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1.
The purpose of this study was to investigate the effects of interval aerobic training combined with strength exercise in the same training session on body composition, and glycaemic and lipid profile in obese rats. Sixteen lean Zucker rats and sixteen obese Zucker rats were randomly divided into exercise and sedentary subgroups (4 groups, n = 8). Exercise consisted of interval aerobic training combined with strength exercise in the same training session. The animals trained 60 min/day, 5 days/week for 8 weeks. Body composition, lipid and glycaemic profiles and inflammatory markers were assessed.

Results showed that fat mass was reduced in both lean and obese rats following the exercise training (effect size (95% confidence interval (CI)) = 1.8 (0.5–3.0)). Plasma low-density lipoprotein–cholesterol and fasting glucose were lower in the exercise compared to the sedentary groups (d = 2.0 (0.7–3.2) and 1.8 (0.5–3.0), respectively). Plasma insulin was reduced in exercise compared to sedentary groups (d = 2.1 (0.8–3.4)). Some exercise × phenotype interactions showed that the highest decreases in insulin, homeostatic model assessment-insulin resistance, fasting and postprandial glucose were observed in the obese + exercise group (all, P < 0.01). The findings of this study suggest that interval aerobic training combined with strength exercise would improve body composition, and lipid and glycaemic profiles, especially in obese rats.  相似文献   


2.
The purpose of this study was to evaluate the effects of 6 weeks of supramaximal exercise training (SET) on performance variables and metabolic changes in sedentary obese adults.

Twenty-four obese adults were randomly allocated into a non-trained (NT) [n = 12; body mass index (BMI) = 33(3)] and SET group [n = 12; BMI = (33(2)]. After baseline metabolic and fitness measurements, the participants completed a 6-week SET intervention. Metabolic, anthropometric, and fitness assessments were repeated post-intervention.

For SET, fasting glucose (4.64(0.15) vs. 4.32(0.22) mmol · l–1; P < 0.01), insulin (23.2(4.6) vs. 13.8(3.3) µmol · ml–1; P < 0.01), homoeostasis model assessment-insulin resistance index (4.78(1.2) vs. 2.65(1.5); P < 0.01) and systolic blood pressure (127(3) vs. 120(3) mmHg; P < 0.01) were significantly lower 24-h post-intervention than at baseline and for the NT group, and these changes remained significant at 72-h and 2-weeks post-intervention (P < 0.01, respectively). Interestingly, nonesterified fatty acids (0.62(0.09) vs. 0.71(0.11) mmol · l–1; P < 0.01) and resting fat oxidation rate (57(11) vs. 63(4)%; P < 0.01) increased significantly from baseline 24-h post-intervention in the SET group and from baseline at 72-h (P < 0.01, respectively) and 2-weeks post-intervention (P < 0.01, respectively). Six weeks of SET improved a number of metabolic and vascular risk factors in obese, sedentary adults, highlighting the potential of SET to provide an alternative exercise model for the improvement of metabolic health in this population.  相似文献   


3.
This study assessed the effectiveness of a 6-week, high-intensity, games-based intervention on physiological and anthropometric indices of health, in normal weight (n = 26; 32.5 ± 8.9 kg) and obese (n = 29; 49.3 ± 8.9 kg) children (n = 32 boys, 23 girls), aged 8–10 years. Children were randomised into an exercise or control group. The exercise group participated in a twice-weekly, 40 min active games intervention, alongside their usual school physical education classes. The control group did not take part in the intervention. Before and after the intervention, participants completed both a maximal and submaximal graded exercise test. The submaximal exercise test comprised of a 6 min, moderate- and 6 min heavy-intensity bout, interspersed with a 5 min recovery. The exercise group demonstrated improvements in maximal oxygen uptake (51.4 ± 8.5 vs 54.3 ± 9.6 ml · kg?1 · min?1) and peak running speed (11.3 ± 1.6 vs 11.9 ± 1.6 km · h?1), and a reduction in the oxygen cost of submaximal exercise between assessments (P < .05). A decrease in waist circumference and increase in muscle mass were observed between assessments for the obese participants randomised to the intervention (both P < .05). This study demonstrates that a short-term, high-intensity games intervention may elicit positive changes in physiological and anthropometric indices of health in normal weight and obese children.  相似文献   

4.
Abstract

The purpose of this study was to evaluate the effects of moderate- to high-intensity resistance and concurrent training on inflammatory biomarkers and functional capacity in sedentary middle-aged healthy men. Participants were selected on a random basis for resistance training (n = 12), concurrent training (n = 11) and a control group (n = 13). They performed three weekly sessions for 16 weeks (resistance training: 10 exercises with 3 × 8–10 repetition maximum; concurrent training: 6 exercises with 3 × 8–10 repetition maximum, followed by 30 minutes of walking or running at 55–85% [Vdot]O2peak). Maximal strength was tested in bench press and leg press. The peak oxygen uptake ([Vdot]O2peak) was measured by an incremental exercise test. Tumour necrosis factor-α, interleukin-6 and C-reactive protein were determined. The upper- and lower-body maximal strength increase for both resistance (+42.52%; +20.9%, respectively) and concurrent training (+28.35%; +21.5%, respectively) groups (P = 0.0001).[Vdot]O2peak increased in concurrent training when comparing pre- and post-training (P = 0.0001; +15.6%). No differences were found in tumour necrosis factor-α and interleukin-6 for both groups after the exercise. C-reactive protein increased in resistance training (P = 0.004). These findings demonstrated that 16 weeks of moderate- to high-intensity training could improve functional capacity, but did not decrease inflammatory biomarkers in middle-aged men.  相似文献   

5.
Irisin is a myokine that is thought to be secreted in response to exercise that may help to prevent obesity and maintain normal glucose metabolism. In this study we investigated the associations between irisin and glucose homeostasis in middle-aged, overweight and obese men (n?= 144) with impaired glucose regulation, and the impact of exercise training on these relationships. The participants underwent 12 weeks of resistance or aerobic (Nordic walking) exercise training three times per week, 60 minutes per session. Venous blood (n?=?105) and skeletal muscle samples (n?=?45) were obtained at baseline and post-intervention. Compared to controls, Nordic walking, but not resistance training, increased irisin levels in plasma (9.6?±?4.2%, P?=?0.014; 8.7?± 4.9%, P?=?0.087; respectively) compared to controls. When considering all subjects, baseline irisin correlated positively with atherogenic index of plasma (r?=?0.244, P?=?0.013) and 2-hour insulin levels (r?=?0.214, P?=?0.028), and negatively with age (r?=??0.262, P?=?0.007), adiponectin (r?=??0.240, P?=?0.014) and McAuley index (r?=??0.259, P?=?0.008). Training-induced FNDC5 mRNA changes were negatively correlated with HbA1c (r?=??0.527, P?=?0.030) in the resistance training group and with chemerin in the Nordic walking group (r?=??0.615, P?=?0.033). In conclusion, 12-weeks of Nordic walking was more effective than resistance training in elevating plasma irisin, in middle-aged men with impaired glucose tolerance. Thus, the change in irisin in response to exercise training varied by the type of exercise but showed limited association with improvements in glucose homeostasis.  相似文献   

6.
The purpose of this study was to evaluate two practical interval training protocols on cardiorespiratory fitness, lipids and body composition in overweight/obese women. Thirty women (mean ± SD; weight: 88.1 ± 15.9 kg; BMI: 32.0 ± 6.0 kg · m2) were randomly assigned to ten 1-min high-intensity intervals (90%VO2 peak, 1 min recovery) or five 2-min high-intensity intervals (80–100% VO2 peak, 1 min recovery) or control. Peak oxygen uptake (VO2 peak), peak power output (PPO), body composition and fasting blood lipids were evaluated before and after 3 weeks of training, completed 3 days per week. Results from ANCOVA analyses demonstrated no significant training group differences for any primary variables (P > 0.05). When training groups were collapsed, 1MIN and 2MIN resulted in a significant increase in PPO (?18.9 ± 8.5 watts; P = 0.014) and time to exhaustion (?55.1 ± 16.4 s; P = 0.001); non-significant increase in VO2 peak (?2.36 ± 1.34 ml · kg?1 · min?1; P = 0.185); and a significant decrease in fat mass (FM) (??1.96 ± 0.99 kg; P = 0.011). Short-term interval exercise training may be effective for decreasing FM and improving exercise tolerance in overweight and obese women.  相似文献   

7.
Abstract

In this study, we examined the correlations between selected markers of isometric training intensity and subsequent reductions in resting blood pressure. Thirteen participants performed a discontinuous incremental isometric exercise test to volitional exhaustion at which point mean torque for the final 2-min stage (2min-torquepeak) and peak heart rate peak (HRpeak) were identified. Also, during 4 weeks of training (3 sessions per week, comprising 4 × 2 min bilateral leg isometric exercise at 95% HRpeak), heart rate (HRtrain), torque (Torquetrain), and changes in EMG amplitude (ΔEMGamp) and frequency (ΔEMGfreq) were determined. The markers of training intensity were: Torquetrain relative to the 2min-torquepeak (%2min-torquepeak), EMG relative to EMGpeak (%EMGpeak), HRtrain ΔEMGamp, ΔEMGfreq, and %MVC. Mean systolic (?4.9 mmHg) and arterial blood pressure (?2.7mmHg) reductions correlated with %2min-torquepeak (r = ?0.65, P = 0.02 and r = ?0.59, P = 0.03), ΔEMGamp (r = 0.66, P = 0.01 and r = 0.59, P = 0.03), ΔEMGfreq (r = ?0.67, P = 0.01 and r = ?0.64, P = 0.02), and %EMGpeak (systolic blood pressure only; r = ?0.63, P = 0.02). These markers best reflect the association between isometric training intensity and reduction in resting blood pressure observed after bilateral leg isometric exercise training.  相似文献   

8.
Abstract

Athletic identity is the extent to which an individual identifies with being an athlete. Strong “running” role identity may contribute to increased restrictive dieting behaviours, potentially placing such individuals at risk for eating disorders. In this study, we examined differences in eating and exercise behaviours/attitudes and athletic identity in obligatory versus non-obligatory runners. Male and female participants completed a battery of questionnaires including the Eating Disorder Inventory, Obligatory Exercise Questionnaire (OEQ), and Athletic Identity Measurement Scale (AIMS). OEQ scores ≥50 were indicative of obligatory exercise. The non-obligatory runners (n = 82) and obligatory runners (n = 91) were compared on the various measures. Obligatory runners scored significantly higher (P < 0.002) on all of the eating attitudes/disorder measures, and the AIMS (P ≤ 0.006). Scores on the AIMS were correlated with all disordered eating measures (P < 0.05). Exercising to maintain identification with the running role may be associated with pathological eating and training practices.  相似文献   

9.
Abstract

This study examined the effects of caffeine, co-ingested with a high fat meal, on perceptual and metabolic responses during incremental (Experiment 1) and endurance (Experiment 2) exercise performance. Trained participants performed three constant-load cycling tests at approximately 73% of maximal oxygen uptake ([Vdot]O2max) for 30 min at 20°C (Experiment 1, n = 8) and to the limit of tolerance at 10°C (Experiment 2, n = 10). The 30 min constant-load exercise in Experiment 1 was followed by incremental exercise (15 W · min?1) to fatigue. Four hours before the first test, the participants consumed a 90% carbohydrate meal (control trial); in the remaining two tests, the participants consumed a 90% fat meal with (fat + caffeine trial) and without (fat-only trial) caffeine. Caffeine and placebo were randomly assigned and ingested 1 h before exercise. In both experiments, ratings of perceived leg exertion were significantly lower during the fat + caffeine than fat-only trial (Experiment 1: P < 0.001; Experiment 2: P < 0.01). Ratings of perceived breathlessness were significantly lower in Experiment 1 (P < 0.01) and heart rate higher in Experiment 2 (P < 0.001) on the fat + caffeine than fat-only trial. In the two experiments, oxygen uptake, ventilation, blood [glucose], [lactate] and plasma [glycerol] were significantly higher on the fat + caffeine than fat-only trial. In Experiment 2, plasma [free fatty acids], blood [pyruvate] and the [lactate]:[pyruvate] ratio were significantly higher on the fat + caffeine than fat-only trial. Time to exhaustion during incremental exercise (Experiment 1: control: 4.9, s = 1.8 min; fat-only: 5.0, s = 2.2 min; fat + caffeine: 5.0, s = 2.2 min; P > 0.05) and constant-load exercise (Experiment 2: control: 116 (88 – 145) min; fat-only: 122 (96 – 144) min; fat + caffeine: 127 (107 – 176) min; P > 0.05) was not different between the fat-only and fat + caffeine trials. In conclusion, while a number of metabolic responses were increased during exercise after caffeine ingestion, perception of effort was reduced and this may be attributed to the direct stimulatory effect of caffeine on the central nervous system. However, this caffeine-induced reduction in effort perception did not improve exercise performance.  相似文献   

10.
Abstract

The purpose of this study was (a) to assess lactate accumulation during isometric exercise, and to quantify the shifts in accumulation following isometric training; and (b) to relate any training-induced changes in lactate accumulation to reductions in resting blood pressure. Eleven male participants undertook isometric training for a 4-week period using bilateral-leg exercise. Training caused reductions in systolic, diastolic, and mean arterial resting blood pressure (of ?4.9 ± 6.3 mmHg, P = 0.01; ?2.6 ± 3.0 mmHg, P = 0.01; and ?2.6 ± 2.3 mmHg, P = 0.001 respectively; mean ± s). These were accompanied by changes in muscle activity, taken as electromyographic activity to reach a given lactate concentration (from 114 ± 22 to 131 ± 27 mV and from 136 ± 25 to 155 ± 34 mV for 3 and 4 mmol · L?1 respectively. Training intensity expressed relative to peak lactate was correlated with reduced resting systolic and mean arterial blood pressure. Training caused significant shifts in lactate accumulation, and reductions in resting blood pressure are strongly related to training intensity, when expressed relative to pre-training peak lactate. This suggests that higher levels of local muscle anaerobiosis may promote the training-induced reductions in resting blood pressure.  相似文献   

11.
Abstract

The aim of this study was to examine the effect of concentric warm-up exercise on eccentrically induced changes in muscle strength, range of motion, and soreness of the elbow flexors. Ten resistance-exercise naïve participants performed intermittent incremental eccentric actions (42 in total) of the elbow flexor muscles of each arm to induce muscle damage. The arms of each participant were randomly assigned either to a pre-eccentric exercise warm-up involving intermittent concentric exercise (warm-up) or no prior exercise (control). Strength, range of motion, and ratings of soreness were recorded before and 1, 2, 3, 4, and 7 days after exercise. Strength, range of motion, and soreness during muscular movements changed over time (P at most 0.01; Cohen's d at least 0.51, medium). There was an interaction (P < 0.001) for strength, showing a smaller reduction after exercise for warm-up than control (P < 0.001, d = 2.44, large effect). The decreased range of motion was less for warm-up than control for the arm while extended (P < 0.001), flexed (P = 0.002), and relaxed (P = 0.004). Muscle soreness was reduced for the warm-up group, while the muscle was flexed, extended, and relaxed compared with control (P < 0.001). The results demonstrate that a concentric warm-up exercise attenuates the reduction in loss of strength, range of motion, and muscle soreness after eccentric-exercise-induced muscle damage and might allow higher intensities of training to be performed.  相似文献   

12.
The purpose of this study was to determine the effectiveness of a 4-week running sprint interval training protocol to improve both aerobic and anaerobic fitness in middle-aged adults (40–50 years) as well as compare the adaptations to younger adults (20–30 years). Twenty-eight inactive participants – 14 young 20–30-year-olds (n = 7 males) and 14 middle-aged 40–50-year-olds (n = 5 males) – completed 4 weeks of running sprint interval training (4 to 6, 30-s “all-out” sprints on a curved, self-propelled treadmill separated by 4 min active recovery performed 3 times per week). Before and after training, all participants were assessed for maximal oxygen consumption (VO2max), 2000 m time trial performance, and anaerobic performance on a single 30-s sprint. There were no interactions between group and time for any tested variable, although training improved relative VO2max (young = 3.9, middle-aged = 5.2%; P < 0.04), time trial performance (young = 5.9, middle-aged = 8.2%; P < 0.001), peak sprint speed (young = 9.3, middle-aged = 2.2%; P < 0.001), and average sprint speed (young = 6.8, middle-aged = 11.6%; P < 0.001) in both young and middle-aged groups from pre- to post-training on the 30-s sprint test. The current study demonstrates that a 4-week running sprint interval training programme is equally effective at improving aerobic and anaerobic fitness in younger and middle-aged adults.  相似文献   

13.
Abstract

Excess protein intake can adversely affect the bone via an increase in calcium excretion, while suitable mechanical loading promotes osteogenesis. We therefore investigated whether vibration exposure could alleviate the bone mineral losses associated with a metabolic acidosis. Ten healthy individuals aged 22 – 29 years (median = 25) underwent three 5-day study periods while monitoring their dietary intake. The study consisted of recording the participants' usual dietary intake for 5 consecutive days. Participants were then randomly divided into two groups, one of which received a protein supplement (2 g · kg?1 body mass · day?1; n = 5) and the other whole-body low-magnitude (3.5 g), low-frequency (30 Hz) mechanical vibration (WBV) delivered through a specially designed vibrating plate for 10 min each day (n = 5). Finally, for the third treatment period, all participants consumed the protein supplement added to their normal diet and were exposed to WBV exercise for 10 min per day. Daily urine samples were collected throughout the experimental periods to determine the excretion of calcium, phosphate, titratable acid, urea, and C-telopeptide. As expected, when the participants underwent the high protein intake, there was an increase in urinary excretion rates of calcium (P < 0.001), phosphate (P < 0.003), urea (P < 0.001), titratable acid (P < 0.001), and C-telopeptide (P < 0.05) compared with baseline values. However, high protein intake coupled with vibration stimulation resulted in a significant reduction in urinary calcium (P = 0.006), phosphate excretion (P = 0.021), and C-telopeptide (P < 0.05) compared with protein intake alone, but did not affect titratable acid and urea output. The participants showed no effect of WBV exercise alone on urinary excretion of calcium, phosphate, urea, titratable acid, or C-telopeptide. The results indicate that vibration stimulation can moderate the increase in bone resorption and reduction in bone formation caused by a metabolic acidosis.  相似文献   

14.
In a randomised controlled trial design, effects of 6 weeks of plyometric training on maximal-intensity exercise and endurance performance were compared in male and female soccer players. Young (age 21.1 ± 2.7 years) players with similar training load and competitive background were assigned to training (women, n = 19; men, n = 21) and control (women, n = 19; men, n = 21) groups. Players were evaluated for lower- and upper-body maximal-intensity exercise, 30 m sprint, change of direction speed and endurance performance before and after 6 weeks of training. After intervention, the control groups did not change, whereas both training groups improved jumps (effect size (ES) = 0.35–1.76), throwing (ES = 0.62–0.78), sprint (ES = 0.86–1.44), change of direction speed (ES = 0.46–0.85) and endurance performance (ES = 0.42–0.62). There were no differences in performance improvements between the plyometric training groups. Both plyometric groups improved more in all performance tests than the controls. The results suggest that adaptations to plyometric training do not differ between men and women.  相似文献   

15.
Abstract

Omentin-1 is a newly discovered protein expressed and secreted from visceral adipose tissue that increases insulin sensitivity. We examined the effects of 12 weeks of aerobic training on serum omentin-1 concentrations together with cardiovascular risk factors in overweight and obese men. Eighteen overweight and obese participants (age 43.1 ± 4.7 years, BMI ≥25 kg · m?2) were assigned to exercise training (n = 9) and control (n = 9) groups. A matched control group of normal weight participants (n = 8; age 42.2 ± 3.8 years, BMI <25 kg · m?2) were also recruited for baseline comparison. The obese exercise group participated in 12 weeks of progressive aerobic training 5 days a week. Measures of serum omentin-1, insulin resistance, lipid profiles, blood pressure, and body composition were obtained before and after the 12 weeks. At baseline, normal weight participants had significantly higher serum omentin-1 concentrations than overweight and obese participants, and there were inverse correlations between omentin-1 and each of waist circumference, fasting glucose, insulin resistance, total cholesterol, triglyceride, and systolic blood pressure (P < 0.05). After the aerobic training, waist circumference, percent body fat, fasting glucose, insulin resistance, triglyceride, total cholesterol, low-density lipoprotein cholesterol, and systolic blood pressure were all significantly decreased (P < 0.05). In contrast, serum omentin-1 concentration was significantly increased after the aerobic programme (P < 0.05), and correlated with changes in insulin resistance (r = ?0.67, P = 0.04), glucose (r = ?0.65, P = 0.05), waist circumference (r = ?0.70, P = 0.03), and aerobic fitness r = ?0.68, P = 0.04). Aerobic training resulted in an improvement in cardiometabolic risk factors in obese participants, and this improvement was accompanied by increased omentin-1 concentrations.  相似文献   

16.
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17.
Abstract

The purpose of this study was to analyse the effect of regular exercise on spleen and peritoneal exudate reactive oxygen species (ROS) and lymphocyte proliferation by splenocytes. Twenty-four female BALB/c mice were randomly divided into trained (n = 12) and untrained (n = 12) groups. These two groups were further divided into mice that were studied at rest (trained/rest, n = 5; untrained/rest, n = 6) and immediately after a 2 h acute bout of exercise (trained/exercise, n = 6; untrained/exercise, n = 6). The animals were bred in the animal facility of the Yonsei University College of Medicine, where they were housed in a temperature- (22 – 24°C) and humidity- (50 – 60%) controlled environment, with a 12 h photoperiod, and provided with food and water ad libitum. The trained mice underwent 10 weeks of endurance swimming training (5 days per week) in water at 26 – 29°C for 60 min. Changes in body mass, proliferative activity and the production of reactive oxygen species from spleen lymphocytes and peritoneal exudate cells were determined. The splenic lymphocytes of the trained mice had much greater proliferative activity than those of the untrained mice (P < 0.05). Trained mice had lower ROS production in splenic lymphocytes and peritoneal exudate cells than untrained mice. In both groups, there was substantial inhibition of proliferative activity stimulated with medium, concanavalin A and lipopolysaccharide following the acute bout of exercise. This may have been caused by excessive ROS production following the acute exercise session.  相似文献   

18.
Recently, there has been growing interest in high-intensity interval training (HIT) as a strategy to improve health. In this pilot study, we examined the feasibility of a 4-week low-volume HIT and its effects on cardiorespiratory fitness (CRF), blood pressure (BP) and enjoyment in overweight and obese youth. Twelve adolescents (body mass index (BMI): 34.8 ± 3.9 kg · m?2, 14.9 ± 1.5 years) participated in 12 sessions of HIT (10 × 60 s cycling bouts eliciting ~90% maximal heart rate, interspersed with 90 s recovery, 30 min/session, 3 sessions/week) over ~4 weeks. All the participants completed the study and exercise attendance averaged 92%. Despite no changes in body weight and total fat, HIT resulted in significant (P < 0.01) increases in CRF (pre: 20.1 versus post: 22.2 ml · kg?1 · min?1) and exercise time (pre: 425 versus post: 509 s) during peak oxygen uptake test, and a reduction in resting systolic BP (pre: 115.8 versus post: 107.6 mmHg). The majority of study participants (83%) enjoyed HIT and more than half of the participants (58%) reported that HIT is a more enjoyable form of exercise compared to other types of exercises. Low-volume HIT is a useful strategy to promote exercise participation and improve cardiovascular health in overweight and obese youth.  相似文献   

19.
Abstract

In this study, we examined the effects of time-of-day-specific strength training on maximum strength and electromyography (EMG) of the knee extensors in men. After a 10-week preparatory training period (training times 17:00–19:00 h), 27 participants were randomized into a morning (07:00–09:00 h, n = 14) and an evening group (17:00–19.00 h, n = 13). Both groups then underwent 10 weeks of time-of-day-specific training. A matched control group (n = 7) completed all testing but did not train. Unilateral isometric knee extension peak torque (MVC) and one-repetition maximum half-squat were assessed before and after the preparatory training and after the time-of-day-specific training at times that were not training-specific (between 09:00 and 16:00 h). During training-specific hours, peak torque and EMG during MVC and submaximum isometric contraction at 40% MVC were assessed before and after the time-of-day-specific training. The main finding was that a significant diurnal difference (P < 0.01) in peak torque between the 07:00 and 17:00 h tests decreased after time-of-day-specific training in the morning group but not in the evening or control groups. However, the extent of this time-of-day-specific adaptation varied between individuals. Electromyography during MVC did not show any time-of-day-specific adaptation, suggesting that peripheral rather than neural adaptations are the main source of temporal specificity in strength training.  相似文献   

20.
Abstract

The purpose of this study was to determine whether aerobic plus resistance training (AT + RT) is more effective than aerobic training (AT) at reducing inflammatory markers and cardiovascular risk in obese adolescents. A total of 139 obese adolescents were enrolled, aged 15–19 years, body mass index (BMI) ≥ 95th percentile and participated in 1 year of interdisciplinary intervention. They were randomised into two groups: AT (n = 55), AT + RT (n = 61). Blood samples were collected to analyse glycaemia, insulin, the lipid profile, leptin and adiponectin concentrations. Insulin resistance was measured by homeostasis model assessment of insulin resistance index (HOMA-IR). The AT + RT group showed better results with regard to decreased body fat mass, low-density lipoprotein concentration (LDL-c) levels, subcutaneous and visceral fat and increased body lean mass. Indeed, a reduction of hyperleptinaemia and an increase in adiponectin concentrations, promoting an improvement in the leptin/adiponectin ratio, was observed. Important clinical parameters were improved in both types of exercise; however, AT + RT was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than AT alone, suggesting clinical applications for the control of intra-abdominal obesity and cardiovascular risk in the paediatric population.  相似文献   

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