Molecularly imprinted polymers as the extracted sorbents of clenbuterol ahead of liquid chromatographic determination     

Sovichea Lay  Hai-ning Yu  Bao-xiang Hu  Sheng-rong Shen 《Journal of Zhejiang University. Science. B》2016,17(6):465-475

A pre-treatment methodology for clenbuterol hydrochloride (CLEN) isolation and enrichment in a complex matrix environment was developed through exploiting molecularly imprinted polymers (MIPs). CLEN-imprinted polymers were synthesized by the combined use of ally-β-cyclodextrin (ally-β-CD) and methacrylic acid (MAA), allyl-β-CD and acrylonitrile (AN), and allyl-β-CD and methyl methacrylate (MMA) as the binary functional monomers. MAA-linked allyl-β-CD MIPs (M-MAA) were characterized by Fourier transform-infrared (FT-IR) spectroscopy and a scanning electron microscope (SEM). Based upon the results, M-MAA polymers generally proved to be an excellent selective extraction compared to its references: AN-linked allyl-β-CD MIPs (M-AN) and MMA-linked allyl-β-CD MIPs (M-MMA). M-MAA polymers were eventually chosen to run through a molecularly imprinted solid-phase extraction (MISPE) micro-column to enrich CLEN residues spiked in pig livers. A high recovery was achieved, ranging from 91.03% to 96.76% with relative standard deviation (RSD) ≤4.45%.  相似文献   

In vitro remineralization of hybrid layers using biomimetic analogs     

Hui-ping Lin  Jun Lin  Juan Li  Jing-hong Xu  Christian Mehl 《Journal of Zhejiang University. Science. B》2016,17(11):864-873

Resin-dentin bond degradation is a major cause of restoration failures. The major aim of the current study was to evaluate the impact of a remineralization medium on collagen matrices of hybrid layers of three different adhesive resins using nanotechnology methods. Coronal dentin surfaces were prepared from freshly extracted premolars and bonded to composite resin using three adhesive resins (FluoroBond II, Xeno-III-Bond, and iBond). From each tooth, two central slabs were selected for the study. The slabs used as controls were immersed in a simulated body fluid (SBF). The experimental slabs were immersed in a Portland cement-based remineralization medium that contained two biomimetic analogs (biomineralization medium (BRM)). Eight slabs per group were retrieved after 1, 2, 3, and 4 months, respectively and immersed in Rhodamine B for 24 h. Confocal laser scanning microscopy was used to evaluate the permeability of hybrid layers to Rhodamine B. Data were analyzed by analysis of variance (ANOVA) and Tukey’s honest significant difference (HSD) tests. After four months, all BRM specimens exhibited a significantly smaller fluorescent area than SBF specimens, indicating a remineralization of the hybrid layer (P≤0.05). A clinically applicable biomimetic remineralization delivery system could potentially slow down bond degradation.  相似文献   

Spotlight on China: Changes in education under China’s market economy     

Guanglun Michael Mu 《Frontiers of Education in China》2016,11(4):545-547

  相似文献   

A study of airfoil parameterization,modeling, and optimization based on the computational fluid dynamics method     

Tian-tian Zhang  Wei Huang  Zhen-guo Wang  Li Yan 《浙江大学学报(A卷英文版)》2016,17(8):632-645

An excellent airfoil with a high lift-to-drag ratio may decrease oil consumption and enhance the voyage. Based on NACA 0012, an improved airfoil is explored in this paper. The class/shape function transformation has been proved to be a good method for airfoil parameterization, and in this paper it is modified to improve imitation accuracy. The computational fluid dynamics method is applied to obtain numerically the aerodynamic parameters of the parameterized airfoil, and the result is proved credible by comparison with available experimental data in the open literature. A polynomial-based response surface model and the uniform Latin hypercube sampling method are employed to decrease computational cost. Finally, the nonlinear programming by quadratic Lagrangian method is utilized to modify the multi-island genetic algorithm, which has an improved optimization effect than the method used on its own. The obtained result shows that the modified class/shape function transformation method produces a better imitation of an airfoil in the nose and tail regions than the original method, and that it will satisfy the tolerance zone of the model in a wind tunnel. The response surface model based on the uniform Latin hypercube sampling method gives an accurate prediction of the lift-to-drag ratio with changes in the design variables. The numerical result of the flow around the airfoil shows reasonable agreement with the experimental data graphically and quantitatively. Ultimately, an airfoil with better capacity than the original one is acquired using the multi-island genetic algorithm based nonlinear programming by quadratic Lagrangian optimization method. The pressure contours and lift-to-drag ratio along with the attack angle have been compared with those of the original airfoil, and the results demonstrate the strength of the optimized airfoil. The process for exploring an improved airfoil through parameterization to optimization is worth referencing in future work.  相似文献   

Chinese middle school teachers’ preferences regarding performance evaluation measures     

Shujie Liu  Xianxuan Xu  James H. Stronge 《Educational Assessment, Evaluation and Accountability》2016,28(2):161-177

Teacher performance evaluation currently is receiving unprecedented attention from policy makers, scholars, and practitioners worldwide. This study is one of the few studies of teacher perceptions regarding teacher performance measures that focus on China. We employed a quantitative dominant mixed research design to investigate Chinese teachers’ preferences for teacher performance measures and the possible reasons for their preferences. Considering the quantitative results, the surveyed Chinese teachers identified fulfillment of additional roles, collaboration with faculty and staff, and students’ test scores as the most important measures for performance evaluation. Qualitatively, the most important measures that the surveyed teachers reported were the teacher’s morality, workload, and students’ test scores.  相似文献   

Assessment of three-dimensional joint kinematics of the upper limb during simulated swimming using wearable inertial-magnetic measurement units     

Silvia Fantozzi  Andrea Giovanardi  Fabrício Anício Magalhães  Rocco Di Michele  Matteo Cortesi  Giorgio Gatta 《Journal of sports sciences》2016,34(11):1073-1080

The analysis of the joint kinematics during swimming plays a fundamental role both in sports conditioning and in clinical contexts. Contrary to the traditional video analysis, wearable inertial-magnetic measurements units (IMMUs) allow to analyse both the underwater and aerial phases of the swimming stroke over the whole length of the swimming pool. Furthermore, the rapid calibration and short data processing required by IMMUs provide coaches and athletes with an immediate feedback on swimming kinematics during training. This study aimed to develop a protocol to assess the three-dimensional kinematics of the upper limbs during swimming using IMMUs. Kinematics were evaluated during simulated dry-land swimming trials performed in the laboratory by eight swimmers. A stereo-photogrammetric system was used as the gold standard. The results showed high coefficient of multiple correlation (CMC) values, with median (first–third quartile) of 0.97 (0.93–0.95) and 0.99 (0.97–0.99) for simulated front-crawl and breaststroke, respectively. Furthermore, the joint angles were estimated with an accuracy increasing from distal to proximal joints, with wrist indices showing median CMC values always higher than 0.90. The present findings represent an important step towards the practical use of technology based on IMMUs for the kinematic analysis of swimming in applied contexts.  相似文献   

Differences in pedalling technique between road cyclists of different competitive levels     

Juan García-López  Sergio Díez-Leal  Ana Ogueta-Alday  Josu Larrazabal  José A. Rodríguez-Marroyo 《Journal of sports sciences》2016,34(17):1619-1626

The purpose of this study was to compare the pedalling technique in road cyclists of different competitive levels. Eleven professional, thirteen elite and fourteen club cyclists were assessed at the beginning of their competition season. Cyclists’ anthropometric characteristics and bike measurements were recorded. Three sets of pedalling (200, 250 and 300 W) on a cycle ergometer that simulated their habitual cycling posture were performed at a constant cadence (~90 rpm), while kinetic and kinematic variables were registered. The results showed no differences on the main anthropometric variables and bike measurements. Professional cyclists obtained higher positive impulse proportion (1.5–3.3% and P < 0.05), mainly due to a lower resistive torque during the upstroke (15.4–28.7% and P < 0.05). They also showed a higher ankle range of movement (ROM, 1.1–4.0° and P < 0.05). Significant correlations (P < 0.05) were found between the cyclists’ body mass and the kinetic variables of pedalling: positive impulse proportion (r = ?0.59 to ?0.61), minimum (r = ?0.59 to ?0.63) and maximum torques (r = 0.35–0.47). In conclusion, professional cyclists had better pedalling technique than elite and club cyclists, because they opted for enhancing pulling force at the recovery phase to sustain the same power output. This technique depended on cycling experience and level of expertise.  相似文献   

Effects of interval aerobic training combined with strength exercise on body composition,glycaemic and lipid profile and aerobic capacity of obese rats     

Irene Coll-Risco  Virginia A. Aparicio  Elena Nebot  Daniel Camiletti-Moirón  Rosario Martínez  Garyfallia Kapravelou 《Journal of sports sciences》2016,34(15):1452-1460

The purpose of this study was to investigate the effects of interval aerobic training combined with strength exercise in the same training session on body composition, and glycaemic and lipid profile in obese rats. Sixteen lean Zucker rats and sixteen obese Zucker rats were randomly divided into exercise and sedentary subgroups (4 groups, n = 8). Exercise consisted of interval aerobic training combined with strength exercise in the same training session. The animals trained 60 min/day, 5 days/week for 8 weeks. Body composition, lipid and glycaemic profiles and inflammatory markers were assessed.

Results showed that fat mass was reduced in both lean and obese rats following the exercise training (effect size (95% confidence interval (CI)) = 1.8 (0.5–3.0)). Plasma low-density lipoprotein–cholesterol and fasting glucose were lower in the exercise compared to the sedentary groups (d = 2.0 (0.7–3.2) and 1.8 (0.5–3.0), respectively). Plasma insulin was reduced in exercise compared to sedentary groups (d = 2.1 (0.8–3.4)). Some exercise × phenotype interactions showed that the highest decreases in insulin, homeostatic model assessment-insulin resistance, fasting and postprandial glucose were observed in the obese + exercise group (all, P < 0.01). The findings of this study suggest that interval aerobic training combined with strength exercise would improve body composition, and lipid and glycaemic profiles, especially in obese rats.  相似文献   

Effects of psychosocial variables in the similarity and interdependence of physical activity levels among adolescent best friend dyads     

Vítor P. Lopes  Carl Gabbard  Luis P. Rodrigues 《Journal of sports sciences》2016,34(9):821-828

Given that physical activity (PA) tends to decrease with age during adolescence, addressing factors that affect change is important. This study examined the similarity and interdependence of PA as influenced by psychosocial factors among adolescent best friend dyads. A total of 660 adolescents, representing 330 best friend dyads, completed questionnaires with regard to PA, sitting time, perceived exercise benefits and barriers, physical self-perception and social support for PA. Dyads were also identified as reciprocal and non-reciprocal best friends; reciprocal means that both considered each other best friends and non-reciprocal were those in which only one considered the other a best friend. Data were analysed using a hierarchical linear model framework. Results indicated significant similarities between reciprocal best friend dyads for PA and sitting time, and for sitting time in non-reciprocal best friends (P values <.01). Psychosocial variables were associated with PA in reciprocal best friend dyads and with sitting time in reciprocal and non-reciprocal best friend dyads. Best friend gender, regular sports practice of the person, perceived exercise barriers of the best friend and best friend social support were the best predictors for PA.  相似文献   

Bedingungen der Bindungswirkung inkrementeller Normen in Fußballvereinen     

Christian Rullang  Eike Emrich  Christian Pierdzioch  Freya Gassmann 《Sportwissenschaft》2016,46(4):275-286

Sports clubs depend on the pooling of resources by their members. The supportive distribution of the resources within a club is facilitated in particular by the effectiveness of incremental standards. A basic prerequisite for a fair distribution of resources is a minimum of community spirit among the members. Based on a nationwide survey of football clubs and an ordinal logistic regression model, factors were determined that reflect the extent of the community spirit within a club. The opening up of the club by payment to players and perceived problems with acquiring and binding of volunteers are associated with a reduction of community spirit. In contrast, the perception that the club activities can be continued in the long term shows a positive correlation to a highly developed community spirit.  相似文献