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1.
ＣＯＭＰＡＲＩＳＯＮＯＦＴＨＥＯＢＳＥＲＶＥＤＣＯ＿２ＤＡＴＡＳＥＴＳＩＮＴＨＥＡＴＬＡＮＴＩＣＯＣＥＡＮＣＯＭＰＡＲＩＳＯＮＯＦＴＨＥＯＢＳＥＲＶＥＤＣＯ＿２ＤＡＴＡＳＥＴＳＩＮＴＨＥＡＴＬＡＮＴＩＣＯＣＥＡＮ￥ＸｕＹｏｎｇ－ｆｕ（Ｉｎｓｔｉｔｕｔ...  相似文献   

2.
ＤＥＶＥＬＯＰＭＥＮＴＯＦＡＶＡＣＵＵＭＳＰＡＲＫＤＩＳＣＨＡＲＧＥＳＯＵＲＣＥＤＥＶＥＬＯＰＭＥＮＴＯＦＡＶＡＣＵＵＭＳＰＡＲＫＤＩＳＣＨＡＲＧＥＳＯＵＲＣＥ￥ＧｕｏＹｕ－ｂｉｎ；ＬｉＦｕ－ｔｉａｎ（ＣｈａｎｇｃｈｕｎＩｎａｔｉｔｉｄｅｏｆＯｐｔｉ...  相似文献   

3.
ＣＲＹＳＴＡＬＳＴＲＵＣＴＵＲＥＳＯＦＣＨＡＲＧＥＴＲＡＮＳＦＥＲＳＡＬＴＳ（ＴＴＭＴＴＦ）_２Ｃｕ_２Ｃｌ_６ＡＮＤＣ_（４０）Ｈ_（７２）Ｎ_６Ｓｅ_４ＮｉＣｈｅｎＸｕｅ－ａｎ；ＹａｎｇＸｕｅ－ｙｏｎｇ；ＷｕＰｅｉ－ｊｉ；ＺｈｕＤａｏ－ｂｅｎ；ＦｕＨｅ?..  相似文献   

4.
ＯＮＤＥＴＥＲＭＩＮＩＮＧＴＨＥＳＯＬＶＡＢＬＥＤＯＭＡＩＮＯＦＡＳＹＳＴＥＭＯＦＥＱＵＡＴＩＯＮＳＷＩＴＨＰＡＲＡＭＥＴＥＲＳ──Ｐａｒｔ１：ＡｌｇｅｂｒａｉｃＰｏｌｙｎｏｍｉａｌＥｑｕａｔｉｏｎｓ￥ＣｈｅｎＪｉｎｃｈｅｎｇ（Ｄｅｐａｒｔｍｅｎｔｏ...  相似文献   

5.
ＡＳＹＭＰＴＯＴＩＣＥＦＦＩＣＩＥＮＣＹＩＮＡＰＡＲＴＬＹＬＩＮＥＡＲＲＥＧＲＥＳＳＩＯＮＭＯＤＥＬＬｉａｎｇＨｕａ（ＩｎｓｔｉｔｕｔｅｏｆＳｙｓｔｅｍｓＳｃｉｅｎｃｅ，ＡｃａｄｅｍｉａＳｉｎｉｃａ，Ｂｅｉｊｉｎｇ１０００８０，Ｐ．Ｒ．Ｃｈｉｎａ）Ａ...  相似文献   

6.
ＤＥＴＥＲＭＩＮＡＴＩＯＮＯＦＣＹＡＮＩＤＥＢＹＡＳＰＥＣＴＲＯＰＨＯＴＯＭＥＴＲＩＣＲＥＶＥＲＳＥＤＦＬＯＷＩＮＪＥＣＴＩＯＮＭＥＴＨＯＤ￥ＪｉｎｇｆｕＬｉｕａｎｄＨｕｉｃｈａｎｇＭａ（ＲｅｓｅｔｒｃｈＣｅｎｔｅｒｆｏｒＥｃｏ－Ｅｎｖｉｒｏｎｍｅｎ...  相似文献   

7.
ＭＥＡＳＵＲＥＭＥＮＴＯＦＳＯＤＡＣＴＩＶＩＴＹＢＹ~（１９）ＦＮＵＣＬＥＡＲＭＡＧＮＥＴＩＣＲＥＳＯＮＡＮＣＥ（ＮＭＲ）ＲＥＬＡＸＡＴＩＯＮＲＡＴＥＺｈａｏＢａｏ－Ｌｕ；ＣｈｅｎＹｕｎ－ＺｕｎａｎｄＸｉｎＷｅｎ－Ｊｕａｎ（ＩｎｓｔｉｔｕｔｅｏｆＢｉ?..  相似文献   

8.
ＳＹＮＴＨＥＳＩＳＡＮＤＰＲＯＰＥＲＴＩＥＳＯＦＨＥＰＡＲＩＮＩＺＥＤＰＯＬＹＭＥＴＨＡＣＲＹＬＩＣＡＣＩＤ￥ＦｅｎｇＰｉｎｚｈｅｎ；ＬｕＪｉａｎｔａｏ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，ＧｒａｄｕａｔｅＳｃｈｏｏｌ，ＡｃａｄｅｍｉａＳｉｎ...  相似文献   

9.
ＣＨＡＲＡＣＴＥＲＩＳＴＩＣＳＯＦＴＨＥＦＲＡＣＴＡＬＳＡＰＰＥＡＲＥＤＯＮＡＬＵＭＩＮＩＵＭＦＯＩＬＩＲＲＡＤＩＡＴＥＤＢＹＩＮＴＥＮＳＥＲＥＬＡＴＩＶＩＳＴＩＣＥＬＥＣＴＲＯＮＢＥＡＭ￥ＧａｏＨｕａｉ－ｌｉｎ；ＰａｎＹｕ－ｌｉ（ＣｈｉｎａＩｎｓｔ...  相似文献   

10.
ＳＩＮＧＬＥ－ＳＷＥＥＰＯＳＣＩＬＬＯＰＯＬＡＲＯ－ＧＲＡＰＨＩＣＡＮＡＬＹＳＩＳＯＦＰ－ＮＩＴＲＯＢＥＮＺＯＩＣＡＣＩＤ￥ＹｕａｎＺｈｕｏ－ｂｉｎ；ＨａｎＦｅｎｇ－ｍｅｉ；ＣｈｅｎＹｏｎｇ；ＷｕＹａｎ－ｘｉａ（ＧｒａｄｕａｔｅＳｃｈｏｏｌ，Ｃｈｉｎ...  相似文献   

11.
Present study investigated the effects of isoproterenol-induced oxidative stress on hemodynamic and ventricular functions in rats. Subcutaneous injections of isoproterenol (85 mg/kg for two consecutive days at 24 h interval) significantly decreased myocardial antioxidant enzymes; superoxide dismutase, catalase and glutathione peroxidase in heart. Isoproterenol-induced oxidative stress was also evidenced by significant depletion of reduced glutathione and increased formation of lipid peroxidation product, thiobarbituric acid reactive substances along with depletion of myocyte injury specific marker enzymes; creatine phosphokinase isoenzyme and lactate dehydrogenase. The deleterious outcome of oxidative stress on hemodyanmic parameters and ventricular function were further evidenced by decreased systolic, diastolic and mean arterial blood pressure, heart rate, ventricular contractility; [(+)LVdP/dt] and relaxation; [(−)LVdP/dt], along with an increased left ventricular end diastolic pressure (LVEDP). Subsequent to changes in heart rate and arterial pressure, isoproterenol also decreased rate pressure product. Present study findings clearly demonstrate the detrimental outcome of isoproterenol induced-oxidative stress on cardiac function and tissue antioxidant defense and substantiate its suitability as an animal model for the evaluation of cardioprotective agents.  相似文献   

12.
STZ诱导的糖尿病对骨密度和血清睾酮的影响（英文）   总被引：2，自引：0，他引：2  
目的：探讨链脲霉素（STZ）诱导的糖尿病对大鼠骨代谢的影响及机制。材料与方法：雄性Wistar大鼠随机分成3组: 正常组（n = 6），糖尿病组（n = 5）和胰岛素治疗糖尿病组 (n = 5)。大鼠尾静脉一次性注射STZ（50 mg/kg 体重），选择空腹12 h血糖大于12 mmol/L的大鼠为本实验所需的糖尿病模型。治疗组大鼠每天在同一时间给予1.8－2.2U的胰岛素。实验周期为持续32天。采用双能X线骨吸收法（DEXA）测定股骨密度，ELISA法测定血清雄性激素睾酮水平，生化分析仪测定血清碱性磷酸酶、钙、磷浓度。结果：糖尿病大鼠的股骨密度和血清睾酮均显著低于正常组（P < 0.01），血清总碱性磷酸酶明显高于正常组和胰岛素治疗组（P < 0.01）。三组之间血钙和血磷的水平无明显差异。胰岛素治疗后糖尿病大鼠的骨密度、血清睾酮与总碱性磷酸酶得到明显的改善。结论：糖尿病严重影响骨密度，胰岛素缺乏及雄性激素降低是导致糖尿病性骨质疏松重要原因。胰岛素治疗能预防骨流失和提高血清睾酮浓度。  相似文献   

13.
Abdominal obesity (AO) has a strong correlation with cardiovascular disease and has been linked to Alzheimer’s disease and type 2 diabetes. We investigated the association between AO and elevated serum butyrylcholinesterase (BChE) activity, insulin resistance and the serum lipid profile, including triglyceride (TG), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) levels in AO and non-AO women subjects. A total of 500 AO subjects (age 49.1 ± 10.5 years), and 142 non-AO women subjects (age 49.9 ± 11.9 years) were enrolled for the general biochemistry tests, serum BChE, fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR). Body mass index, waist circumference, Blood pressure (BP), plasma glucose (Glu), triglyceride (TG), BChE, insulin, HOMA-IR were significantly higher and HDL-C levels were significantly lower in AO subjects (p < 0.05). Waist circumference was significantly correlated with BP, Glu, TG, BChE, insulin and HOMA-IR in AO subjects. Multiple logistic regression demonstrated that AO was associated with elevated BChE, HOMA-IR, hypertension and reduced HDL-C after adjusting for these variables. AO is associated with elevated BChE, insulin resistance, HT and reduced HDL-C. These may predict the development of type 2 diabetes mellitus and may be associated with cognitive disorder in the future, both are mediated through insulin resistance.  相似文献   

14.
为探讨风湿性心脏病二尖瓣狭窄左房血栓形成临床相关因素，对69例风心二狭患者行经胸及食管超声心动图检查，并用发色底物显色法测定血浆组织型纤溶酶原激活物活性（tPA)，组织型纤溶酶原激活物抑制物1(PAI-1)活性，抗凝血酶Ⅲ（AT-Ⅲ）活性。结果显示风心二狭左房血栓形成者与无血栓形成者比较年龄偏大，症状持续时间较长，心房纤颤发生率高。超声心动图可见血栓形成者左房内径较大，左室射血分数低下，二尖瓣口面积较小，明显二尖瓣关半闭不全情况少见，且左房血栓形成者均有左房自发性回声（SEC），发生率明显高于无左房血栓形成者。血凝学检查左房形成血栓者红细胞压积（Hct）较高，AT－Ⅲ活性低于无左房血栓形成者（P＜0．01），而纤溶活力左房血栓形成者反而高于无左房血栓形成者，表现为tPA活性较高，PAI－1活性相对较低（P＜0．05）。多元回归分析表明左房SEAC、AT－Ⅲ活性、年龄、二尖瓣口面积是左房血栓形成的独立相关因素。说明风心二狭患者左房血栓的形成不仅与血流的机械性梗阻，而且与机体抗栓能力的下降有关。  相似文献   

15.
为探讨老年高血压病左室肥厚（LVH）与部分神经体液因素之间的关系及与室性早搏，心肌缺血的相关性，老年高血压病伴左室肥厚60例为A组，单纯老年高;血压病60例为B组，对比观察心率变异，肾素（Ren)，血管紧张素（AT－II），醛固酮（Ald)，胰岛素峰值（Ins),24h动态心电图和血压等指标，结果显示：1）A组病人交感神经张力明显增高，迷走神经活性下降不明显，室性早搏的发生与交感神经张力增高有关；室性早搏与心肌缺血具有相关性；2）A组病人与Ald及Ins水平有关，与Ren和AT－II无明显相关；3）A组病人与室性早搏和心肌缺血明显相关，结论表明，老年高血压病在室肥厚患者交感神经张力增高，Ald及Ins水平升高，与室性早搏，心肌缺血具有正相关。  相似文献   

16.
Growth retardation is one of the significant changes in chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Disturbances in growth hormone (GH) are held responsible for several complications in CKD. GH is a protein based peptide hormone which directly or indirectly regulates renal functions to ensure homeostasis. We investigated the effects of growth hormone on plasminogen activators (PA) in rat kidney, PA and plasminogen activator inhibitor (PAI), glucose and fibrinogen in plasma and serum lipid profile. Rats were injected daily with 250 mU GH kg-1 body weight subcutaneously for one week. Growth hormone treatment increased PA activity significantly in rat kidneys as compared to controls. No changes were seen in PA, PAI and fibrinogen levels in the plasma of two groups of rats. There was significant decrease in plasma glucose, total cholesterol and LDL-cholesterol levels in serum of treated group resulting in the decrease of HDL/LDL and total cholesterol/cholesterol ratios. However, triglycerides and VLDL showed significant higher activity in the serum of treated group as compared to controls. Our data suggests that GH administration might improve renal function by increasing PA activity in kidney as well as by reducing the cholesterol content in blood. GH may be effective in improving growth failure as it helps to maintain the normal homeostatic balance.  相似文献   

17.
中草药对仔猪生长性能和血清生化参数的影响   总被引：7，自引：0，他引：7  
试验选用21日龄断奶的三元杂交（杜洛克×长白×大约克）仔猪60头，按完全区组设计分为3组，处理1饲喂添加0.2%中草药复方添加剂日粮，处理2饲喂添加0.02％硫酸粘杆菌素日粮，处理3饲喂基础日粮。饲喂一定时间后考察仔猪生长性能、腹泻指数、血清生化参数和器官指数等指标的变化。结果表明，中草药复方添加剂能提高仔猪ADG，降低F/G(P<0.05)，防治断奶仔猪腹泻效果强于硫酸粘杆菌素（P<0.05）；该添加剂还能提高血清TP, ALB和TCHO含量以及GOT, GPT, AMY和LPS活性，降低GLU和TG含量以及CK活性。上述结果提示，本试验所用中草药复方添加剂能够缓解仔猪断奶应激，增强机体抵抗力，促进生长。  相似文献   

18.
Role of Vitamin D supplementation was studied in patients with hypertension. One hundred hypertensive patients (group I) were given conventional antihypertensive drugs while another 100 patients (group II), in addition, were supplemented with Vitamin D3 (33,000 IU, after every 2 weeks, for 3 months). Besides diastolic and systolic blood pressure, serum calcium, phosphorous, alkaline phosphatase, albumin, albumin-corrected calcium, and 24 h urinary creatinine levels were estimated in both the groups before the start of treatment and after 3 months. Vitamin D supplementation showed a more significant decrease in systolic blood pressure. This group also showed a significant increase in serum calcium as well as albumin-corrected calcium with a decrease in phosphorous. Results of the study confirm that Vitamin D supplementation has a role in reducing blood pressure in hypertensive patients and that it should be supplemented with the antihypertensive drugs. More extensive studies with a larger group, to draw a definite conclusion, are in progress.  相似文献   

19.

Introduction

The study of cardiac response to strenuous and continuous exercise is crucial to understanding the physiology of endurance. N-terminal proB-type natriuretic peptide (NT-proBNP) is a potential marker for monitoring myocardial wall stress, and troponins (TnT and TnI) are widely used in the diagnosis of cardiac ischemia and infarction. Strenuous exercise may generate transitory ischemia, myocardial stress, and diastolic left ventricular dysfunction, inducing the increased production of both these biomarkers. We measured changes in NT-proBNP and TnT in elite cyclists during a 3-week stage race, a model of strenuous exercise.

Materials and methods:

The study population was 9 professional cyclists participating in the 2011 Giro d’Italia. Pre-analytical and analytical phases scrupulously followed official recommendations. Anthropometric data, net energy expenditure and cardiac indexes (rate, diastolic and systolic blood pressure) were recorded. Blood samples were drawn pre-race (day −1) and at days 12 and 22; NT-proBNP and highly sensitive-troponin (Hs-TnT) concentrations were assayed and corrected for plasma volume changes.

Results:

Body-mass index decreased and energy expenditure increased by 52% during the race. NT-proBNP concentrations increased [day −1: 23.52 ng/L (9.67–34.33); day 12: 63.46 ng/L (22.15–93.31); P = 0.039; day 22: 89.26 ng/L (34.66–129.78) vs. day −1; P < 0.001] and correlated with heart rate (r = −0.51; P = 0.006), systolic pressure (r = 0.39; P = 0.046) and energy expenditure (r = 0.70; P < 0.001). TnT concentrations did not vary, but a widened TnT amplitude distribution was observed.

Conclusions:

Increases in NT-proBNP correlated with higher energy expenditure over a 3-week cycling stage race, possibly indicating myocardial stress.  相似文献   

20.
Elevated free radical generation in inflamed joints and impaired antioxidant system has been implicated in rheumatoid arthritis (RA). Green tea extracts (GTE) have been shown to reduce inflammation in inflammatory arthritis murine model. This study investigates possible mechanisms by which vitamin C and GTE protect joints in RA rat model. This study included forty adult male rats that were divided into four groups (10 rats each); control group, collagen II induced RA group (CII), CII treated with vitamin C (CII + Vit C) and CII treated with GTE (CII + GTE) in physiology laboratory, Assiut University, Egypt. After 45 days of treatment, plasma levels of lipid peroxides (LPO), nitric oxide (NO), ceruloplasmin (CP), superoxide dismutase (SOD), uric acid (UA) and glutathione (GSH) were detected using colorimetric methods, PGE2 using ELISA and copper (Cu) and zinc (Zn) using spectrometer. In CII group, levels of LPO, NO, PGE2, UA, CP, Cu were higher while SOD, GSH, Zn were lower than controls. In groups treated with vitamin C and GTE, levels of SOD, GSH were increased while levels of LPO, NO, PGE2, Cu, CP were decreased compared with CII group. Levels of UA were decreased and Zn increased in GTE treated group compared with CII group. GTE treated group showed higher Zn and low Cu levels compared with vitamin C treated group. This study suggests proper GTE and vitamin C intake may effectively normalize the impaired oxidant/antioxidant system and delaying complication of RA.  相似文献   

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