Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Dealing with disagreement: The roles of topic familiarity and disagreement explanation in evaluation of conflicting expert claims and sources     

《Learning and Instruction》2020

Learners may increasingly encounter conflicting expert reports. However, little is known about how they deal with this challenge. We examined how learners' familiarity with a controversial historical topic affects their epistemic judgments of conflicting expert claims and sources, the interplay of their claim and source evaluation strategies, and their meta-epistemic understanding of the legitimacy of the disagreement (absolutist, multiplist, and evaluativist perspectives). In two studies, topic familiarity increased agreement with belief-consistent expert claims and the perceived trustworthiness of the expert who presented these claims. Topic familiarity also impacted the coordination of evaluation strategies and led to greater reliance on knowledge-based validation. However, topic familiarity did not affect meta-epistemic understanding of the legitimacy of the controversy. In the second study, reading an explanation about reasons for disagreements between historians resulted in higher evaluativism. Teaching about expert disagreement may be a productive approach for promoting appreciation of the diversity of knowledge.  相似文献   

中职体育教学中学生团队意识的培养探析     

覃永江 《当代体育科技》2020,(12):127-128

当前,我国社会市场对人才的要求越来越多,而在众多要求中团队精神已经成为学生学习、求职、从事行业工作必备的条件。中职生是一群特殊的群体,其专业学习具有很强的职业性与目的性,在为中职生开展的体育教学中培养学生的团队意识非常重要。本文结合笔者多年的工作实践,探讨中职体育教学培养学生团队意识的策略,以供参考。  相似文献   

Analyzing Food Science Research for Publishing Characteristics as a Model for Understanding the Needs of Researchers     

Lutishoor Salisbury  Jeremy J. Smith  Abayomi Omotola Omolewu 《资料收集管理》2020,45(4):335-353

Abstract

This paper provides a methodology to study the characteristics of the research output from a university department. The faculty publications and their cited references over a 10-year period were used as the basis for this study to identify their publishing patterns and the types of material they are publishing; a core set of journals and other resources they are publishing in and citing over this period; the characteristics of the journals in which they publish and cite; the degree of openness of their publications and their citation advantage; and the age of resources that are referenced.  相似文献   

电视新闻策划的实践思考     

夏冰 《浙江传媒学院学报》2003,10(3):18-20

新闻策划是对新闻报道活动的策划,电视新闻策划是现代社会受众和电视自身发展的需要。电视新闻的策划重在发挥电 视传播的优势,强调整体的协作。  相似文献   

我国球场观众暴力遏制策略的研究   总被引：16，自引：3，他引：13  

石岩 《体育与科学》2003,24(5):13-16

采用文献资料、访谈与现场研究等方法探讨我国球场观众暴力的遏制策略问题。在介绍中外防范与治理球场观众暴力主要方法的基础上，针对我国球场观众暴力防治工作现状与问题，提出了6条遏制策略。研究结果可供政府有关部门在防治球场观众暴力时参考。  相似文献   

中国传统文化与学校体育可持续发展   总被引：2，自引：0，他引：2  

吴刚 《湖北体育科技》2003,22(2):156-157,160

中国传统文化是学校体育可持续发展的外环境因素，它主要由儒家、道家和禅宗文化构成，具有中庸和平、泛道德性、人文精神、非独立性、静止停滞、乡土情结等特质，通过研究它的理性因素对学校体育可持续发展的正面影响和非理性因素带来的负面影响，来探讨在学校体育思想、内容和方法上应采取的发展对策。  相似文献   

谈谈高校外文图书采访改革   总被引：15，自引：0，他引：15  

韩冬丽 《江西图书馆学刊》2003,33(2):21-22

外图书采访一直是高校图书馆献资源建设的重点之一，结合本馆外图书采访的实际工作经验，提出改革外图书采购模式的若干看法。  相似文献   

网络型电子期刊编目原则探讨   总被引：12，自引：0，他引：12  

沈芸芸  张广钦 《大学图书馆学报》2003,21(3):79-82

网络型电子期刊的编目原则问题是进行该类型资源编目首先要解决的问题,本文针对网络型期刊的特点探讨了两种原则以及相应的著录要求,即:单记录原则(在印刷版/原始记录中给出访问路径);为网络版期刊单独建立记录的原则。笔者建议采用后者,并讨论了网络型电子期刊的著录信息源的选取。  相似文献   

电子出版物的著录   总被引：1，自引：0，他引：1  

杨绍兰 《河南图书馆学刊》2003,23(5):31-34

电子出版物是信息及网络时代文献信息资源的重要组成部分，对改善现代图书馆的馆藏建设和服务将产生较大的影响。本文主要对电子出版物的著录进行了探讨。  相似文献