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1.
A comprehensive review of weak decays of charmed hadrons (D0/ +, and ) based on analyses of the threshold data from e+e− annihilation in the BESIII experiment is presented. Current experimental challenges and successes in understanding decays of the charmed hadrons are discussed. Precise calibrations of quantum chromodynamics and tests of the standard model are provided by measurements of purely leptonic and semi-leptonic decays of charmed hadrons, and lepton universality is probed in purely leptonic decays of charmed mesons to three generations of leptons. Quantum correlations in threshold data samples provide access to strong phases in the neutral D meson decays and probe the decay dynamics of the charmed Λc baryon. Charm physics studies with near-threshold production of charmed particle pairs are unique to BESIII, and provide many important opportunities and challenges.  相似文献   

2.
Charmonium is a bound state of a charmed quark and a charmed antiquark, and a charmoniumlike state is a resonant structure that contains a charmed quark and antiquark pair but has properties that are incompatible with a conventional charmonium state. While operating at center-of-mass energies from 2 to 5 GeV, the BESIII experiment can access a wide mass range of charmonium and charmoniumlike states, and has contributed significantly in this field. We review BESIII results involving conventional charmonium states, including the first observation of the M1 transition ψ(2S) → γηc(2S) and the discovery of the ψ2(3823) state; and report on studies of charmoniumlike states, including the discoveries of the Zc(3900) and Zc(4020) tetraquark candidates, the resolution of the fine structure of the Y(4260) state, the discovery of the new production process e+e− → γX(3872) and the uncovering of strong evidence for the commonality among the X(3872), Y(4260) and Zc(3900) states. The prospects for further research at BESIII and proposed future facilities are also presented.  相似文献   

3.
Hadron spectroscopy provides a way to understand the dynamics of the strong interaction. For light hadron systems, only phenomenological models or lattice quantum chromodynamics (QCD) are applicable, because of the failure of perturbation expansions for QCD at low energy. Experimental data on light hadron spectroscopy are therefore crucial to provide necessary constraints on various theoretical models. Light meson spectroscopy has been studied using charmonium decays with the Beijing Spectrometer Experiment (BES) at the Beijing Electron-Positron Collider, operating at 2.0–4.6 GeV center-of-mass energy, for nearly three decades. Charmonium data with unprecedented statistics and well-defined initial and final states provide BESIII with unique opportunities to search for glueballs, hybrids and multi-quark states, as well as perform systematic studies of the properties of conventional light mesons. In this article, we review BESIII results that address these issues.  相似文献   

4.
BaBar实验组在→■2～*（1430）ω衰变中观测到大的电荷不对称性.我们指出增强的张量介子发射图贡献可以解释这种不对称性.从实验结果中提取出张量介子发射图的贡献,将其应用到～0→a2（1320）～- π～+衰变中.预言的结果比以往的理论预言要大很多.该结果将在不久的KEK-SuperB、LHCb实验中得到检验.  相似文献   

5.
In this review, the theorelical study on D-physics is summarized including D-(?) mixing, D meson decays, diquark contributions to D-physics, 1/Nc expansion, final state interactions and some discussions about BEPC and BES.  相似文献   

6.
In this review,the theoretical study on D-physics is summarized including D-D mixing,D meson decays,diquark contributions toD-physics,1/N_c expansion,final state interactions and some discussionsabout BEPC and BES.  相似文献   

7.
The purpose of this study is optimizing the l-arginine (l-Arg) doses on the basis of chemical structure in regional accessible tumor therapy to settle down a new protocol for the treatment of cancer. 3H-thymidine-based cell proliferation assay was performed in vitro on tumor cell lines of fibrosarcoma (FS), lymphosarcoma-ascitic and on normal cell line of NIH 3T3 after treatment with different concentrations of l-Arg in phosphate buffered saline (PBS). The cultures were harvested after 22 h and the incorporated radioactivity was counted to identify their histologic grades as described in earlier studies. In vivo therapy of murine tumors was conducted where FS cells injected subcutaneously at ventro-lateral position of mice. Various drug delivery schedules were injected into the centre of tumor base, once a day for 4 days. Tumor diameter and survivals were monitored where the day of sacrifice was considered for monitoring the survival period. By identifying the histologic grades of the treated cultures in vitro and in vivo by different concentrations of l-Arg, the corresponding energy of such concentrations were determined. An efficient model with a good fit (R2 = 0.98) was established to describe the energy yield by l-Arg dose. The equivalence between the tumor histologic grade and energy of the l-Arg dose delivered in saline (PBS) environment is the optimum condition for regional tumor therapy achieves higher survival rate. The selective cytotoxicity to tumor cells with minimal damage to normal cells by l-Arg due to its chemical structure suggests to be considered the most promising drug for regional therapy of the accessible tumors like breast cancers of early stage with no distant metastasis.  相似文献   

8.
Spatial resolution defines the physical limit of microscopes for probing biomolecular localization and interactions in cells. Whereas synchrotron-based X-ray microscopy (XRM) represents a unique approach for imaging a whole cell with nanoscale resolution due to its intrinsic nanoscale resolution and great penetration ability, existing approaches to label biomolecules rely on the use of exogenous tags that are multi-step and error-prone. Here, we repurpose engineered peroxidases as genetically encoded X-ray-sensitive tags (GXET) for site-specific labeling of protein-of-interest in mammalian cells. We find that 3,3′-diaminobenzidine (DAB) polymers that are in-situ catalytically formed by fusion-expressed peroxidases are visible under XRM. Using this new tag, we imaged the protein location associated with the alteration of a DNA-methylation pathway with an ultra-high resolution of 30 nanometers. Importantly, the excellent energy resolution of XRM enables multicolor imaging using different peroxidase tags. The development of GXET enlightens the way to nanoscopic imaging for biological studies.  相似文献   

9.
On electrets     
(I) Evidence has been given that the so-called permanent electrets of Eguchi are not permanent, but that their polarization decays with the time. At room temperatures this decay is too slow to be observed directly; but it is the decay of the polarization that, at least in part, accounts for the presence of the free charges that are always observed. At higher temperatures the results that have been obtained are consistent with the view that the rate of decay of the polarization increases very rapidly with the temperature; so much so that the polarization may be almost completely destroyed at a temperature which is not high enough to cause any appreciable softening of the waxes that form the substance of the electrets.(2) As is to be expected from Lord Kelvin's hypothesis as to the cause of pyro-electricity, these electrets have been shown to possess the pyro-electric property.(3) The piezo-electric effect, which always accompanies the pyro-electric property, has been shown to be exhibited by these electrets.  相似文献   

10.
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11.
Normal polymorpho nuclear leucocytes (PMNL) when assaulted with diabetic serum factorin-vitro, recorded enhanced generation of oxygen free radical, and lysosomal degranulation. It also caused a decrease in the cytosolic superoxide dismutase activity. Time-plot studies revealed PMNL susceptibility to diabetic serum factor for oxidative injury and concomitant decrease in SOD, consequential for lysosomal degranulation.  相似文献   

12.
In view of several reports that there is a lack of balance in free radicals in case of bronchial asthma (1) the effect of free radicals on cell membrane was studied by estimating the membrane bound protein Na+, K+-ATPase activity and the intracellular sodium level in patients of bronchial asthma before and after a short course (one week) of oral corticosteroid (prednisolone 0.75–1mg/kg body weight) therapy. Results showed that there is a definite statistically significant rise in free radical level and intracellular sodium level and a significant lowering of Na+, K+-ATPase activity in case of untreated bronchial asthma. After short course of therapy with oral corticosteroids, the free radical level and intracellular sodium level decreased significantly, together with a significant rise of the Na+, K+-ATPase activity. Also, a significant negative correlation (r=−0.74) between the lipid peroxide level and the Na+,-K+-ATPase activity was found in these cases.  相似文献   

13.
Eight weeks of latent iron deficiency in weaned female rats of Sprague Dawley strain maintained on experimental low-iron diet (18–20 mg/Kg) did not significantly change the gross body weight and tissue weights of brain and liver. Packed cell volume (PCV) and hemoglobin concentration remained unaltered. However, non-heme iron content in liver and brain decreased significantly (P<0.001). The activities of glutamate dehydrogenase, glutamic acid decarboxylase, and GABA-transaminase (GABA-T) in brain decreased by 15%, 11.4% and 25.7% respectively. However, this decrease was not statistically significant. Binding of3H Muscimol at pH 7.5 and 1 mg protein/assay increased by 143% (P<0.001) in synaptic vesicular membranes from iron-deficient rats as compared to the controls.3H glutamate binding to the synaptic vesicles was also carried out under similar condition. However, the L-glutamate binding was reduced by 63% in the vesicular membranes of iron deficient animals. These studies in dicate that iron plays an important functional role in both excitatory and inhibitory neurotransmitter receptors.  相似文献   

14.
Eight weeks of latent iron deficiency in weaned female rats of Sprague Dawley strain maintained on experimental low-iron diet (18–20 mg/kg) did not significantly change the gross body, weight and tissue weights of brain and liver. Packed cell volume (PCV) and hemoglobin concentration remained unaltered. However, non-heme iron content in liver and brain decreased significantly (p<0.001). The activities of glutamate dehydrogenase, glutamic acid decarboxylase, and GABA-transaminase (GABA-T) in brain decreased by 15%, 11.4% and 25.7% respectively. However, this decrease was not statistically significant. Binding of3H Muscimol at pH 7.5 and 1 mg protein/assay increased by 143% (p<0.001) in synaptic vesicular membranes from iron-deficient rats as compared to the controls.3H glutamate binding to the synaptic vesicles was also carried out under similar condition. However, the L-glutamate binding was reduced by 63% in the vesicular membranes of iron deficient animals. These studies indicate that iron plays important functional role in both excitatory and inhibitory neurotransmitter receptors.  相似文献   

15.
Prostaglandins and (PG) have been reported to be an important gastric acid suppressive factor. However, the mechanism underlying is yet to be clearly established. In vitro study with gastric microsomes in presence of both PGE2 and PGI2 shows a stimulation of gastric H+ K+-ATPase activity below 1X10−6M and 2.5X10−7M concentrations respectively. However, with further increase in concentrations of both PGE2 and PGI2, H+, K+-ATPase activity shows an inhibition but PGI2 completely obliterates the K+ stimulated part of H+, K+-ATPase activity at higher concentration. The H+-ion transport study using chambered frog gastric mucosa shows that both PGE2 and PGI2 inhibit H+-ion transport at 5X10−6 M and 10X10−6M concentrations respectively but the effect of PGI2 is reversible. These differential effects of PGE2 and PGI2 on microsomal H+, K+-ATPase and on H+ transport my be caused by the differential effects of these phospholipid mediators with the gastric mucosal cell membrane. This in vitro investigation shows the role of prostaglandin (s) as a physiological switch/regulator of gastric H+ ion transport leading to the cessation of gastric acid secretion.  相似文献   

16.
Electromagnetic form factors are fundamental observables that describe the electric and magnetic structure of hadrons and provide keys to understand the strong interaction. At the Beijing Spectrometer (BESIII), form factors have been measured for different baryons in the time-like region for the first time or with the best precision. The results are presented with examples focused on but not limited to the proton/neutron, the Λ, with a strange quark, and the Λc, with a charm quark.  相似文献   

17.
Clonorchis sinensis or the Chinese liver fluke is one of the most prevalent parasites affecting a major population in the oriental countries. The parasite lacks lipid generating mechanisms but is exposed to fatty acid rich bile in the liver. A secretory phospholipase A2, an enzyme that breaks down complex lipids, is important for the growth of the parasite. The enzyme is also implicated in the pathogenesis leading up to the hepatic fibrosis and its complications including cancer. The five isoforms of this particular enzyme from the parasite therefore qualify as potential drug targets. In this study, a detailed structural and ligand binding analysis of the isoforms has been done by modeling. The overall three dimensional structures of the isoforms are well conserved with three helices and a β-wing stabilized by four disulfide bonds. There are characteristic differences at the calcium binding loop, hydrophobic channel and the C-terminal domain that can potentially be exploited for drug binding. But the most significant feature pertains to the catalytic site where the isoforms exhibit three variations of either a histidine-aspartate-tyrosine or histidine-glutamate-tyrosine or histidine-aspartate-phenylalanine. Molecular docking studies show that isoform specific residues and their conformations in the substrate binding hydrophobic channel make unique interactions with certain inhibitor molecules resulting in a perfect tight fit. The proposed ligand molecules have a predicted affinity in micro-molar to nano-molar range. Interestingly, few of the ligand binding interaction patterns is in accordance to the phylogenetic studies to thereby establish the usefulness of evolutionary mechanisms in aiding ligand design. The molecular diversity of the parasitic PLA2 described in this study provides a platform for personalized medicine in the therapeutics of clonorchiasis.

Electronic supplementary material

The online version of this article (doi:10.1007/s12291-013-0377-1) contains supplementary material, which is available to authorized users.  相似文献   

18.
高能物理一直是信息技术发展的主要推动者之一。现代高能物理产生的海量数据对计算机技术提出巨大的挑战。为了应对这些挑战,国内外高能物理领域的科学家根据数据处理的特点建立新的计算平台用于传输、储存及分析处理PB量级的数据。文章介绍了现代高能物理实验及数据处理的发展,并描述了高能物理的计算模型以及以网格技术为代表的数据密集型计算平台;详细介绍了数据密集型网格平台在LHC实验、BESIII实验中的应用以及中国的数据密集型网格平台。并对云计算等新技术在高能物理领域的应用进行了展望。  相似文献   

19.
高等学校创新要素汇聚,是粤港澳大湾区建设国际科技创新中心重要的策源地。高校科研效率的高低对于大湾区构建高水平科技创新体系,提升原始创新能力具有重要的战略意义。文章以粤港澳大湾区部分高校为研究对象,基于投入产出考虑,采用DEA方法,首先,从整体上测算2016-2019年高校的科研效率,然后,分别对8所高校的科研效率进行具体分析。结果表明：整体上看,粤港澳大湾区高校科研效率呈现上升趋势,最高效率水平达到1.393;高校之间科研效率存在差异,且差异水平较大。基于此,为提升高校科研效率,应完善高校科研资源配置;建立多样化的激励机制;转变科研理念,强化高校科研成果转化。  相似文献   

20.
This paper studies the problem of the stochastic stability and H∞ disturbance attenuation for linear continuous-time time-delay systems that possess randomly Markovian jumping parameters. A delay-dependent sufficient condition on the stochastic stability with given H∞ performance is proposed using the stochastic Lyapunov–Krasovskii stability theory. The conditions are formulated as a set of coupled linear matrix inequalities.  相似文献   

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