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1.
The Franklin Institute, Philadelphia, Pennsylvania, awards the 2011 Benjamin Franklin Medal in Chemistry to Professor Kyriacos C. Nicolaou for his extraordinary contributions to chemistry, biology, and medicine through the advancement of the art of synthesis as exemplified by the elegant total syntheses of some of nature's most complex biologically active molecules. Nicolaou is recognized as a world leader in the field of total synthesis for his work in chemical synthesis and chemical biology. His total syntheses are legendary, distinguished for their elegance and practicality. Among his most celebrated achievements are the total syntheses of calicheamicin γ1I, Taxol®, brevetoxin B, vancomycin, and thiostrepton. The impact of his work transcends total synthesis, for it often leads to the discovery and invention of new synthetic strategies and technologies as well as biological tools and drug candidates, thereby facilitating discoveries in biology and medicine. Nicolaou's influence on science and society extends beyond his research discoveries. Through his didactic lectures and writings, he motivates and inspires students into the sciences and informs the public about the importance of science and education to society.  相似文献   

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3.
The Franklin Institute, Philadelphia, Pennsylvania, awards the 2010 Benjamin Franklin Medal in Computer and Cognitive Science to Professor Shafrira Goldwasser for fundamental work contributing to the theoretical foundation of modern cryptography and leading to techniques that mathematically guarantee secure access to the internet. More precisely, she is recognized for key contributions in provable security and in particular for interactive and zero-knowledge proofs and their application to cryptography and complexity theory.  相似文献   

4.
Rosalind Franklin is best known for her informative X-ray diffraction patterns of DNA that provided vital clues for James Watson and Francis Crick's double-stranded helical model. Her scientific career did not end when she left the DNA work at King's College, however. In 1953 Franklin moved to J. D. Bernal's crystallography laboratory at Birkbeck College, where she shifted her focus to the three-dimensional structure of viruses, obtaining diffraction patterns of Tobacco mosaic virus (TMV) of unprecedented detail and clarity. During the next five years, while making significant headway on the structural determination of TMV, Franklin maintained an active correspondence with both Watson and Crick, who were also studying aspects of virus structure. Developments in TMV research during the 1950s illustrate the connections in the emerging field of molecular biology between structural studies of nucleic acids and of proteins and viruses. They also reveal how the protagonists of the "race for the double helix" continued to interact personally and professionally during the years when Watson and Crick's model for the double-helical structure of DNA was debated and confirmed.  相似文献   

5.
The Franklin Institute, Philadelphia, Pennsylvania awards the 2011 Benjamin Franklin Medal in Earth and Environmental Science to Professor Jillian F. Banfield for her pioneering work in the fields of geochemistry and environmental microbiology, in particular her discoveries of the underlying principles of mineral formation and alteration by microbes and her efforts to advance the understanding of the form, composition, and distribution of minerals in the presence of living organisms.  相似文献   

6.
The Franklin Institute, Philadelphia, Pennsylvania, awarded the Benjamin Franklin Medal in Engineering to Robert E. Newnham for his invention of multiphase piezoelectric transducers and their spatial architecture which revolutionized the field of acoustic imaging. The background and significance of his research is presented. Attention is focused on the impact his research prompted in the field of medical imaging, in particular non-invasive, real-time visualization of internal tissue and organs of human body using ultrasound energy. Societal impact of Dr. Newnham's work is also pointed out.  相似文献   

7.
The Franklin Institute, Philadelphia, Pennsylvania, awarded the 2001 Benjamin Franklin Medal in Physics to Alan H. Guth for his efforts to advance our knowledge of physical science and its application of the inflationary scenario, in which the universe undergoes a rapid expansion in the first stages of the Big Bang.  相似文献   

8.
The Franklin Institute, Philadelphia, PA awarded the 2001 Benjamin Franklin Medal in Chemistry to K. Barry Sharpless for his important innovative scientific contributions to the field of asymmetric catalytic oxidation, which resulted in highly enantioselective processes for the epoxidation, dihydroxylation and aminohydroxylation of olefins.  相似文献   

9.
The Franklin Institute, Philadelphia, PA awarded the 2006 Benjamin Franklin Medal in civil engineering to Ray W. Clough for revolutionizing engineering and scientific computation, and engineering design methods through his formulation and development of the finite element method, and for his innovative leadership in applying the method to the field of earthquake engineering with special emphasis on the seismic performance of dams.  相似文献   

10.
The Benjamin Franklin Medal in Computer and Cognitive Science is awarded to Dr. Richard M. Karp for his contributions to the understanding of computational complexity. His work helps programmers find workable solution procedures avoiding approaches that would fail to find a solution in a reasonable amount of time. Scientific, commercial, or industrial situations where his work applies include establishing least-cost schedules for industrial production, transportation routing, circuit layout, communication network design, and predicting the spatial structure of a protein from its amino acid sequencing.  相似文献   

11.
Part of the theory and all the experiments reported on in this paper were condensed into a four-page discussion or addendum to Professor Den Hartog's original paper on “Amplitudes of Non-Harmonic Vibrations” at the time of its presentation at the June Meeting of the A.S.M.E. in Chicago, 1933. Upon the instigation of Professor Den Hartog and the Editor of the Journal of the Franklin Institute, the original discussion has been brought into the present form.  相似文献   

12.
The Franklin Institute, Philadelphia, Pennsylvania, awarded the 2005 Benjamin Franklin medal in physics to Yoichiro Nambu for his seminal contributions which introduced the modern concept of broken symmetry to elementary particle physics, for his invention of the particle property called color which is the key to quark confinement, and for his ground-breaking work on the theory of string-like elementary particles.  相似文献   

13.
The Franklin Institute of Philadelphia awards the 2011 Benjamin Franklin Medal in Physics to Nicola Cabibbo for his pioneering work in the field of elementary particle physics, with special emphasis on his role in furthering our understanding of the underlying symmetries that relate one elementary particle interaction to another.  相似文献   

14.
The scientific theme for the 2005 Bower Award was Chemistry, specifically the field of Catalysis. The Franklin Institute, Philadelphia, Pennsylvania, awarded the 2005 Bower Award and Prize for achievement in Science to Henri B. Kagan for his seminal discovery of fundamental chemical principles that explain the impact of catalyst shape on its effectiveness in controlling chemical reactions, thus greatly simplifying the manufacture of pharmaceutically important compounds. Henri Kagan is widely recognized as a pioneer in the field of asymmetric catalysis. Starting in the early 1970s, his reports of the synthesis of the chiral bidentate diphosphine ligand and the demonstration of its use with soluble rhodium compounds to catalyze the efficient production of large enantiomeric excesses of chiral molecules in asymmetric hydrogenations has had far reaching effects on research in the field asymmetric catalysis. The concept of using chiral bidentate ligands of C2 symmetry has led the way for numerous developments in asymmetric catalysis. Later in 1986 his introduction of the concept and investigations into “nonlinear effects in asymmetric synthesis” using catalysts with chiral ligands that were not optically pure challenged the widely accepted assumption that the enantiomeric excess which is possible correlates linearly with the optical purity of the chiral ligands. He reported the first example in asymmetric catalysis where the optical purity of the product significantly exceeded the optical purity of the chiral ligand.  相似文献   

15.
The Franklin Institute, Philadelphia, Pennsylvania, awarded the 2001 Benjamin Franklin Medal in Earth Science to Rob Van der Voo for his outstanding contributions to the field of paleomagnetism and his reconstruction of ancient continental positions that have lead to a better understanding of plate tectonic processes for the past billion years of Earth history.  相似文献   

16.
The Franklin Institute, Philadelphia, Pennsylvania, awarded the 2003 Benjamin Franklin medal in Earth Science to Norman Phillips and Joseph Smagorinsky for their seminal and pioneering studies that led to the first successful predictions of the weather using numerical methods, and to an understanding of the general circulation of the atmosphere. In addition, Smagorinsky played a leading role in establishing the current global observational network for the atmosphere, and Phillips’ leadership fostered the development of effective methods for the use of observations in data assimilation systems.  相似文献   

17.
The Franklin Institute, Philadelphia, PA, awarded the 2004 Benjamin Franklin Medal in Mechanical Engineering to Roger Bacon for his fundamental research on the production of graphite whiskers and the determination of their microstructure and properties, for his pioneering development efforts in the production of the world's first continuously processed carbon fibers and the world's first high modulus and high-strength carbon fibers, and for his contributions to the development of carbon fibers from alternative starting materials.  相似文献   

18.
The Franklin Institute of Philadelphia awarded the 2002 Benjamin Franklin Medal in Chemistry to Norman L. Allinger for his pioneering work in computational chemistry in the field of molecular mechanics with his development of the MM series of force fields, their widespread application to the fundamental understanding of molecular structure and energetics, and their implementation as a significant tool to practicing chemists.  相似文献   

19.
The separation of target nucleic acid sequences from biological samples has emerged as a significant process in today''s diagnostics and detection strategies. In addition to the possible clinical applications, the fundamental understanding of target and sequence specific hybridization on surface modified magnetic beads is of high value. In this paper, we describe a novel microfluidic platform that utilizes a mobile magnetic field in static microfluidic channels, where single stranded DNA (ssDNA) molecules are isolated via nucleic acid hybridization. We first established efficient isolation of biotinylated capture probe (BP) using streptavidin-coated magnetic beads. Subsequently, we investigated the hybridization of target ssDNA with BP bound to beads and explained these hybridization kinetics using a dual-species kinetic model. The number of hybridized target ssDNA molecules was determined to be about 6.5 times less than that of BP on the bead surface, due to steric hindrance effects. The hybridization of target ssDNA with non-complementary BP bound to bead was also examined, and non-specific hybridization was found to be insignificant. Finally, we demonstrated highly efficient capture and isolation of target ssDNA in the presence of non-target ssDNA, where as low as 1% target ssDNA can be detected from mixture. The microfluidic method described in this paper is significantly relevant and is broadly applicable, especially towards point-of-care biological diagnostic platforms that require binding and separation of known target biomolecules, such as RNA, ssDNA, or protein.  相似文献   

20.
DNA纳米技术是设计和构建具有一定用途的人工核酸纳米结构。DNA纳米技术中的一个重要挑战就是如何有效设计和构建具有明确功能的纳米尺度的结构和器件。计算机辅助工具是预测、设计、建模以及描绘DNA结构的最强有力的工具。计算机辅助设计DNA结构以及识别有效的自组装路径让DNA作为一种独特的材料在构建纳米结构领域中显露锋芒。文章总结了DNA纳米结构设计的原理,介绍了一些用于DNA结构设计的算法以及一些用户友好软件。同时,对DNA纳米技术中构建DNA逻辑门以及DNA计算方面的最新研究进展做了介绍。  相似文献   

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