共查询到20条相似文献，搜索用时 31 毫秒
1.
Michelle Gittelman 《Research Policy》2006,35(7):1052-1068
The biotechnology industry is a striking example of the disconnect between the location of knowledge creation and its commercial development. I argue that national technological performance in biotechnology is critically affected by institutions governing scientific careers, which shape the professional identities and boundary-spanning activities of research scientists. I test this in a comparison of the United States and France. Drawing on fieldwork and analysis of patent data, I compare institutional frameworks and estimate models of forward patent citations. The models show that entrepreneurial firms are associated with high-performing innovations in this sector whereas large established firms perform poorly in both countries, and highlight the importance of institutions in creating country-specific combinations of human capital with organizational capabilities. 相似文献
2.
Many young biotechnology firms act as intermediaries in tripartite alliance chains. They enter upstream partnerships with public sector research institutions, and later form commercialization alliances with established, downstream firms. We examine the alliance activity in a large sample of biotechnology firms and find: (i) firms with multiple in-licensing agreements are more likely to attract revenue-generating alliances with downstream partners; however, (ii) the positive relationship between in-licenses and downstream alliances attenuates as firms mature, and (iii) the diversity and the quality of the academic connections of firms’ principals influences their chances of successfully acquiring commercialization rights to scientific discoveries in universities. 相似文献
3.
地理邻近对企业创新绩效的影响 总被引：1，自引：0，他引：1
本文运用2003-2016年中国生物技术企业的面板数据,考察了地理邻近对企业创新绩效的影响,同时将企业内部网络特征纳入研究框架,分析了企业内部网络的集聚度和平均路径长度对地理邻近与企业创新绩效关系的调节作用。研究结果表明,地理邻近促进企业创新绩效的提升;企业内部网络的集聚度正向调节地理邻近对企业创新绩效的促进作用;企业内部网络的平均路径长度负向调节地理邻近对企业创新绩效的促进作用。本文研究结论对中国企业的内部知识结构设计提供借鉴。 相似文献
4.
The creation of new knowledge is a haphazard process: not every sector in an economy is equally involved. The effect of industry structure on innovativeness has been a focus of attention for a long time by both academics and policymakers. In a much quoted article, using unique data - new-product announcements - Acs and Audretsch [Acs, Z.J., Audretsch, D.B., 1988. Innovation in large and small firms: an empirical analysis. American Economic Review 78(4), 678-690] identified several characteristics of industry structure and their effects on innovativeness. By analyzing a new and more consciously compiled database, we re-examine their original claims. Our results largely support their findings: industry concentration and degree of unionization for instance hamper innovation; skilled labor promotes it. Our findings diverge in one significant respect from theirs: we suggest that the large firms do not contribute more to an industry’s innovativeness than small firms. At the industry level, we find strong support for the Schumpeter Mark I perspective of creative destruction by small firms rather than creative accumulation by large firms. In addition, we show that less dedicated innovators prove more susceptible to firm-external industry factors than more committed innovators. An unfavorable competitive environment decreases the likelihood that less successful innovators will announce new products. 相似文献
5.
In the defence industry the recent development of a ‘market for technology’, the creation of new European high-technology companies as well as transformations in government agencies have driven firms to reposition their technological and organizational skills. Our objective is to show that the transformations that have occurred in the past 10 years have not only redefined skills and the organization of production, but also have given a more strategic place to knowledge management (KM) practices. We provide a contextual and historical overview based on qualitative interviews, in order to better understand the relation between KM and innovative behaviour in this industry. We build an original industrial and technological database comprising various samples that provides quantitative information concerning KM and innovative practices. The results of the statistical analysis reveal the specificity of firms in this industry. Taking account of the size of these firms and their technological intensity, we show that the behaviour of defence industry firms in terms of KM practices, differs from that of other firms. This is evident from their technological performance, and innovation and patenting intensity. This structural tendency is explained as an innovative behaviour in the French national innovation system rather than merely a ‘trend’. 相似文献
6.
Fiona Murray 《Research Policy》2004,33(4):643-659
While science-based entrepreneurial firms are a key feature of the modern economy, our insights into their organization and productivity remain limited. In particular, our understanding of the mechanisms through which academic inventors shape entrepreneurial firms established to commercialize their scientific ideas is based upon a traditional perspective that highlights the importance of human capital. Based on a study of biotechnology firms and their academic inventors, this paper examines the extent and mechanisms through which academic scientists contribute not only human capital but also social capital to entrepreneurial firms. The paper makes two contributions to our understanding of the academic-firm interface: First, it establishes that the social capital of academic scientists is critical to firms because it can be transformed into scientific networks that embed the firm in the scientific community through a variety of mechanisms. Second, the paper argues that an academic inventor’s career plays a critical role in shaping his social capital, thus scientific careers mediate the networks and potential for embeddedness that an academic inventor brings to a firm. Specifically, the foundations of an academic’s social capital can be traced to two sources: The first element that the firm may leverage is the academic’s local laboratory network—a network to current and former students and advisors established by the inventor through his laboratory life. The second form of social capital is a wider, cosmopolitan network of colleagues and co-authors established through the social patterns of collaboration, collegiality and competition that exemplify scientific careers. These findings suggest that scientific careers are central in shaping an academic’s social capital which can be translated into critical scientific networks in which entrepreneurial firms become embedded. 相似文献
7.
This paper analyses the role of repeated ties in the high-tech pharmaceutical biotechnology industry, a sector that is characterized by a strong dual market structure. Our most important finding is that previous ties in pairs of large pharmaceutical companies and small biotechnology firms have a negative effect on their subsequent partnering. An explanation for this result is found in the context of understanding the specifics of large-small coalitions in a high-tech dual market structure. Unlike what is known about repeated ties in many other industries, this high-tech dual market structure indicates that R&D partnerships between a small number of very large companies and a large group of dependent, small firms are not characterized by mutual dependence, similarity, or equality. 相似文献
8.
Interactions between public research organizations and industry can be conceptualized as having three main stages: drivers of interaction, channels of interaction, and the perceived benefits from collaboration. Both of the agents differ in terms of the incentives they have to collaborate and the behaviors they adopt during the collaboration process. Following a three-stage model based on Crépon et al. (1998), this paper discusses the impact of drivers of collaboration on channels of interaction, and the impact of these channels on the perceived benefits by researchers and firms. The methodology also allows firm-level benefits from interaction to be connected with researchers’ characteristics via the analysis of four common channels of interaction for firms and researchers. The study is based on original data collected through two surveys, carried out in Mexico during 2008, of R&D and product-development managers of firms and of academic researchers. Our results show that all channels of interaction play an important role in determining benefits; however, they differ in terms of their impact on short- or long-term benefits for firms. The channels related to joint and contract R&D, property rights, and human resources are the best, as they have a higher impact on long-term benefits for firms. Policy implications derived from this study focus on specific actions that enhance those researchers’ characteristics related to the best channels for fostering long-term benefits for firms. 相似文献
9.
《国际创新研究学报(英文)》2022,6(3):196-215
This study examines technological capability accumulation and the Brazilian rice industry's technological trajectory. Multiple case design was chosen, with an analysis of seven firms involved in the Brazilian rice industry. The results indicate three factors: The first was the identification of technological landmarks for firms in this sector (peeling and polishing, electronic grain selection, electronic packaging, use of forklifts and palletizers, and Industry 4.0). The second is related to the fact that different firms implemented innovative activities and technologies at different speeds, originating from the sector's different technological trajectories. The third is associated with identifying activities within the Brazilian rice industry that can be generalized to other food industries. These results have implications for formulating public policies in the sector, such as creating producer support mechanisms (research and technology transfer institutions), qualification of professionals, and encouragement for economic efficiency and competition. 相似文献
10.
Emilie-Pauline Gallié 《Research Policy》2012,41(4):780-794
In attempting to protect their innovations, firms can choose from a range of mechanisms, which may be either non-statutory (trade secrets, design complexity, and lead-time advantage over competitors) or statutory (patent, design registration, trademark, copyright). Yet, little is known about how firms do actually make their choices from among these different appropriability mechanisms. The aim of this paper is to determine how French firms’ use of intellectual property protection mechanisms relates to the type of innovation, the characteristics of the market sector in which they operate, the firms’ characteristics, and their human resources strategies. Our empirical model draws on four French databases covering the period 2001-2004. Our results show that the choice of a means of protection matters and emerges out of a complex strategy. Our results also reveal that the different statutory and non-statutory means of protection are complementary within their own categories but hardly so between categories. 相似文献
11.
This paper examines interdependencies between firms’ activities in the realms of open science and commercial product development. We present a theoretical framework that outlines when a firm’s involvement in academic communities enhances its innovative performance in terms of new products in development. We argue that the disclosure of more, valuable R&D work in quality scholarly publications and collaborations with academic partners positively affect firm innovation. We further hypothesize a differential effect of adopting open science strategies on the innovation type, being more pronounced for radical innovations than for incremental innovations. We empirically analyze a unique panel dataset containing information on the product innovation performance and R&D activities of 160 UK therapeutic biotechnology firms over the period 1998- 2009. Our results from count data models on the number of new products in development provide empirical support for our hypotheses. 相似文献
12.
Alliances with established organizations provide young firms with resources necessary for survival. We build on recent organizational research examining the effect of upper echelons on attracting powerful intermediaries to understand how young biotechnology firms establish alliances with established organizations. Drawing upon the concept of homophily, we test hypotheses regarding the extent to which young firms and partners match along specific homophily dimensions. Our findings from an event-history analysis of 3,200 career histories of managers who took biotechnology firms public between 1979 and 1996 show that alliance formation is related to status homophily and role-based homophily between young and established organizations. 相似文献
13.
Biotechnology firms operate in a high-risk and high-reward environment and are in a constant race to secure venture capital (VC) funds. Previous contributions to the literature show that the VC firms tend to invest locally in order to monitor their investments and to provide operating assistance to their target firms. Further, biotechnology is a knowledge-based industry that tends to exhibit spatial clusters, and the firms in such industries may collocate to benefit from gaining access to local markets for specialized inputs (e.g., skilled researchers) and from local knowledge spillovers and network externalities. If such gains exist, we expect that the collocated firms should exhibit positively correlated performance, including in their ability to attract venture capital funds. The purpose of this paper is to empirically measure the strength and spatial extent of the relationships among the amount of funds raised by proximate biotechnology firms. We model these relationships with a spatial autoregression (SAR) model, and we control for characteristics of the biotechnology firms and the VC firms that provide their funds as well as site-specific factors. Based on our fitted SAR model, we find that the amount of venture capital raised by a particular biotechnology firm is significantly influenced by the number of VC firms and the VC funding levels raised by biotechnology firms located within a 10-mile radius, but these relationships are not statistically significant beyond this range. 相似文献
14.
Shin-Horng Chen 《Research Policy》2004,33(2):337-349
Although it is evident that technology is becoming increasingly globalized, resulting in the expansion of R&D internationalization by firms, despite this discernible trend, the substantial body of literature in this area is based mainly on the experience of the developed country. This paper aims to contribute to the understanding of this issue by examining the R&D internationalization of a newly-industrializing country, Taiwan being a prime example, and its connection with the global production network. We begin with an examination of the literature on R&D internationalization and globalization, based upon which we propose a conceptual framework adapted from Dunning’s eclectic paradigm. In doing so, we set out to develop arguments based not only on the reasons why cross-strait R&D internationalization may be undertaken by Taiwanese information technology (IT) firms, but also the likely patterns of their R&D portfolios across the strait. Drawing on an original questionnaire survey and firm-level interviews, the paper presents and discusses empirical data on the cross-strait R&D deployment of Taiwanese IT firms. It then goes a stage further, using the ‘smiling curve’, to put forward a ‘holistic’ view of the cross-border innovation network in the IT hardware industry, in order to determine what cross-strait R&D internationalization means to the global production network. 相似文献
15.
This paper presents a taxonomy of entrepreneurial behaviour vis-à-vis technology, derived from empirical research on a specific sector, that of the chemicals industry in Venezuela. The research focuses heavily on the accumulation of minor innovations through which enterprises acquire their technical knowledge and know how, their technological learning. We have tried to give a precise empirical meaning to that notion in order to understand which are the most important variables that affect the technical learning process. Both the process of technological learning and the technical external linkages — in particular with foreign firms — of Venezuelan companies seem to be the fundamental factors in understanding the development of a new competitive industry which adopts a new products-oriented strategy. But not all firms do respond to such a scheme and it is thus necessary to develop a taxonomy of the industrial sector both for scholarly reasons as well as a policy guide. 相似文献
16.
Do capabilities evolve differently as a function of the firm's unique ties or through the cumulative exposure to specific types of knowledge? We view capability evolution with respect to a firm's accumulation of knowledge-derived assets—patents. This study proposes that capabilities evolve by way of a firm's solo and joint invention experiences, and contends that these capabilities are uniquely shaped by the firm's history of patenting with two specific types of ties, upstream and downstream partners. Using a sample of 11,593 patents produced by 256 biotechnology firms from 1985 to 2006, we find that prior joint invention experience diversifies the capabilities of the firm and broadens its strategic options. In uncovering an inverted ‘U’ relationship, we also find that capabilities evolve differently according to the firm's unique joint invention experiences. Moreover, firms that continue to engage in more joint invention experiences develop broader capabilities than firms that retreat from this strategy and pursue solo inventions, whereby more specialized capabilities develop. Focusing on how R&D strategies impact capability development, our findings extend research on capabilities by accounting for how the path dependent role of shared property rights influences the technological trajectory of the firm. 相似文献
17.
The main purpose of this paper is to describe the firm-level learning processes by indigenous firms in China, identify the differences between learning processes in small tigers and large dragons, such as China. This paper first sketches the history of the China’s color TV (CTV) industry in which learning processes take place to put the companies case studies into context. Then, this paper examines closely the actual experience of two major Chinese firms in their practice of technological learning. Finally, this paper finds that the most significant difference between learning processes in Chinese firms and these four other tigers’ firms is that, firms from four other tigers usually rely almost exclusively on export markets, but Chinese firms are mostly local market-focused.A novel contribution of this paper is its analysis of the issue: the two Chinese firms have followed not an export-growth path, but an local market-focused path, which proved to be much less successful in countries, such as India, Latin America, Africa and former Soviet Union. The success of this process in China hinges on the five critical factors: (1) a number of multinational firms are increasing their presence in China; (2) there is vibrant competition among domestic firms; (3) the huge domestic market is a key incentive for local firms to invest in technological learning; (4) Chinese central government takes a phased approach to liberalization of the domestic market; (5) there have a number of risk taking entrepreneurs with strategic version, who make investment decisions on learning. These factors should not be easily available to other developing countries. In this regard, China’s experience has limited application to other developing countries. 相似文献
18.
Alex Coad 《Research Policy》2019,48(1):37-50
Do firms in the same sector converge towards the same R&D intensities? Previous research has often assumed this to be true. A closer examination, using microdata from the EU Industrial R&D Investment Scoreboard for the years 2000–2015, shows considerable heterogeneity in R&D intensities among firms in the same sector, and that this heterogeneity persists over time. Statistical tests of convergence show that the variation in R&D intensities does not decrease over time (i.e. no σ-convergence), although firms with an R&D intensity below the industry average do seem to catch up with the leaders (i.e. evidence of β-convergence). Overall, firms in the same industry do not converge to a common R&D intensity. Policy implications are discussed. 相似文献
19.
Tourism firms operate in a competitive sector where innovating is often a condition for survival. This article presents a theoretical framework for understanding tourist firms’ innovative behaviour and innovation systems in tourism. The innovativeness of tourism firms and its determinants are investigated by analysing quantitative as well as qualitative data comparing Spain and Denmark. A taxonomy of tourism firms is suggested and the firms’ characteristics which influence their innovativeness are presented. Additionally, the role of innovation networks is discussed, as is the role of innovation systems. The article suggests that large size, professionalism, but also entrepreneurship among small tourism firms are important determinants of innovation. Varied innovation networks are another determinant as are supportive innovation systems. These determinants favour Spanish firms, which are more innovative than Danish ones. In the final section, policy recommendations are presented. 相似文献
20.
《普罗米修斯》2012,30(1):85-100
Knowledge management (KM) approaches have developed traditionally from the knowledge-based view (KBV), a derivative of the resource-based view (RBV). Drawing on the relational and industry structure views, this paper presents a framework for analysing knowledge management practices in the biotechnology industry. These firms exhibit sophisticated and strategic KM practices and deploy a range of strategies in leveraging competitive advantage through their intellectual property practices. The paper demonstrates that the current KBV needs to be modified and extended to reflect current KM practice within Australian biotechnology firms through examining their use and management of intellectual property. 相似文献