共查询到20条相似文献,搜索用时 31 毫秒
1.
Vasavidevi V. Bet Kishor H. Deshpande Adinath N. Suryakar Rajesh D. Ankush Raghavendra V. Katkam 《Indian journal of clinical biochemistry : IJCB》2006,21(2):177-180
Crystal aggregation and retention are critical events for the formation of kidney stones. There is a close association between
crystal development and free radical activity in vivo. In the present study 30 subjects presenting with urolithiasis were
included. Serum levels of total lipid peroxides, nitric oxide (as nitrite), α-tocopherol, plasma ascorbic acid (vitamin C)
and erythrocyte superoxide dismutase activity were measured. These findings were compared with 30 age matched control subjects
irrespective of sex. Student's ‘t’ test was applied for statistical analysis. There was a significant increase in lipid peroxides
(p<0.001), where as significant decrease in nitrite (p<0.01) and α-tocopherol (p<0.001) levels were observed. Plasma ascorbate
(p>0.05) and erythrocyte superoxide dismutase activity (p>0.05) was also found to be decreased but the difference was not
statistically significant which suggests that oxidative stress is evident in urolithiasis with depletion in antioxidant status
where as decrease in nitric oxide may be less abetting in disease condition. 相似文献
2.
V. N. Thorat A. N. Suryakar A. S. Sardeshmukh S. S. Sarawade 《Indian journal of clinical biochemistry : IJCB》2004,19(2):32-35
In the present study, the role of serum lipid peroxide and serum nitric oxide as oxidants and erythrocytic superoxide dismutase
& serum vitamin E as antioxidants were determined in the 50 neonates with hypoxic ischaemic encephalopathy. (HIE) as against
25 healthy neonates as controls 50 patients of HIE were further divided into two groups i. e. mild and moderate HIE patients.
All subjects were in the age group of 37–41 weeks of gestation. The levels of serum lipid peroxide, serum nitric oxide and
erythrocytic superoxide dismutase were significantly elevated in both groups of neonates with HIE than those of controls (P<0.001),
whereas serum vitamin E levels were significantly decreased in both groups of HIE patients than those of controls (P<0.001).
A positive correlation was obtained between serum lipid peroxide and erythrocytic superoxide dismutase (r=+0.86). Alterations
in the status of oxidants and antioxidants indicate role of free radicals in the development of HIE. 相似文献
3.
J Kato Alice Abraham Ruram S Sekharjit Singh S Bilasini Devi Th Ibetombi Devi W Gyaneshwar Singh 《Indian journal of clinical biochemistry : IJCB》2007,22(1):128-130
The present, study was conducted to determine the level of malondialdehyde (MDA) as an index of free radial induced lipid
peroxidation and antioxidant vitamins-vitamins A, vitamin C and vitamin E in 75 confirmed cases of urolithiasis. Significantly
high level of MDA (p<0.001) with significantly low levels of vitamin E (p<0.001) and vitamin A (p<0.001) with no significant
decrease in vitamin C (p>0.05) were observed in the plasma of urolithiasis cases as compared to normal controls. In conclusion,
it appears that a role of lipid peroxidation and oxidative function exists in the pathogenesis of urolithiasis. But, the exact
mechanism how this occurs remains to be elucidated. 相似文献
4.
Abdel-Raheim M. A. Meki Enas Ahmed Hamed Khaled A. Ezam 《Indian journal of clinical biochemistry : IJCB》2009,24(3):280-287
Elevated free radical generation in inflamed joints and impaired antioxidant system has been implicated in rheumatoid arthritis
(RA). Green tea extracts (GTE) have been shown to reduce inflammation in inflammatory arthritis murine model. This study investigates
possible mechanisms by which vitamin C and GTE protect joints in RA rat model. This study included forty adult male rats that
were divided into four groups (10 rats each); control group, collagen II induced RA group (CII), CII treated with vitamin
C (CII + Vit C) and CII treated with GTE (CII + GTE) in physiology laboratory, Assiut University, Egypt. After 45 days of
treatment, plasma levels of lipid peroxides (LPO), nitric oxide (NO), ceruloplasmin (CP), superoxide dismutase (SOD), uric
acid (UA) and glutathione (GSH) were detected using colorimetric methods, PGE2 using ELISA and copper (Cu) and zinc (Zn) using spectrometer. In CII group, levels of LPO, NO, PGE2, UA, CP, Cu were higher while SOD, GSH, Zn were lower than controls. In groups treated with vitamin C and GTE, levels of
SOD, GSH were increased while levels of LPO, NO, PGE2, Cu, CP were decreased compared with CII group. Levels of UA were decreased and Zn increased in GTE treated group compared
with CII group. GTE treated group showed higher Zn and low Cu levels compared with vitamin C treated group. This study suggests
proper GTE and vitamin C intake may effectively normalize the impaired oxidant/antioxidant system and delaying complication
of RA. 相似文献
5.
S. Kumari S. Panda M. Mangaraj M. K. Mandal P. C. Mahapatra 《Indian journal of clinical biochemistry : IJCB》2008,23(2):158-162
Hyperglycemia and dyslipidemia in diabetes mellitus induce increased lipid peroxidation and peroxyl radical formation, an
important mechanism in genesis of microangiopathy. We took up a study on oxidative stress, measured by plasma MDA and antioxidant
vitamin status in type − 2 DM patients with and without retinopathy and compared them with a control non-diabetic group. Lipid
peroxidation marker MDA was significantly elevated (p < 0.001) in both the diabetic groups whereas, serum vitamin E and vitamin
C registered a significant fall (p<0.001) as compared to controls. Our correlation study revealed a significant positive association
between plasma MDA with both fasting and 2hr post prandial plasma glucose (r=0.81, p < 0.001, r=0.92, p <0.001) suggesting
the role of hyperglycemia in free radical production. Plasma MDA also depicted significant positive relation (p< 0.001) with
all lipid parameters except serum HDLc pointing the role of dyslipidemia towards lipid peroxidation. Plasma MDA level was
also found to be negatively correlated with both the vitamins (p<0.001, p<0.001) in the study group explaining their protective
consumption in the oxidative process prevailing in diabetic retinopathy. 相似文献
6.
Rahul A. Ghone K. M. Kumbar A. N. Suryakar R. V. Katkam N. G. Joshi 《Indian journal of clinical biochemistry : IJCB》2008,23(4):337-340
Repeated blood transfusion in beta thalassemia major patients may lead to peroxidative tissue injury by secondary iron overload.
In the present study, 72 children with beta thalassemia major were included. Serum levels of total lipid peroxides, Iron,
Total Iron Binding Capacity, Copper, Zinc, Vitamin E, plasma Total Antioxidant Capacity, activity of Erythrocyte Superoxide
Dismutase, were measured. The findings were compared with 72 age matched healthy controls irrespective of sex. A significant
increase in the levels of lipid peroxide and Iron (p<0.001), whereas, significant decrease in the levels of vitamin-E, Total
Antioxidant Capacity and Total Iron Binding Capacity (p<0.001) was observed. Serum Zinc was significantly increased (p<0.001)
with significant decrease in the levels of copper (p<0.001). Non Significant increase in the activity of Erythrocyte Superoxide
Dismutase (p>0.05) was found in the patients when compared with controls. This suggest that oxidative stress and reduced antioxidant
defense mechanism play an important role in pathogenesis of beta thalassemia major. 相似文献
7.
Sarita N. Chavan Umesh More Shruti Mulgund Vishal Saxena Alka N. Sontakke 《Indian journal of clinical biochemistry : IJCB》2007,22(2):101-105
Osteoporosis encompasses a wide spectrum of conditions associated with imbalance of osteoclastic and osteoblastic activities.
The increased activity of osteoclasts leads to increased free radical formation and hence lipid peroxidation. Present study
probes into the role of antioxidants as a palliative treatment for osteoporosis. It involved 50 healthy controls and 75 clinically
diagnosed osteoporosis patients. Both the groups underwent baseline assessment of biochemical markers viz. osteoblastic markers:
serum Alkaline phosphatase. Free or ionic calcium and Inorganic phosphorus, osteoclastic markers: serum Tartarate resistant
acid phosphatase and Malondialdehyde and the antioxidant status: serum Superoxide dismutase and Erythrocyte reduced glutathione.
The osteoporotic group was then divided into groups A (Vitamin E-Evinal 400 mg), B (Vitamin C-Celin 500 mg), C (Vitamin E+C-Evinal+Celin)
for antioxidant supplementation for a period of 90 days. The results reveal that there is significant fall in concentration
of serum MDA (p<0.001), TrACP (p<0.01). Improvement in antioxidant status is reflected by significant rise in concentration
of serum SOD (p<0.001) and erythrocyte GSH (p<0.001) after 90 days of antioxidant supplementation in osteoporosis. The findings
indicate that on the whole bone status improved with prolonged antioxidant vitamin supplementation, which can be used as a
palliative treatment for osteoporosis. The efficacy is not affected whether the vitamins are administered singly or conjointly. 相似文献
8.
Rachita Nanda Pramila K. Mishra U. K. Das S. B. Rout P. C. Mohapatra A. Panda 《Indian journal of clinical biochemistry : IJCB》2004,19(1):93-96
Serum malondialdehyde was measured in sixty-one falciparum malaria cases, which include thirty uncomplicated, and thirty-one
complicated with acute renal failure. Twenty-six healthy individuals were also studied as controls. Serum malondialdehyde
level was found to be significantly elevated in falciparum malaria induced acute renal failure cases when compared with uncomplicated
falciparum malaria (p<0.001) and healthy controls (p<0.001). A positive correlation with the raised urea, creatinine and bilirubin
levels were significant (r=0.62, p<0.025; r=0.65, p<0.05 and r=0.72, p<0.001 respectively) indicating the severity of complication
with rise of lipid peroxides in falciparum malaria induced acute renal failure cases. 相似文献
9.
Kiran Dahiya A. D. Tiwari Vijay Shankar Simmi Kharb Rakesh Dhankhar 《Indian journal of clinical biochemistry : IJCB》2006,21(1):157-160
Phototherapy has been related to increased oxidative stress and lipid peroxidation. In the present study, thirty full term
jaundiced neonates with appropriate weight were analyzed before and after completion of phototherapy for malondialdehyde (MDA),
reduced glutathione (GSH), total thiols, vitamin C and superoxide dismutase (SOD) levels in hemolysate and albumin levels
in plasma. These parameters were analyzed in cord blood samples of 20 healthy neonates as control. It was observed that levels
of MDA were elevated significantly (p<0.001) in patients as compared to controls and that the levels increased significantly
after phototherapy (p<0.001). Levels of SOD were also found to be increased significantly as compared to controls and the
levels rose after phototherapy (p<0.001). On the other hand, the levels of non-enzymatic antioxidants such as GSH, total thiols
and vitamin C were significantly low (p<0.001) as compared to controls and the levels decreased significantly after phototherapy
(p<0.001). The plasma albumin levels also were found to be decreased significantly after phototherapy (p<0.01). Therefore,
phototherapy increases oxidative stress and should be used with care. 相似文献
10.
Krishna Mohan Surapneni V. S. Chandrasada Gopan 《Indian journal of clinical biochemistry : IJCB》2008,23(1):41-44
The changes in the erythrocyte lipid peroxidation products (MDA), levels of glutathione (GSH), ascorbic acid and plasma vitamin
E (non enzymatic antioxidant parameters) and activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase
(GPX), catalase in erythrocytes and plasma glutathione - S - transferase (GST) activity were estimated in patients with rheumatoid
arthritis. This work was undertaken to assess oxidative stress and anti oxidant status in patients with rheumatoid arthritis.
It was observed that there was a significant increase in erythrocyte MDA levels, activities of SOD, GPX, plasma GST and a significant decrease in erythrocyte GSH, ascorbic acid, plasma vitamin E levels and catalse activity in
patients with rheumatoid arthritis when compared to controls. The results of our study suggests higher oxygen free radical
production, evidenced by increased MDA and decreased GSH, ascorbic acid, vitamin E and Catalase activity, support to the oxidative
stress in rheumatoid arthritis. The increased activities of antioxidant enzymes may be a compensatory regulation in response
to increased oxidative stress. 相似文献
11.
A. G. Kulkarni A. N. Suryakar A. S. Sardeshmukh D. B. Rathi 《Indian journal of clinical biochemistry : IJCB》2003,18(2):136-149
Oxidative stress plays an important role in the development of malarial anemia. The present study was undertaken to study
the role of oxidant and antioxidants in the patients ofPlasmodium falciparum malaria (n=25),Plasmodium vivax malaria (n=25) as against the normal control subjects (n=25). The parameters included are the hematological [hemoglobin,
erythrocyte adenosine deaminase (ADA) activity, ADP-induced platelet aggregation] and serum total lipid peroxide as an index
of oxidative stress and antioxidants [erythrocytic superoxide dismutase (SOD) activity, serum vitamin E] & serum iron.
Significant alterations in all above parameters were noted in both groups of malaria patients as compared to control subjects.
Maximum significant alterations in hematological parameters were noticed inP. falciparum infection as compared toP. vivax malaria (p<0.001). Substantial rise in serum total lipid peroxides and a significant reduction in antioxidants such as serum
vitamin E and serum iron were noted inP. falciparum malaria as compared toP. vivax malaria (p<0.001), whereas maximum decline in erythrocytic SOD activity was observed inP. vivax infection as compared toP. falciparum malaria (p<0.05). Follow-up examination revealed the restoration of the levels of all biochemical parameters to the normal
level after 20 days of antimalarial therapy.
The study specified severity ofP. falciparum malaria and also functional duality of oxidant. 相似文献
12.
R. B. Bhogade A. N. Suryakar N. G. Joshi R. Y. Patil 《Indian journal of clinical biochemistry : IJCB》2008,23(3):233-237
Hemodialysis represents a chronic stress status for its recipients. Many hypotheses state that this may be associated with
oxidative stress. Thus, there may be deficiency of antioxidants like erythrocytic superoxide dismutase, catalase, vitamin
E or increased generation of free radicals like superoxide anions. A study was carried out to investigate oxidant and antioxidant
status in chronic renal failure patients undergoing hemodialysis and effect of vitamin E supplementation on these two status.
Blood samples were collected from patients before and after hemodialysis and from controls. The samples were analyzed for
quantitation of MDA as index of lipid peroxide, nitric oxide, vitamin E, vitamin C and enzymatic antioxidants namely erythrocyte
SOD and catalase. As compared to controls, the levels of serum MDA were significantly increased and activities of erythrocyte
SOD and catalase, levels of serum nitric oxide, serum vitamin E and plasma vitamin C were significantly decreased both before
and after hemodialysis. The efficiency of vitamin E therapy in hemodialysis patients was assessed by re-evaluating oxidant
and antioxidant status of same patients after supplementation of vitamin E. Vitamin E supplementation caused decrease in serum
MDA and increase in levels of serum nitric oxide, vitamin E, vitamin C and activities of erythrocytic SOD and catalase. Our
results suggest the presence of oxidative stress and the possible preventive role of vitamin E therapy in hemodialysis patients. 相似文献
13.
Guruprasad Rao Ullas Kamath Chaerkadi Raghothama K. Sujatha Pradeep Pragna Rao 《Indian journal of clinical biochemistry : IJCB》2003,18(2):80-86
The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal
erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born after premature
rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05)
as compared to controls. Proteolytic activity in the erythrocytes of mothers in this group was also significantly high (p<0.01).
In patients delivered by lower segment cesarian section, lipid peroxidation and proteolytic activity in maternal erythrocytes
were significantly high (p<0.05 and p<0.001 respectively). In patients with prolonged second stage of labour, lipid peroxidation
and proteolytic activity in maternal erythrocytes was significantly higher than in controls (p<0.001 and p<0.05 respectively).
In this group, endogenous protein damage due to oxidative stress was significantly high both in the mother and the fetus (p<0.001
and p<0.05 respectively). 相似文献
14.
D. Vijayakumar K. Suresh S. Manoharan Ph.D. 《Indian journal of clinical biochemistry : IJCB》2006,21(1):105-105
The main objective of the study was to assess the oxidative stress in plasma and erythrocytes of rheumatoid arthritis patients
by measuring the levels of thiobarbituric acid reactive substances (TBARS), non-enzymatic antioxidants (vitamin E, C and reduced
glutathione) and enzymatic antioxidants [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHPx)]. This
study has been conducted on twenty-two adult female rheumatoid arthritis patients and an equal number of healthy subjects.
Elevated lipid peroxidation and multidirectional changes in the antioxidant defence system were noticed in patients with rheumatoid
arthritis. The enhanced lipid peroxidation accompanied by disturbance in antioxidant status indicates that rheumatoid arthritis
patients are more prone to free radical mediated oxidative damage. 相似文献
15.
K. S. Motghare Anil Bhutey B. B. Murrhar Madhur Gupta A. W. Meshram Y. Balsubramanium 《Indian journal of clinical biochemistry : IJCB》2001,16(2):213-215
With the growing interest in the concept of free radicals in the pathogenesis of myocardial ischemia, it was thought worthwhile
to study the changes in lipid peroxides and antioxidant enzyme glutathione peroxidase (GPx) in ischemic heart disease (IHD).
The study was carried out on 76 patients of IHD-38 of acute myocardial infarction (AMI) and 38 of stable ischemic heart disease
(SIDH). They were age and sex matched with 38 normal healthy controls. A significant increase (p<0.001) in lipid peroxides
as malondialdehyde (MDA) (5.9±0.7 mmol/L) and a decrease in GPx (24.6±2.2 U/gmHb) was found in patients of AMI when compared
with controls. There was no significant difference in these values in SIHD. Thus this study confirms the earlier findings
that MDA and GPx are useful parameters in IHD and their magnitude is dependent on severity and/or duration of ischemia. We
suggest that these tests would be of use in smaller institutions with limited facilities. 相似文献
16.
Santoshi R. Ghodake A. N. Suryakar R. D. Ankush K. Shaikh A. V. Katta 《Indian journal of clinical biochemistry : IJCB》2010,25(1):82-85
Nephrotic syndrome is the common chronic disorder characterized by alteration of permeability of the glomerular capillary
wall, resulting in its inability to restrict the urinary loss of proteins. Nephrotic syndrome is characterized by heavy proteinuria,
hypoalbuminemia, hyperlipidemia associated with peripheral edema. The molecular basis of glomerular permselectivity remains
largely unknown. In recent years it has been proposed that Nephrotic syndrome is a consequence of an imbalance between oxidant
and antioxidant activity. The present study was aimed to test that the reactive oxygen species are the mediators of excessive
protein permeability and other complications of Nephrotic syndrome. For this 30 adults with Nephrotic syndrome were studied.
The control group comprised 30 healthy adults matched for age. Serum levels of lipid peroxides, nitric oxide (NO⊙), α- tocopherol,
ascorbic acid, erythrocyte superoxide dismutase activity, serum albumin, uric acid, cholesterol and plasma total antioxidant
capacity were measured. Student’s ‘t’ test was applied for statistical analysis. There was a significant increase in lipid
peroxide (1.58 ± 0.42 in controls, 3.64 ±1.3 in patients) (P<0.001) levels in study group as compared with controls. α-tocopherol
(12.95 ± 1.04 in controls, 9.93 ± 1.43 in patients) (P<0.001), erythrocyte SOD activity(1.88 ± 0.9 in controls 1.07 ± 0.5
in patients) (P=0.01), serum albumin(4.06 ± 0.50 in controls, 3.04 ± 0.11 in patients) (P<0.001), and plasma total antioxidant
capacity (847.33 ± 126.83 in controls, 684.00±102.94 in patients) (P<0.001) were significantly decreased. There was non-significant
increase in uric acid (P>0.05), a non-significant decrease in NO⊙ (38.48 ± 15.47 in controls 37.47 ± 14.27 in patients) (P>0.05)
and ascorbic acid levels ascorbic acid,( 0.95 ± 0.31in controls 0.79 ± 0.30 in patients) (P>0.05) in study group as compared
with controls. Imbalance between oxidants and antioxidants may contribute to pathogenesis of proteinuria and related complications
in nephrotic syndrome. 相似文献
17.
Y. S. Mahindrakar A. N. Suryakar R. D. Ankush R. V. Katkam K. M. Kumbhar 《Indian journal of clinical biochemistry : IJCB》2007,22(1):91-94
New findings on organization of blood cell cytoskeleton represent an exciting aspect of modem cell biology and hematology,
which is an interesting investigation to study diabetes. The present study was undertaken in 150 subjects. Out of these, 30
subjects were controls (Group I) and 30 were type-2 diabetics without any complication (Group II), while remaining 90 subjects
were type-2 diabetics with complication (Group III). We determined erythrocyte spectrin and hemoglobin glycosylation and also
estimated plasma lipid peroxide, nitric oxide and erythrocyte glutathione peroxidase activity to assess the status of oxidative
stress. There was a significant increase in spectrin (P<0.001) and hemoglobin (P<0.001) glycosylation in Group II and III
as compared to Group I and spectrin glycosylation was nearly three times more as compared to hemoglobin, whereas plasma levels
of lipid peroxide (P<0.001) as well as nitric oxide (P<0.001) were found to be significantly increased and GPx activity (P<0.001)
was significantly decreased in Group II and III as compared to Group I. However, it was also observed that spectrin (P>0.05)
and hemoglobin (P>0.05) glycosylation was not significantly different in Group II and III. In contrast, there was significant
rise in lipid peroxide (P<0.001), nitric oxide (P<0.001) and fall in GPx activity (P<0.001) in Group III when compared to
Group II. Increased erythrocyte protein glycosylation and oxidative stress is clearly evident from our study. However, to
understand the exact interplay between these two mechanisms, further studies are required. 相似文献
18.
R. D. Ankush A. N. Suryakar N. R. Ankush 《Indian journal of clinical biochemistry : IJCB》2009,24(2):184-189
This study was undertaken to evaluate the levels of plasma magnesium, lipid peroxides, nitric oxide end products, erythrocyte
membrane lipid peroxides, erythrocyte reduced glutathione and erythrocyte superoxide dismutase activity in type-2 diabetes
mellitus patients. 60 patients with type-2 diabetes mellitus and 30 healthy control subjects were included in this study.
Among 60 type-2 diabetic patients, 30 patients were without complication and 30 patients were with various complications.
Decreased levels of plasma magnesium, erythrocyte reduced glutathione and erythrocyte superoxide dismutase activity while
increased levels of plasma lipid peroxides, nitric oxide end products and erythrocyte membrane lipid peroxides were observed
in patients with type-2 diabetes mellitus. We propose that, under the shadow of hypomagnesaemia, there is excessive production
of reactive oxygen species and reactive nitrogen species as reflected by elevated lipid peroxides and nitric oxide end products
concomitant with dwindled antioxidants and suggest their association with late complications in type-2 diabetes mellitus. 相似文献
19.
Neela Patil Vishwas Chavan N. D. Karnik 《Indian journal of clinical biochemistry : IJCB》2007,22(1):45-51
Free radicals play an important role in the pathogenesis of tissue damage in many clinical disorders, including atherosclerosis.
Antioxidants protect the body from damage caused by free radicals. In this study we investigated oxidative stress, antioxidants
and inflammatory molecules in patients with acute myocardial infarction. This study has been carried out on 106 patients with
acute myocardial infarction, (89 men and 17 females). The control group consisted of 50 healthy, age-matched subjects (40
men and 10 females). Levels of Glucose, lipid profile, glutathione reduced, glutathione peroxidase, Superoxide dismutase,
Glycosylated hemoglobin, fibrinogen, vitamin C, vitamin E, malondialdehyde, ceruloplasmin, adenosine deaminase, lysozyme and
sialic acid were measured. Malondialdehyde and ceruloplasmin levels were significantly high and antioxidants such as vitamin
C, vitamin E, glutathione reduced, glutathione peroxidase and superoxide dismutase were significantly decreased in diabetic
and non-diabetic AMI patients as compared with control (p<0.001). Inflammatory markers showed significant rise in diabetic
patients as compared with controls. Our results clearly show increased inflammation and oxidative stress in patients with
acute myocardial infarction. Depression of antioxidant system in these patients confirms this conclusion. 相似文献
20.
D. Vijayakumar K. Suresh S. Manoharan 《Indian journal of clinical biochemistry : IJCB》2005,20(1):52-55
The present study has investigated the levels of lipids, lipoprotein cholesterol (HDL and LDL cholesterol), thiobarbituric
acid reactive substances (TBARS) and vitamin E in plasma and erythrocyte membranes of twenty two clinically diagnosed adult
rheumatoid arthritis patients and an equal number of age matched healthy subjects. The levels of lipids and lipoprotein cholesterol
were markedly reduced in patients with rheumatoid arthritis as compared to healthy subjects. The altered lipid pattern may
be related to decreased lipoprotein cholesterol, fatty acids and impairment in antioxidant defence mechanism. 相似文献