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1.
Mamatha T. Shenoy Benedicta D’Souza Lalesh Naik Akshatha Vivian D’Souza Madan Gopal Rajan 《Indian journal of clinical biochemistry : IJCB》2015,30(3):360-362
Tumor lysis syndrome has been observed in patients with malignancies with high cellular burden and high cell turnover, tumor sensitive to therapy, especially after initiating medical treatment. It very rarely occurs spontaneously. The case described here is of 6 months male infant who presented with fever since 1 month and loose stools associated with blood since 15 days. The laboratory investigations showed lactate dehydrogenase (LDH) of 6,192 IU/L and serum uric acid 18.2 mg/dl along with pancytopenia. The infant presented with electrolyte abnormalities and renal failure. 相似文献
2.
Highly motile Phytophthora sojae (P. sojae) zoospores of an oomycete plant pathogen and antioomycete candidate chemicals were encapsulated into microdroplets. Random fast self-motion of P. sojae zoospores was overcome by choosing an appropriate flow rate for a zoospore suspension. To influence stochastic loading of zoospores into a microfluidic channel, a zoospore suspension was directly preloaded into a microtubing with a largely reduced inner diameter. A relatively high single zoospore encapsulation rate of 60.5% was achieved on a most trivial T-junction droplet generator platform, without involving any specially designed channel geometry. We speculated that spatial reduction in the diameter direction of microtubing added a degree of zoospore ordering in the longitudinal direction of microtubing and thus influenced positively to change the inherent limitation of stochastic encapsulation of zoospores. Comparative phenotypic study of a plant oomycete pathogen at a single zoospore level had not been achieved earlier. Phenotypic changes of zoospores responding to various chemical concentration conditions were measured in multiple droplets in parallel, providing a reliable data set and thus an improved statistic at a low chemical consumption. Since each droplet compartment contained a single zoospore, we were able to track the germinating history of individual zoospores without being interfered by other germinating zoospores, achieving a high spatial resolution. By adapting some existing droplet immobilization and concentration gradient generation techniques, the droplet approach could potentially lead to a medium-to-high throughput, reliable screening assay for chemicals against many other highly motile zoospores of pathogens. 相似文献
3.
Poonam Gautam Taruna Madan W. N. Gade P. Usha Sarma 《Indian journal of clinical biochemistry : IJCB》2006,21(2):12-19
Allergenic/antigenic proteins are known to induce Type I and Type III hypersensitivity reactions leading to allergic bronchopulmonary
aspergillosis (ABPA) in immunocompetent host. The common structural features or intrinsic properties of the allergens/antigens
leading to allergenicity in a host are not well understood. In the current report, comparative analysis of proteins on two
dimensional gel electrophoresis (2D-3) and specific IgE immunoblots ofA. fumigatus secretory proteins (1st, 2nd and 3rd week culture filtrate proteins) was carried out. We observed a total of 159 proteins in 1st, 2nd and 3rd week culture filtrates ofA. fumigatus. Specific IgE immunoreactivity was observed in 75 proteins with different intensity. Third week culture filtrate showed maximum
number of proteins, 142, and specific IgE immunoreactive proteins, 65. MALDI-TOF analysis resulted in putative identification
of two allergens as hypothetical protein YBL057c fromSaccharomyces cereviseae and unnamed protein product fromDebaryomyces hansenii (similar to IPF14568 ofCandida albicans). Identification of a repertoire of specific IgE immunoreactive proteins will facilitate the studies on structure-function
relationship of these proteins relevant for diagnosis and pathogenesis. 相似文献
4.
Mauritius, a country that represents one of the leading advocates of e-Governance in Sub-Saharan Africa, has taken significant action to improve e-readiness dimensions and as such ranks high in terms of e-readiness index with respect to other Sub-Saharan African countries, based on the United Nations Global e-Government Readiness index. A close look at the usage rate of e-Government services such as online application, however, reveals that it is very low while online transaction is still rhetoric. This paper therefore assesses whether the high e-readiness index gives a true indication of the citizens' e-readiness using available secondary data sources. It further explores the factors facilitating and inhibiting citizens' e-readiness through the administration of a survey questionnaire. The main findings reveal that the barriers inhibiting citizens' e-readiness are resistance to change, absence of opportunities for e-participation and e-consultation, and lack of awareness. The main facilitators of citizens' e-readiness emanating from the analysis are awareness campaigns which tease out the advantages of online public services compared to traditional methods of service delivery, building of trust in government, and managing change. 相似文献
5.
Bhetariya PJ Madan T Basir SF Varma A Usha SP 《Indian journal of clinical biochemistry : IJCB》2011,26(2):104-119
The medical, agricultural and biotechnological importance of the primitive eukaryotic microorganisms, the Fungi was recognized
way back in 1920. Among various groups of fungi, the Aspergillus species are studied in great detail using advances in genomics and proteomics to unravel biological and molecular mechanisms
in these fungi. Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus, Aspergillus nidulans and Aspergillus terreus are some of the important species relevant to human, agricultural and biotechnological applications. The potential of Aspergillus species to produce highly diversified complex biomolecules such as multifunctional proteins (allergens, antigens, enzymes)
and polyketides is fascinating and demands greater insight into the understanding of these fungal species for application
to human health. Recently a regulator gene for secondary metabolites, LaeA has been identified. Gene mining based on LaeA
has facilitated new metabolites with antimicrobial activity such as emericellamides and antitumor activity such as terrequinone
A from A. nidulans. Immunoproteomic approach was reported for identification of few novel allergens for A. fumigatus. In this context, the review is focused on recent developments in allergens, antigens, structural and functional diversity
of the polyketide synthases that produce polyketides of pharmaceutical and biological importance. Possible antifungal drug
targets for development of effective antifungal drugs and new strategies for development of molecular diagnostics are considered. 相似文献
6.
Madan L. Gupta 《Assessment & Evaluation in Higher Education》2004,29(1):63-73
Students in a physical sciences course were introduced to cooperative learning at the University of Queensland, Gatton Campus. Groups of four to five students worked together in tutorial and practical sessions. Mid-term and practical examinations were abolished and 40% of total marks were allocated to the cooperative learning activities. A peer- and self-assessment system was successfully adapted to account for individual performance in cooperative learning group assignments. The results suggest that cooperative learning was very well received by students, and they expressed willingness to join cooperative learning groups in other courses. In addition, cooperative learning offered many benefits to students in terms of graduate attributes such as teamwork, communication, lifelong learning and problem-solving. 相似文献
7.
Development and validation of a brief screening version of the Childhood Trauma Questionnaire 总被引：16，自引：0，他引：16
Bernstein DP Stein JA Newcomb MD Walker E Pogge D Ahluvalia T Stokes J Handelsman L Medrano M Desmond D Zule W 《Child abuse & neglect》2003,27(2):169-190
OBJECTIVE: The goal of this study was to develop and validate a short form of the Childhood Trauma Questionnaire (the CTQ-SF) as a screening measure for maltreatment histories in both clinical and nonreferred groups. METHOD: Exploratory and confirmatory factor analyses of the 70 original CTQ items were used to create a 28-item version of the scale (25 clinical items and three validity items) and test the measurement invariance of the 25 clinical items across four samples: 378 adult substance abusing patients from New York City, 396 adolescent psychiatric inpatients, 625 substance abusing individuals from southwest Texas, and 579 individuals from a normative community sample (combined N=1978). RESULTS: Results showed that the CTQ-SF's items held essentially the same meaning across all four samples (i.e., measurement invariance). Moreover, the scale demonstrated good criterion-related validity in a subsample of adolescents on whom corroborative data were available. CONCLUSIONS: These findings support the viability of the CTQ-SF across diverse clinical and nonreferred populations. 相似文献
8.
AbstractAthletes have been shown to have greater movement imagery abilities than non-athletes. However, since these differences were observed using questionnaires where participants subjectively judged the vividness of performing imagined movements, it is possible that responses could be biased by other factors such as social desirability. One possible solution is to use an objective test, such as the Test of Ability in Movement Imagery (TAMI; Madan, C. R., & Singhal, A. (2013). Introducing TAMI: An objective test of ability in movement imagery. Journal of Motor Behavior, 45, 153–166.). Unfortunately, young adults perform relatively well on the TAMI, leaving little room for statistical sensitivity in observing higher scores. Here we propose an alternate scoring method for the TAMI that resolves this limitation by weighing items according to their difficulty. We apply this scoring method to existing data and show that this improves the TAMI’s selectivity to measuring ability in movement imagery, rather than related imagery processes. Thus, we have successfully improved the TAMI to be more suited for use with athletic populations. 相似文献
9.
P. Usha Sarma P V G K Sarma Taruna Madan 《Indian journal of clinical biochemistry : IJCB》2000,15(1):43-50
Diseases caused by pathogenic filamentous fungi, are an emerging threat to public health in the wake of increasing incidence of HIV and tuberculosis. At this point, discovery and development of fungal therapeutics and diagnostics are serious challenges for biomedical researchers. Recent technological advances in genomics and proteomics offer great scope for development of preventive and therapeutic measures for fungal diseases.Aspergillus, one of the medically important filamentous pathogenic fungi causes a wide spectrum of clinical disorders ranging from allergic aspergillosis to systemic invasive aspergillosis. Increase in incidence of drug resistance and the cytotoxic effects are two serious limitations of the antifungal drugs presently in use. This is primarily due to lack of understanding of biological mechanisms operative in these fungi. Today, it is possible to understand the biological mechanisms of the fungus for its colonisation, survival and invasion of the host. Future developments based on such leads can result in development of precise and specific diagnostic, therapeutic and preventive measures for a wide clinical spectrum of fungal diseases. 相似文献