhunia R. S. Alli M. V. R. Reddy B. C. Harinath 《Indian journal of clinical biochemistry : IJCB》1999,14(2):143-148
Brugia malayi microfilarial excretory-secretory (mf ES) antigens obtained byin vitro maintenance of mf are important tools in the immunodiagnosis of bancroftian filariasis. To increase the yield of mf ES products,
the effect of nutritional supplements on the culture medium (RPMI 1640) and the maintenance temperature were studied. Supplementation
of RPMI 1640 medium with organic acids and sugars of Grace's insect culture medium forin vitro maintenance of 10 lakhs of mf in 40 ml medium increased the yield of mf ES antigen from 152 μg to 364 μg of mean protein,
content and the mean antigen titre from 200 to 400. Supplementation with phenyl methyl sulphonyl fluoride (PMSF) and shift
in the culture temperature resulted in a further increase in the yield of mf ES antigen to 502 μg of mean total protein with
an antigen titre of 800. The modification resulted in a net increase of 3 fold in the protein content and 4 fold in the antigen
titre of ES products. The above modifications in thein vitro maintenance of mf did not affect the diagnostic quality of mf ES antigen, which gave a sensitivity and specificity of 80%
and 90% respectively in detection of filarial IgG antibodies inWuchereria bancrofti infected cases. 相似文献
17.
深海极端环境塑造了特殊的生命过程,资源潜力巨大,对其探测与研究是国际地球科学前沿,但深海严苛的高压环境极大地限制了深海采样及探测技术的应用。深海原位探测技术可以在不改变被测物位置及状态的条件下,获取深海样品的组分及含量信息,因此被越来越广泛地应用到深海极端环境的研究工作中。深海极端环境原位探测技术拥有广阔的前景,但作为一种新兴的探测技术仍需解决诸多科学难题。文章总结了国际和国内深海极端环境原位探测技术的研究进展,在分析当前我国深海极端环境研究现状基础上,提出未来我国深海极端环境原位探测技术发展对策。 相似文献
18.
P. Sharma M. Bose Isa Mohd S. Bagdi H. G. Raj 《Indian journal of clinical biochemistry : IJCB》2000,15(2):83-87
Genomic DNA from a clinical isolate ofMycobacterium avium-intracellulare complex was purified and cloned in PBR 322 at the tetracycline resistance site using Bam HI restriction enzyme. A 16 kb cloned
fragment was purified, radiolabeled and used as a probe. Genomic DNA isolated from nineteen MAC strains, threeM. tuberculosis strains and oneM. kansasii strain were digested with Eco RI restriction enzyme, Southern blotted and hybridized with the 16 kb cloned and labeled fragment.
Twelve MAC strains showed positive hybridization although five strains gave faint signals. Positive hybridization was noted
in two out of the threeM. tuberculosis strains, possibly due to shared DNA homology. No signal was received from the singleM. kansasii strain used in this study. 相似文献
19.
【目的】通过对《中国化学快报》办刊经验的总结和遇到问题的剖析,探讨中国英文科技期刊的发展之路。【方法】对《中国化学快报》近年的发展历程进行研究,从中发现中国英文科技期刊发展过程的共性问题,并进行提炼总结。【结果】中国英文科技期刊的生存环境已得到较大改善,但在评价体系等大政策的影响下,优质稿件匮乏、人才流失严重、国际显示度低等共性问题依然存在。【结论】在大政策暂时无法突破的现状下,加强内功修炼,寻找适合自身发展的办刊道路,尽快提高中国英文科技期刊的办刊水平。 相似文献
20.
Aqueous root extract ofAchyranthes aspera was incorporated in the experimental diet ofLabeo rohita (rohu). Control diet was prepared without root extract. Feeding of fishes with experimental diet has significantly (p<0.05)
enhanced the serum anti-proteases level than fishes fed with control diet. 相似文献