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Information and communication technology (ICT) development initiatives have begun to acknowledge the power and importance of cultural and community-focused belief systems. Yet the vast majority of such initiatives tend to preidentify developmental goals that communities hold. Paulo Freire's writings have influenced development initiatives by introducing the possibility of working with communities to orient projects. While these “participatory” initiatives have involved soliciting community feedback relative to a research project whose goals were formulated in the university or development institution, they do not go far enough to harness actual visions held by communities. It is important to conceptualize a model and methodology of engaging communities to develop and articulate their own goals of information access and ultimately, an indigenous approach toward cultural, political, and economic aspects of development. This approach holds promise to sustain communities within a return on the investment and efforts of the researcher or institution. This article closes by describing a current initiative in Southern India that reflects the described methodology.  相似文献   
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In this communication, we show the modulatory potential of papaverine, an opium alkaloid and a well known vasodilator agent on the ethanol-induced hepatic oxidative stress in male Wistar rats. Ethanol treatment (50% v/v) enhanced lipid peroxidation significantly accompanied by a decline in the activities of glutathione peroxidase (G-Px), glutathione reductase (GR) and depletion in levels of hepatic glutathione (GSH). Ethanol administration increased hepatic glutathione-s-transferases (GST). Enhanced lipid peroxidation induced by ethanol was significantly reduced when papverine was coadministered (P<0.05). In addition, the depleted levels of glutathione and inhibited activities of G-Px and GR recovered significantly (P<0.05) levelling off to control values on co-exposure. Papaverine (200 mg/kg bw) effectively antagonised the ethanol-induced lipid peroxidation and impaired glutathione levels and glutathione dependent enzyme systems. Our results suggest that papaverine is an effective chemopreventive agent in the liver and may suppress the ethanol-induced hepatotoxicity.  相似文献   
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Alfred Wegener, an astronomer by training and meteorologist by profession, visualised that there was once a single very large landmass on the surface of the earth. Gradually it broke up into smaller fragments which drifted away to form the present continents. In a few cases, the drifting fragments subsequently collided, coalesced and formed larger landmasses again. Wegener could thus explain in a simple way (i) similarities in shapes of continental coast lines separated by wide oceans, (ii) similarities in the rocks and fossils occurring on such coasts and in the fauna and flora inhabiting them, (iii) the formation of several major mountain ranges of the world, and (iv) the evidence in rocks on past climates of the earth.  相似文献   
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This is a highly useful illustrative step‐by‐step resource for teachers and administrators planning for or already teaching online. It offers great ideas, strategies, practical examples, online tools and design principles for all those associated with online teaching, whether they are beginners or experienced. I recommend you buy a copy of this book for your own use if its content is likely to be relevant to you. Ramesh Sharma  相似文献   
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