排序方式： 共有101条查询结果，搜索用时 15 毫秒
91.
Eun-Jin YANG Ji-Young MOON Min-Jin KIM Dong Sam KIM Chan-Shick KIM Wook Jae LEE Nam Ho LEE Chang-Gu HYUN 《Journal of Zhejiang University. Science. B》2010,11(5):315-322
Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough,boils,goiters,stomach ailments,and urinary diseases,and for reducing the incidence of tumors,ulcers,and headaches.Despite the fact that seaweeds are frequently used in the practice of human health,little is known about the role of seaweed in the context of inflammation.This study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line(RAW 264.7) under the stimulation of lipopolysaccharide(LPS).Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory mediators.Our results revealed that extracts from five seaweeds,Laurencia okamurae,Grateloupia elliptica,Sargassum thun-bergii,Gloiopeltis furcata,and Hizikia fusiformis,were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide(NO),prostaglandin E2(PGE2),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α).Based on these results,the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential thera-peutic applications in the regulation of the inflammatory response. 相似文献
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本刊1998年第9期《手脑并用,发展思维》一文从素质教育的视角,提到了教学领域中对儿童形象思维的培养、树立科学的教学质量观和效率观、小学教育阶段知识和能力培养的关系等热点问题,引起了读者的关注。不少教师来稿就文中一些问题阐明自己的观点。我们认为,这些讨论在一定意义上已经超出了问题的本身,而是反映了不同的教育观念。道理不说不透,观念不辩不明。本期刊发的两篇文章就教学中知识与能力的关系各抒己见,相信对读者有所启迪。同时欢迎更多的读者来稿参加以上问题的讨论,达到提高认识,转变教育观念的目的,从而使实施素质教育成为每个教师的自觉行为。 相似文献
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文章针对体育与美育的天然联系，指出体育是学校美育的重要途径。从体育美和美育存在于体育中两方面论述了在体育教学中实施美育的必要性，以及就如何在体育教学中实施美育提出了自己的见解。 相似文献
95.
Zhang Shusheng 《中国科学院研究生院学报》1997,(1)
A simple and reproduciable method for determining guanine by high performance capillary electrophoresis is presented. The method involved the use of 2-amino-5-mercapto-3,4-dithiazole as internal standard and 40mmol/L borax-H3PO4 (pH2)-5% EtOH as.the background electrolyte. The result showed that the linear range for guanine is 5-300 mg/L with the recovery of 94%-98% , the detection limit of 2. 80 mg/L and the RSD of 3. 1%. The satisfactory result was obtained when it was used to detect the concentration of guanine in acyclovir product. 相似文献
96.
We prepared an SbSn intermetallic compound powder with a mixture of equal molar amounts of antimony （Sb） and tin （Sn） by melt-annealing and high-energy ball milling, and characterized the obtained substance with XRD （X-ray diffraction）, DSC （differential scanning calorimetry）, SEM （scanning electron microscopy）, and XPS （X-ray photoelectron spectroscopy）. The prepared SbSn has a hexagonal structure with a melting point of 425 ℃. The particles have a dendritic appearance in micromorphology images. More Sb atoms are enriched on the surface than Sn atoms. A desulfurization efficiency of up to 33.92% can be obtained when applying this powder as a medium in the electric desulfurization of crude oil under the following conditions an emulsion with a volumetric ratio of water to oil at 20：80, a surfactant mass fraction in the emulsion of 0.18%, a processing time of 17 h, and a voltage of 9.68 V. SbSn could be a promising catalyst for desulfurizing crude oil. The desulfurization performance is ascribed to the electron cavities formed by current induction. 相似文献
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Pek Leng NG ;Nor Fadilah RAJAB ;Sue Mian THEN ;Yasmin Anum MOHD YUSOF ;Wan Zurinah WAN NGAH ;Kar Yong PIN ;Mee Lee LOOI 《Journal of Zhejiang University. Science. B》2014,15(8):692-700
研究目的：探讨萎叶（PB）提取物对5-氟尿嘧啶（5-FU）抑制结肠癌细胞HT29和HCT116生长的影响。研究方法：HT29和HCT116细胞分别给予PB、5-FU以及两种药物联合治疗24小时,应用等效线图法分析PB和5-FU的药效学相互作用,AnnexinV／PI染色法检测HT29和HCT116细胞的凋丁L=情况,高效液相色谱法排除PB和5-FU间任何可能的相互化学作用。重要结论：联合PB,低剂量5-FU可以在短时间内起到细胞毒作用,而单独应用PB或5-FU治疗较联合治疗可以诱导更多细胞发生凋亡。进一步采用等效线图法分析显示PB和5-Fu的联合作用在抑制结肠癌细胞HT29和HCT116的生长中分别体现出协同和拮抗作用。因此可以认为在HT29细胞中,PB使得较低剂量5-FU发挥最大抑制结肠癌细胞生长效果,然而在HCT116细胞中,PB没有显著降低5-FU的药物浓度,说明PB和5-FU的相互作用不仅仅体现在诱导细胞凋亡方面。 相似文献
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For a single-motor parallel hybrid electric vehicle, during mode transitions （especially the transition from electric drive mode to engine/parallel drive mode, which requires the clutch engagement）, the drivability of the vehicle will be signifi- cantly affected by a clutch torque induced disturbance, driveline oscillations and jerks which can occur without adequate controls. To improve vehicle drivability during mode transitions for a single-motor parallel hybrid electric vehicle, two controllers are proposed. The first controller is the engine-side controller for engine cranking/starting and speed synchronization. The second controller is the motor-side controller for achieving a smooth mode transition with reduced driveline oscillations and jerks under the clutch torque induced disturbance and system uncertainties. The controllers are all composed of a feed-forward control and a robust feedback control. The robust controllers are designed by using the mu synthesis method. In the design process, control- oriented system models that take account of various parameter uncertainties and un-modeled dynamics are used. The results of the simulation demonstrate the effectiveness of the proposed control algorithms. 相似文献
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研究目的：创新要点：研究方法：重要结论：采用广义估计方程模型对存在时间相关件的事故频次数据进行建模,并与传统广义线性模型的估计效果进行对比。
通过广义估计方程来考虑事故频次建模中数据的时间相关性,从而提高参数估计准确度以及模型预测精度。基于4年高速公路交通事故频次数据,建立考虑时间相关性的广义估计方程以及传统的广义线性模型,并采用统计指标对模型效果进行对比。1．事故频次数据样本最对预测精度影响很大;2．广义估引方程能够有效考虑事故频次数据中存住的时间相关性;3．广义估计方程的参数估计比传统广义线性模型史准确,且精度更高。 相似文献
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Wen-biao CHEN Jian-rong HUANG Xiang-qi YU Xiao-cong LIN Yong DAI 《Journal of Zhejiang University. Science. B》2015,16(3):235-250,166
目的:寻找来源于Alport综合征患者与正常对照者的多能干细胞差异性表达的microR NA,并对差异性表达的microR NA靶基因进行预测。创新点:本研究不同于一般的试验标本,试验标本是来源于尿肾脏管细胞诱导而成的多能干细胞。基于Alport综合征是遗传疾病,我们对一遗传家系进行了系统的分析。寻找特异性的差异性表达microR NA及其靶基因,从基因水平对Alport综合征进行研究。方法:在前期工作中,成功地从实验者与对照者的尿肾脏管细胞诱导成多能干细胞。运用高通量测序技术分析并发现实验者与对照者之间差异性表达的microR NA。对差异性表达的microR NA靶基因进行预测,并进行靶基因聚集分析,研究靶基因主要参与的生物学过程。同时进行靶基因信号传导通路的分析,研究靶基因主要参与的细胞信号传导通路。结论:在实验组与对照组之间,发现了30个具有显著差异性表达的microR NAs,包括19个上调表达与11个下调表达。差异性表达的microR NA的靶基因主要聚集在细胞膜和细胞代谢过程;靶基因主要参与嘌呤代谢通路与丝裂原活化蛋白激酶(MAPK)通路。 相似文献