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41.
Gabriel Lima-Oliveira Gian Luca Salvagno Giuseppe Lippi Elisa Danese Matteo Gelati Martina Montagnana Geraldo Picheth Gian Cesare Guidi 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(3):343-349
Background:
Presently the necessity of fasting time for coagulation tests is not standardized. Our hypothesis is that this can harm patient safety. This study is aimed at evaluating whether a light meal (i.e. breakfast) can jeopardize laboratory coagulation tests.Materials and methods:
A blood sample was firstly collected from 17 fasting volunteers (12 h). Immediately after blood collection, the volunteers consumed a light meal. Then samples were collected at 1, 2 and 4 h after the meal. Coagulation tests included: activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (Fbg), antithrombin III (AT), protein C (PC) and protein S (PS). Differences between samples were assessed by Wilcoxon ranked-pairs test. The level of statistical significance was set at P < 0.05. Mean % differences were determined and differences between and baseline and 1, 2 and 4h samples were compared with reference change value (RCV).Results:
A significantly higher % activity of AT was observed at 1 h and 4 h after meal vs. baseline specimen [113 (104–117) and 111 (107–120) vs. 109 (102–118), respectively; P = 0.029 and P = 0.016]. APTT at 2 h was found significantly lower than baseline samples [32.0 (29.9–34.8) vs. 34.1 (32.2–35.2), respectively; P = 0.041]. The results of both Fbg and PS tests were not influenced by a light meal. Furthermore, no coagulation tests had significant variation after comparison with RCV.Conclusion:
A light meal does not influence the laboratory coagulation tests we assessed, but we suggest that the laboratory quality managers standardize the fasting time for all blood tests at 12 hours, to completely metabolize the lipids intake. 相似文献42.
This paper deals with asymptotic rejection of a multi-sinusoidal signal for linear single-input single-output stable systems with unknown structure. An adaptive orthogonal signals generator is used to both reconstruct the disturbance and cancel its effect on the system output. An interesting feature is that the disturbance is removed by the generated internal signals with no additional dynamics in the cancellation algorithm. A fractional-order controller is designed which guarantees the closed-loop stability of the system if the location of the plant frequency response at the estimated frequencies lies in a half-plane passing through the origin of the complex plane, i.e. no information about the order of the system to be controlled, the relative degree, the nature of its poles and zeros, is required. The case of multi-sinusoidal disturbance is also analyzed. Simulations and comparisons with existing approaches are presented that highlight the performances of the proposed method. 相似文献
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Aslan Sinem Agrawal Ankur Alyuz Nese Chierichetti Rebecca Durham Lenitra M. Manuvinakurike Ramesh Okur Eda Sahay Saurav Sharma Sangita Sherry John Raffa Giuseppe Nachman Lama 《Educational technology research and development : ETR & D》2022,70(1):205-230
Educational technology research and development - Parents recognize the potential benefits of technology for their young children but are wary of too much screen time and its potential deficits in... 相似文献
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Johnny Padulo Davide Filingeri Karim Chamari Gian Mario Migliaccio Giuseppe Calcagno Gerardo Bosco 《Journal of sports sciences》2013,31(12):1120-1126
AbstractThe aim of this study was to investigate the effects of a single bout of whole-body vibration (WBV) on running gait. The running kinematic of sixteen male marathon runners was assessed on a treadmill at iso-efficiency speed after 10 min of WBV and SHAM (i.e. no WBV) conditions. A high-speed camera (210 Hz) was used for the video analysis and heart rate (HR) was also monitored. The following parameters were investigated: step length (SL), flight time (FT), step frequency (SF), contact time (CT), HR and the internal work (WINT). Full-within one-way analysis of variance (ANOVA) of the randomised crossover design indicated that when compared to SHAM conditions, WBV decreased the SL and the FT by ~4% (P < 0.0001) and ~7.2% (P < 0.001), respectively, and increased the SF ~4% (P < 0.0001) while the CT was not changed. This effect occurred during the first minute of running: the SL decreased ~3.5% (P < 0.001) and SF increased ~3.3% (P < 0.001). During the second minute the SL decreased ~1.2% (P = 0.017) and the SF increased ~1.1% (P = 0.02). From the third minute onwards, there was a return to the pre-vibration condition. The WINT was increased by ~4% (P < 0.0001) during the WBV condition. Ten minutes of WBV produced a significant alteration of the running kinematics during the first minutes post exposure. These results provide insights on the effects of WBV on the central components controlling muscle function. 相似文献
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ABSTRACTThe aim of this study was to evaluate the effects of sleep hygiene (SH) education on sleep quality in soccer players after a late-evening small-sided-game (SSG) training session. Twenty-nine non-professional players were recruited and allocated to either an experimental group (EG, n = 17) that received SH education, or a control group (CG, n = 12). SSG consisted of 3 × 4 min in a 4vs4, with 3 min of recovery and was performed at 8.00 p.m. Sleep quality was monitored via actigraphy and sleep diary entries before (PRE) and two nights after (POST1, POST2) the SSG. Sleep latency (SL) differed between the two groups at POST1 (4.9 ± 5.4 vs. 15.5 ± 16.1 for EG and CG, respectively; p = 0.017, effect size [ES] = 2.0); SL values were lower at POST1 compared to PRE for the EG (?47%; p = 0.021, ES = 0.6). Subjective sleep quality was better in the EG than the CG at POST1 (8.6 ± 1.0 vs. 7.1 ± 2.0 for EG and CG, respectively; p = 0.016, ES = 0.9) with a significant improvement over PRE-values (+11.0%, p = 0.004, ES = 0.8). Although SL and subjective sleep quality did not decrease significantly from POST1 to POST2 values at POST2 no longer differed significantly form baseline and, hence, indicate that observed effects may be short-lasting. No other objective sleep indices were influenced by late-evening training or SH practices implemented by the EG. Soccer players may benefit from acute SH strategies to reduce the time to sleep onset after late-evening training sessions. 相似文献
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Emmanuel J Favaloro Giuseppe Lippi 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(3):329-341
The tests currently employed within most haemostasis laboratories to monitor anticoagulant therapy largely comprise the prothrombin time (PT)/ International Normalised Ratio (INR) and the activated partial thromboplastin time (APTT). These are respectively used to monitor Vitamin K antagonists (VKAs) such as warfarin, and unfractionated heparin. Additional tests that laboratories may also employ for assessing or monitoring unfractionated heparin include thrombin time (TT) and the anti-Xa assay, which can also be used to monitor low molecular weight heparin. Several new anti-thrombotic agents have recently emerged, or are in the final process of clinical evaluation. These novel drugs that include Dabigatran etexilate and Rivaroxaban would not theoretically require monitoring; however, testing is useful in specific situations. The tests currently used to monitor VKAs and heparin are typically either too sensitive or too insensitive to the new drugs to be used as ‘typically performed in laboratories’, and may thus require some methodological adjustments to increase or decrease their sensitivity. Alternately, different tests may be better employed in these assessments. Whatever the case, laboratories may soon be performing a reduced or possibly increased number of tests, the same kind of tests but perhaps differently, or conceivably different assay panels. Specific laboratory guidance on the choice of the appropriate test to be ordered according to the drug being administered, as well as on appropriate interpretation of test results, will also be necessary. The current report reviews the current state of play and provides a glimpse to the possible future of the coagulation laboratory. 相似文献
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Lippi G Cervellin G Aloe R Montagnana M Salvagno GL Guidi GC 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):127-129