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1.
目的探讨血脂浓度与Ⅱ型糖尿病并发症的关系.方法检测我区保健所住院病人Ⅱ型糖尿病患者血清脂蛋白浓度,分析其与Ⅱ型糖尿病并发症的关系.结果Ⅱ型糖尿病患者血清脂蛋白浓度[TG(3.56±1.91)TC(4.81±1.00)]明显高于对照组[TG(1.52±0.85)TC(3.05±0.93),P＜0.05或P＜0.01].结论糖尿病不仅有糖代谢异常,同时还伴有脂质代谢异常,老年糖尿病患者不仅要控制血糖,还要很好地测定和控制血脂的浓度,从而早期防治并发症和减少心脑血管病的发生.  相似文献   

2.
目的:探讨2型糖尿病肾病患者血清IGF-1、PEDF、IL-18水平变化及其与不同尿微量白蛋白/肌酐比值的相关性及临床意义。方法:选取在我院住院的2型糖尿病患者223例,依据尿微量白蛋白/尿肌酐比值(ACR)水平分为单纯糖尿病组(A组)82例、微量蛋白尿组(B组)70例、临床蛋白尿组(C组)71例,选取我院体检中心健康体检者30例为对照(NC)组.采用ELISA法检测血清IGF-1、PEDF、IL-18水平,检测ACR、FPG、FINS、HbA1c、BUN、CREA、UA、TG、CHOL、HDL、LDL、Cys-C,计算胰岛素抵抗指数(HOMA-IR)。结果:4组患者在年龄、病程、BMI、ACR、Cys-C、FPG、FINS、HbA1c、BUN、CREA、UA、TG、CHOL、LDL比较,差异有统计学意义(P0.05),HDL比较,差异无统计学意义(P0.05)。2型糖尿病患者血清IGF-1、PEDF、VEGF、IL-18水平明显高于对照组,差异有统计学意义(P0.05)。Pearson相关分析显示,ACR与病程、血糖、HbA1c、CHOL、LDL、Cys-C、IGF-1、PEDF、IL-18、VEGF、BMI呈正相关(P0.05);与年龄、FINS、TG呈负相关(P0.05)。多元线性回归分析显示,IGF-1、PEDF、VEGF、CR EA、LDL、IL-18、HOMA-IR是ACR的独立影响因素(P0.05)。结论:2型糖尿病及2型糖尿病肾病患者早期就存在IGF-1、PEDF、IL-18水平异常,IGF-1、PEDF、IL-18水平增加2型糖尿病及早期肾脏损伤风险。IGF-1、PEDF、IL-18可作为2型糖尿病患者血糖控制情况及2型糖尿病肾病损伤早期发现的有价值的监测指标,预防2型糖尿病患者肾脏损伤,改善患者生活质量。  相似文献   

3.
实验性自由基形成检测及应用   总被引：2，自引：0，他引：2  
胡柏成 《科技通报》1998,14(1):55-58
用过氧化氢、醋酸铜、人血清分别作为羟自由基形成的基质、催化剂,被作用物,以检测过氧化脂质（ＬＰＯ）含量间接反映羟自由基形成量．结果表明,血清中加入同浓度过氧化氢和不同浓度的醋酸铜,其ＬＰＯ量与铜离子浓度呈正比;单加醋酸铜形成少量羟自由基,其ＬＰＯ含量与铜离子浓度也呈正比;单加过氧化氢不形成羟自由基,其ＬＰＯ含量反与过氧化氢浓度呈反比．经同条件过氧化的糖尿病、冠心病、高血压病人血清ＬＰＯ量较正常人血清（经过氧化）明显升高（Ｐ＜０．０１）,表明三种病人血清（细胞外）抗氧化能力明显下降,故体内Ｖ．Ｃ、Ｖ．Ｅ、β－胡萝卜素等对提高机体抗氧化能力,降低ＬＰＯ含量是有明显作用的  相似文献   

4.
本文随机测定了６０例特发性股骨头坏死患者和６０名健康人的全血中谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）的活性和血清过氧化脂质（Ｌｐｏ）的含量。发现特发性股骨头坏死患者血中ＧＳＨ－ＰＸ活性降低（Ｐ＜０．００１）,血清Ｌｐｏ含量则明显升高（Ｐ＜０．００１）,提示：体内氧自由基代谢紊乱参与特发性股骨头坏死的病理过程。  相似文献   

5.
HCV基因型与丙肝病毒含量及转氨酶的关系   总被引：2，自引：0，他引：2  
HCV基因型的分布随地区而异，同时HCV基因型具有重要临床意义。HCV基因型与感染途径、疾病的严重性及感染后的转归等有关。HCV基因型与HCVRNA含量有明显的相关性，HCV基因工、Ⅱ型感染者血清HCVRNA含量显著高于HCV基因Ⅲ型感染者。HCV基因Ⅱ型患者肝功能损害明显，血清ALT上升水平高，此与HCV基因Ⅱ型感染者血清HCVRNA含量显著高于HCV基因Ⅲ型感染者，肝组织损伤较重有关。  相似文献   

6.
金属硫蛋白Ⅰ、Ⅱ在正常人皮肤中的表达及其意义，重症肌无力患者血清可溶性Fas水平变化及其临床意义，29例惊恐障碍患者血清脂质水平对照研究，大肠癌肝转移的诊治进展，  相似文献   

7.
探讨血清同型半胱氨酸对2型糖尿病早期肾损伤患者中的变化,评价其临床应用价值。通过测定56例正常蛋白尿患者(NA组)、60例微量蛋白尿患者(MA组)、68例临床蛋白尿患者(CDN组)和60例健康体检者(对照组)的血清Hcy浓度,并比较各组的β2-微球蛋白、尿素氮(BUN)、肌酐(CREA)及尿微量白蛋白排泄率。结果显示,T2DM患者血清Hcy含量高于健康对照组,各组间差异具有统计学意义(P0.01或P0.05);血清Hcy含量与β2-MG、UAER、BUN和CREA水平呈正相关(r分别为0.66、0.59、0.43、0.40),P0.05。提示两者联合检测可以动态观察糖尿病肾脏的病变程度,帮助早期诊断2型糖尿病肾病,具有很好的临床应用价值。  相似文献   

8.
目的探讨拉萨地区Ⅱ型糖尿病合并OSAHS患者与人体的体重指数、颈围及腰臀比的关系。方法对我科60例患有Ⅱ型糖尿病,合并OSAHS观察组与非合并OSAHS对照组间的体重指数、颈围及腰臀比进行数据分析,比较两组参数的差异。结果观察组与对照组之间在体重指数、颈围及腰臀比等方面存在差异性,具有统计学意义(P值均<0.05)。结论Ⅱ型糖尿病合并超常的体重指数、颈围及腰臀比患者应行多导睡眠监测,进行OSAHS的筛查,及早发现并治疗OSAHS有助于糖尿病患者血糖等指标的控制。  相似文献   

9.
目的 为探讨高原地区糖尿病患者的临床表现特征,并寻求合理的治疗方案。方法：采用自身对照法,对住院确诊的糖尿病患者空腹血糖,尿糖,餐前餐后进行动态观察。进行基础治疗（包括饮食控制,药物治疗）,使用达美康与复方丹参滴凡合用。结果：发现该方法对ＮＩＤＤＭ型糖尿病患者的血糖与尿糖有转阴和稳定作用（Ｐ〈０．０１）,而该地区糖尿病患病率又以Ⅱ型糖尿病为多,多数病人为继发,结论达美康与复方丹参滴凡合用,适用Ⅱ型  相似文献   

10.
Ⅱ型糖尿病是一种胰岛素分泌相对不足的疾病，是一种常见病、多发病。随着人们生活水平的提高，它的发病率逐年上升，给患者及家庭生活带来极大痛苦和不便。现代医学治疗糖尿病主要采用药物刺激胰腺分泌胰岛素来降低血糖，但在调节胰岛细胞的分泌功能上尚缺乏有效治疗手段。笔者自2002年6月至2003年4月采用奇经梅花磁针灸综合疗法治疗Ⅱ型糖尿病获得满意效果，现报告如下：  相似文献   

11.
In diabetes, persistent hyperglycemia results in increased production of free radicals especially oxygen free radicals, which can cause cell destruction and tissue injury resulting in cell dysfunction. With the premise that oxidative stress is a major cause of diabetic complications, we conducted a controlled laboratory based investigation on level of lipid peroxide levels in the serum of Type 1 and Type 2 diabetic patients attending Muhimbili National Hospital. From our clinical data it was observed that majority of the patients had higher waist to hip ration and body mass index, which suggests that the patients were either overweight or obese. The enrolled diabetic patients had higher lipid peroxide levels than controls and also Type 2 patients had higher lipid peroxide levels than Type 1 patients. Moreover, patients with known complications had higher lipid peroxide levels than patients without complications. The lipid peroxide levels in the diabetic patients were significantly different from that of the control subjects enrolled in the study. A majority of the diabetic patients had a poorly controlled blood sugar. Our finding hints that despite the fact that diabetic patients in our clinic are on follow up, they are at a risk of developing coronary heart diseases, neuropathy and other secondary diabetic complications.  相似文献   

12.
The study was designed to find out the correlation between lipid peroxidation, lipoprotein levels to severity and complication of diabetes mellitus. Degree of lipid peroxidation was measured in terms of malondialdehyde (MDA) along with lipid profile and blood glucose in diabetes mellitus. It is categorised into insulin dependent diabetes mellitus (IDDM), non insulin dependent diabetes mellitus (NIDDM) and diabetes mellitus(DM) with complication. Total 112 known diabetic patients and 52 non-diabetic controls were studied. These patients were grouped as per the concentration of fasting blood glucose level i.e. controlled, poorly controlled, and uncontrolled group. There are significant increase in the lipid peroxide (MDA) and lipid profile except HDL cholesterol which is decreased, has been found in all groups as compared to controls In NIDDM group lipid peroxidation was markedly increased than IDDM group and it was higher in DM with complications. Other finding observed was that the level of lipid peroxide increased as per the increase in concentration of blood glucose. The increase lipid peroxidation in the hyperglycemic condition may be explained, as the superoxide dismutase enzyme which is antioxidant becomes inactive due the formation of superoxide radical within the cell. Maximum lipid peroxidation leads to the damage of the tissue and organs which results into complication in diabetic patients. High levels of total cholesterol appear due to increased cholesterol synthesis. The triglyceride levels changes according to the glycemic, control. The increase may be due to overproduction of VLDL-TG. It is concluded that good metabolic control of hyperglycemia will prevent in alteration in peroxidation and the lipid metabolism, which may help in good prognosis and preventing manifestation of vascular and secondary complication in diabetes mellitus.  相似文献   

13.
老年期痴呆患者血中氧自由基反应的相关指标   总被引：4，自引：0，他引：4  
为探讨氧自由基与老年痴呆发生发展的关系,分别测定了２７例阿尔采默型霉年期痴呆,２７例多发梗塞性痴呆患者和３７例同龄的健康老年人血清中超氧化物歧化酶及其同功酶活性和ＬＰＯ含量。结果显示：ＳＤＡＴ和ＭＩＤ患者的Ｔ－ＳＯＤ,ＣｕＺｎ－ＳＯＤ活性和ＬＰＯ含量均显著高于同龄的对照组,其中ＣｕＺｎ－ＳＯＤ的异常阳性率最高,达５９．３％;Ｔ－ＳＯＤ,ＣｕＺｎ－ＳＯＤ在不同病程的三组间有显著差异。  相似文献   

14.
New findings on organization of blood cell cytoskeleton represent an exciting aspect of modem cell biology and hematology, which is an interesting investigation to study diabetes. The present study was undertaken in 150 subjects. Out of these, 30 subjects were controls (Group I) and 30 were type-2 diabetics without any complication (Group II), while remaining 90 subjects were type-2 diabetics with complication (Group III). We determined erythrocyte spectrin and hemoglobin glycosylation and also estimated plasma lipid peroxide, nitric oxide and erythrocyte glutathione peroxidase activity to assess the status of oxidative stress. There was a significant increase in spectrin (P<0.001) and hemoglobin (P<0.001) glycosylation in Group II and III as compared to Group I and spectrin glycosylation was nearly three times more as compared to hemoglobin, whereas plasma levels of lipid peroxide (P<0.001) as well as nitric oxide (P<0.001) were found to be significantly increased and GPx activity (P<0.001) was significantly decreased in Group II and III as compared to Group I. However, it was also observed that spectrin (P>0.05) and hemoglobin (P>0.05) glycosylation was not significantly different in Group II and III. In contrast, there was significant rise in lipid peroxide (P<0.001), nitric oxide (P<0.001) and fall in GPx activity (P<0.001) in Group III when compared to Group II. Increased erythrocyte protein glycosylation and oxidative stress is clearly evident from our study. However, to understand the exact interplay between these two mechanisms, further studies are required.  相似文献   

15.
In the present study, 58 diabetic patients (type II) comprising uncomplicated (27) and complicated (31) cases along with 38 healthy matched controls were investigated for glycosylated hemoglobin (HbA1), glycosylated serum proteins (GSP) and serum lipid profile viz. triacylglycerol, total cholesterol, HDL-cholesterol (HDL-C), VLDL-C, LDL-C and their ratios. HbA1 and GSP were significantly elevated in diabetic group as a whole when compared with controls (p<0.01), but comparison of mean values of complicated and uncomplicated group revealed (though higher in complicated) that the difference between two groups was not statistically significant (p>0.05). Follow-up studies showed that while GSP levels reflect variations in blood glucose over a shorter period of 15 days, those of HbA1 do so for about 3 months. HbA1 correlated with fasting blood glucose (p<0.01), whereas GSP showed correlation with both fasting (p<0.01) and postprandial (p<0.05) blood glucose. Hypercholesterolemia and hypertriacylglycerolemia were observed (p<0.01) in both the groups. However no significant change was seen in HDL-C (p>0.05) even after accounting for sex in both the groups. Interestingly TC:HDL-C was elevated significantly (p<0.01) in the above groups. These findings seem to suggest that at the levels of hyperglycemia, hypercholesterolemia and hypertriacylglycerolemia observed, some patients are prone to develop complications earlier.  相似文献   

16.
There was increase in erythrocyte lipid peroxidation and adenosine deaminase (ADA) activity in red blood cells (RBC's), white blood cells (WBC's) and plasma, in 30 patients of confirmed diabetes mellitus, 10 each of insulin dependent diabetes mellitus (IDDM or type I), non-insulin dependent diabetes mellitus (NIDDM or type II) and diabetes with ketoacidosis when compared with 20 healthy individuals (controls). Glycosylated hemoglobin A1c%, plasma free fatty acid (FFA) and glycerol levels were also elevated in all the cases when compared with controls. The increase was more in diabetic ketoacidosis group. Significant positive correlations were seen between erythrocyte lipid peroxidation and ADA activities in RBC's, WBC's and plasma. It is suggested that decreased tissue adenosine levels due to increase in ADA activity, is related to the severity of hyperglycemia and lipid peroxidation in diabetes mellitus.  相似文献   

17.
In the present study the antioxidative potential ofMomordica charantia, Azadirachta indica, Allium sativum andOcimum sanctum was assessed in streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed when the above herbal hypoglycemic agents were given to diabetic rats. On the basis of our results we conclude thatM. charantia, A. indica, A. sativum andO. sanctum are not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant potential.  相似文献   

18.
The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born after premature rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05) as compared to controls. Proteolytic activity in the erythrocytes of mothers in this group was also significantly high (p<0.01). In patients delivered by lower segment cesarian section, lipid peroxidation and proteolytic activity in maternal erythrocytes were significantly high (p<0.05 and p<0.001 respectively). In patients with prolonged second stage of labour, lipid peroxidation and proteolytic activity in maternal erythrocytes was significantly higher than in controls (p<0.001 and p<0.05 respectively). In this group, endogenous protein damage due to oxidative stress was significantly high both in the mother and the fetus (p<0.001 and p<0.05 respectively).  相似文献   

19.
The present study demonstrates the possibility of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity during intrauterine growth retardation. The erythrocyte MDA levels were significantly elevated in mothers of IUGR babies when compared to controls (p<0.01). The endogenous protein damage due to oxidative stress was significantly higher in IUGR mothers when compared to controls (p<0.05). Similarly the proteolytic activity in erythrocyte lysates against oxidatively damaged hemoglobin was significantly increased in mothers of IUGR babies compared to controls (p<0.001). In fetuses born with IUGR, both lipid peroxidation and proteolytic activity were significantly increased when compared to normal newborns (p<0.01). The result of this study indicates that oxidative stress was induced both in IUGR babies and their mothers which is manifested as increased lipid peroxidation and protein oxidant damage.  相似文献   

20.
This study was undertaken to evaluate the levels of plasma magnesium, lipid peroxides, nitric oxide end products, erythrocyte membrane lipid peroxides, erythrocyte reduced glutathione and erythrocyte superoxide dismutase activity in type-2 diabetes mellitus patients. 60 patients with type-2 diabetes mellitus and 30 healthy control subjects were included in this study. Among 60 type-2 diabetic patients, 30 patients were without complication and 30 patients were with various complications. Decreased levels of plasma magnesium, erythrocyte reduced glutathione and erythrocyte superoxide dismutase activity while increased levels of plasma lipid peroxides, nitric oxide end products and erythrocyte membrane lipid peroxides were observed in patients with type-2 diabetes mellitus. We propose that, under the shadow of hypomagnesaemia, there is excessive production of reactive oxygen species and reactive nitrogen species as reflected by elevated lipid peroxides and nitric oxide end products concomitant with dwindled antioxidants and suggest their association with late complications in type-2 diabetes mellitus.  相似文献   

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