Learning and teaching: issues for teacher education     

Jo-Anne Reid  Diane Mayer  Ninetta Santoro  Michael Singh 《Asia-Pacific Journal of Teacher Education》2012,40(4):343-345

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Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital     

Bhawna M. Singh  B. Goswami  V. Mallika 《Indian journal of clinical biochemistry : IJCB》2010,25(2):141-145

The effect of thyroid status on insulin sensitivity is of great interest but despite various studies there is conflicting data on this subject. The study group comprised of 25 female subjects each with subclinical hypothyroidism, overt hypothyroidism and euthyroid controls. Serum samples of all the patients were assayed for thyroid profile, Insulin and lipid profile. Homeostasis model of assessment (HOMA-IR) was employed to assess the level of insulin resistance. Patients with hypothyroidism demonstrated insulin resistance and dyslipidemia as observed by the higher HOMA-IR and cholesterol and triglyceride levels respectively as compared to the controls. A significantly positive correlation between TSH and HOMA-IR level was also observed in the hypothyroidism group. Thyroid dysfunction leads to alterations in glucose and lipid metabolism which is an important risk factor for cardiovascular diseases. The dyslipidemia and insulin resistance should be managed aggressively to reduce the impending risk.  相似文献   

Evaluation of plasma hormone concentrations using Enzyme-Immunoassay/Enzyme-linked Immunosorbent assay in healthy Indian men: Effect of ethnicity     

M. Sachidhanandam  S. N. Singh  A. K. Salhan  Uday Sankar Ray 《Indian journal of clinical biochemistry : IJCB》2010,25(2):153-157

The study involved three ethnic groups of India; Rajputs, Gorkhas and South-Indians. Each group consisted of ∼40 healthy, male soldiers between 20–50 years. The reference ranges for cortisol, testosterone, prolactin, arginine vasopressin and proAtrial natriuretic peptide_1–98 were determined using Enzyme-Immunoassay (EIA) while plasma levels of thyroid-stimulating hormone, triiodothyronine, free-triiodothyronine, thyroxine and freethyroxine were measured using Enzyme-linked immunosorbent assay (ELISA). The results indicated that plasma hormone concentrations were within physiological range and inter-ethnic differences were most prominent between north- (Rajputs and Gorkhas) and south- Indians. In comparison to Radioimmunoassay, the EIA method for prolactin, thyroid-stimulating hormone, free-thyroxine gave higher values while the ELISA method for triiodothyronine, free-triiodothyronine, and thyroxine gave lower values. These differences are due to differences in assay standards and design.  相似文献   

Modification of Jaffe’s kinetic method decreases bilirubin interference: A preliminary report     

R. Vaishya  Sarika Arora  B. Singh  V. Mallika 《Indian journal of clinical biochemistry : IJCB》2010,25(1):64-66

The negative interference of bilirubin on serum creatinine determined by the kinetic alkaline picrate (Jaffe) reaction is the unresolved problem. Though high performance liquid chromatography and gas chromatography with mass spectroscopy have been proposed to be gold standards for creatinine estimation but they are not readily available in most of the clinical chemistry laboratories due to economic and technical constraints. Most of the present day analyzers use Jaffe’s kinetic method without deproteinization. Though enzymatic methods are now routinely used as most accurate method but they are not acceptable due to cost constraints. Hence this study was planned to find out a possible solution to the problem of bilirubin interference by a minor modification in the commonly used Jaffe method so that it is amenable for use on the currently used analyzers.  相似文献   

Effect of Metformin on Hormonal and Biochemical Profile in PCOS Before and After Therapy     

Singh B  Panda S  Nanda R  Pati S  Mangaraj M  Sahu PK  Mohapatra PC 《Indian journal of clinical biochemistry : IJCB》2010,25(4):367-370

Insulin resistance and the resultant hyperinsulinemia exacerbate the reproductive abnormalities of Polycystic Ovarian Syndrome by increasing ovarian androgen productions and decreasing serum sex hormone binding globulin. The present study was conducted to estimate serum insulin and testosterone level in 44 PCOS cases and 32 control patients. Simultaneously the role of metformin (an insulin sensitizing agent) in modulating insulin resistance and serum androgen level was also analyzed. A significant rise in serum insulin and testosterone (P < 0.001) was observed in cases in comparison to control. Fasting Plasma Glucose to insulin ratio, a marker of insulin resistance revealed a significant fall in PCOS group. Follow up of cases with metformin for 3 months revealed a significant fall in serum insulin (P < 0.05) with improvement in insulin resistance along with a nonsignificant fall in testosterone level. Serum insulin registered a significant positive correlation (P < 0.05) with serum testosterone revealing its etiological association. Thus administration of drugs ameliorating insulin levels is expected to provide new therapeutic modality for PCOS.  相似文献   

Creating the KM mindset: why is it so difficult?     

Smith  Heather  McKeen  James  Singh  Satyendra 《知识管理研究与实践》2010,8(2):112-120

Knowledge Management Research & Practice - The knowledge management (KM) mindset is a precursor to a knowledge-sharing culture. It is often assumed that developing a KM mindset is somewhat...  相似文献   

Liberalism,Parental Rights,Pupils’ Autonomy and Education     

Basil R. Singh 《Educational studies》1998,24(2):165-182

Liberals, from Mill to Rawls see personal autonomy as paramount in civil society. They see human dignity to consist essentially in personal autonomy, that is, ‘in the ability of each person to determine for himself or herself a view of the good life’ (Taylor, C. (1992) p. 27). Multiculturalism and “The Politics of Recognition” p. 57 (Princeton, Princeton University Press). This emphasis on personal autonomy underlies much of liberal emphasis on freedom of conscience, justice, rights and fairness. Its core thesis is that a just society seeks not to promote any particular view of the good life, but enables its citizens to pursue their own ends consistent with a similar liberty for all others. Yet, when some citizens in America attempted to pursue their own view of the good life, they came up against head‐on conflict with the liberal state. These groups saw civic education with its emphasis on individual choice, on reflecting and weighing of alternative viewpoints and on personal autonomy, as threatening to their way of life and to their fundamental religious beliefs, and consequently they challenged the state in the courts. What ensued raised profound educational problems for educating children, parental rights, and the right of the State in a liberal democratic society, which are discussed in this paper.  相似文献   

A poser     

Manpreet Singh 《Resonance》1998,3(10):99-99

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Ultrasound: A boon in the synthesis of organic compounds     

Vasundhara Singh  Kanwal Preet Kaur  Anupam Khurana  G. L. Kad 《Resonance》1998,3(9):56-60

The use of ultrasound for promoting chemical reactions is described.  相似文献   

Unsung heroes. Allow us to introduce: Roger Kaufman     

Lisa Singh  Sheryl Narahara 《Performance Improvement》2001,40(6):16-18

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