Association of Elevated Serum Lipoprotein(a), Inflammation,Oxidative Stress and Chronic Kidney Disease with Hypertension in Non-diabetes Hypertensive Patients     

Surapon?TangvarasittichaiEmail author  Patcharin?Pingmuanglaew  Orathai?Tangvarasittichai 《Indian journal of clinical biochemistry : IJCB》2016,31(4):446-451

Hypertension is the most common cardiovascular risk factor. Lipoprotein(a) [Lp(a)], inflammation, oxidative stress and chronic kidney disease (CKD) exacerbate the response to tissue injury and acts as markers of the vascular disease, especially in glomerulosclerosis. We compared the clinical characteristics of 138 non-diabetes hypertensive women (ndHT) patients with 417 non-diabetes normotensive subjects and tested the association of hypertension with Lp(a), inflammation, CKD and oxidative stress by using multiple logistic regression. BP, BMI, waist circumference, creatinine, Lp(a), inflammation and malondialdehyde levels were significantly higher and CKD state in the ndHT patients (p < 0.05). Multiple logistic regression showed hypertension associated with increased Lp(a), inflammation, ORs and 95 % CIs were 2.52 (1.33, 4.80), 2.75 (1.44, 5.27) after adjusting for their covariates. Elevated serum Lp(a) and inflammation levels concomitants with increased oxidative stress and CKD were the major risk factors associated with hypertension and implications for the increased risk of HT and vascular disease.  相似文献   

The effect of extremely high glucose concentrations on 21 routine chemistry and thyroid Abbott assays: interference study     

Serap ?uhadar  Mehmet K?seo?lu  Yasemin ?inpolat  Güler Bu?dayc?  Murat Usta  Tuna Semerci 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2016,26(1):53-60

Introduction

Extremely high glucose concentrations have been shown to interfere with creatinine assays especially with Jaffe method in peritoneal dialysate. Because diabetes is the fastest growing chronic disease in the world, laboratories study with varying glucose concentrations. We investigated whether different levels of glucose spiked in serum interfere with 21 routine chemistry and thyroid assays at glucose concentrations between 17-51 mmol/L.

Materials and methods

Baseline (group I) serum pool with glucose concentration of 5.55 (5.44-5.61) mmol/L was prepared from patient sera. Spiking with 20% dextrose solution, sample groups were obtained with glucose concentrations: 17.09, 34.52, and 50.95 mmol/L (group II, III, IV, respectively). Total of 21 biochemistry analytes and thyroid tests were studied on Abbott c8000 and i2000sr with commercial reagents. Bias from baseline value was checked statistically and clinically.

Results

Creatinine increased significantly by 8.74%, 31.66%, 55.31% at groups II, III, IV, respectively with P values of < 0.001. At the median glucose concentration of 50.95 mmol/L, calcium, albumin, chloride and FT4 biased significantly clinically (-0.85%, 1.63%, 0.65%, 7.4% with P values 0.138, 0.214, 0.004, < 0.001, respectively). Remaining assays were free of interference.

Conclusion

Among the numerous biochemical parameters studied, only a few parameters are affected by dramatically increased glucose concentration. The creatinine measurements obtained in human sera with the Jaffe alkaline method at high glucose concentrations should be interpreted with caution. Other tests that were affected with extremely high glucose concentrations were calcium, albumin, chloride and FT4, hence results should be taken into consideration in patients with poor diabetic control.Key words: assay interference, glucose interference, preanalytical phase, creatinine, Jaffe kinetic assay, thyroid function tests  相似文献   

Editorial zum Themenheft: ,,Datenbanksysteme‘‘     

Theo H?rder 《Informatik - Forschung und Entwicklung》2007,11(2):125-126

  相似文献   

Critical factors influencing secondary school pupil’s decisions to study computing in tertiary education: Gender differences     

Evrikleia?Tsagala  Maria?KordakiEmail author 《Education and Information Technologies》2007,12(4):281-295

This paper aims to determine the factors affecting the decisions of both male and female secondary school pupils whether or not to pursue undergraduate studies in Computing. It is based on research conducted in Greece, on a sample of 248 pupils, 135 of whom were female. All were aged 17 and about to decide on their future undergraduate studies. Questionnaires were used, addressing issues in the following four main categories: a) the reasons pupils chose/rejected Computing, b) how family and friends, the media and the school environment contribute to their decision, c) how pupils perceived their future after studying Computing and d) how pupils perceived the profile of a computer professional in terms of gender.

Maria KordakiEmail:

  相似文献   

Editorial     

Jér?me Rossier 《International Journal for Educational and Vocational Guidance》2012,12(3):167-170

  相似文献   

Integrierte Entwicklung von Automotive-Software mit AutoFocus     

Andreas Bauer  Jan Romberg  Bernhard Sch?tz 《Informatik - Forschung und Entwicklung》2005,49(3):194-205

Zur Beherrschung der komplexen vernetzten und verteilten Funktionen von Automotive-Software ist eine Beschreibung des zu erstellenden Systems auf verschiedenen Abstraktionsebenen und schrittweise überg?nge zwischen diesen Ebenen notwendig. Neben der Definition geeigneter Ebenen werden zur Unterstützung echtzeitkritischer Systemanteile ein einheitliches Berechnungsmodell, ebenenspezifische Beschreibungstechniken, sowie methodische Regeln für diese Abstraktionsebenen eingeführt und in den Werkzeugprototypen AutoFocus integriert.  相似文献   

Dimensions of variability in embedded operating systems     

Wolfgang Schr?der-Preikschat  Daniel Lohmann  Fabian Scheler  Olaf Spinczyk 《Informatik - Forschung und Entwicklung》2007,22(1):5-22

Design, implementation, and re-engineering of operating systems are still an ambitious undertaking. Despite, or even because, of the long history of theory and practice in this field, adapting existing systems to environments of different conditions and requirements as originally specified or assumed, in terms of functional and/or non-functional respects, is anything but simple. Especially this is true for the embedded systems domain which, on the one hand, calls for highly specialized and application-aware system abstractions and, on the other hand, cares a great deal for easily reusable implementations of these abstractions. The latter aspect becomes more and more important as embedded systems technology is faced with an innovation cycle decreasing in length. Software for embedded systems needs to be designed for variability, and this is in particular true for the operating systems of this domain. The paper discusses dimensions of variability that need to be considered in the development of embedded operating systems and presents approaches that aid construction and maintenance of evolutionary operating systems. CR subject classification  C.3; D.2.11; D.2.13; D.4.7  相似文献   

Efficient reverse k-nearest neighbor estimation     

Elke Achtert  Christian B?hm  Peer Kr?ger  Peter Kunath  Alexey Pryakhin  Matthias Renz 《Informatik - Forschung und Entwicklung》2007,15(3):179-195

The reverse k-nearest neighbor (RkNN) problem, i.e. finding all objects in a data set the k-nearest neighbors of which include a specified query object, has received increasing attention recently. Many industrial and scientific applications call for solutions of the RkNN problem in arbitrary metric spaces where the data objects are not Euclidean and only a metric distance function is given for specifying object similarity. Usually, these applications need a solution for the generalized problem where the value of k is not known in advance and may change from query to query. In addition, many applications require a fast approximate answer of RkNN-queries. For these scenarios, it is important to generate a fast answer with high recall. In this paper, we propose the first approach for efficient approximative RkNN search in arbitrary metric spaces where the value of k is specified at query time. Our approach uses the advantages of existing metric index structures but proposes to use an approximation of the nearest-neighbor-distances in order to prune the search space. We show that our method scales significantly better than existing non-approximative approaches while producing an approximation of the true query result with a high recall.  相似文献   

Optimale Dimensionswahl bei der Bearbeitung des Similarity Join     

Christian B?hm  Hans-Peter Kriegel 《Informatik - Forschung und Entwicklung》2002,6(6):68-76

  相似文献   

Introduction to the Open File     

Jean-Jacques?DucretEmail author 《Prospects》2004,34(4):397-399

  相似文献