Gravity-oriented microfluidic device for uniform and massive cell spheroid formation     

Lee K  Kim C  Young Yang J  Lee H  Ahn B  Xu L  Yoon Kang J  Oh KW 《Biomicrofluidics》2012,6(1):14114-141147

We propose a simple method for forming massive and uniform three-dimensional (3-D) cell spheroids in a multi-level structured microfluidic device by gravitational force. The concept of orienting the device vertically has allowed spheroid formation, long-term perfusion, and retrieval of the cultured spheroids by user-friendly standard pipetting. We have successfully formed, perfused, and retrieved uniform, size-controllable, well-conditioned spheroids of human embryonic kidney 293 cells (HEK 293) in the gravity-oriented microfluidic device. We expect the proposed method will be a useful tool to study in-vitro 3-D cell models for the proliferation, differentiation, and metabolism of embryoid bodies or tumours.  相似文献   

Adolescent Decision-Making Processes Regarding University Entry: A model incorporating cultural orientation,motivation and occupational variables     

Jung  Jae Yup 《Tertiary Education and Management》2013,19(2):97-112

This study attempts to provide a new perspective on current shifts in knowledge production through analysing the relationship between research and education. The study, based on interviews and questionnaires, focuses on the interaction within applied research centres with a close industry cooperation. The results suggest that the interaction between research and education benefits from a collaborative environment, since researchers hold positive attitudes towards integrating research, education and collaboration, and students are given the opportunity to work within applied research projects. The findings are discussed in terms of researchers’ ability to handle their scholarly tasks of research, teaching, and collaboration, and the importance for acknowledging research collaborations from both research and teaching perspectives.  相似文献   

Exercise cardiac power and the risk of heart failure in men: A population-based follow-up study     

Sudhir Kurl  Sae Young Jae  Timo H.Makikallio  Ari Voutilainen  Magnus J.Hagnas  Jussi Kauhanen  Jari A.Laukkanen 《运动与健康科学(英文)》2022,11(2):266-271

Background:Little is known about exercise cardiac power(ECP),defined as the ratio of directly measured maximal oxygen uptake with peak systolic blood pressure during exercise,on heart failure(HF)risk.We examined the association of ECP and the risk of HF.Methods:This was a population-based cohort study of 2351 men from eastern Finland.The average time to follow-up was 25 years.Participants participated at baseline in an exercise stress test.A total of 313 cases of HF occurred.Results:Men with low ECP(<9.84 mL/mmHg,the lowest quartile)had a 2.37-fold(95%confidence interval(95%CI):1.68-3.35,p<0.0001)hazards ratio of HF as compared with men with high ECP(>13.92 mL/mmHg,the highest quartile),after adjusting for age.Low ECP was associated with a 1.96-fold risk(95%CI:1.38-2.78,p<0.001)of HF after additional adjustment for conventional risk factors.After further adjustment for left ventricular hypertrophy,the results hardly changed(hazards ratio=1.87,95%CI:1.31-2.66,p<0.001).One SD increase in ECP(3.16 mL/mmHg)was associated with a decreased risk of HF by 28%(95%CI:17%-37%).Conclusion:ECP provides a noninvasive and easily available measure from cardiopulmonary exercise tests in predicting HF.However,ECP did not provide additional value over maximal oxygen uptake.  相似文献   

Thinking Counterfactually Supports Children’s Evidence Evaluation in Causal Learning     

Jae Engle  Caren M. Walker 《Child development》2021,92(4):1636-1651

Often, the evidence we observe is consistent with more than one explanation. How do learners discriminate among candidate causes? The current studies examine whether counterfactuals help 5-year olds (N = 120) select between competing hypotheses and compares the effectiveness of these prompts to a related scaffold. In Experiment 1, counterfactuals support evidence evaluation, leading children to privilege and extend the cause that accounted for more data. In Experiment 2, the hypothesis that accounted for the most evidence was pitted against children’s prior beliefs. Children who considered alternative outcomes privileged the hypothesis that accounted for more observations, whereas those who explained relied on prior beliefs. Findings demonstrate that counterfactuals recruit attention to disambiguating evidence and outperform explanation when data contrast with existing beliefs.  相似文献   

Supervising an international teaching practicum: building partnerships in postcolonial contexts     

Jae Major  Ninetta Santoro 《牛津教育评论》2016,42(4):460-474

Teaching practicum experiences, including those in international contexts, are based on partnerships between institutions and host schools, and the partnership between the pre-service teacher, the cooperating teacher and the university supervisor. This article explores the relationship between pre-service teachers and cooperating teachers in an international practicum in the Solomon Islands. It considers the way the cooperating teachers were positioned within the partnership, and raises questions about the way the university engages with host schools and teachers in international contexts, particularly in developing countries. Drawing on postcolonial theory, we investigate the complexity and contradictions in relationships between the pre-service teachers and cooperating teachers. We conclude by offering suggestions for valuing the role of cooperating teachers in these contexts.  相似文献   

U.S. and Korean children's comprehension of fraction names: a reexamination of cross-national differences     

Paik JH  Mix KS 《Child development》2003,74(1):144-154

Two experiments tested the claim that the transparency of Korean fraction names promotes fraction concepts (Miura, Okamoto, Vlahovic-Stetic, Kim, & Han, 1999). In Experiment 1, U.S. and Korean first and second graders made similar errors on a fraction-identification task, by treating fractions as whole numbers. Contrary to previous findings, Korean children performed at chance when a whole-number representation was included. Nonetheless, Korean children outperformed their U.S. peers overall. In Experiment 2, U.S. children's performance improved when fraction names were used that explicitly referred to part-whole relations like Korean fraction names. U.S. children's scores actually exceeded those of Korean children. Thus, although the differences in fraction names may influence children's performance, this may not account for the reported cross-national differences.  相似文献   

Preschool teachers and classroom aides: Same context,similar perceptions of children's behaviors?          下载免费PDF全文

Sofia O. Major  Maria J. Seabra‐Santos  Maria F. Gaspar 《Psychology in the schools》2018,55(7):801-814

This study explored the correspondence and differences between school staff perceptions of preschool children's social skills and behavior problems. One hundred preschoolers were assessed by 14 pairs of teachers and classroom aides with the Preschool and Kindergarten Behavior Scales – 2^nd Edition (PKBS‐2 Portuguese version). Indexes of agreement and disagreement were calculated. Risk levels and item analyses of PKBS‐2 scores according to both informants' ratings were compared. A higher level of agreement was obtained for social skills scores than for behavior problems (mean correlation of .62). No statistically significant differences between informants were obtained for the risk levels, and item analyses revealed a similar pattern of behaviors that were most and least rated by both informants. Results indicate that the classroom aides' perspective on preschool assessment represents a reliable input, which justifies that they network with teachers in addressing preschoolers' social‐emotional and behavioral challenges.  相似文献   

Reflection on the education policy orientation in post-May 31 reform in Korea     

Chong Jae Lee  Yong Kim 《Asia Pacific Education Review》2016,17(3):413-426

For the last 70 years, since the establishment of the Republic of Korea, Korean education has achieved universal expansion of educational opportunity from elementary to secondary to higher education. Planning, centralized policy making, top-down implementation, and administrative control had been the standards of the first few decades of Korean education. The so-called May 31 education reform implemented in 1995 made a turning point for these approaches to education policy and administration by highlighting autonomy, openness, diversity, accountability, consumer centeredness, market control, and governance for quality education. However, these government-driven education reform initiatives have resulted in limiting the expected outcomes. In this paper, the authors call for a new approach to education policy and administration and propose supporting school innovation, empowering an internal accountability system in governance. The authors also suggest a search for normative values for democratic communitarianism as a new philosophical foundation of education policy framework, beyond instrumental values of education.  相似文献   

Inclusive educational leadership to establish a co-operative school cluster trust? Exploring perspectives and making links with leadership for learning     

Sue Swaffield  Louis Major 《International Journal of Inclusive Education》2019,23(11):1149-1163

ABSTRACT

One remarkable feature of the contemporary school landscape in England is the number of schools that have chosen the co-operative framework to shape their work and relationships. When a group of schools decides to become a co-operative trust, leadership challenges arise both in the process of establishing an inclusive collaborative cluster and in living out co-operative values. To add to the limited literature on co-operative school leadership, a study in a school cluster trust explored headteachers’, governors’ and teachers’ perspectives and beliefs through interviews, group discussions and questionnaires. These data sources revealed some of the motivations for, benefits of, and strategies to support inter-school collaboration guided by the co-operative values of democracy, solidarity, equality, equity, self-help and self-responsibility. Importantly, a range of perspectives on the extent to which leadership was viewed as, and appeared to be, an inclusive practice undertaken by all members of the cluster was identified. A particular contribution of this work is that it exemplifies resonances between the values and principles of the co-operative movement and those of the Leadership for Learning framework. Since these two models are being increasingly adopted and integrated into a variety of educational settings, the research findings may inform leadership practice more widely.  相似文献   

OCCUPATIONAL/CAREER INDECISION FOR ECONOMICALLY DISADVANTAGED HIGH SCHOOL STUDENTS OF HIGH INTELLECTUAL ABILITY: A MIXED‐METHODS COGNITIVE PROCESS MODEL          下载免费PDF全文

Jae Yup Jung  Marie Young 《Psychology in the schools》2017,54(7):718-735

A mixed‐methods design was employed to identify the cognitive processes that lead to occupational/career indecision for economically disadvantaged adolescents of high intellectual ability. In the first phase, interview data collected from 26 economically disadvantaged intellectually gifted Australian adolescents were analyzed using grounded theory to develop two alternative models of cognitive processes that lead to occupational/career indecision. In the second phase, these models were quantitatively tested and refined using structural equation modeling of survey data collected from 917 economically disadvantaged intellectually gifted Australian adolescents. The finally accepted model, identified using a competing models strategy, suggested that valuing the thoughts of family on general matters is positively predictive of a desire to live up to one's potential and the experience of amotivation about the occupational decision. In turn, occupational amotivation appears to be positively associated with occupational indecision, but negatively associated with multipotentiality and a desire to fulfill one's potential.  相似文献