CIDE gene expression in adipose tissue,liver, and skeletal muscle from obese and lean pigs     

Yue-qin Qiu  Xue-fen Yang  Xian-yong Ma  Yun-xia Xiong  Zhi-mei Tian  Qiu-li Fan  Li Wang  Zong-yong Jiang 《Journal of Zhejiang University. Science. B》2017,18(6):492-500

The expression of the cell death-inducing DNA fragmentation factor α-like effector (CIDE) family including Cidea, Cideb, and Cidec was significantly increased in mouse and human models of obesity. However, there was less information on these genes’ expression in pigs. Here, we hypothesized that different fat accumulation between lean (Duroc×Landrace×Yorkshire gilts, DLY) and obese (Lantang) pigs was attributed to porcine CIDE-modulating lipid metabolism. Our data showed that Cidea and Cidec were expressed at a high level in adipose tissue, and at a relatively high level in skeletal muscle, whereas Cideb was mainly expressed in the liver in both breeds of pig. Lantang pigs had higher white adipose and skeletal muscle Cidea and Cidec mRNA abundance, and hepatic and muscle Cideb mRNA than DLY pigs. Lipid metabolism-related genes including sterol regulatory element binding protein 1c (SREBP-1c), hepatocyte nuclear factor-4α (HNF-4α), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), fatty acid synthase (FASN), diacylglycerol O-acyltransferase 1 (DGAT1), and DGAT2 showed a higher expression level in adipose tissue from obese pigs than in that from lean pigs. Lantang pigs exhibited higher mRNA abundance for liver SREBP-1c, HNF-4α, and PGC-1α, and higher skeletal muscle SREBP-1c, HNF-4α, PGC-1α, and DGAT2 expression, as compared with DLY pigs. However, the perlipin2 mRNA levels in adipose tissues, liver, and skeletal muscle were significantly lower in obese pigs than in their lean counterparts. Furthermore, plasma non-esterified fatty acid (NEFA), glucose, and triacylglycerol (TAG) levels were greater in obese pigs than in lean pigs. Finally, data from correlation analysis further found that CIDE mRNA expression was positively correlated with back fat thickness (BFT), abdominal fat mass (AFM), and the levels of NEFA, TAG, and glucose in the two breeds. Collectively, these data revealed that the porcine CIDEs possibly modulated lipid metabolism and contributed to the development of fat deposition and obesity in Lantang pigs.  相似文献   

中学英语单词与大学英语单词互相衔接的调查与研究     

覃军艳  蒋桂红  范振辉 《贺州学院学报》2004,20(1):52-54

文章通过对中学生英语词汇学习的调查,了解中学生学习词汇的情况,并针对大学生英语词汇学习的现状,提出了中学英语单词与大学英语单词互相衔接的重要性以及做好衔接工作的一些建议。  相似文献   

A novel multi-objective optimization method for the pressurized reservoir in hydraulic robotics     

Xiao-ping Ouyang  Bo-qian Fan  Hua-yong Yang  Shuo Ding 《浙江大学学报(A卷英文版)》2016,17(6):454-467

The pressurized reservoir is a closed hydraulic tank which plays a significant role in enhancing the capabilities of hydraulic driven robotics. The spring pressurized reservoir adopted in this paper requires comprehensive performance, such as weight, size, fluid volume, and pressure, which is hard to balance. A novel interactive multi-objective optimization approach, the feasible space tightening method, is proposed, which is efficient in solving complicated engineering design problems where multiple objectives are determined by multiple design variables. This method provides sufficient information to the designer by visualizing the performance trends within the feasible space as well as its relationship with the design variables. A step towards the final solution could be made by raising the threshold on performance indicators interactively, so that the feasible space is reduced and the remaining solutions are more preferred by the designer. With the help of this new method, the preferred solution of a spring pressurized reservoir is found. Practicability and efficiency are demonstrated in the optimal design process, where the solution is determined within four rounds of interaction between the designer and the optimization program. Tests on the designed prototype show good results.  相似文献   

HBME-1、CK19基因在甲状腺结节的表达状态及诊断价值     

韩晓晨  张凡 《河北北方学院学报(医学版)》2006,23(4):1-5

目的：研究分析HBME-1、CK19基因在甲状腺结节的表达状态及诊断价值。方法：回顾性分析天津肿瘤医院头颈外科1975．1～1998．1月收治的初治甲状腺乳头状癌行甲状腺癌联合根治术的有完整随访资料的93例患者临床、组织病理和免疫组织化学染色资料，与同期收治的15例结节性甲状腺肿、16例甲状腺腺瘤相比较。对常规HE染色证实上述病变的蜡块分别行HBME-1和CK19免疫组织化学染色。结果：93例甲状腺乳头状癌病例中，HBME-1基因阳性表达甲状腺乳头状癌为51例（54．8％），甲状腺良性病变为5例（16．1％）；CK19基因阳性表达甲状腺乳头状癌为39例（41．9％），甲状腺良性病变为4例（12．9％）。两种基因在甲状腺乳头状癌和良性病变中的阳性表达均存在统计学差异。HBME-1、CK19基因表达与甲状腺乳头状癌患者的性别、年龄、肿瘤大小、局部侵犯、颈淋巴结转移无明显相关性。结论：HBME-1、CK19基因在甲状腺乳头状癌中表达增强，在甲状腺结节的鉴别诊断中是有用的辅助手段。CK19在区分甲状腺乳头状癌和乳头状增生中是一个很好的标志物。  相似文献   

完善高等学校内部职工奖惩制度的思考   总被引：2，自引：0，他引：2  

程永清  范宏 《陕西广播电视大学学报》2005,7(3):46-47,50

奖惩制度是人力资源管理的重要组成部分，长期以来高等学校在奖惩制度方面缺位较多，高校内部的奖惩工作没有发挥很好的作用。本文讨论了高等学校奖惩制度的缺失和给高校管理工作带来的负面影响，提出了完善高等学校奖惩制度的设想。  相似文献   

Cu-ZnO/Al2O3催化仲丁醇制备甲乙酮     

林武滔  李增富  邱凡 《三明学院学报》2007,24(4):420-424

用Cu-ZnO/Al2O3催化仲丁醇制备甲乙酮。研究了催化剂的焙烧温度和焙烧时间、仲丁醇脱氢反应的温度和压力以及仲丁醇的流量对仲丁醇转化率和甲乙酮选择性的影响。结果表明,催化剂的焙烧温度为300-400℃,焙烧时间为6h,脱氢反应的温度为300℃,压力为0.2Mpa,仲丁醇的流量为140mL/h时,仲丁醇的转化率和甲乙酮的选择性较好。  相似文献   

尝试新的教学(续一)--《新世纪国家基础教育课程标准实验教材·数学》(七年级·上)介绍     

马复  史炳星  孔凡哲 《教育学报》2001,(11):1-5

本文简单地介绍了"实验教材"(七年级·上的第3、4章)的若干教学和评价建议.  相似文献   

公司设立中的几个法律问题刍议     

王凡 《四川教育学院学报》2005,21(5):46-50

本文研究公司设立中的几个重要法律问题。笔者通过分析发起人在公司设立中的责任，设立中公司的地位，以及设立中公司对发起人责任的承担等几个方面，试图对设立中公司的几个热点问题提出自己的一些见解。  相似文献   

我国传媒产业价值链构建的必要性与可行性分析   总被引：1，自引：0，他引：1  

樊士德 《湖南大众传媒职业技术学院学报》2006,6(6):67-70

当传媒真正成为产业,“产业价值链”便成为一个不可回避的话题。本文结合传媒产业发展规律的特殊性,从竞争优势、交易费用、链接点整合效应、外在压力以及产业政策、资本市场、内在动力等方面,分别对我国传媒产业价值链的构建进行了必要性与可行性分析,以期对传媒产业经营实践有所裨益。  相似文献   

观念差异与合作关系探析     

王帆 《教学与研究》2020,(1):64-73

本文从观念差异的界定入手,分析了观念差异对合作的影响。虽然观念差异不是影响或决定合作的决定性因素,但却是影响合作的持续性因素。相似性是合作的起点,但差异性带来的互补性则可能成为合作推进的持续动力。差异并不必然导致冲突,相近或类似的观念也可能带来冲突。差异并不是影响合作的唯一变量,但处理不好差异的问题或持有错误的差异观却有可能直接影响到合作的进程。差异间能够实现理解和互动也能促进合作的发展。虽然不是所有差异都可以实现合作,但差异间实现合作却是可行的、也是可能的。减少差异增进合作是一种类型,化解差异增进合作是另一个层次。人类必须实现差异间的和谐共存,协调差异、化解分歧、促进合作。中国外交正在努力实现由"求同存异"到"求同合异"的转变。  相似文献