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Rinchen D Bhutia Bhumika Upadhyay M Maneesh 《Indian journal of clinical biochemistry : IJCB》2006,21(2):39-41
The present study was designed to determine the association between extent of hepatocellular injury and plasma level of thiobarbituric
acid reactive substances (TBARS) in pre term infants with cholestasis. Preterm infants (<35 weeks gestation) admitted to the
neonatal intensive care unit were enrolled (with their parents informed consent) in either the ‘cholestasis’ group (if their
direct bilirubin was >2 mg/dl) (n=25) or in the control group (n=16). Blood samples for measurement of TBARS, direct bilirubin
and transaminases were obtained with-in 24 hours of enrollment. The cholestasis and control groups were comparable with respect
to gestational age, birth weight and Apgar score. Serum direct bilirubin, SGOT (EC 2.6.1.1) and SGPT (EC 2.6.1.2) levels were
significantly high in the cholestasis group. Plasma levels of TBARS in cholestasis group were correlated with SGOT (F=276.92;
P<0.0001) and SGPT (F=355.17; P<0.0001) and differed significantly between cholestatic and control infants. Our findings suggest
that oxidative stress in preterm infants with cholestasis is associated with hepatocellular injury. 相似文献
2.
M. Maneesh Sanjiba Dutta Amit Chakrabarti D M Vasudevan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):138-142
Infertility is well-established harmful effect in chronic alcoholism and so far, there is no effective treatment for this
condition. The study was conducted to determine the effects of alpha tocopherol on ethanol induced testicular injuries in
male albino rats of Wistar strain. Five groups (n=6) of animals were used. Group I served as control. Group II received daily
1.6g ethanol/kg body weight/day for 4 weeks orally. Group III received 1.6g ethanol+80mg alpha tocopherol/kg body weight/day
for four weeks orally. Group IV received 1.6g ethanol/kg body weight for/day 4 weeks and followed by 80mg alpha tocopherol/kg
body weight/day for four weeks orally. Group V received 1.6g ethanol/kg body weight/day orally for 4 weeks, followed by 4
weeks abstinence. Twently-four hours after the last treatment the rats were sacrificed using anesthetic ether. Testes were
removed and used for the estimation of extent of lipid peroxidation and tissue levels of antioxidants and steroidogenic enzymes.
Alpha tocopherol treatment increased the activities of testicularΔ
5, 3β-HSD. Moreover, the treatment was also associated with significant decrease in testicular oxidative stress. Ethanol-induced
oxidative stress and decreased steroidogenesis can be reversed by treatment with alpha tocopherol. 相似文献
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M. Maneesh H. Jayalakshmi T A Singh Amit Chakrabarti 《Indian journal of clinical biochemistry : IJCB》2006,21(1):165-168
In view of association of diabetes mellitus and male infertility, present study was designed to investigate the functional
status of hypothalamic pituitary gonadal (HPG) axis in diabetic men. Thirty-five diabetic men (BMI 22.24±0.21) in the age
group 20–40 (30.6±4.7) years were selected. Twenty-five healthy men (BMI 23.85±0.25), in the same age group (29.5±4.8) served
as control. Blood samples were collected for hormonal and biochemical estimations. Diabetic men had significantly low serum
testosterone with low LH and FSH, hypercholesterolemia, hypertriglyceridemia, hypoalbuminemia and increased oxidative stress.
Low serum testosterone in diabetic men was accompanied by low LH and FSH; the inability of the pituitary gland to respond
appropriately to a decline in testosterone implying central effect of high serum glucose on the interaction between the nervous
and endocrine system. Nutritional deficiency, increased oxidative stress and increased aromatase activity due to excessive
body fat might have also contributed to low serum testosterone. 相似文献
5.
Maneesh Mailankot H. Jayalekshmi Amit Chakrabarti D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2009,24(1):94-97
To investigate reversibility of ethanol induced testicular injuries on treatment with L-ornithine-L-aspartate, male Wistar
rats were treated with ethanol (1.6g/kg b.wt/day) and L-ornithine- L-aspartate (200mg/kg b.wt/ day) for 4 weeks. L-ornithine-L-aspartate
effectively prevented the ethanol induced body and testes weight reduction; changes in testicular weight well correlated with
body weight. Drug exhibited an ability to counteract ethanol induced oxidative challenge as it effectively reduced testicular
TBARS and increased tissue ascorbic acid, GSH and activities of superoxide dismutase, catalase, GSH-Red and Se-GSH-Px. However
the drug didn’t show promising effect on inhibitory effect of ethanol on testicular D5, 3-beta and 17-beta HSD (hydroxy steroid
dehydrogenase). 相似文献
6.
The excessive generation of reactive oxygen species (ROS) by abnormal spermatozoa and contaminating leukocytes has been defined
as one of the few etiologies for male infertility. Administration of antioxidants in patients with ‘male factor’ infertility
has begun to attract considerable interest. The main difficulty of such an approach is our incomplete understanding of the
role of free radicals in normal and abnormal sperm function leading to male infertility. Mammalian spermatozoa membranes are
very sensitive to free radical induced damage mediated by lipid peroxidation, as they are rich in polyunsaturated fatty acids.
Limited endogenous mechanisms exist to reverse these damages. ROS attacks the fluidity of the sperm plasma membrane and the
integrity of DNA in the sperm nucleus. ROS induced DNA damage accelerate the germ cell apoptosis. Unfortunately spermatozoa
are unable to repair the damage induced by excessive ROS as they lack the cytoplasmic enzymes required to accomplish the repair.
Assessment of such oxidative stress status (OSS) may help in the medical treatment. Treatment strategies must be directed
toward lowering of ROS levels to keep only a small amount necessary to maintain normal cell function. 相似文献
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M Maneesh H Jayalekshmi Sanjiba Dutta Amit Chakrabarti D M Vasudevan 《Indian journal of clinical biochemistry : IJCB》2005,20(2):62-67
The study was undertaken to evaluate the possible involvement of oxidative stress in the pathogenesis of ethanol induced testicular
atrophy in rats. Adult male rats were orally administered ethanol at a dose of 1.6 g/kg body weight/day for four weeks. Twenty-four
hours after the last treatment the rats were sacrificed using anesthetic ether. Testes were removed and weighed. Apoptosis
was studied by using the Feulgen reaction on 5 μ thin paraffin sections of testis. Testicular homogenate was prepared and
centrifuged. The supernatant was used for the estimation of extent of lipid peroxidation and antioxidant defense status. There
was significant reduction in body weight: and in testicular weight and diameter in ethanol treated rats. Extent of germ cell
apoptosis was significantly high in ethanol treated rats. Ethanol treated rats showed significantly high tissue TBARS level
and glutathione S-transferase activity; and low tissue ascorbic acid, reduced glutathione, superoxide dismutase, catalase,
glutathione peroxidase and glutathione reductase activities. Chronic ethanol administration resulted in high oxidative stress
in the testes either due to increased extent of lipid peroxidation or due to decreased antioxidant defenses, and thereby induces
germ cell apoptosis leading to testicular atrophy. 相似文献
8.
M Maneesh H Jayalekshmi T Suma S Chatterjee A Chakrabarti T A Singh 《Indian journal of clinical biochemistry : IJCB》2005,20(1):129-130
Evidence of increased oxidative stress in patients of osteoarthritis in comparison with healthy control subjects was investigated
by measuring the thiobarbituric acid reactive substances (TBARS), vitamin C, reduced glutathione (GSH) and the activities
of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in erythrocytes. It was observed that osteoarthritis
patients were more susceptible to oxidative damage than controls as evident from increased TBARS and decreased ascorbic acid,
GSH, catalase and GPx in erythrocytes. Significant increase in SOD activity found in patients might be an adaptive response.
With the understanding of the role of antioxidants in arthritis, it is becoming increasingly clear that these agents seem
to be beneficial in osteoarthritis. 相似文献
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Rohith Valsalan Hazel gonsalves Maneesh Mailankot Navin Mulamani Shubha Sheshadri 《Indian journal of clinical biochemistry : IJCB》2009,24(4):436-438
Wolfram syndrome, a rare genetic disorder is characterized by juvenile onset diabetes mellitus and optic atrophy. We describe
two cases of wolfram syndrome belonging to same family; 25 year old female and her only 15 year old brother. In female, diabetes
mellitus and optic atrophy were manifested in 1st decade, diabetes insipidus in 2nd decade and hypoacusis at the age of 25 years. Her ophthalmic evaluation revealed bilateral optic atrophy, decreased vision
and peripheral constriction of visual field. However she didn’t have any renal dysfunction which is also considered to be
one of the features of the syndrome. Though associated psychiatric features are later manifestations of the syndrome she was
admitted with alleged suicidal consumption at the age of 25 years. The brother was asymptomatic except for the diabetes mellitus
and insipidus. 相似文献
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