Art investment and asymmetrical information     

Richard B. Coffman 《Journal of Cultural Economics》1991,15(2):83-94

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Tattoo Designs and Locations in the Old U.S. Navy     

B.R. Burg 《Journal of American culture (Malden, Mass. : 2003)》1995,18(1):69-75

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Editorial     

A. J. B. 《Educational Studies in Mathematics》1988,19(2):117-118

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A Virtual Notebook for biomedical work groups     

G A Gorry  A M Burger  R J Chaney  K B Long  C M Tausk 《Bulletin of the Medical Library Association》1988,76(3):256-267

During the past several years, Baylor College of Medicine has made a substantial commitment to the use of information technology in support of its corporate and academic programs. The concept of an Integrated Academic Information Management System (IAIMS) has proved central in our planning, and the IAIMS activities that we have undertaken with funding from the National Library of Medicine have proved to be important extensions of our technology development. Here we describe our Virtual Notebook system, a conceptual and technologic framework for task coordination and information management in biomedical work groups. When fully developed and deployed, the Virtual Notebook will improve the functioning of basic and clinical research groups in the college, and it currently serves as a model for the longer-term development of our entire information management environment.  相似文献   

Vertical microbubble column–A photonic lab-on-chip for cultivation and online analysis of yeast cell cultures     

Stefanie Demming  Gena Peterat  Andreu Llobera  Hannah Schmolke  Alexander Bruns  Michael Kohlstedt  Ala‘aldeen Al-Halhouli  Claus-Peter Klages  Rainer Krull  Stephanus Büttgenbach 《Biomicrofluidics》2012,6(3)

This paper presents a vertically positioned microfluidic system made of poly(dimethylsiloxane) (PDMS) and glass, which can be applied as a microbubble column (μBC) for biotechnological screening in suspension. In this μBC, microbubbles are produced in a cultivation chamber through an integrated nozzle structure. Thus, homogeneous suspension of biomass is achieved in the cultivation chamber without requiring additional mixing elements. Moreover, blockage due to produced carbon dioxide by the microorganisms—a problem predominant in common, horizontally positioned microbioreactors (MBRs)—is avoided, as the gas bubbles are released by buoyancy at the upper part of the microsystem. The patterned PDMS layer is based on an optimized two-lithographic process. Since the naturally hydrophobic PDMS causes problems for the sufficient production of microbubbles, a method based on polyelectrolyte multilayers is applied in order to allow continuous hydrophilization of the already bonded PDMS-glass-system. The μBC comprises various microelements, including stabilization of temperature, control of continuous bubble formation, and two optical configurations for measurement of optical density with two different sensitivities. In addition, the simple and robust application and handling of the μBC is achieved via a custom-made modular plug-in adapter. To validate the scalability from laboratory scale to microscale, and thus to demonstrate the successful application of the μBC as a screening instrument, a batch cultivation of Saccharomyces cerevisiae is performed in the μBC and compared to shake flask cultivation. Monitoring of the biomass growth in the μBC with the integrated online analytics resulted in a specific growth rate of 0.32 h⁻¹, which is almost identical to the one achieved in the shake flask cultivation (0.31 h⁻¹). Therefore, the validity of the μBC as an alternative screening tool compared to other conventional laboratory scale systems in bioprocess development is proven. In addition, vertically positioned microbioreactors show high potential in comparison to conventional screening tools, since they allow for high density of integrated online analytics and therefore minimize time and cost for screening and guarantee improved control and analysis of cultivation parameters.  相似文献   

Dielectrophoretic differentiation of mouse ovarian surface epithelial cells, macrophages, and fibroblasts using contactless dielectrophoresis     

Salmanzadeh A  Kittur H  Sano MB  C Roberts P  Schmelz EM  Davalos RV 《Biomicrofluidics》2012,6(2):24104-2410413

Ovarian cancer is the leading cause of death from gynecological malignancies in women. The primary challenge is the detection of the cancer at an early stage, since this drastically increases the survival rate. In this study we investigated the dielectrophoretic responses of progressive stages of mouse ovarian surface epithelial (MOSE) cells, as well as mouse fibroblast and macrophage cell lines, utilizing contactless dielectrophoresis (cDEP). cDEP is a relatively new cell manipulation technique that has addressed some of the challenges of conventional dielectrophoretic methods. To evaluate our microfluidic device performance, we computationally studied the effects of altering various geometrical parameters, such as the size and arrangement of insulating structures, on dielectrophoretic and drag forces. We found that the trapping voltage of MOSE cells increases as the cells progress from a non-tumorigenic, benign cell to a tumorigenic, malignant phenotype. Additionally, all MOSE cells display unique behavior compared to fibroblasts and macrophages, representing normal and inflammatory cells found in the peritoneal fluid. Based on these findings, we predict that cDEP can be utilized for isolation of ovarian cancer cells from peritoneal fluid as an early cancer detection tool.  相似文献   

Microfluidic three-dimensional hydrodynamic flow focusing for the rapid protein concentration analysis     

Sungmin Hong  Pei-Hsiang Tsou  Chao-Kai Chou  Hirohito Yamaguchi  Chin B. Su  Mien-Chie Hung  Jun Kameoka 《Biomicrofluidics》2012,6(2)

A simple microfluidic 3D hydrodynamic flow focusing device has been developed and demonstrated quantitative determinations of quantum dot 525 with antibody (QD525-antibody) and hemagglutinin epitope tagged MAX (HA-MAX) protein concentrations. This device had a step depth cross junction structure at a hydrodynamic flow focusing point at which the analyte stream was flowed into a main detection channel and pinched not only horizontally but also vertically by two sheath streams. As a result, a triangular cross-sectional flow profile of the analyte stream was formed and the laser was focused on the top of the triangular shaped analyte stream. Since the detection volume was smaller than the radius of laser spot, a photon burst histogram showed Gaussian distribution, which was necessary for the quantitative analysis of protein concentration. By using this approach, a linear concentration curve of QD525-antibody down to 10 pM was demonstrated. In addition, the concentration of HA-MAX protein in HEK293 cell lysate was determined as 0.283 ± 0.015 nM. This approach requires for only 1 min determining protein concentration. As the best of our knowledge, this is the first time to determinate protein concentration by using single molecule detection techniques.  相似文献   

The value of a non-sport-specific motor test battery in predicting performance in young female gymnasts   总被引：3，自引：2，他引：1  

Vandorpe B  Vandendriessche JB  Vaeyens R  Pion J  Lefevre J  Philippaerts RM  Lenoir M 《Journal of sports sciences》2012,30(5):497-505

Gymnastics talent identification focuses on the identification of young gymnasts who display characteristics for potential success in the future. The aim of this study was to identify which current performance characteristics are related to performance in competition 2 years later. Twenty-three female gymnasts aged 7-8 years completed a multidimensional test battery measuring anthropometric, physical, and coordinative characteristics and were technically evaluated by expert coaches. Two years later, the all-around competition results of those gymnasts now participating in elite (n = 12) and sub-elite (n = 11) competition were obtained. None of the initial measurements significantly correlated with the results of the sub-elite gymnasts 2 years later. For the elite gymnasts, a non-sport-specific motor test battery correlated strongly with the competition result, with more than 40% of the variation in competition performance being explained by the result on that test 2 years earlier. Neither the coaches' judgement nor the anthropometric and physical characteristics were sensitive enough to predict performance. A motor coordination test might be valuable in the early identification of gymnasts, as its discriminative and predictive qualities might be sufficiently powerful for selection within a relatively homogeneous population of gymnasts exhibiting similar anthropometric and physical profiles.  相似文献   

Does extensive on-water rowing increase muscular strength and endurance?     

Lawton TW  Cronin JB  McGuigan MR 《Journal of sports sciences》2012,30(6):533-540

The purpose of this study was to compare changes in aerobic condition, strength, and muscular endurance following 8 weeks of endurance rowing alone or in combination with weight-training. Twenty-two elite rowers were assigned to (1) rowing (n = 10, 250-270 km · week?1) or (2) rowing (n = 12, 190-210 km · week?1) plus four weight-training sessions each week. Pre and post mean and standardized effect-size (ES) differences in aerobic condition (watts at 4 mmol · L?1) and strength (isometric pull, N), prone bench-pull (6-repetition maximum, 6-RM), 5- and 30-repetition leg-press and 60-repetition seated-arm-pull (J, performed on a dynamometer) normalized by body mass and log-transformed were analysed, after adjusting for gender. The standardized differences between groups were trivial for aerobic condition (ES [±90% CI] = 0.15; ±0.28, P = 0.37) and prone bench-pull (ES = 0.27; ±0.33, P = 0.18), although a moderate positive benefit in favour of rowing only was observed for the seated-arm-pull (ES = 0.42; ±0.4, P = 0.08). Only the weight-training group improved isometric pull (12.4 ± 8.9%, P < 0.01), 5-repetition (4.0 ± 5.7%, P < 0.01) and 30-repetition (2.4 ± 5.4%, P < 0.01) leg-press. In conclusion, while gains in aerobic condition and upper-body strength were comparable to extensive endurance rowing, weight-training led to moderately greater lower-body muscular-endurance and strength gains.  相似文献   

Influence of a conservative sleep management strategy during a solo Pacific Ocean crossing on anxiety and perceived fatigue: a case study     

Hagin V  Gonzales BR  Candau RB  Groslambert A 《Journal of sports sciences》2012,30(4):395-402

The aim of this case study was to determine whether a sailor's deliberate choice of a conservative strategy to manage sleep deprivation would allow him to cross the Pacific Ocean and to minimize his state of anxiety and perceived fatigue. The participant, who had more than 10 years' sailing experience in severe conditions, was tested on a small catamaran without any living quarters during a solo Pacific Ocean crossing. Estimations of sleep hours, state anxiety, and perceived fatigue were self-reported by the sailor on a daily basis using a specific questionnaire. The most important finding is that the sailor's deliberate sleep strategy, 5.4 h sleep per day (24% less than on-shore), was enough to keep his anxiety and perceived fatigue within acceptable limits and enabled him to achieve his goal, which was the first crossing of the Pacific Ocean on a catamaran of less than 6 m. In conclusion, our results suggest that the sailor observed in the present case study was able to minimize anxiety and perceived fatigue with adequate sleep to optimize his performance, security, and to achieve his goal.  相似文献