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1.
本文对最常见反映甲状腺功能的指标———游离甲状腺素、游离三碘甲腺原氨酸、促甲状腺激素、促甲状腺激素受体抗体、抗甲状腺球蛋白抗体、抗甲状腺过氧化物酶抗体及反三碘甲腺原氨酸进行阐述。 相似文献
2.
探讨人绒毛膜促性腺激素(hCG)是否具有垂体促甲状腺激素(TSH)样作用。方法:应用放射免疫方法(RIA)对65例旱孕妇女hCG与甲状腺激素水平进行测定。结果:早孕妇女Ⅰ组(停经35—50天)3,3’,5’-三碘甲状腺原氨酸(rT_3)水平升高,与正常对照组差异显著(P<0.01);早孕妇女Ⅱ组(停经51—80天)甲状腺素(T_4)、游离甲状腺素(FT_4)、rT_3水平均升高,与正常对照组差异显著(P<0.01);而两组早孕妇女的三碘甲状腺原氨酸(T_3)、游离三碘甲状腺原氨酸(FT_3)水平与正常对照组无明显差异(P>0.05)。结论:hCG具有TSH样作用,早孕妇女甲状腺激素水平升高为hCG促使甲状腺功能增强所致。 相似文献
3.
三碘甲腺原氨酸(T3)是由人体甲状腺分泌物之一,能够部分反应甲状腺的功能。测定其在血清中含量,对甲状腺功能检查有重要的意义,通常在甲状腺机能亢进的诊断上作 相似文献
4.
甲状腺（thyroid gland）是人体最大的内分泌腺，其分泌物称甲状腺激素，即四碘甲状腺原氨酸（T4)和三碘甲状腺原氨酸（T3）,甲状腺激素作用十分广泛，几乎遍及全身组织，主要是调节机体的物质代谢和能量代谢、生长发育、特别是对中枢神经系统的发育和功能有着尤为重要的影响，在日常生活中，其功能障碍严重影响着人们的身体健康和精神生活，必须引起足够的重视。 相似文献
5.
甲状腺（thyroidgland）是人体最大的内分泌腺，其分泌物称甲状腺激素，即四碘甲状腺原氨酸（T4）和三碘甲状腺原氨酸（T3）。甲状腺激素作用十分广泛，几乎遍及全身组织，主要是调节机体的物质代谢和能量代谢、生长发育，特别是对中枢神经系统的发育和功能有着尤为重要的影响。在日常生活中，其功能障碍严重影响着人们的身体健康和精神生活，必须引起足够的重视。 相似文献
6.
目的观察大补阴丸对甲亢大鼠模型的治疗作用。方法用优甲乐灌服制作大鼠甲亢模型,观察该方对模型大鼠的影响。将大鼠随机分成6组:正常对照组、甲亢模型组、西药对照组、大补阴丸低剂量组、大补阴丸中剂量组、大补阴丸高剂量组,21d后放免法测定血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)含量。结果大补阴丸能降低甲亢大鼠血清FT3、FT4、T3、T4含量,提高血清TSH。结论大补阴丸能够显著改善甲状腺激素水平。 相似文献
7.
四碘甲腺原氨酸,即甲状腺素(T_4),三碘甲腺原氨酸(T_3),促甲状腺素(TSH)是甲状腺及垂体前叶分泌的具有生物活性的三种激素,在不同的甲状腺疾病中,它们在血中浓度会产生相应的改变。我们采用T_3、 相似文献
8.
近年来由于内分泌激素测定的普遍应用,不但对甲状腺疾病的诊断、治疗及疗效观察起积极的作用,而且在一些危重的非甲状腺疾病中甲状腺激素发生明显的变化。并且对疾病的严重程度与患者血清中三碘甲状腺原氨酸(T_3)、甲状腺素(T_4)水平有明显相 相似文献
9.
碘缺乏对孕妇及胎儿的影响 总被引：1，自引：0，他引：1
碘是人体必需的微量营养素,是甲状腺合成甲状腺激素的基本原料。甲状腺激素不仅能促进人体生长发育、维持正常生理活动,而且对人脑的发育起着关键性的作用。碘摄入不足会影响甲状腺激素的合成水平,从而影响机体正常的生长发育。1孕妇的碘需要量人体内储存碘的能力并不强,只能依 相似文献
10.
张广明 《河北北方学院学报(医学版)》1994,(3)
对房颤伴充血性心力衰竭的器质性心脏病患者,洋地黄是首选药物。但单用洋地黄对部分患者的心室率控制并不满意,因此我们以胺碘酮与地高辛联用治疗房颤伴充血性心力衰竭,取得满意疗效,现报告如下。 临床资料 1 病例选择 房颤伴充血性心力衰竭患者23例,男15例,女8例,40-49岁9例,50-59岁11例,60-65岁3例。心功能(NYHA分级)Ⅱ-Ⅳ级。扩张型心肌病9例,冠心病8例,风湿性瓣膜病6例。 2 治疗及观察方法 入院后均给予利 相似文献
11.
目的 :探讨小剂量醛固酮拮抗剂螺内酯治疗老年人重度慢性充血性心力衰竭 (CHF)疗效和安全性。方法 :采用多中心、随机、单盲、安慰剂对照、平行组试验。入选老年重度CHF患者 15 2例 ,随机分为螺内酯组 (A组 )和对照组 (B组 ) ,均予标准三联抗心衰治疗 ,A组联用螺内酯 (2 0～ 4 0mg/d) ,B组联用与螺内酯外观相同的淀粉安慰剂。治疗前和治疗后 2周、4周、8周分别进行心功能 (NYHA)分级评估 ,心电图、超声心动图、血常规、生化等检查 ,并进行对照。结果 :治疗 8周后A、B两组心功能分级、无创心排量指标均显著改善 (P <0 .0 5 ) ;与B组比较 ,A组改善更显著 (P <0 .0 5 )。无肝、肾功能损害及血脂、血糖升高 ,未见高血钾症 ,毒副作用少。结论 :应用螺内酯治疗老年人重度CHF疗效肯定、可靠、安全性好、值得推广。 相似文献
12.
目的 探讨血清IL-6和NT-proBNP在慢性心力衰竭患者中的临床诊断价值.方法 选择80例慢性心力衰竭患者为CHF组,60例健康人群作为对照组.采用双抗体夹心免疫法检测两组人群的血清IL-6和NT-proBNP浓度,并对检测结果进行统计学分析.结果 CHF组患者的血清IL-6和NT-proBNP浓度均明显高于对照组,且随心衰严重程度的加重而增高,两组间差异有统计学意义（P＜0.01）.冠心病组IL-6浓度明显高于其他原发病因组,组间差异有统计学意义（P＜0.01）,CHF患者不同原发病因组NT-proBNP浓度差异无统计学意义（P＞0.05）.结论 IL-6和NT-proBNP参数均与CHF的发生及严重程度密切相关,联合检测可用于对CHF的早期诊断. 相似文献
13.
朱海燕 《泰州职业技术学院学报》2010,10(3):29-30,59
目的观察慢性充血性心力衰竭（CHF）患者的血胰岛素和糖代谢变化,并探讨依那普利对CHF患者胰岛素敏感性的影响。方法CHF患者69例,依那普利（n=37）（第一周10mg,1次／d,后三周20mg,1次／d）和地高辛（n=32）（第一周0．25mg,1次／d,后三周0．125mg,1次／d）,治疗前和治疗4周后检测空腹血糖（FPG）、空腹血清胰岛素（FINS）和空腹血清C肽（CP）水平,并计算出FPG／FINS比值、胰岛素敏感性指数IAI值[IAI=－ln（FPG×FINS）]作为机体胰岛素敏感性评价指标,分别比较两组患者治疗前后的胰岛素敏感性变化。结果治疗4周后,依那普利组CHF患者的胰岛素敏感性显著增加,而地高辛组患者胰岛素敏感性无显著变化。结论依那普利有改善CHF患者IR的作用。 相似文献
14.
Objective: To study the clinical therapy and prognosis in children with transient congenital hypothyroidism (CH).Methods: Fifty-seven children with CH diagnosed after neonatal screening were treated with low-dosage levothyroxine (L-T4).Follow-up evaluation included the determination of TT3, TT4 and TSH serum levels and the assessment of thyroid gland morphology, bone age, growth development and development quotients (DQ). A full check-up was performed at age 2, when the affected children first discontinued the L-T4 treatment for 1 month, and one year later. Development quotients were compared (16.25±3.87) μg/d. Mean duration of therapy was (28.09±9.56) months. No significant difference was found between study group and control group in the DQ test (average score (106.58± 14.40) vs (102.4±8.6), P＞0.05) and 96.49% of the CH children achieved a test score above 85. Bone age, 99mTc scans and ultrasonographic findings were all normal, and evaluation of physical development was normal too, as were the serum levels of TT3, TT4 and TSH after one year of follow-up. Conclusion: A L-T4 dosage of and physical development at age 2. So it is possible for CH children to stop taking medicine if their laboratory findings and physical development are all normal after regular treatment and 2～3 years of follow-up. 相似文献
15.
介绍了临床应用β-阻滞剂治疗慢性充血性心力衰竭(CHF)的发展.应用β-阻滞剂治疗CHF可显著改善临床症状,降低死亡率,特别是对特发性DCM的疗效最为显著.β-阻滞剂治疗CHF应当在病情稳定后开始使用.介绍了不同β-阻滞剂的作用特点以及具体应用方法,并针对可能发生的药物不良反应提出了防治方法. 相似文献
16.
目的:检测子宫内膜异位症患者手术前后外周血T淋巴细胞亚群变化,了解病人细胞免疫功能状况。方法:采用间接免疫荧光法检测子宫内膜异位症患者体内CD3~ 、CD4~ 、CD8~ 细胞水平,并取同龄正常妇女作为对照。结果:(1)手术前与正常妇女相比,子宫内膜异位症患者体内存在CD8~ 细胞比例升高,CD4~ 细胞比例和CD4~ /CD8~ 比值下降;(2)手术后病人CD8~ 细胞逐渐回降,而CD4~ 细胞和CD4~ /CD8~ 比值呈现回升趋势。结论:子宫内膜异位症患者存在T细胞免疫异常,这种异常可在手术治疗后得以恢复。 相似文献
17.
Inter-and intra-hemispheric EEG coherence in patients with mild cognitive impairment at rest and during working memory task 总被引：6，自引：0，他引：6
Objective： To assess functional relationship by calculating inter- and intra-hemispheric electroencephalography （EEG） coherence at rest and during a working memory task of patients with mild cognitive impairment （MCI）. Methods： The sample consisted of 69 subjects： 35 patients （n = 17 males, n = 18 females; 52-71 years old） and 34 normal controls （n = 17 males, n = 17 females; 51 -63 years old）. Mini-mental state examination （MMSE） of two groups revealed that the scores of MCI patients did not differ significantly from those of normal controls （P〉0.05）. In EEG recording, subjects were performed at rest and during working memory task. EEG signals from F3-F4, C3-C4, P3-P4, T5-T6 and O1-O2 electrode pairs are resulted from the inter-hemispheric action, and EEG signals from F3-C3, F4-C4, C3-P3, C4-P4, P3-O1, P4-O2, T5-C3, T6-C4, T5-P3 and T6-P4 electrode pairs are resulted from the intra-hemispheric action for delta （1.0-3.5 Hz）, theta （4.0-7.5 Hz）, alpha-1 （8.0-10.0 Hz）, alpha-2 （10.5-13.0 Hz）, beta-1 （13.5-18.0 Hz） and beta-2 （18.5-30.0 Hz） frequency bands. The influence of inter- and intra-hemispheric coherence on EEG activity with eyes closed was examined using fast Fourier transformation from the 16 sampled channels. Results： During working memory tasks, the inter- and intra-hemispheric EEG coherences in all bands were significantly higher in the MCI group in comparison with those in the control group （P〈0.05）. However, there was no significant difference in inter- and intra-hemispheric EEG coherences between two groups at rest. Conclusion： Experimental results comprise evidence that MCI patients have higher degree of functional connectivity between hemispheres and in hemispheres during working condition, It suggests that MCI may be associated with compensatory processes during working memory tasks between hemispheres and in hemispheres. Moreover, failure of normal cortical connections may exist in MCI patients. 相似文献
18.
目的:探讨促红细胞生成素(EPO)在重度慢性心力衰竭(chronic heart faiture,CHF)伴贫血的患者中应用的有效性。方法:选择自2004.8～2005.8月间住院的重度CHF(心功能Ⅲ～Ⅳ级)伴贫血的患者,采用前瞻性队列研究,随机分为治疗组和对照组,两组患者均给予常规抗心衰治疗,治疗组加用重组促红细胞生成素(rhEPO)注射及铁剂口服治疗,随访1年,比较两组在客观指标上的差别。结果:两组患者在心脏射血分数(LVEF)、6min步行距离及死亡率上均有明显差异。结论:在常规控制心衰治疗的基础上,给予EPO抗贫血干预,可延缓重度CHF伴贫血患者的病情进展,降低死亡率。 相似文献
19.
Study on EEG power and coherence in patients with mild cognitive impairment during working memory task 总被引：3，自引：0，他引：3
蒋正言 《Journal of Zhejiang University. Science. B》2005,6(12):1213-1219
To investigate the features of electroencephalography (EEG) power and coherence at rest and during a working memory task of patients with mild cognitive impairment (MCI). Thirty-five patients (17 males, 18 females; 52～71 years old) and 34 sex- and age-matched controls (17 males, 17 females; 51～63 years old) were recruited in the present study. Mini-Mental State Examination (MMSE) of 35 patients with MCI and 34 normal controls revealed that the scores of MCI patients did not differ significantly from those of normal controls (P＞0.05). Then, EEGs at rest and during working memory task with three levels of working memory load were recorded. The EEG power was computed over 10 channels: right and left frontal (F3, F4), central (C3,C4), parietal (P3, P4), temporal (TS, T6) and occipital (O1, O2); inter-hemispheric coherences were computed from five electrode pairs of F3-F4, C3-C4, P3-P4, T5-T6 and O1-O2 for delta (1.0～3.5 Hz), theta (4.0～7.5 Hz), alpha-1 (8.0～10.0 Hz), alpha-2 (10.5～13.0 Hz), beta-1 (13.5～18.0 Hz) and beta-2 (18.5～30.0 Hz) frequency bands. All values of the EEG power of MCI patients were found to be higher than those of normal controls at rest and during working memory tasks. Furthermore, the values of EEG power in the theta, alpha-1, alpha-2 and beta-1 bands of patients with MCI were significantly high (P＜0.05) in comparison with those of normal controls. Correlation analysis indicated a significant negative correlation between the EEG powers and MMSE scores. In addition, during working memory tasks, the EEG coherences in all bands were significantly higher in the MCI group in comparison with those in the control group (P＜0.05). However, there was no significant difference in EEG coherences between two groups at rest. These findings comprise evidence that MCI patients have higher EEG power at rest, and higher EEG power and coherence during working conditions. It suggests that MCI may be associated with compensatory processes at rest and during working memory tasks. Moreover, failure of normal cortical connections may be exist in MCI patients. 相似文献
20.
Jiang ZY 《Journal of Zhejiang University. Science. B》2005,6(4):259-264
To investigate inter- and intra-hemispheric electroencephalography (EEG) coherence at rest and during photic stimulation of patients with Alzheimer‘s disease (AD). Thirty-five patients (12 males, 23 females; 52-64 y) and 33 sex- and age-matched controls (12 males, 21 females; 56-65 y) were recruited in the present study. EEG signals from C3-C4, P3-P4, TS-T6 and O1-O2 electrode pairs resulted from the inter-hemispheric action, and EEG signals from C3-P3, C4-P4, P3-O1, P4-O2, C3-O1, C4-O2, TS-O1 and T6-O2 electrode pairs resulted from the intra-hemispheric action. The influence of inter- and intra-hemispheric coherence on EEG activity with eyes closed was examined, using fast Fourier transformation from the 16 sampled channels. The frequencies of photic stimulation were fixed at 5, l0 and 15 Hz, respectively. The general decrease of AD patients in inter- and intra-hemispheric EEG coherence was more significant than that of the normal controls at the resting EEG, with most striking decrease observed in the alpha-1 (8.0-9.0 Hz) and alpha-2 (9.5-12.5 Hz) bands. During photic stimulation, inter- and intra-hemispheric EEG coherences of the AD patients having lower values in the alpha (9.5-10.5 Hz) band than those of the control group. It suggests that under stimulated and non-stimulated conditions, AD patients had impaired inter- and intra-hemispheric functional connections, indicating failure of brain activation in alpha-related frequency. 相似文献