Carl Sandburg's 'Limited': the quality of response     

Anthony J. Black 《English in Education》1974,8(1):44-51

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Software briefs     

Lynn Cox 《Archives and Museum Informatics》1988,2(2):45-46

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MACOS Revisited     

Anthony Adams 《Cambridge Journal of Education》1974,4(3):104-113

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Evolution of Graduate Education in Electrical Engineering in Metropolitan Areas     

Giordano  Anthony B. 《Education, IRE Transactions on》1962,5(1):32-36

The evolution of graduate education in electrical engineering began in the early 1890' s and progressed at a rapid pace in the 1920' s, particularly in metropolitan areas conscious of community needs. In these areas, evening programs held the spotlight because of the ever-demanding need to provide graduate engineers with advanced knowledge. Such cooperation between community interests and colleges has resulted in a wide variety of patterns of part-time study on campus and, more recently, off campus. The later development is viewed with criticism in several educational circles although off-campus programs are filling tremendous requirements arising from industrial concentrations not within easy reach of a university or college. The evolution seems to indicate that off campus programs are not a passing fancy and that such requirements are very likely to be best satisfied in the long run by the establishment of graduate centers with a faculty in residence. As an example, the Polytechnic Graduate Center on Long Island is described. (The Center, actually located in Farmingdale, N. Y., began its operation on September 25, 1961, with a graduate student body of nearly 700 in day and evening programs involving advanced courses in Aerospace Engineering, Electrical Engineering, Electrophysics, Mathematics, Mechanical Engineering, Physics, and Industrial Management. Close to 150 part-time day students are attending on a released-time basis, in addition to 45 full-time students in residence.)  相似文献   

Change and experiment in sixth forms     

Anthony Adams 《Higher Education Quarterly》1968,23(1):56-65

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Geometrical effects in microfluidic-based microarrays for rapid, efficient single-cell capture of mammalian stem cells and plant cells     

Lawrenz A  Nason F  Cooper-White JJ 《Biomicrofluidics》2012,6(2):24112-2411217

In this paper, a detailed numerical and experimental investigation into the optimisation of hydrodynamic micro-trapping arrays for high-throughput capture of single polystyrene (PS) microparticles and three different types of live cells at trapping times of 30 min or less is described. Four different trap geometries (triangular, square, conical, and elliptical) were investigated within three different device generations, in which device architecture, channel geometry, inter-trap spacing, trap size, and trap density were varied. Numerical simulation confirmed that (1) the calculated device dimensions permitted partitioned flow between the main channel and the trap channel, and further, preferential flow through the trap channel in the absence of any obstruction; (2) different trap shapes, all having the same dimensional parameters in terms of depth, trapping channel lengths and widths, main channel lengths and widths, produce contrasting streamline plots and that the interaction of the fluid with the different geometries can produce areas of stagnated flow or distorted field lines; and (3) that once trapped, any motion of the trapped particle or cell or a shift in its configuration within the trap can result in significant increases in pressures on the cell surface and variations in the shear stress distribution across the cell’s surface. Numerical outcomes were then validated experimentally in terms of the impact of these variations in device design elements on the percent occupancy of the trapping array (with one or more particles or cells) within these targeted short timeframes. Limitations on obtaining high trap occupancies in the devices were shown to be primarily a result of particle aggregation, channel clogging and the trap aperture size. These limitations could be overcome somewhat by optimisation of these device design elements and other operational variables, such as the average carrier fluid velocity. For example, for the 20 μm polystyrene microparticles, the number of filled traps increased from 32% to 42% during 5–10 min experiments in devices with smaller apertures. Similarly, a 40%–60% reduction in trapping channel size resulted in an increase in the amount of filled traps, from 0% to almost 90% in 10 min, for the human bone marrow derived mesenchymal stem cells, and 15%–85% in 15 min for the human embryonic stem cells. Last, a reduction of the average carrier fluid velocity by 50% resulted in an increase from 80% to 92% occupancy of single algae cells in traps. Interestingly, changes in the physical properties of the species being trapped also had a substantial impact, as regardless of the trap shape, higher percent occupancies were observed with cells compared to single PS microparticles in the same device, even though they are of approximately the same size. This investigation showed that in microfluidic single cell capture arrays, the trap shape that maximizes cell viability is not necessarily the most efficient for high-speed single cell capture. However, high-speed trapping configurations for delicate mammalian cells are possible but must be optimised for each cell type and designed principally in accordance with the trap size to cell size ratio.  相似文献   

A microfluidic device for on-chip agarose microbead generation with ultralow reagent consumption     

Linda Desbois  Adrien Padirac  Shohei Kaneda  Anthony J. Genot  Yannick Rondelez  Didier Hober  Dominique Collard  Teruo Fujii 《Biomicrofluidics》2012,6(4)

Water-in-oil microdroplets offer microreactors for compartmentalized biochemical reactions with high throughput. Recently, the combination with a sol-gel switch ability, using agarose-in-oil microdroplets, has increased the range of possible applications, allowing for example the capture of amplicons in the gel phase for the preservation of monoclonality during a PCR reaction. Here, we report a new method for generating such agarose-in-oil microdroplets on a microfluidic device, with minimized inlet dead volume, on-chip cooling, and in situ monitoring of biochemical reactions within the gelified microbeads. We used a flow-focusing microchannel network and successfully generated agarose microdroplets at room temperature using the “push-pull” method. This method consists in pushing the oil continuous phase only, while suction is applied to the device outlet. The agarose phase present at the inlet is thus aspirated in the device, and segmented in microdroplets. The cooling system consists of two copper wires embedded in the microfluidic device. The transition from agarose microdroplets to microbeads provides additional stability and facilitated manipulation. We demonstrate the potential of this method by performing on-chip a temperature-triggered DNA isothermal amplification in agarose microbeads. Our device thus provides a new way to generate microbeads with high throughput and no dead volume for biochemical applications.  相似文献   

Dancers with patellar tendinopathy exhibit higher vertical and braking ground reaction forces during landing     

Fietzer AL  Chang YJ  Kulig K 《Journal of sports sciences》2012,30(11):1157-1163

Dancers are exposed to the effects of repetitive jumping and leaping as are other athletes that tend to develop patellar tendinopathy. Greater vertical ground reaction forces occur during landing from a dance leap than during takeoff and during other common athletic activities. The purposes of this study were: (1) to compare the landing ground reaction force profiles of participants with and without clinically diagnosed patellar tendinopathy, and (2) to determine the strength of the relationship between landing angle, and braking impulse. Eighteen elite pre-professional dancers (12 healthy, 6 with patellar tendinopathy; both groups 50% male) performed sauts de chat for kinetic and kinematic analysis. Dancers with patellar tendinopathy demonstrated greater peak vertical ground reaction force and impulse (36% and 15% greater, respectively). Dancers with patellar tendinopathy demonstrated greater peak braking ground reaction force and impulse (82% and 126% greater, respectively). Landing angle explained 67% of the braking impulse. Dancers with patellar tendinopathy exhibited greater vertical and braking impulses than healthy dancers. Braking impulse was strongly correlated with landing angle. While there was no difference between groups in landing angle, dancers with patellar tendinopathy exhibited greater braking impulse than their non-tendinopathic counterparts, even at similar landing angles.  相似文献   

Active relatives and health-related physical fitness in European adolescents: The HELENA Study     

M Martín-Matillas  FB Ortega  JR Ruiz  D Martínez-Gómez  G Vicente-Rodríguez  A Marcos  L Béghin  A Kafatos  M González-Gross  M Zaccaria  D Molnár  S De Henauw  M Sjöström  LA Moreno  MJ Castillo On Behalf Of The Helena Study 《Journal of sports sciences》2012,30(13):1329-1335

Abstract High physical fitness in childhood and adolescence is positively associated with favourable health-related outcomes. Our aim was to examine the relationship between relatives' (father, mother, brother, sister, and best friend) physical activity engagement and encouragement on adolescents' physical fitness. Adolescents were part of the HELENA study, a multi-centre study conducted in 10 cities from nine European countries in 2006-2008. Participants were 3288 adolescents (48% boys, 52% girls) aged 12.5-17.5 years with valid data on at least one of the three fitness variables studied: muscular strength (standing long jump), speed/agility (4×10 m shuttle run), and cardiorespiratory fitness (20 m shuttle run). The adolescents reported their relatives' physical activity engagement and encouragement. Analysis of covariance showed that relatives' physical activity engagement (father, mother, brother, and best friend) was positively related to cardiorespiratory fitness (P?相似文献   

Information literacy and library attitudes of occupational therapy students     

Kipnis DG  Frisby AJ 《Medical reference services quarterly》2006,25(4):11-20

Information literacy, often described as a person's ability to effectively find and evaluate answers to questions using a variety of information resources, is of particular importance to health care workers. This paper presents the results of an information literacy survey presented to occupational therapy (OT) students at Thomas Jefferson University during a series of required class activities. Also described are the authors' activities with the faculty and courses at Jefferson. The survey was made available to first-, second-, third-, and fourth-year occupational therapy students along with nursing students and pharmacy students. The survey is designed to identify research habits, skills, and preferences. Results confirm some commonly held perceptions about searching skills of young adults and an interesting dichotomy in students' learning habits. The paper concludes with a discussion of recommendations to OT faculty and librarians on how to improve information literacy education. The survey can be obtained by contacting the authors.  相似文献