The organization of educational research in the Czechoslovak Socialist Republic     

Emilie Langová  Anna Střížová 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1962,8(1):78-81

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Advances in urinary protein biomarkers for urogenital and non-urogenital pathologies     

Johanna Pedroza-Díaz  Sarah R?thlisberger 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2015,25(1):22-35

The discovery of protein biomarkers that reflect the biological state of the body is of vital importance to disease management. Urine is an ideal source of biomarkers that provides a non-invasive approach to diagnosis, prognosis and prediction of diseases. Consequently, the study of the human urinary proteome has increased dramatically over the last 10 years, with many studies being published. This review focuses on urinary protein biomarkers that have shown potential, in initial studies, for diseases affecting the urogenital tract, specifically chronic kidney disease and prostate cancer, as well as other non-urogenital pathologies such as breast cancer, diabetes, atherosclerosis and osteoarthritis. PubMed was searched for peer-reviewed literature on the subject, published in the last 10 years. The keywords used were “urine, biomarker, protein, and/or prostate cancer/breast cancer/chronic kidney disease/diabetes/atherosclerosis/osteoarthritis”. Original studies on the subject, as well as a small number of reviews, were analysed including the strengths and weaknesses, and we summarized the performance of biomarkers that demonstrated potential. One of the biggest challenges found is that biomarkers are often shared by several pathologies so are not specific to one disease. Therefore, the trend is shifting towards implementing a panel of biomarkers, which may increase specificity. Although there have been many advances in urinary proteomics, these have not resulted in similar advancements in clinical practice due to high costs and the lack of large data sets. In order to translate these potential biomarkers to clinical practice, vigorous validation is needed, with input from industry or large collaborative studies.Key words: urine, protein, biomarker  相似文献   

Physicochemical and Functional Properties of Vegetable and Cereal Proteins as Potential Sources of Novel Food Ingredients     

Cintya Soria-Hernández  Sergio Serna-Saldívar  Cristina Chuck-Hernández 《Food Technology and Biotechnology》2015,53(3):269-277

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The relevance of intellectual capital disclosure: empirical evidence from Spanish universities     

Yolanda?Ramírez-CórcolesEmail author  Montserrat?Manzaneque-Lizano 《知识管理研究与实践》2015,13(1):31-44

The reporting of intellectual capital (IC) in higher education institutions is of vital importance, mainly owing to the fact that knowledge is the main output and input in these institutions. Furthermore, the increasing social concern about establishing procedures of accountability and ensuring information transparency in public universities prompted us to consider the need to disclose information on their IC. In this study, we developed a questionnaire that was sent to members of the Social Councils of Spanish public universities in order to identify the intangible elements about which university stakeholders demand most information. It was also used to see which groups of universities have stakeholders who are more proactive to the disclosure of IC. Our results represent a starting point for public universities to identify the most commonly requested information about IC. Universities can then develop an IC report that fits their own characteristics and environment.  相似文献   

Effect of Tara (Caesalpinia spinosa) Pod Powder on the Oxidation and Colour Stability of Pork Meat Batter During Chilled Storage     

Monika Skowyra  Urszula Janiewicz  Anna Marietta Salejda  Gra?yna Krasnowska  María Pilar Almajano 《Food Technology and Biotechnology》2015,53(4):419-427

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Pawns in a Chess Game     

Gloria García González 《Media History》2015,21(4):412-425

The Spanish Service was established in June 1939, two months after the end of the civil war in Spain and shortly before the start of the Second World War. Its implementation was strongly affected by these conflicts in the context of new international relations. Therefore, this study of the Spanish Service during 1939–1945 allows not only a better understanding of the communicational strategies developed by the BBC, but also of the complex Anglo-Spanish relations and the important role played by the Spanish-language broadcasts therein. The study is mainly based on archival documents from the National Archives in London and memoirs.  相似文献   

User experience of government documents: A framework for informing design decisions     

Leonardo Madariaga  Miguel Nussbaum  Faustino Marañón  Cristóbal Alarcón  María Alicia Naranjo 《Government Information Quarterly》2019,36(2):179-195

People still use documents in many everyday government processes. From tax payments to passport requests, citizens have to interact with low-interactivity information artifacts such as reports, maps and datasets, among many others. Despite efforts to improve information delivery in the public sector, effective information usage remains a critical topic of action and research. The user experience of government documents has rarely been assessed, despite them being regularly published and frequently used. Considering this, the two following research questions arise: 1) How can government documents be classified (or grouped) in terms of user experience? 2) How can the user experience of government documents be monitored over time in order to inform design decisions? Working with a public agency in Chile, we develop and test a classification and monitoring framework based on two online surveys (N?=?338 and N?=?298). We then propose a framework for understanding user experience of government documents in these three dimensions: interaction goal, volume of information and ease of understanding. Using a graphical representation to classify user experience provides greater visibility of the current status of information produced by a public organization. Furthermore, by monitoring the user experience of a government document at different times, organizations can understand the effect of their design decisions and improve their service quality by implementing user-centered processes.  相似文献   

The Potential of Conjoint Analysis for Communication Research     

Elena Pelzer 《Communication Research Reports》2019,36(2):136-147

Surveys on choices oftentimes rely on Likert-type scales. However, they prevent researchers from identifying the relative importance of different stimulus features for the choice decision. Here, it is shown that conjoint analysis offers a variety of advantages emerging from its use of questions that force the subject to trade off conflicting attribute levels. This study discusses some problems of Likert-type scale measures and shows when conjoint analysis may solve some of these problems. Differences between measurements are illustrated in a uses and gratifications study, assessing convergent validity on Likert-type scale measures with traditional conjoint analysis and choice-based conjoint analysis. Results show that subjects prefer “cognitive needs” by Likert-type scale measures against “tension release needs” by both conjoint analyses. The different outcome is independent from linguistic variation and from dual-process models of information processing. Implications for communication research are discussed.  相似文献   

Red pigment production by Penicillium purpurogenum GH2 is influenced by pH and temperature     

Méndez A  Pérez C  Montañéz JC  Martínez G  Aguilar CN 《Journal of Zhejiang University. Science. B》2011,12(12):961-968

The combined effects of pH and temperature on red pigment production and fungal morphology were evaluated in a submerged culture of Penicillium purpurogenum GH2, using Czapek-Dox media with d-xylose as a carbon source. An experimental design with a factorial fix was used: three pH values (5, 7, and 9) and two temperature levels (24 and 34 °C) were evaluated. The highest production of red pigment (2.46 g/L) was reached with a pH value of 5 and a temperature of 24 °C. Biomass and red pigment production were not directly associated. This study demonstrates that P. purpurogenum GH2 produces a pigment of potential interest to the food industry. It also shows the feasibility of producing and obtaining natural water-soluble pigments for potential use in food industries. A strong combined effect (p<0.05) of pH and temperature was associated with maximal red pigment production (2.46 g/L).  相似文献   

Discrimination of Biomechanically Possible and Impossible Hand Movements at Birth          下载免费PDF全文

Elena Longhi  Irene Senna  Nadia Bolognini  Hermann Bulf  Paolo Tagliabue  Viola Macchi Cassia  Chiara Turati 《Child development》2015,86(2):632-641

The development of human body perception has long been investigated, but little is known about its early origins. This study focused on how a body part highly relevant to the human species, namely the hand, is perceived a few days after birth. Using a preferential‐looking paradigm, 24‐ to 48‐hr‐old newborns watched biomechanically possible and impossible dynamic hand gestures (Experiment 1, N = 15) and static hand postures (Experiment 2, N = 15). In Experiment 1, newborns looked longer at the impossible, compared to the possible, hand movement, whereas in Experiment 2 no visual preference emerged. These findings suggest that early in life the representation of the human body may be shaped by sensory‐motor experience.  相似文献