Modulation of an activity response with associative and nonassociative fear in the rat: A lighting differential influences the form of defensive behavior evoked after fear conditioning     

Godsil BP  Blackmore MA  Fanselow MS 《Learning & behavior》2005,33(4):454-463

Rats confronted with the onset of a light gradient display a transient increase in locomotion called theactivity response (AR) and a dark preference (Godsil & Fanselow, 2004). These experiments demonstrate that the magnitude of the AR can be blunted with Pavlovian fear-conditioning procedures via associative and nonassociative fear. Although manifested in decreased locomotion, the blunted AR effect was not due to increased freezing or immobility behaviors. Instead, rats displayed reduced rearing and an increase in a class of behaviors calledstationary activity. These results suggest that the lighting differential supplied by the cue influences the topography of defensive behavior and reduces the expression of freezing. This procedure provides a means by which to examine learned and unlearned defensive responses to the same stimulus.  相似文献   

An investigation of the Gregorian chronology of early Islamic history : A Pilot Study     

Shaykh Muhammad al‐casnazāni al‐Husseini  Jamāl N. Hussein  Shetha al‐Dargazelli  Hamid M. An‐Ni'aymi  Louay J. Fatoohi 《Al-Masaq: Islam & the Medieval Mediterranean》1994,7(1):227-266

This pilot study presents a lunar and Gregorian chronology of the Sira, that is the biography of the prophet Muhammad. The paper discusses the problems surrounding the chronology of very early Islamic history, namely, the pre‐Hijra era. This history is not covered by the Hijra calendar, and therefore, historians dated its events using other primitive dating systems, resulting in considerable difficulties and inaccuracies when comparing Gregorian dates of this early Islamic history. In order to overcome this problem and establish an accurate chronology of the early Islamic history, the introduction of a new lunar calendar (the Muhammadi calendar) which starts with the birth month and year of the prophet Muhammad, and covers all Islamic history including the pre‐Hijra era, is suggested. The Muhammadi calendar was used to study the earliest three versions of the Sira. All dated events of the Sira were compiled from these sources and presented, for the first time, according to their historical order. The Muhammadi dates of these events were then calculated. For the first time, a computer program was designed to convert the Muliammadi dates to their Christian equivalent. The program was then used to compute the Gregorian dates of the events of the Sira.  相似文献   

Root causes of errant ordered radiology exams: Results of a needs assessment     

Benjamin D. Duman  Seung Youn Chyung  Steven W. Villachica  Donald Winiecki 《Performance Improvement》2011,50(1):17-24

A comprehensive needs assessment was conducted at ATA hospital to determine the root causes of a high number of errant radiology orders from requesting physicians. The Human Performance Technology Model, Gilbert's Behavior Engineering Model, and Rummler and Brache's Nine Performance Variables Model guided the needs assessment process. Three solutions were proposed. The development of the long‐term solution, a software utility, has been initiated. The Behavior Engineering Model was used to identify possible solutions to post‐training performance gaps identified during the evaluation.  相似文献   

Various Anticoagulants and Fluoride do not Affect HbA1C Level     

Maneesh Mailankot  Thushara Thomas  P. Praveena  Juliet Jacob  Jobin Rajan Benjamin  D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2012,27(2):209-209

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Study of C-Reactive Protein and Myocardial Infarction in the Indian Population     

Kavita Shalia  Sudha Savant  Vijaya A. Haldankar  Tulip Nandu  Poonam Pawar  Siddhi Divekar  V. K. Shah  Purvi Bhatt 《Indian journal of clinical biochemistry : IJCB》2012,27(1):74-82

To analyse the association of high sensitivity C-reactive (hsCRP) protein levels and −717A/G single nucleotide polymorphism of CRP with acute myocardial infarction (AMI) in the Indian population. Study population included 100 MI cases wherein 32 patients had experienced previous MI (MI-Group-1), 68 MI cases were recruited at presentation (MI-Group-2) and equal number of age and gender matched healthy individuals. hsCRP levels were determined by ELISA and genotyping of −717A/G was carried out by polymerase chain reaction-based restriction digestion method. The −717A/G genotypes did not influence hsCRP level and their distribution did not differ between groups. However, in the present study hsCRP demonstrated significant correlation with BMI in controls of both the genders and with triglycerides in females of AMI at presentation who otherwise are with low risk profile. Identifying traditional risk factors associated with inflammation may help in controlling the acute event.  相似文献   

A Comparative Study of Bone Scan Findings and Serum Levels of Tumor Marker CA15-3 in Patients with Breast Carcinoma     

Meera S. Ghadge  Purva P. Naik  Bijaynath P. Tiwari  Ruprekha M. Hegde  Tanaji J. Matale 《Indian journal of clinical biochemistry : IJCB》2012,27(1):97-99

Breast cancer is one of the most frequent malignancies in the world. Available staging procedures to detect breast cancer are bone scan, chest X-ray, liver ultrasonography, computerized tomography, estimation of tumor markers like carbohydrate antigen (CA15-3) and carcino embryonic antigen. These procedures are expensive and may not be required in all cases. Out of 70 patients studied, 55 had normal CA15-3 and 15 had elevated levels of Ca15-3. Eight (14.5%) of the 55 patients with normal CA15-3 had abnormal bone scan. Fifteen patients had CA15-3 levels above the normal range and among these 9 (60%) had abnormal bone scan. While prime facie it would appear that a high level of CA15-3 correlate with abnormal bone scan, it is also true that the numbers are small at present and conclusions about the validity of CA15-3 as marker of bone metastasis may be premature.  相似文献   

Current status and development of percutaneous coronary intervention in China     

Yong Huo 《Journal of Zhejiang University. Science. B》2010,11(8):631-633

##正##Dr.Gruntzig et al.(1979) successfully completed the world's first percutaneous coronary intervention (PCI),a percutaneous transluminal coronary  相似文献   

Mathematical models of canine right and left atria cardiomyocytes     

Ling Xia  Ying-lan Gong  Xiu-wei Zhu  Yu Zhang  Qi Sun  Heng-gui Zhang 《Journal of Zhejiang University. Science. B》2010,11(6):402-416

The aim of this study is to build two mathematical models of canine ionic currents specific to right atria and left atria.The canine left atria mathematical model was firstly modified from the Ramirez-Nattel-Courtemanche(RNC) model using the recently available experimental data of ionic currents and was further developed based on our own experimental data.A model of right atria was then built by considering the differences between right atria and left atria.The two developed models well reproduced the exper...  相似文献   

Neurochip based on light-addressable potentiometric sensor with wavelet transform de-noising     

Qing-jun Liu  Wei-wei Ye  Hui Yu  Ning Hu  Li-ping Du  Ping Wang 《Journal of Zhejiang University. Science. B》2010,11(5):323-331

Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.Here we report a kind of neurochip with rat pheochromocytoma(PC12) cells hybrid with LAPS and a method of de-noising signals based on wavelet transform.Cells were cultured on LAPS for several days to form networks,and we then used LAPS system to detect the extracellular potentials with signals d...  相似文献   

Congenital atresia of the left main coronary artery in an infant     

Su Ye Sohn  Gi Young Jang  Byung Min Choi 《Journal of Zhejiang University. Science. B》2010,11(7):539-541

Congenital atresia of the left main coronary artery is a rare occurrence, and surgical revascularizationbypass graft is required. We here report a rare case of congenital coronary anomaly in an infant. A 10-month-old male infant was admitted to the hospital with heart failure symptoms. Echocardiographic examinations revealed mitral valve regurgitation and ischemic changes of the anterolateral papillary muscle and chordae. Coronary angiography showed atresia of the left main coronary artery with a severe hypoplastic left anterior descending artery and a circumflex coronary artery. Unfortunately, sudden cardiac arrest occurred after catheterization and the infant did not recover despite of immediate cardiopulmonary resuscitation. Further studies are needed to find a newer diagnostic method to detect coronary anomaly in an infant, and coronary angiography, if necessary, has to be performed very carefully.  相似文献