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1.
急性运动对人体细胞免疫功能的影响   总被引:7,自引:0,他引:7  
为探索运动对细胞免疫功能的影响,检测了7名男运动员一次急性疲劳性运动前和运动后即刻、3h、24h的外周血TLT、IH活性和皮质醇及胰岛素浓度的变化。结果:在运动后即刻,TLT显著增强,IL—2活性和血浆皮质醇浓度分别略有上升和下降;在运动后3h,前2项指标和血浆皮质醇浓度分别明显增强和降低。这3项指标在运动后24h均恢复到运动前水平。IL-2活性变化与皮质醇变化有显著负相关关系。胰岛素在运动前后无明显变化。结果表明:一次急性适度运动可提高人体的细胞免疫功能,并可持续数小时。这种变化与血浆皮质醇浓度下降有一定关系。  相似文献   

2.
为了探索运动应激对Th1和Th2偏移的影响及其与皮质醇(Cor)、血乳酸(BLA)和血尿素氮(BUN)的关系。以非体育专业男大学生为研究对象,空腹,以200W蹬车2min,间歇5min,重复运动至极度疲劳。检测运动前、运动后即刻和运动后3h Th1型细胞因子干扰素-γ(IFN-γ)、Th2型细胞因子白细胞介素-4(IL-4)、T-淋巴细胞转换指数(T-LTI)、血清免疫球蛋白(IgG、IgA、IgM)以及血清皮质醇(Cor)、血乳酸(BLA)和尿素氮(BUN)浓度等。结果:IFN-γ、IFN-γ,与IL-4比值和T-LTI在运动后即刻和运动后3h分别下降了37%、30%、31%、31%、39%和28%(P〈0.001);IL-4和血清IgG、IgA和IgM在运动前后无明显变化;血清Cor、BLA和BUN浓度在运动后即刻分别增加了的95%、314%、31%(P〈0.001),休息3h后仍无明显恢复。IFN-γ,和IFN-γ,与IL-4比值分别与T-LTI呈正相关(P〈0.05)。IFN-γ与IL-4比值分别与Cor、BUN、BLA以及IFN-γ分别与Cor、BUN之间均呈负相关(P〈0.05);T-LTI分别与Cor、BLA、BUN呈负相关(P〈0.05)。IFN-γ与Ig以及IL-4与BLA、BUN无显著相关。结果说明运动应激时Th1和Th2向Th2方向偏移,细胞免疫功能下调。这些变化与血清Cor和BLA、BUN浓度增加有关。  相似文献   

3.
本文以通过特质焦虑量表测量的24名不同特质焦虑类型的体院男生为实验对象,对其进行了不同心理状态下20min的篮球对抗赛,并就运动免疫学研究争议较多的IL-1、IL-2、免疫球蛋白,分别对其安静时、运动前即刻、运动后即刻采集血样,经化验和统计分析发现:(1)心理应激对运动员血清中IL-I和IL-2水平都产生影响,尤其对IL-I影响显著。(2)高特质焦虑运动员在心理应激和运动负荷后血浆IL-1和IL-2活性的变化水平比低特质焦虑运动员更为明显。(3)心理应激、急性运动对运动员免疫球蛋白水平无明显影响。  相似文献   

4.
运动应激所致血清IL-1β和IL-6浓度增加及其作用研究   总被引:2,自引:1,他引:1  
何伟 《体育科学》2006,26(7):33-35,74
目的:探索运动应激时血清白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)浓度变化及其与糖代谢和细胞免疫的关系。方法:非体育专业男大学生,空腹,以200W蹬车2min,间歇5min,重复运动至极度疲劳。检测运动前、运动后即刻和运动后3h血清IL-1β、IL-6、皮质醇(Cor)、血糖(GLU)和血乳酸(BLA)浓度以及T-淋巴细胞转换指数(T-LTI)变化。结果:在运动后即刻,血清GLU、BLA、IL-1β、IL-6和Cor浓度增加幅度分别达运动前的40%、314%、75%、110%和95%(P〈0.001),而T-LTI则下降了31%(P〈0.001),经3h休息,Cor、GLU和T-LTI未完全恢复,但BLA、IL-1β和IL-6基本恢复;IL-1β、IL-6、Cor分别与GLU和BLA呈正相关(P〈0.05),但与T-LTI均呈负相关(P〈0.05);Cor分别与IL-1β和IL-6呈正相关(P〈0.05)。结论:IL-1β和IL-6在运动应激期间主要参与糖代谢的调节,对细胞免疫功能有一定抑制作用。  相似文献   

5.
目的:获取大负荷跑台运动引起大鼠心肌收缩力动态性变化的信息,总结其变化特征,探讨其变化与心肌自由基、钙离子水平的关系。方法:成年雄性SD大鼠32只,随机分为空白对照组(A组)、运动后即刻组(B组)、运动后3 h组(C组)与运动后24 h组(D组)。运动心力监测仪监测D组大鼠运动前与运动后不同时相的心力信号。测定血清cTnI浓度;测定心肌SOD活性、MDA含量与Ca2+浓度。结果:第一心音幅值在运动后即刻已有下降,随后连续多时相显著低于运动前水平,至运动后24 h时完全恢复。运动引起血清cTnI浓度显著升高,引起心肌SOD活性显著下降、MDA含量显著升高与Ca2+浓度显著升高;上述变化均以C组最明显。结论:大负荷运动引起大鼠心肌收缩力下降,以运动后恢复期最明显,但为可逆性;心肌收缩力下降可能与心肌自由基增多、钙超载有关。  相似文献   

6.
目的:探索运动应激对人体外周血T-淋巴细胞膜Na -K 泵和转换功能的影响及其与运动性高乳酸和高K 血症的关系。方法:非体育专业男大学生,空腹,以200W蹬车2min,间歇5min,重复运动至极度疲劳。检测运动前、运动后即刻和运动后3h血清K 和血乳酸(BLA)浓度、人体外周血T-Na -K 泵活性和T-淋巴细胞转换指数(T-LTI)。结果:在运动后即刻T-Na -K 泵和T-LTI分别下降至运动前的35%和31%(P<0.001),血清K 和BLA浓度增加幅度分别达运动前的46%和314%(P<0.001),经3h休息,T-Na -K 泵活性和T-LTI仍明显低于运动前,但血清K 和BLA浓度基本恢复;BLD和血清K 分别与T-Na -K 泵和T-LTI呈负相关(P<0.05)。结论:运动应激时T-Na -K 泵活性和T-LTI下降,运动性高血K 和高乳酸血症对细胞免疫功能有一定抑制作用。  相似文献   

7.
耐力运动对大鼠肾脏组织自由基代谢的影响   总被引:14,自引:2,他引:12  
测定大鼠在进行耐力运动前及运动后即刻、2h、4h及6h肾脏组织脂质过氧化水平(LPO)、超氧化物歧化酶活性(SOD)和谷胱甘肽过氧化物酶活性(GSH—Px)变化表明,大鼠肾脏组织在运动结束后即刻LPO显著升高(P<0.01),SOD活性升高不显著(P>0.05)和GSH—Px)活性显著下降(P<0.05)。运动后恢复期中,LPO呈现下降趋势,而SOD和GSH—Px活性呈现上升趋势,表明耐力运动提高了大鼠肾脏组织抗氧化酶活性,增强了对抗自由基能力。  相似文献   

8.
目的 观察联合抗氧化剂对运动员一次性大强度离心运动后不同时相下肢肌肉疼痛等级和血IL-6、CK、CK-MM、LDH的影响,探讨联合抗氧化剂减缓运动员运动延迟性肌肉酸痛(DOMS)的作用和机制.方法 运动员16名,随机均衡分为对照组(A组)和联合抗氧化剂组(B组),运动前2周至运动后2天每天分别口服安慰剂或VE、VC与Se组成的联合抗氧化剂.服药两周后进行一次大强度离心跑台运动,建立DOMS模型,在服药前、运动前和运动后即刻、24 h、48 h分别测定运动员肘正中静脉血IL-6、CK、CK-MM、LDH水平及运动后相应时相下肢肌肉酸痛程度.结果 (1)运动员运动后下肢肌肉酸痛程度逐日加重,B组运动后各时相酸痛程度均显著轻于A组.(2)B组血浆IL-6运动后各时项均低于A组同时项,其中运动后24 h呈非常显著性差异.(3)B组血清CK、CK-MM运动后各时相均低于A组,其中运动后48 h二指标活性显著低于A组.(4)B组血清LDH运动后各时相均低于A组.结论 联合抗氧化剂能有效减轻大强度离心运动导致的运动应激和炎症反应,保护肌细胞膜的完整性,减轻DOMS.  相似文献   

9.
目的:探讨大蒜素与联合抗氧化剂干预对运动员大强度离心运动后不同时相肌肉酸痛程度、血浆白细胞介素6(IL-6)水平变化的影响.方法:运动员 24 名,随机均衡分为对照组(A组)、联合抗氧化剂组(B组)和大蒜素组(C组),运动前2周至运动后2天每天分别口服安慰剂、联合抗氧化剂或大蒜素肠溶胶丸.服药两周后进行一次大强度离心跑台运动,建立运动员运动延迟性肌肉酸痛(DOMS)模型,在服药前、运动前和运动后即刻、24 h、48 h分别测定运动员肘正中静脉血IL-6浓度及运动后相应时相肌肉酸痛程度.结果:3组运动员运动后肌肉酸痛程度均呈延迟性,B、C组运动员运动后各时相肌肉酸痛程度与血浆IL-6浓度均低于A组同时相.C组运动员肌肉酸痛程度运动后各时相均高于B组同时相,而血浆IL-6的浓度运动后各时相均低于B组同时相,但均无显著性差异.结论:联合抗氧化剂与大蒜素均可减轻运动员离心运动导致的DOMS,抑制IL-6的产生;大蒜素可能通过降低运动应激,减小肌纤维损伤与炎症反应等作用,抑制运动后血浆IL-6浓度的升高;联合抗氧化剂可通过几种抗氧化成分的协同作用,减轻大强度离心运动导致的DOMS.  相似文献   

10.
目的:评价大强度耐力训练对大学生运动员心脏标志物、血清铁、血红蛋白、白介素-6和心功能的影响.方法:随机选取30名男性学生运动员,在100 min内完成20 000m长跑和哈佛台阶试验,心率控制在180~200次/min.在运动前(T1)、运动后即刻(T2)和运动后3 h(T3)测定运动员的心率、血压、血浆NT-proBNP、血清铁、血红蛋白以及白介素-6的表达.结果:运动后即刻的心率、收缩压、舒张压、NT-proBNP含量较运动前显著增加(P<0.05),血清铁和白介素-6含量较运动前显著降低(P<0.05),血红蛋白含量无显著性变化;运动后3h,心率、收缩压、舒张压、血浆NT- proBNP、血清铁、血红蛋白以及白介素-6的表达均与运动前无显著性差异.结论:大强度耐力训练后心脏损伤标志物NT- proBNP含量显著性增高,应该是对运动刺激的一种生理适应,不具有病理性改变意义.白介素-6浓度发生显著性上升,并不能表明发生运动性炎性反应,并未对心功能造成伤害.血清铁含量的下降,表明运动并未过量,没有对机体造成损伤.  相似文献   

11.
运动对机体免疫功能有急慢性以及正负性影响。有规律的适度运动可增强免疫功能而降低感染风险。急性运动后肌源性IL-6释放增加,IL-10上升从而抑制细胞免疫功能。急性运动增强自然杀伤细胞活性但是降低白细胞的吞噬功能。长时间的高强度运动可能会通过抑制黏膜IgA分泌而增加上呼吸道感染风险。定期补充抗氧化剂如维生素C和E以及在运动过程中摄入碳水化合物有助于预防免疫抑制。平衡营养饮食匹配合理的运动计划可支持和促进免疫系统。  相似文献   

12.
Li TL  Gleeson M 《Journal of sports sciences》2004,22(11-12):1015-1024
The purpose of this study was to establish the effect of exercise at different times of day on saliva flow rate, immunoglobulin A (sIgA) concentration and secretion rate, and alpha-amylase activity, and to establish how these parameters change following a second exercise bout performed on the same day. In a counterbalanced design, eight male volunteers participated in three experimental trials separated by at least 4 days. On the trial with afternoon exercise only, the participants cycled for 2 h at 60% VO2max starting at 14:00 h. On the other two trials, participants performed either two bouts of exercise at 60% VO2max for 2 h (the first started at 09:00 h and the second started at 14:00 h) or a separate resting trial. Unstimulated saliva samples were obtained 10 min before exercise, after 58 - 60 min and during the last 2 min of exercise, and at 1 h and 2 h after exercise. Venous blood samples were taken 5 min before exercise and immediately after exercise for both bouts. Participants remained fasted between 23:00 h on the day before the trials and 18:00 h on the day of the trial. Circadian variations were found in sIgA concentration, which decreased with time from its highest value in the early morning to its lowest value in the evening, and salivary alpha-amylase secretion rate, which increased from its lowest value in the morning to its highest value in the late afternoon. Cycling at 60% VO2max for 2 h significantly decreased saliva flow rate, increased sIgA concentration and alpha-amylase activity, but did not influence sIgA secretion rate. Performing prolonged cycling at different times of day did not differentially affect the salivary and plasma hormonal responses in the short term. Performance of a second prolonged exercise bout elicited a greater plasma stress hormone response but did not appear to compromise oral immunity acutely. These findings also suggest that, in terms of saliva secretion, sIgA and alpha-amylase responses, a 3 h rest is enough to recover from previous strenuous exercise. During such exercise, sympathetic stimulation appears to be strong enough to inhibit saliva flow rate; however, it appears that it does not increase sIgA output via transcytosis.  相似文献   

13.
The aim of this study was to determine the effect of carbohydrate (CHO) versus placebo (PLA) beverage consumption on the immune and plasma cortisol responses to a soccer-specific exercise protocol in 8 university team soccer players. In a randomized, counterbalanced design, the players received carbohydrate or placebo beverages before, during and after two 90 min soccer-specific exercise bouts (3 days apart) designed to mimic the activities performed and the distance covered in a typical soccer match. Blood and saliva samples were collected before, during and after the exercise protocol. Plasma lactate concentration increased to approximately 4 mmol x l(-1) at 45 and 90 min of exercise in both treatments (P<0.01). Plasma glucose concentration was significantly lower after 90 min of exercise with ingestion of the placebo than the carbohydrate (PLA: 4.57+/-0.12 mmol x l(-1); CHO: 5.49+/-0.11 mmol x l(-1); P<0.01). The pattern of change in plasma cortisol, circulating lymphocyte count and saliva immunoglobulin A secretion did not differ between the carbohydrate and placebo trials. Blood neutrophil counts were 14% higher 1 h after the placebo trial than the carbohydrate trial (PLA: 4.8+/-0.5x10(9) cells x l(-1); CHO: 4.2+/-0.5x10(9) cells x l(-1); P = 0.06), but the treatment had no effect on the degranulation response of blood neutrophils stimulated by bacterial lipopolysaccharide. We conclude that, although previous studies have shown that carbohydrate feeding is effective in attenuating immune responses to prolonged continuous strenuous exercise, the same cannot be said for a soccer-specific intermittent exercise protocol. When overall exercise intensity is moderate, and changes in plasma glucose, cortisol and immune variables are relatively small, it would appear that carbohydrate ingestion has only a minimal influence on the immune response to exercise.  相似文献   

14.
The aim of this study was to determine the effect of carbohydrate (CHO) versus placebo (PLA) beverage consumption on the immune and plasma cortisol responses to a soccer-specific exercise protocol in 8 university team soccer players. In a randomized, counterbalanced design, the players received carbohydrate or placebo beverages before, during and after two 90min soccer-specific exercise bouts (3 days apart) designed to mimic the activities performed and the distance covered in a typical soccer match. Blood and saliva samples were collected before, during and after the exercise protocol. Plasma lactate concentration increased to ~4 mmol.l-1 at 45 and 90 min of exercise in both treatments (P? 0.01). Plasma glucose concentration was significantly lower after 90 min of exercise with ingestion of the placebo than the carbohydrate (PLA: 4.57 +/- 0.12 mmol.l-1; CHO: 5.49 +/- 0.11 mmol.l-1; P? 0.01). The pattern of change in plasma cortisol, circulating lymphocyte count and saliva immunoglobulin A secretion did not differ between the carbohydrate and placebo trials. Blood neutrophil counts were 14% higher 1 h after the placebo trial than the carbohydrate trial (PLA: 4.8 =/- 0.5 x 10 9 cells.l-1; CHO:4.2 +/- 0.5 x 10 9 cells.l-1; P=0.06),but the treatment had no effect on the degranulation response of blood neutrophils stimulated by bacterial lipopolysaccharide. We conclude that, although previous studies have shown that carbohydrate feeding is effective in attenuating immune responses to prolonged continuous strenuous exercise, the same cannot be said for a soccer-specific intermittent exercise protocol. When overall exercise intensity is moderate,and changes in plasma glucose, cortisol and immune variables are relatively small, it would appear that carbohydrate ingestion has only a minimal influence on the immune response to exercise.  相似文献   

15.
Ingesting carbohydrate beverages during prolonged exercise is associated with fewer numbers of circulating neutrophils and attenuated neutrophil functional responses, yet there is little information about the effect of fluid intake alone on immune responses to prolonged exercise. The aim of this study was to examine the influence of regular fluid ingestion compared with no fluid ingestion on plasma cortisol, circulating neutrophil and lipopolysaccharide (LPS)-stimulated neutrophil degranulation responses to prolonged cycling. In a randomized design, nine recreationally active males cycled for 2 h at 65% VO2max on two occasions with either fluid ingestion (lemon-flavoured water, fluid trial) before and during the exercise, or with no fluid intake at all (no fluid trial). Venous blood samples were obtained at rest, immediately after exercise and 1 h after exercise. Immediately after exercise, the plasma cortisol concentration was significantly higher in the no fluid trial than in the fluid trial (592 +/- 62 vs 670 +/- 63 nmol x l(-1), P < 0.05). Circulating numbers of neutrophils increased 4.5-fold (P < 0.01) and LPS-stimulated elastase release per neutrophil decreased 34 +/- 7% (P < 0.01) immediately after exercise; there were no differences between trials. These results suggest that in ambient environmental conditions, fluid ingestion alone has a negligible effect on circulating neutrophil and LPS-stimulated neutrophil degranulation responses to prolonged exercise.  相似文献   

16.
The purpose of this study was to assess the effect of carbohydrate (CHO) feeding during different periods of two 90-min cycling bouts (the first bout began at 09:00?h and the second bout began at 13:30 h) at 60% maximal oxygen uptake(VO2max) on saliva flow rate and saliva immunoglobulin A (sIgA) responses to the second exercise bout. The study consisted of three investigations: carbohydrate supplementation during (1) the first hour of the recovery interval (CHO-REC), (2) during the first bout of exercise and (3) during the second bout of exercise. Each investigation included two trials completed in a counterbalanced order and separated by at least 4 days. Participants consumed a lemon-flavoured 10% w/v carbohydrate beverage or placebo (22 ml.kg-1 body mass) in the first hour of the recovery interval (n=8) and 500 ml just before exercise, followed by 250 ml every 20 min during exercise in the first (n=9) and second exercise bouts (n=9). Timed unstimulated saliva samples were collected at 10 min before exercise, after 48-50 min of exercise and during the last 2 min of exercise, at 1 h post exercise, 2 h post exercise (first exercise bout only), and 18 h post exercise (second exercise bout only). Venous blood samples were taken 5 min before exercise and immediately after exercise for both exercise bouts in all trials. The main findings of the present study were as follows. First, carbohydrate ingestion during both exercise bouts, but not during the recovery interval, better maintained plasma glucose concentrations and attenuated the increase in plasma adrenaline and cortisol concentrations after the second exercise bout compared with placebo. Second, carbohydrate feeding had no effect on saliva flow rate and sIgA secretion rate compared with placebo. Third, saliva flow rate and sIgA concentration returned to pre-exercise bout 1 values within 2 h in all trials. Fourth, there was no delayed effect of exercise on oral immunity. These findings suggest that carbohydrate ingestion during the first or second bout of exercise, but not during the recovery interval, is likely to better maintain plasma glucose concentrations and attenuate the responses of plasma stress hormones to a second exercise bout than ingestion of fluid alone. Two bouts of 90 min cycling at 60% VO2max on the same day appears to inhibit saliva flow rate during the second exercise bout but does not alter sIgA transcytosis. Our results show that carbohydrate ingestion during any period of two prolonged exercise bouts does not induce different effects on oral immunity compared with placebo.  相似文献   

17.
The purpose of this study was to assess the effect of carbohydrate (CHO) feeding during different periods of two 90-min cycling bouts (the first bout began at 09:00?h and the second bout began at 13:30?h) at 60% maximal oxygen uptake ([Vdot]O2max) on saliva flow rate and saliva immunoglobulin A (sIgA) responses to the second exercise bout. The study consisted of three investigations: carbohydrate supplementation during (1) the first hour of the recovery interval (CHO-REC), (2) during the first bout of exercise and (3) during the second bout of exercise. Each investigation included two trials completed in a counterbalanced order and separated by at least 4 days. Participants consumed a lemon-flavoured 10% w/v carbohydrate beverage or placebo (22?ml?·?kg?1 body mass) in the first hour of the recovery interval (n = 8) and 500?ml just before exercise, followed by 250?ml every 20?min during exercise in the first (n = 9) and second exercise bouts (n = 9). Timed unstimulated saliva samples were collected at 10?min before exercise, after 48?–?50?min of exercise and during the last 2?min of exercise, at 1?h post exercise, 2?h post exercise (first exercise bout only), and 18?h post exercise (second exercise bout only). Venous blood samples were taken 5?min before exercise and immediately after exercise for both exercise bouts in all trials. The main findings of the present study were as follows. First, carbohydrate ingestion during both exercise bouts, but not during the recovery interval, better maintained plasma glucose concentrations and attenuated the increase in plasma adrenaline and cortisol concentrations after the second exercise bout compared with placebo. Second, carbohydrate feeding had no effect on saliva flow rate and sIgA secretion rate compared with placebo. Third, saliva flow rate and sIgA concentration returned to pre-exercise bout 1 values within 2?h in all trials. Fourth, there was no delayed effect of exercise on oral immunity. These findings suggest that carbohydrate ingestion during the first or second bout of exercise, but not during the recovery interval, is likely to better maintain plasma glucose concentrations and attenuate the responses of plasma stress hormones to a second exercise bout than ingestion of fluid alone. Two bouts of 90?min cycling at 60% [Vdot]O2max on the same day appears to inhibit saliva flow rate during the second exercise bout but does not alter sIgA transcytosis. Our results show that carbohydrate ingestion during any period of two prolonged exercise bouts does not induce different effects on oral immunity compared with placebo.  相似文献   

18.
通过观查40例Ⅱ型糖尿病合并高血压的患者练习太极拳前后血压,血糖,胰岛素及受体的变化,研究太极拳锻炼对Ⅱ型糖尿病合并高血压患者疗效的影响以及可能的作用机制。在常规药物治疗的基础上参加规定的太极拳动作的学习及锻炼3个月。分别采集各实验组和对照组在锻炼前和锻炼12周结束后空腹状态下血液,进行如下指标的测试:血糖、胰岛素、糖化血红蛋白。结果显示运动组治疗后24小时血压、白天收缩压比治疗前有所下降,经统计学处理有显著性差异,但其他各项值虽有数量上的变化,但经统计学处理,与治疗前比较,无显著性差异。运动组血糖水平下降,胰岛素水平升高,高、低亲和力受体个数(r)和高低亲和力受体容量(R)显著升高。  相似文献   

19.
In the present study, we assessed the effects of exercise intensity on salivary immunoglobulin A (s-IgA) and salivary lysozyme (s-Lys) and examined how these responses were associated with salivary markers of adrenal activation. Using a randomized design, 10 healthy active men participated in three experimental cycling trials: 50% maximal oxygen uptake (VO2max), 75%VO2max, and an incremental test to exhaustion. The durations of the trials were the same as for a preliminary incremental test to exhaustion (22.3 min, sx = 0.8). Timed, unstimulated saliva samples were collected before exercise, immediately after exercise, and 1 h after exercise. In the incremental exhaustion trial, the secretion rates of both s-IgA and s-Lys were increased. An increase in s-Lys secretion rate was also observed at 75%VO2max. No significant changes in saliva flow rate were observed in any trial. Cycling at 75%VOmax and to exhaustion increased the secretion of alpha-amylase and chromogranin A immediately after exercise; higher cortisol values at 75%VO2max and in the incremental exhaustion trial compared with 50%VO2max were observed 1 h immediately after exercise only. These findings suggest that short-duration, high-intensity exercise increases the secretion rate of s-IgA and s-Lys despite no change in the saliva flow rate. These effects appear to be associated with changes in sympathetic activity and not the hypothalamic - pituitary - adrenal axis.  相似文献   

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