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21.
WOMBAT A tool for mixed model analyses in quantitative genetics by restricted maximum likelihood (REML) 总被引:31,自引:0,他引:31
Meyer K 《Journal of Zhejiang University. Science. B》2007,8(11):815-821
WOMBAT is a software package for quantitative genetic analyses of continuous traits, fitting a linear, mixed model; estimates of covariance components and the resulting genetic parameters are obtained by restricted maximum likelihood. A wide range of models, comprising numerous traits, multiple fixed and random effects, selected genetic covariance structures, random regression models and reduced rank estimation are accommodated. WOMBAT employs up-to-date numerical and computational methods. Together with the use of efficient compilers, this generates fast executable programs, suitable for large scale analyses. Use of WOMBAT is illustrated for a bivariate analysis. The package consists of the executable program, available for LINUX and WINDOWS environments, manual and a set of worked example, and can be downloaded free of charge from http://agbu. une.edu.au/~kmeyer/wombat.html 相似文献
22.
The current article proposes a new theory of infant pointing involving multiple layers of intentionality and shared intentionality. In the context of this theory, evidence is presented for a rich interpretation of prelinguistic communication, that is, one that posits that when 12-month-old infants point for an adult they are in some sense trying to influence her mental states. Moreover, evidence is also presented for a deeply social view in which infant pointing is best understood--on many levels and in many ways--as depending on uniquely human skills and motivations for cooperation and shared intentionality (e.g., joint intentions and attention with others). Children's early linguistic skills are built on this already existing platform of prelinguistic communication. 相似文献
23.
Individual, family, and neighborhood factors distinguish resilient from non-resilient maltreated children: a cumulative stressors model 总被引:2,自引:0,他引:2
OBJECTIVE: Children who are physically maltreated are at risk of a range of adverse outcomes in childhood and adulthood, but some children who are maltreated manage to function well despite their history of adversity. Which individual, family, and neighborhood characteristics distinguish resilient from non-resilient maltreated children? Do children's individual strengths promote resilience even when children are exposed to multiple family and neighborhood stressors (cumulative stressors model)? METHODS: Data were from the Environmental Risk Longitudinal Study which describes a nationally representative sample of 1,116 twin pairs and their families. Families were home-visited when the twins were 5 and 7 years old, and teachers provided information about children's behavior at school. Interviewers rated the likelihood that children had been maltreated based on mothers' reports of harm to the child and child welfare involvement with the family. RESULTS: Resilient children were those who engaged in normative levels of antisocial behavior despite having been maltreated. Boys (but not girls) who had above-average intelligence and whose parents had relatively few symptoms of antisocial personality were more likely to be resilient versus non-resilient to maltreatment. Children whose parents had substance use problems and who lived in relatively high crime neighborhoods that were low on social cohesion and informal social control were less likely to be resilient versus non-resilient to maltreatment. Consistent with a cumulative stressors model of children's adaptation, individual strengths distinguished resilient from non-resilient children under conditions of low, but not high, family and neighborhood stress. CONCLUSION: These findings suggest that for children residing in multi-problem families, personal resources may not be sufficient to promote their adaptive functioning. 相似文献
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Far from all who complete teacher education end up working as teachers throughout their entire career. At first sight the value of teacher education, in terms of efficiency, seems to be a failure. In the present article we argue that teacher attrition, when defined as whether one is working as teacher or not, is a too blunt measure to gauge whether teacher education has been valuable. With a unique dataset, where we have detailed information on 87 Swedish teacher graduates’ working life across 23 years, we can consider whether activities and/or experiences point to an apparent use of teacher education. In conclusion, we find that in order to get informative estimates of its value it is important to consider it from different perspectives and to consider attrition related to the total working time spent in educational settings across a career rather than percentage leaving teaching after a set of years 相似文献
26.
The aim of this study was to determine the physiological responses to orienteering by examining the interrelationships between the information provided by a differential global positioning system (dGPS) about an orienteer's route, speed and orienteering mistakes, portable metabolic gas analyser data during orienteering and data from incremental treadmill tests. Ten male orienteers completed a treadmill threshold test and a field test; the latter was performed on a 4.3 km course on mixed terrain with nine checkpoints. The anaerobic threshold, threshold of decompensated metabolic acidosis, respiratory exchange ratio, onset of blood lactate accumulation and peak oxygen uptake (VO2peak) were determined from the treadmill test. Time to complete the course, total distance covered, mean speed, distance and timing of orienteering mistakes, mean oxygen uptake, mean relative heart rate, mean respiratory exchange ratio and mean running economy were computed from the dGPS data and metabolic gas analyser data. Correlation analyses showed a relationship between a high anaerobic threshold and few orienteering mistakes (r = - 0.64, P < 0.05). A high threshold of decompensated metabolic acidosis and VO2peak were related to a fast overall time (r = -0.70 to -0.72, P < 0.05) and high running speed (r = 0.64 to 0.79, P < 0.05 and P < 0.01, respectively), and were thus the best predictors of performance. 相似文献
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Comparison of two Actigraph models for assessing free-living physical activity in Indian adolescents
Corder K Brage S Ramachandran A Snehalatha C Wareham N Ekelund U 《Journal of sports sciences》2007,25(14):1607-1611
This aim of this study was to compare the new Actigraph (GT1M) with the widely used Model 7164. Seven days of free-living physical activity were measured simultaneously using both the Model 7164 and GT1M in 30 Indian adolescents (mean age 15.8 years, s = 0.6). The GT1M was on average 9% lower per epoch than model 7164, thus a correction factor of 0.91 is suggested for comparison between the two monitors. The differences between monitors increased in magnitude with intensity of activity (P < 0.001) but remained randomly distributed (r = 0.01, P = 0.96). No significant difference was observed between monitors for time spent in moderate (P = 0.31) and vigorous (P = 0.34) physical activity when using the same epoch length. The Model 7164 classified less time as sedentary (P < 0.001) and more time as light-intensity activity (P < 0.001) than the GT1M. In conclusion, data from the GT1M can be compared with historical data using average counts per minute with a correction factor, and the two models might be comparable for assessing time spent in moderate to vigorous physical activity in children when using the same epoch length. 相似文献