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1.
Kannapiran M Nisha D Madhusudhana Rao A 《Indian journal of clinical biochemistry : IJCB》2010,25(4):380-384
Serum creatinine (SCr) levels are frequently used as a screening test to assess impaired renal function; however, patients
can have significantly decreased glomerular filtration rate (GFR) with normal SCr values and making the recognition of kidney
dysfunction more difficult. Hence, this study was designed to determine the extent of misclassification of the patients who
have significantly reduced GFR as calculated by reexpressed four variable modification of diet in renal disease (MDRD) equation
but, normal range of SCr. The study included 1040 in and out patients referred by physicians for serum creatinine measurement.
When an exclusion criterion was applied 928 patients were qualified for the study. SCr was measured in 928 patients by a Roche
kinetic compensated Jaffe’s assay. GFR was calculated using reexpressed four variable MDRD study equation. Of the 928 patients
270 (29.1%) had renal dysfunction on the basis of eGFR (<60 ml/min/1.73 m2). However, with SCr only 162 (17.5%) patients had abnormal renal function (>1.5 mg/dl) and SCr values misrepresented (108)
11.6% patients with impaired kidney function. In addition, more females, about 15% were failed to detect by SCr method in
contrast to males of 9%. This study documented that, a large proportion of patients with impaired renal function are not diagnosed
if clinicians rely solely on normal SCr as evidence of normal renal function. Inclusion of eGFR calculated by re-expressed
4 variable MDRD equation may facilitates the early identification and intervention of patients with renal impairment. 相似文献
2.
Pradeep Naik B. Premsagar M. Mallikarjuna 《Indian journal of clinical biochemistry : IJCB》2015,30(1):94-98
The acute renal failure is the frequent medical complication observed in liver transplant patients. The objective of this study was to determine the cause of acute renal failure in post liver transplant patients. A total of 70 patients who underwent (cadaveric 52, live 18) liver transplantation were categorized based on clinical presentation into two groups, namely hepatorenal failure (HRF, n = 29), and Hepatic failure (HF, n = 41). All the patients after the liver transplant had received tacrolimus, mycophenolate and steroids. We analyzed the modification of diet in renal disease, (MDRD) serum urea, creatinine and albumin before and after 5th and 30th day of liver transplant and data was categorized into survivors and non-survivors group. In HRF survivor group, serum creatinine, and urea levels were high and, albumin, MDRD were low in pre- transplant and reached to normal levels on 30th day of post transplant, and 79.3 % of patients in this group showed resumption of normal kidney function. On the contrary in HRF nonsurvivor group, we did not observed any significant difference and 20.7 % of patients showed irreversible changes after the liver transplant. In HF survivor group, 82.9 % of liver failure patients did not show any deviation in serum creatinine, urea, albumin and MDRD, whereas in HF non survivor group, 17.1 % of liver failure patients who had HCV positive before the transplant developed acute renal failure. The levels of creatinine, urea, albumin and MDRD were normal before the transplant and on day 30th, the levels of albumin and MDRD were significantly low whereas serum urea, creatinine levels were high. In conclusion, based on these observations, an diagnosis and treatment of Acute renal failure is important among the liver transplantation cases in the early postoperative period. 相似文献
3.
Madhusudhana Rao A Anand U Anand CV 《Indian journal of clinical biochemistry : IJCB》2011,26(1):28-31
Numerous lines of evidence implicate a role of myeloperoxidase (MPO) in the pathogenesis of cardiovascular disease (CVD).
It is a well accepted fact that patients with chronic kidney disease (CKD) are at an increased risk for CVD. MPO is a pro-oxidant
enzyme which could be involved in the increased susceptibility of these patients to CVD. Hence, the levels of plasma MPO was
determined in healthy controls as well as in patients with CKD [stratified with the level of their kidney failure as CKD stages
II–V (end stage renal disease)]. Plasma MPO was assayed by a spectrophotometric method. Serum urea and creatinine were estimated
on a clinical chemistry analyzer using standard laboratory procedures. The mean plasma MPO levels were significantly lower
with advancing stages of renal failure (P < 0.001). There was a positive correlation between MPO and GFR (r = +0.89, P < 0.001) and a negative correlation with urea (r = −0.85, P < 0.001) and creatinine (r = −0.82, P < 0.001). While an inverse association was observed between plasma MPO and urea in CKD patients, such an association was
not observed in control subjects (P = 0.43). In conclusion, the decline in plasma MPO levels may be due to the inhibitory effect of uraemic toxins on the enzyme. 相似文献
4.
T. K. Saha Arabinda Mohan Bhattarai H. S. Batra Mithu Banerjee Pratibha Misra Vivek Ambade 《Indian journal of clinical biochemistry : IJCB》2015,30(3):271-274
Increase in urine albumin excretion rate (AER) precede a fall in glomerular
filtration rate in patients developing diabetic chronic kidney disease (CKD). Our
results have shown that 7 (50 %) of diabetic and hypertensive individuals with
decreased GFR do not have increased AER. In this cross-sectional study, we measured
AER of 75 patients with type 2 diabetes and hypertension by immunoturbidimetric
method. We correlated the results with eGFR values obtained by Cockcroft–Gault and
MDRD method. The method used was not a compensated method. We measured serum
creatinine by modified Jaffe’s kinetic method in autoanalyzer XL-600. Analysis of
data showed positive correlation between eGFR and microalbuminuria by both the
methods with eGFR <60 mL/min/1.73 m2. Pearson’s
correlation co-efficient (r) was 0.9 (p = 0.0001)
by Cockcroft–Gault formula and 0.69 (p = 0.0063)
by MDRD formula. Our results concluded that there was positive correlation between
AER and eGFR <60 mL/min/1.73 m2. We have recognized
that these two parameters provide a complimentary benefit in management of cases
with CKD. 相似文献
5.
Nilima N. Dongre Adinath N. Suryakar Arun J. Patil Jeevan G. Ambekar Dileep B. Rathi 《Indian journal of clinical biochemistry : IJCB》2011,26(4):400-406
The purpose of this study was to find out the effect of lead exposure on systolic and diastolic blood pressure, heme biosynthesis
related and hematological parameters of automobile workers. For this study 30 automobile workers were selected and compared
with 30 age matched healthy control subjects. Significantly increased blood lead (364%, P < 0.001) and urinary lead (176%, P < 0.001) levels were observed in automobile workers (study group) as compared to controls. Systolic blood pressure (5.32%,
P < 0.05) and diastolic blood pressure (5.87%, P < 0.05) were significantly increased in the automobile workers as compared to controls. The significantly decreased non-activated
erythrocyte δ-aminolevulinic acid dehydratase (δ-ALAD) (−18.51%, P < 0.01) and activated δ-ALAD (−13.29%, P < 0.05) levels were observed in automobile workers as compared to normal healthy control subjects. But the ratio of activated/non-activated
δ-ALAD was significantly increased (43.83%, P < 0.001) in automobile workers as compared to controls. Excretions of δ-aminolevulinic acid (83.78%, P < 0.001) and porphobilinogen (37%, P < 0.001) in urine were significantly increased in the study group as compared to the controls. In automobile workers heamoglobin
(−11.51%, P < 0.001), hematocrit (−4.06%, P < 0.05), mean corpuscle volume (−3.34%, P < 0.05), mean corpuscle hemoglobin (−5.66%, P < 0.01), mean corpuscle hemoglobin concentration (−7.67%, P < 0.001), red blood cell count (−14.6%, P < 0.001) were significantly decreased and total white blood cell count (11.44%, P < 0.05) increased as compared to the controls. The results of this study clearly indicate that the absorption of lead is
more in automobile workers and it affects on blood pressure, heme biosynthesis and hematological parameters observed in this
study group. 相似文献
6.
Zubieta-Calleja G Zubieta-Castillo G Zubieta-Calleja L Ardaya-Zubieta G Paulev PE 《Indian journal of clinical biochemistry : IJCB》2011,26(1):62-65
As the oxygen tension of inspired air falls with increasing altitude in normal subjects, hyperventilation ensues. This acute
respiratory alkalosis, induces increased renal excretion of bicarbonate, returning the pH back to normal, giving rise to compensated
respiratory alkalosis or chronic hypocapnia. It seems a contradiction that so many normal people at high altitude should permanently
live as chronic acid–base patients. Blood gas analyses of 1,865 subjects at 3,510 m, reported a P
aCO2 (arterial carbon dioxide tension ± SEM) = 29.4 ± 0.16 mmHg and pH = 7.40 ± 0.005. Base excess, calculated with the Van Slyke
sea level equation, is −5 mM (milliMolar or mmol/l) as an average, suggesting chronic hypocapnia. THID, a new term replacing
“Base Excess” is determined by titration to a pH of 7.40 at a P
aCO2 of 5.33 kPa (40 mmHg) at sea level, oxygen saturated and at 37°C blood temperature. Since our new modified Van Slyke equations
operate with normal values for P
aCO2 at the actual altitude, a calculation of THID will always result in normal values—that is, zero. 相似文献
7.
The anti oxidative effect of administration of 100 mg/kg bw and 200 mg/kg bw of the flower powder of Cassia auriculata (CFP) for 45 days to normoglycemic and diabetic rats (streptozotocin induced) was studied. Anti oxidative effect was not
observed in normoglycemic rats in the experiment. There was significant (P > 0.05) increase in the level of Thio Barbituric Acid Reactive Substances (TBARS), hydroperoxide and conjugated dienes and
significant (P > 0.05) decrease in the catalase, superoxide dismutase and glutathione peroxidase activities and in the level of ascorbic
acid, vitamin E and reduced glutathione in diabetic rats. The flower powder of Cassia auriculata significantly (P > 0.05) decreased the TBARS, hydroperoxide and conjugated dienes and increased the antioxidant enzymes (catalase, superoxide
dismutase and glutathione peroxidase) and non enzymic anti oxidants (ascorbic acid, vitamin E and reduced glutathione). The
antioxidatve effect of 200 mg/kg bw CFP was significantly (P > 0.05) better than 100 mg/kg bw CFP and the reference drugs (tolbutamide and metformin). The mode of action of CFP remains
to be elicited. 相似文献
8.
Activities of human hepatic drug metabolizing enzymes N-acetyl transferase (NATS) had earlier been recognized as a cause of inter-individual variation in the metabolism of drugs.
Therefore acetylation of many drugs in human exhibit genetic polymorphism. The aim of the study was to investigate if acetylator
status predispose diabetic mellitus patients more to the complications of renal disease, One hundred and twenty (120) diabetics
consisting of (50) Type 1 (T1) and 70 Type 2 (T2) diabetes mellitus patients and 100 healthy individuals as controls were classified as slow or rapid acetylator using sulphamethazine
(SMZ) as an in vivo probe. The percentage acetylation, recovery of SMZ, creatinine clearance and presence of urinary albumin
were determined. A significant difference (P < 0.05) was observed in the percentage of SMZ acetylated between slow and rapid acetylators in control, T1 and T2 subjects. The ratios of slow to rapid acetylators for T1, T2 and control subjects were 1:4, 3:2 and 2:3 respectively. No significant differences were observed in the percentage of SMZ
recovered in the urine of slow and rapid acetylators that are diabetics. The difference in creatinine clearance of slow and
rapid acetylators in T1 and T2 were significant (P < 0.05). 29% out of 120 (24.2%) diabetics (T1 and T2) exhibited albuminuria out of which 25 (86.2%) had slow acetylator status. These findings suggest that slow acetylator status
in diabetes mellitus could be a predisposing factor in the development of renal complications. This underscores the need for
a rapid pharmacogenetic testing and therapeutic drug monitoring in such patients. However this inference could be further
validated with a larger sample size. 相似文献
9.
Yadav A Jyoti P Jain SK Bhattacharjee J 《Indian journal of clinical biochemistry : IJCB》2011,26(2):193-196
The increasing incidence of obesity, leading to metabolic complications is now recognized as a major public-health problem.
Insulin resistance is a central abnormality of the metabolic syndrome, or syndrome X, originally hypothesized by Reaven Insulin
resistance is more strongly linked to intra abdominal fat than to fat in other depots. Adipose tissue secretes numerous factors
(adipokines) known to markedly influence lipid and glucose/insulin metabolism, oxidative stress, and cardiovascular integrity.
Some of these adipokines have been shown to directly or indirectly affect insulin sensitivity through modulation of insulin
signaling and the molecules involved in glucose and lipid metabolism. A pilot study was conducted with 80 healthy subjects
who were non diabetic, non hypertensive and having no family history of hypertension, the aim was to evaluate the correlation
of adiponectin and leptin levels with obesity and insulin resistance markers in healthy north Indian adult population. Serum
leptin, adiponectin and insulin was estimated by sandwich ELISA method. In our study, Leptin correlated significantly with
BMI (P value of 0.0000), WC (P value = 0.007), and HC (P value = 0.000). leptin showed significant positive correlation with fasting insulin (P value 0.002), post prandial insulin (P value = 0.000) and HOMA-IR (P value = 0.002). Adiponectin showed significant positive correlation with triglycerides (P value = 0.038), strong negative correlation with HDL-cholesterol (P value = 0.017). Serum concentrations of leptin are associated with central body fat distribution. Insulin resistance and
adiponectin is associated with dyslipidemia and these all disorders may ultimately lead to metabolic syndrome. 相似文献
10.
Shilpa Reddy Ganasyam Talluri Bhaskar Rao Y. S. R. Murthy Akka Jyothy Madireddy Sujatha 《Indian journal of clinical biochemistry : IJCB》2012,27(1):69-73
Type 2 diabetes mellitus (DM) is a multifactorial disease where both genetic and environmental factors contribute to its pathogenesis.
Estrogen plays an important role in type 2 DM pathogenesis. A number of polymorphisms have been reported in the estrogen receptor
(ESR1), including the XbaI and PvuII restriction enzyme polymorphisms of ESR1,which may be involved in disease pathogenesis. Metallothioneins (MT) act as potent
antioxidants against various oxidative damages. Very few studies have indicated the association between Estrogen Receptor-α,
MT1 gene polymorphisms with type2 DM. A total of 100 type 2 diabetic women and 100 age, sex matched controls were recruited.
Using the PCR based RFLP method, the PvuII and XbaI polymorphisms of ESR1 and in MT1A (rs8052394 and rs11076161) gene polymorphisms were analysed. The genotype distribution and frequency of mutated allele showed no significant differences
between diabetic and non-diabetic groups in PvuII (χ2 = 2.443; P = 0.1181) or XbaI (χ2 = 1.789; P = 0.1812) and rs8052394 (χ2 = 1.154; P = 0.2840) or rs11076161 (χ2 = 0.4141; P = 0.5199), polymorphisms. This is the first Indian study to conclude that ESR1 and MT1 gene polymorphisms are not associated
with increased susceptibility to type 2 diabetes in Indian women. 相似文献
11.
The correlation between antioxidant capacity and oxidative damage during aging has been reported in several tissues in different
species. Glutathione-S-transferases (GST) can metabolise endogenous and exogenous toxins and carcinogens by catalysing the
conjugation of diverse electrophiles with reduced glutathione (GSH). We observe a significant (P < 0.001) increase in plasma GST activity as a function of human age (r = 0.5675). A significant (P < 0.001) positive correlation (r = 0.8979) is observed between GST activity and total plasma antioxidant potential measured
as ferric reducing ability of the plasma (FRAP). GST activity and red cell intracellular GSH also show a significant positive
correlation (r = 0.7014). We hypothesize that the increased activity of plasma GST is a manifestation of increased generation
of ROS and a concomitant decrease in the level of plasma antioxidant capacity during aging. 相似文献
12.
We recruited 59 individuals of known HIV serostatus after informed consent however, 44 were serodiscordant heterosexual partners
[serodiscordant seronegative (SSN group) and serodiscordant seropositive (SSP group)] while 15 were seronegative healthy individuals
(SNH). In the case–control study we choose to determine Malondialdehyde (MDA) concentration as a marker of lipid peroxidation
index (oxidative stress) spectrophotometrically and quantify HIV mRNA by Real Time-nucleic acid sequence based amplification
assay (RT-NASBA). Here our result show for the first time a high concentration of lipid peroxidation product (MDA, 116.6%)
with a significant (P < 0.05) increase in HIV serodiscordant seropositive subjects over their seronegative partners. However, Spearman rank correlation
statistics of SSP group showed a positive correlation value (P < 0.01, r = 0.89) between MDA and mRNA and a negative correlation between MDA and T-cell ratio (P < 0.01, r = 0.96).The study may strongly indicate a possible lipid peroxidation product threshold for predicting HIV infection and
progression in serodiscordant heterosexual partners. 相似文献
13.
Impact of Chronic Lead Exposure on Selected Biological Markers 总被引:1,自引:0,他引:1
Ambica P. Jangid P. J. John D. Yadav Sandhya Mishra Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2012,27(1):83-89
Lead poisoning remains a major problem in India due to the lack of awareness of its ill effects among the clinical community.
Blood lead, δ-aminolevulinic acid dehydratase (δ-ALAD) and zinc protoporphyrin (ZPP) concentrations are widely used as biomarkers
for lead toxicity The present study was designed to determine the impact of chronic lead exposure on selected biological markers.
A total of 250 subjects, of both sexes, ranging in age from 20 to 70 years, were recruited. On the basis of BLLs, the subjects
were categorized into four groups: Group A (BLL: 0–10 μg/dl), Group B (BLL: 10–20 μg/dl). Group C (BLL: 20–30 μg/dl) and Group
D (BLL: 30–40 μg/dl) having BLLs of 3.60 ± 2.71 μg/dl, 15.21 ± 2.65 μg/dl, 26.82 ± 2.53 μg/dl and 36.38 ± 2.83 μg/dl, respectively.
Significant changes in biological markers due to elevated BLLs were noted. The relation of BLL and biological markers to demographic
characteristics such as sex, habits, diet and substances abuse (smoking effect) were also studied in the present investigation.
Males, urban population, non-vegetarians, and smokers had higher blood lead levels. δ-ALAD activity was found to be significantly
lower with increased BLL (P < 0.001), while the ZPP level was significantly higher with increased BLL (P < 0.001). Further, BLL showed a negative correlation with δ-ALAD (r = −0.425, P < 0.001, N = 250) and a positive correlations with ZPP (r = 0.669, P < 0.001, N = 250). Chronic lead exposure affects the prooxidant-antioxidant equilibrium leading to cellular oxidative stress. 相似文献
14.
India seems to have the highest prevalence of osteoporosis. With growing awareness of osteoporosis and its impact on life
span especially in India, special attention is being paid to early detection, management and treatment of postmenopausal osteoporosis
in women. Measurement of BMD and osteocalcin are of value in estimating bone turnover rates. The aim of this study is (1)
to measure the specific, sensitive bone formation marker such as osteocalcin and BMD in postmenopausal osteoporosis women
and postmenopausal non-osteoporosis women; (2) the follow up study to evaluate the impact of specific antiresorptive therapy
(alendronate + calcium + vitamin D) regimen in postmenopausal osteoporosis by assaying osteocalcin and BMD. Sixty clinically
diagnosed postmenopausal osteoporosis patients and 60 normal subjects (postmenopausal non-osteoporosis women) were recruited
as control. Mean bone mineral density T score and Z score was significantly decreased (P < 0.001) in postmenopausal osteoporosis patients as compared to controls. Highly significant increase in the mean score of
BMD—T score and Z score from baseline to post therapy of 3 months was observed in postmenopausal osteoporosis women. Serum osteocalcin levels
were significantly increased (P < 0.001) as compared to control group. Serum osteocalcin levels were decreased significantly (P < 0.001) from baseline to post therapy of 3 months in postmenopausal osteoporosis women. BMD is the best quantifiable predictor
of osteoporotic fracture and osteocalcin is specific, sensitive, promising, currently used marker for better prognosis of
osteoporosis and for monitoring responses to antiresorptive therapy. 相似文献
15.
Singh B Panda S Nanda R Pati S Mangaraj M Sahu PK Mohapatra PC 《Indian journal of clinical biochemistry : IJCB》2010,25(4):367-370
Insulin resistance and the resultant hyperinsulinemia exacerbate the reproductive abnormalities of Polycystic Ovarian Syndrome
by increasing ovarian androgen productions and decreasing serum sex hormone binding globulin. The present study was conducted
to estimate serum insulin and testosterone level in 44 PCOS cases and 32 control patients. Simultaneously the role of metformin
(an insulin sensitizing agent) in modulating insulin resistance and serum androgen level was also analyzed. A significant
rise in serum insulin and testosterone (P < 0.001) was observed in cases in comparison to control. Fasting Plasma Glucose to insulin ratio, a marker of insulin resistance
revealed a significant fall in PCOS group. Follow up of cases with metformin for 3 months revealed a significant fall in serum
insulin (P < 0.05) with improvement in insulin resistance along with a nonsignificant fall in testosterone level. Serum insulin registered
a significant positive correlation (P < 0.05) with serum testosterone revealing its etiological association. Thus administration of drugs ameliorating insulin
levels is expected to provide new therapeutic modality for PCOS. 相似文献
16.
Jafar T Agrawal S Mahdi AA Sharma RK Awasthi S Agarwal GG 《Indian journal of clinical biochemistry : IJCB》2011,26(3):296-302
The pathogenesis of idiopathic nephrotic syndrome is not completely understood. We postulate that cytokine gene polymorphisms
may influence susceptibility or clinical course in Idiopathic Nephrotic Syndrome. Polymorphisms of IL-4, IL-6, and TNF-α cytokines
were investigated in 150 children with Idiopathic Nephrotic Syndrome and 569 healthy controls by using polymerase chain reaction
and restriction fragment length polymorphism. On comparing patient with controls strong association were found for IL-6, TNF-α
and IL-4 at allelic level (IL-6-G174C (G vs. C): P = <0.001; OR = 6.33, TNF-α-G308A (G vs. A): P = <0.001; OR = 1.99, IL-4-C590T (C vs. T): P = 0.048; OR = 1.38). Further when SR group was compared with SS group significant association was found at genotypic level
in all the studied genetic polymorphisms. Studied cytokine gene polymorphisms may influence susceptibility to idiopathic nephrotic
syndrome and might affect steroid response in INS patients. 相似文献
17.
Acute myocardial Infarction is one of the major causes of morbidity & mortality in world and atherosclerosis is the major
cause of ischemic heart disease. In order to determine the better clinical marker of atherosclerosis, we estimated serum low-density
lipoprotein (LDL-C) and high sensitivity C-reactive protein (hsCRP). Hundred patients of myocardial infarction and 100 controls
irrespective of age and sex were studied for these parameters over a period of 2 years. The statistical analysis showed that
the serum hsCRP was significantly raised in myocardial infarction cases than controls (P < 0.01) but LDL-C was not (P > 0.05). We conclude that the serum hsCRP has better predictive value for risk of atherosclerosis. 相似文献
18.
Benedicta D’Souza Rajeevalochana Parthasarathy Sreekantha Vivian D’Souza 《Indian journal of clinical biochemistry : IJCB》2011,26(4):396-399
The serum acid phosphatase (ACP) activity and Hemoglobin (Hb) levels were measured in malaria patients and nonmalarial fever
patients. The results were compared with normal healthy control subjects. ACP was significantly increased (P < 0.001) in all the malaria patients. ACP was significantly higher in Plasmodium falcifarum malaria and mixed malaria when compared to Plasmodium vivax malaria. Hb levels were significantly decreased in all the malaria patients which indicates that malaria parasite uses host
erythrocyte Hb as a major nutrient source. There is negative correlation(r = −0.478) between ACP and Hb in malaria patients, which is highly significant. These results suggest that the measurement
of ACP could be used as a marker for malaria. 相似文献
19.
The EGF-R, also known as HER-1 or erbB-1 (EGF-R/HER-1/erbB-1), is a member of the human epithelial receptor tyrosine kinase
family. sEGF-R is considered to play a role in cardiac (patho)physiology. We aimed to investigate whether soluble EGF-R is
increased in congestive heart failure (CHF) patients and if related to disease severity. Soluble EGF-R, vitamin D, parathyroid
hormone (PTH) was studied, and being evaluated in relation to Ca2+, lipids, hsCRP, fibrinogen, serotonin, norepinepherine (NE). The study compared non-smoker, non-obese male CHF patients (n = 50) with age and gender-matched essential hypertension (HTN) patients (n = 20). Moreover, comparison with healthy control volunteers (n = 20) were employed. EGF-R/HER-1/erbB-1 was higher (P = 0.013) in 50 CHF male patients mean 12 ± 0.7 fmol/ml, than in 20 HTN, 9.25 ± 0.6 fmol/ml or in 20 controls, 6.25 ± 1 fmol/ml.
Serum EGF-R levels correlated positively with hsCRP and NE, and were highest among CVD patients (n = 70) as well as negatively with vitamin D and HDL-C. EGF-R/HER-1/erbB-1 levels are increased in HTN and more in CHF patients.
This study confirms a strong association between catecholamines as well as EGF-R/HER-1/erbB-1 levels with PTH and low vitamin
D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD. Moreover, contributing to the complex
process of the inflammatory component of atherosclerosis in hypertensive patients that leads eventually to CHF. 相似文献
20.
Benign prostate hyperplasia (BPH) is a common condition in aged men and result from prolong chronic inflammation in prostate
gland. Cytokines are important molecules responsible for inflammation. Single nucleotide polymorphisms (SNPs) in promoter
region of cytokine genes have been shown to alter the level of cytokines. Hence we evaluated the association of pro-inflammatory
and anti-inflammatory cytokine SNPs in a North Indian cohort of BPH patients. We observed that IL-1B −511 CT + TT genotypes conferred protective effect for susceptibility to BPH (OR 0.39, P 0.001). Our results also demonstrated that TNF-A −1031 C allele to be associated with risk for BPH (OR 1.89, P < 0.0001). Moreover, we also observed twofold risk for IL-10 −1082 cytokine gene polymorphism (OR 1.96, P 0.048). No association was observed with risk of BPH for IFN-G +874, IL-1 RN VNTR, IL-6 −174, IL-10 −819 and TGF-B +28. Our findings of IL-1B −511, TNF-A −1031 and IL-10 −1082 suggested that these variants play important role in susceptibility to BPH. Future studies in large cohort of different
ethnicity BPH groups are warranted to establish definite associations with other cytokine gene polymorphisms as well. 相似文献