Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease     

Jun Y Cho  Dae Y Hwang  Tae S Kang  Dong H Shin  Jin H Hwang  Chae H Lim 《Journal of sports sciences》2013,31(11):943-951

In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on Aβ-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of Aβ-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease.  相似文献   

The Influence of Chosun Marathon Bogeuphoe on Realisation of Korea's National Identity during the US Military Government Era (1945–1948)     

Moongi Cho 《国际体育史杂志》2013,30(3):297-314

Chosun Marathon Bogeuphoe was a Korean marathoner training centre, which was organised in August 1947, in the era of poverty and social upheaval under the US Army Military Government in Korea (USAMGIK), and produced the world top-class marathoners, including Suh Yun-bok, Ham Kee-yong and Choi Yun-chil. This study aims to investigate the sport historical significance of the Bogeuphoe in terms of operation, organisation, venues and funds by content analysis of John R. Hodge's telegraphic messages, the record of Special Committee for Anti-ethnic-act Investigation, the primary historical materials including 1947 Boston Marathon winner, Suh Yun-bok's notes, newspapers, photographs, autobiography, memoirs and interviews with Ham Kee-yong, the 1950 Boston Marathon winner. The findings of this study are that the Chosun Marathon Bogeuphoe contributed greatly to bring forth Korea's golden age in marathon history and served as a diplomatic advance guard in enhancing Korea's national prestige abroad and opening up a way-out for the nation's independence. This gives a valuable lesson to recent sport administrators and sport associations occasionally blamed for their unsuitable management despite the affluence of human and material resources. This study is expected to add to the literature to be used as a reference for the study of Korean sport associations' history.  相似文献   

Content analysis of the 20 most influential articles in PIQ     

Yonjoo Cho  Sunyoung Park 《Performance Improvement Quarterly》2012,25(3):7-22

The purpose of this study is to examine key research themes in human performance technology (HPT) through content analysis of the 20 most influential articles identified in Cho, Jo, Park, Kang, and Chen (2011). Three questions guiding this inquiry are: (1) What are the key themes of the 20 most influential articles in PIQ, (2) What information do the 20 most influential articles add to an understanding of HPT, and (3) What are the implications of the content analysis for HPT research practices? Five key themes emerged from the content analysis, including instructional design, HPT scholarship, performance technology, performance support, and transfer of training. HPT scholarship was the most distinctive key research theme in this study. The qualitative details about the 20 most influential articles were provided, related issues were discussed, and implications for research practice were articulated.  相似文献   

Accelerating chronically unresponsive children to tier 3 instruction: what level of data is necessary to ensure selection accuracy?     

Compton DL  Gilbert JK  Jenkins JR  Fuchs D  Fuchs LS  Cho E  Barquero LA  Bouton B 《Journal of learning disabilities》2012,45(3):204-216

Response-to-intervention (RTI) approaches to disability identification are meant to put an end to the so-called wait-to-fail requirement associated with IQ discrepancy. However, in an unfortunate irony, there is a group of children who wait to fail in RTI frameworks. That is, they must fail both general classroom instruction (Tier 1) and small-group intervention (Tier 2) before becoming eligible for the most intensive intervention (Tier 3). The purpose of this article was to determine how to predict accurately which at-risk children will be unresponsive to Tiers 1 and 2, thereby allowing unresponsive children to move directly from Tier 1 to Tier 3. As part of an efficacy study of a multitier RTI approach to prevention and identification of reading disabilities (RD), 129 first-grade children who were unresponsive to classroom reading instruction were randomly assigned to 14 weeks of small-group, Tier 2 intervention. Nonresponders to this instruction (n = 33) were identified using local norms on first-grade word identification fluency growth linked to a distal outcome of RD at the end of second grade. Logistic regression models were used to predict membership in responder and nonresponder groups. Predictors were entered as blocks of data from least to most difficult to obtain: universal screening data, Tier 1 response data, norm referenced tests, and Tier 2 response data. Tier 2 response data were not necessary to classify students as responders and nonresponders to Tier 2 instruction, suggesting that some children can be accurately identified as eligible for Tier 3 intervention using only Tier 1 data, thereby avoiding prolonged periods of failure to instruction.  相似文献   

Reference Education: Lessons from Our Students     

Loriene Roy  Ye Seul Cho  Regis Junearick  Tina Lassiter  Christopher McCluney  Jayeeta Roy 《The Reference Librarian》2013,54(4):304-309

Students reflecting on their time as students in a school of information provide advice and commentary for their faculty. By revealing their challenges as well as their successes, educators can themselves reflect on the impact of their teaching and the potential it has to assist students on their career paths.  相似文献   

The effectiveness of a popular science promotion program on nanotechnology for elementary school students in I-Lan City     

Show-Yu Lin  Ming-Ta Wu  Ya-I Cho 《Research in Science & Technological Education》2013,31(1):22-37

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Stakeholders’ views of South Korea’s higher education internationalization policy     

Young Ha Cho  John D. Palmer 《Higher Education》2013,65(3):291-308

The study investigated the stakeholders’ perceptions of South Korea’s higher education internationalization policy. Based on the research framework that defines four policy values—propriety, effectiveness, diversity, and engagement, the convergence model was employed with a concurrent mixed method sampling strategy to analyze the stakeholders’ perceptions. According to the findings, the stakeholders perceived that the government’s internationalization policy to date has contributed to the international competitiveness of Korean universities by and large in a quantitative manner. Their views however signaled that the government should consider the quality and identity of Korean higher education institutions when designing and implementing internationalization policy. Based on the implications that the findings have in the policy context, this study suggested two points for future policy research into Korean higher education internationalization: (1) develop a glonacal definition of world-classness for Korean universities and (2) build up a mixture model of centralization and decentralization for the government-university relations, which encourages internal self-governance of Korean universities.  相似文献   

Health Literacy,Social Support,and Health Status Among Older Adults     

Shoou-Yih D. Lee  Ahsan M. Arozullah  Young Ik Cho  Kathleen Crittenden  Daniel Vicencio 《Educational gerontology》2013,39(3):191-201

The study examines whether social support interacts with health literacy in affecting the health status of older adults. Health literacy is assessed using the short version of the Test of Functional Health Literacy in Adults. Social support is measured with the Medical Outcome Study social support scale. Results show, unexpectedly, that rather than buffering the negative effect of low health literacy, social support has a more positive impact on physical health in older adults with high health literacy. Implications for improving the health status of older adults through health literacy and social support are discussed.  相似文献   

The Influence of Cultural Factors and Demographics on the Valuation of Art     

Mika Cho 《The International Journal of Art & Design Education》1997,16(3):319-323

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How user comments affect news processing and reality perception: Activation and refutation of regional prejudice     

Eun-Ju Lee  Hyun Suk Kim  Jaeho Cho 《Communication monographs》2017,84(1):75-93

An experiment (N?=?177) examined how user-generated comments on a crime news article, which attribute the reported crime to the local residents’ predispositions, affect individuals’ processing of the news and their reality perception. Participants who viewed the regionalism-invoking comments estimated the crime rates of the featured region to be higher than those exposed to regionalism-irrelevant or regionalism-counterbalancing comments, and such effects were more pronounced for those with a stronger regional self-identity. Moreover, those who read regionalism-related comments, either regionalism-invoking or regionalism-counterbalancing, (a) recalled better the locations featured in the focal and the subsequent, yet unrelated, news articles and (b) attributed greater responsibility to news media coverage for the persistence of regionalism, as compared to those who viewed regionalism-irrelevant comments.  相似文献