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The effects of training on FNDC5/irisin and its association with fitness and metabolic marker improvements induced by training have been poorly investigated in humans. Thus, the present study assessed the effects of combined training (CT) on FNDC5/irisin levels, metabolic markers and fitness adaptations in obese men. Middle-age obese men (age 49.13?±?5.75, body mass index (BMI) 30.86?±?1.63) were randomly distributed in the CT group (n?=?12) and control group (CG n?=?10). The CT consisted of strength followed by aerobic training, 3 times/week, for 24 weeks. Body composition, physical fitness, plasma FNDC5/irisin, biochemical markers and metabolic scores/index were evaluated. CT maintained FNDC5/irisin levels (µg/mL) (pre: 4.15?±?0.32, post: 4.21?±?0.32; p?=?.96) and improved body composition, metabolic and physical fitness markers. In the CG, decreased FNDC5/irisin (µg/mL) (pre: 4.36?±?0.23, post: 3.57?±?0.94; p?=?.01) and reduced strength (supine exercise/kg) (pre: 71?±?14.7, post: 60.1?±?14.05; p?<?.01) were observed, along with a trend to increase HOMA-IR (pre: 2.63?±?1.11, post: 3.14?±?1.27; p?=?.07) and other indicators of metabolic deterioration. An inverse correlation was found between the change (Δ%) in levels of FNDC5/irisin and Δ% glucose, Δ% total cholesterol, Δ% triglycerides and Δ% waist circumference, in addition to a positive relation with Δ% muscle strength. In conclusion, CT maintained FNDC5/irisin levels and provided metabolic and fitness benefits. The correlation between FNDC5/irisin changes and metabolic parameters, as well as the FNDC5/irisin reduction associated with fitness and metabolic worsening in the CG, suggests a relationship between FNDC5/irisin and a healthy metabolic status in humans.  相似文献   
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Purpose: This study was a 2-phase activist research project aimed at co-creating a prototype pedagogical model for working with youth from socially vulnerable backgrounds in a sport context. This article addresses the learning aspirations (learning outcomes) that emerged when we created spaces for youth to develop strategies to manage the risks they face in their community. Method: This study took place in a socially and economically disadvantaged neighborhood in a Brazilian city where we worked with a group of 17 boys aged 13 to 15 years old, 4 coaches, a pedagogic coordinator, and a social worker. During a 6-month period, we collected multiple sources of data including field journal entries/observations (38) and audio records of youth work sessions (18), coaches' work sessions (16), combined coaches and youth work sessions (3), and meetings between the lead and the 2nd author for debriefing and planning sessions (36). Results: By using an activist approach, 4 learning aspirations emerged: becoming responsible/committed, learning from mistakes, valuing each other's knowledge, and communicating with others. Conclusion: Findings suggest there is a need for more sports programs that start from young people's concrete needs and life situations and look to create places for youth to see alternative possibilities and take action.  相似文献   
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The aim of this study was to assess the validity (Study 1) and reliability (Study 2) of a novel intermittent running test (Carminatti's test) for physiological assessment of soccer players. In Study 1, 28 players performed Carminatti's test, a repeated sprint ability test, and an intermittent treadmill test. In Study 2, 24 players performed Carminatti's test twice within 72 h to determine test-retest reliability. Carminatti's test required the participants to complete repeated bouts of 5 × 12 s shuttle running at progressively faster speeds until volitional exhaustion. The 12 s bouts were separated by 6 s recovery periods, making each stage 90 s in duration. The initial running distance was set at 15 m and was increased by 1 m at each stage (90 s). The repeated sprint ability test required the participants to perform 7 × 34.2 m maximal effort sprints separated by 25 s recovery. During the intermittent treadmill test, the initial velocity of 9.0 km · h(-1) was increased by 1.2 km · h(-1) every 3 min until volitional exhaustion. No significant difference (P > 0.05) was observed between Carminatti's test peak running velocity and speed at VO(2max) (v-VO(2max)). Peak running velocity in Carminatti's test was strongly correlated with v-VO(2max) (r = 0.74, P < 0.01), and highly associated with velocity at the onset of blood lactate accumulation (r = 0.63, P < 0.01). Mean sprint time was strongly associated with peak running velocity in Carminatti's test (r = -0.71, P < 0.01). The intraclass correlation was 0.94 with a coefficient of variation of 1.4%. In conclusion, Carminatti's test appears to be avalid and reliable measure of physical fitness and of the ability to perform intermittent high-intensity exercise in soccer players.  相似文献   
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This paper studies parameter estimation for a class of linear, continuous, time-varying dynamic systems whose state-space model's matrices are affine combinations of static matrix coefficients and the aforementioned time-varying scalar parameters. It is assumed that the coefficient matrices are all known, that the state is mensurable, and that the parameters are bounded piecewise continuous functions of time. Estimation methods are developed from basic equations for a single parameter first, and later extended to multiple parameters.  相似文献   
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The quasi-totality of social scientists who studied screening for cervical tumours identified such screening with a single method: the Pap smear (exfoliative cytology). This article explains that this method was not valid everywhere. The history of screening for cervical cancer in Brazil displays an alternative method for detecting cervical malignancies: a direct observation of the cervix with a specific instrument--the colposcope. The development of this method in Brazil in the 1940s and 1950s reflected a complex mixture of professional interests, government policies, and regional, local and charitable initiatives. While the use of colposcopy for cervical tumour screening was phased out in the 1970s and 1980s, the long lifespan and widespread diffusion of this method illuminates the irreducible contingency of specific developments in science, technology and medicine. Seen from the vantage point of Brazil, the Western model for preventing cervical malignancies no longer appears self-evident Alternative choices might have led to the development of different material and visual cultures of medicine, stimulated different patterns of medical specialization and division of medical labour, produced different links between malignancies, women, gynaecologists, epidemiologists and public health experts, and shaped different health policies.  相似文献   
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ABSTRACT

We used collective analytical autoethnography (CAAE) to investigate experiences of academic bullying and mobbing in our study. Specifically, four autoethnographers shared and analyzed personal experiences of being mobbed and bullied, described their perceptions of workplace bullying, its manifestations, and explored the emotional, social, psychological and career consequences associated with being bullied and mobbed at work. In addition, the autoethnographers reflected on different resources used to cope with mobbing and bullying experiences and revealed – peer mentorship and social support – as instrumental in helping them cope with both the physical and emotional distresses associated with the bullying and mobbing experiences. Implications from the findings and suggestions for future research are also presented.  相似文献   
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Cooperative organization has been proposed as a means to improve the usefulness of virtual libraries. Information interchange among library and other academic applications is often hindered by the lack of application interoperability. This hindrance may be overcome through the development of standards that allow for digital libraries to exchange and share information with other applications. The Graduate Program in Production Engineering (PPGEP) of the Federal University of Santa Catarina (UFSC) launched its Theses and Dissertations Bank (BTD) in 1995. BTD is possibly the first online academic digital library of theses. From a digital document repository, BTD evolved into a system that combines bibliometry and informetry features. BTD is used by students and faculty in their research activities, but also by decision makers from industry and academia. They use it, respectively, to search for specialists and to measure interest and knowledge interchange among PPGEP research areas. This article presents the history, features, and development prospects for the BTD project. The integration of BTD with other academic applications, especially those of the Brazilian national science and technology platform, is emphasized.  相似文献   
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In Brazil, the transition to corporate management of soccer clubs started in the 1990s. When the ‘Lei Pelé’ was enacted in 1998, expectations were very high that the Brazilian clubs would become modernized institutions capable of surviving in the recently developed soccer business. However, the results that clubs reported in their financial statements a decade later do not show the desirable evolution. This essay looks back at this modernization process while analysing the clubs’ results and their financial ratios with the aim of understanding their main difficulties and how successful they have been in trying to modernize.  相似文献   
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