Evaluation of FSH,LH and testosterone levels in different subgroups of infertile males     

S. Ramesh Babu  M. D. Sadhnani  M. Swarna  P. Padmavathi  P. P. Reddy 《Indian journal of clinical biochemistry : IJCB》2004,19(1):45-49

Gonadotropins (FSH, LH) and testosterone are the prime regulators of germ cell development. Abnormal spermatogenesis is often associated with altered serum gonadotropins and testosterone. FSH, LH and testosterone levels were estimated in 96 infertile men of whom 35 were azoospermic, 35 were oligozoospermic, 11 were with varicocele and 15 were with histopathological abnormalities like hypospermatogenesis, spermatid arrest and sertoli-cell only syndrome. Results showed statistically significant (p<0.05), increase in the mean FSH and LH levels in all the infertile males studied when compared with the fertile controls (n=35). However, there is no significant difference in the mean levels of testosterone between the infertile and fertile men.  相似文献   

Hypolipidemic Activity of Cassia tora Seeds in Hyperlipidemic Rats     

Vishnu Kumar Awasthi  Farzana Mahdi  Ramesh Chander  Ashok Kumar Khanna  Jitendra Kumar Saxena  Ranjana Singh  Abbas Ali Mahdi  Raj Kumar Singh 《Indian journal of clinical biochemistry : IJCB》2015,30(1):78-83

The hypolipidemic activity of Cassia tora (Chakvat, Chakunda) (Family: Caesalpiniaceae) seeds extract have been studied in two models of hyperlipidemia in rats. In an acute model, hyperlipidemia was induced by injecting a single dose of Triton WR-1339 (400 mg/kg, b.w.) intraperitonially in rats. Feeding with C. tora seed extract at the dose of 500 mg/kg, b.w. exerted significant lipid lowering effect as assessed by the reversal of plasma levels of total cholesterol, phospholipids, triglyceride and reactivation of post heparin lipolytic activity. In the chronic model, hyperlipidemia was induced by feeding with cholesterol rich-HFD in rats. The treatment with seeds extract of C. tora (500 mg/kg, b.w.) simultaneously for 15 days also caused lowering of lipid levels in plasma and liver following reactivation of plasma post heparin lipolytic activity and hepatic lipoprotein lipase activity in animals. The hypolipidemic activity of C. tora seeds was compared with a standard drug guggulipid (200 mg/kg, b.w.) in both models.  相似文献   

Efficacy of Turmeric as Adjuvant Therapy?in Type 2 Diabetic Patients     

N. Maithili Karpaga Selvi  M. G. Sridhar  R. P. Swaminathan  R. Sripradha 《Indian journal of clinical biochemistry : IJCB》2015,30(2):180-186

It is known that there is a significant interplay of insulin resistance, oxidative stress, dyslipidemia, and inflammation in type 2 diabetes mellitus (T2DM). The study was undertaken to investigate the effect of turmeric as an adjuvant to anti-diabetic therapy. Sixty diabetic subjects on metformin therapy were recruited and randomized into two groups (30 each). Group I received standard metformin treatment while group II was on standard metformin therapy with turmeric (2 g) supplements for 4 weeks. The biochemical parameters were assessed at the time of recruitment for study and after 4 weeks of treatment. Turmeric supplementation in metformin treated type 2 diabetic patient significantly decreased fasting glucose (95 ± 11.4 mg/dl, P < 0.001) and HbA1c levels (7.4 ± 0.9 %, P < 0.05). Turmeric administered group showed reduction in lipid peroxidation, MDA (0.51 ± 0.11 µmol/l, P < 0.05) and enhanced total antioxidant status (511 ± 70 µmol/l, P < 0.05). Turmeric also exhibited beneficial effects on dyslipidemia LDL cholesterol (113.2 ± 15.3 mg/dl, P < 0.01), non HDL cholesterol (138.3 ± 12.1 mg/dl, P < 0.05) and LDL/HDL ratio (3.01 ± 0.61, P < 0.01) and reduced inflammatory marker, hsCRP (3.4 ± 2.0 mg/dl, P < 0.05). Turmeric supplementation as an adjuvant to T2DM on metformin treatment had a beneficial effect on blood glucose, oxidative stress and inflammation.  相似文献   

Cadmium, carcinogen, co-carcinogen and anti carcinogen     

Ramesh Chandra  Sujata K. Dass  Priyanka Tomar  Manisha Tiwari 《Indian journal of clinical biochemistry : IJCB》2001,16(2):145-152

As a stress agent, inducing apoptosis and blocking it, Cd can have both helpful and harmful effects. The atmosphere is a thin envelope which makes the worid a global village. Cd is the most toxic metal in air. As both the first and second messenger of the stress response, it is synergistically toxic with all other stressors, including many other carcinogens. Elimination of Pb and its replacement with added benzene in gasoline appears to have increased the toxicity of atmospheric Cd. With scientific understanding of the molecular basis of Cd's role in carcinogenesis and anti-carcinogenesis, primary cancer prevention can be practiced by reducing Cd and chemical air pollution and educating the public on smoke cessation, healthy eating habits and stress reduction. Using the existing information on Cd and its effects, determinations could be made on established cancers so that individualized treatment protocols can be developed to improve patient care.  相似文献   

Effects of some antituberculous and anti-leprotic drugs on cathepsins B,H and L     

Ramesh C. Kamboj  Neera Raghav  Ashwani Mittal  Shiwani Khurana  Rachna Sadana  Hari Singh 《Indian journal of clinical biochemistry : IJCB》2003,18(2):39-47

The cysteine proteinases like cathepsins B, L and H are main hydrolytic enzymes present in lysosomes and play an important role in intracellular protein degradation. Tuberculosis and leprosy, both are tissue- destructive diseases. Main drugs used in chemotherapy of these diseases may inhibit the main lysosomal cysteine proteinases i.e. cathepsins B, L and H released during tissue destruction and thus prevent the further destruction of tissue by these enzymes. So the aim of this study is to see the effect of antituberculous and antileprotic drugs on these proteolytic enzymes. The effect of commonly used antituberculous and antileprotic drugs was screened on the activities of purified brain lysosomal cysteine proteinases namely cathepsins B [EC 3.4.22.1], L [EC 3.4.22.15] and H [EC 3.4.22.16]. Among the antileprotic drugs, only clofazimine inhibited the enzymic activities whereas dapsone had no effect whatsoever. In antituberculous drugs, rifampicin was the most inhibitory while isoniazid had little inhibitory potency. Streptomycin and pyrazinamide did not effect the activities at all. As regards the mechanism of inhibition, clofazimine and isoniazid inhibited the enzymes in a non-competitive manner with K values of 0.25 mM and 5.0 mM for cathepsin B, 0.071 mM and 0.833 mM for cathepsin L and 1.513 mM and 0.885 mM for cathepsin H, While rifampicin could effect in a competitive manner with K_i values of 0.03 mM, 0.125 mM and 0.027 mM for cathepsin B, L and H respectively.  相似文献   

Wegener and his Theory of continental drift     

Ramesh Chander 《Resonance》2005,10(12):58-75

Alfred Wegener, an astronomer by training and meteorologist by profession, visualised that there was once a single very large landmass on the surface of the earth. Gradually it broke up into smaller fragments which drifted away to form the present continents. In a few cases, the drifting fragments subsequently collided, coalesced and formed larger landmasses again. Wegener could thus explain in a simple way (i) similarities in shapes of continental coast lines separated by wide oceans, (ii) similarities in the rocks and fossils occurring on such coasts and in the fauna and flora inhabiting them, (iii) the formation of several major mountain ranges of the world, and (iv) the evidence in rocks on past climates of the earth.  相似文献   

Developments in statistical education     

Ramesh Kapadia 《Educational Studies in Mathematics》1980,11(4):443-461

This paper describes recent work carried out by the Schools Council Project on Statistical Education. The Project advocates a problem-solving approach towards the teaching of statistics in secondary schools (11–16 years age range). It sees statistics as an interdisciplinary subject primarily concerned with data. The article illustrates these important aspects with teaching materials which have been developed and tested extensively in a variety of schools. Finally an evaluation and assessment of the project's work is presented.The author worked with the project for three and a half years and has made extensive use of working documents produced by the project team in preparing this paper. He would particularly like to thank the director, Mr. Peter Holmes, for permitting the use of these documents. The author was formerly at the School Council Project on Statistical Education, University of Sheffield, Sheffield, England and is now at the Mathematics Department, Polytechnic of the South Bank, London SE1 0AA, England.  相似文献   

The debate about the age of the earth     

Ramesh Chander 《Resonance》1999,4(5):52-60

Kelvin and the geologists argued about the age of the earth for nearly four decades. But the fate of Kelvin’s view was sealed when the results of research on radioactivity became available at the beginning of the twentieth century.  相似文献   

Serum levels of bone alkaline phosphatase in breast and prostate cancers with bone metastasis     

Girija Ramaswamy  Vasanti R. Rao  Lakshmi Krishnamoorthy  G. Ramesh  R. Gomathy  D. Renukadevi 《Indian journal of clinical biochemistry : IJCB》2000,15(2):110-113

BALP activity in the sera of metastatic patients of breast and prostate malignancy has increased significantly. Our studies with patients in India conform the earlier reports that BALP may have a useful complementary role in the early diagnosis of bone metastases.  相似文献   

Inhibitory effect of metalloporphyrins in conjunction with cholesterol on hepatic phospholipase A2 activityin vivo in rats     

Ramesh Chandra  Manisha Tiwari  Ritu Aneja  Sujata K. Dass  Archana Sharma 《Indian journal of clinical biochemistry : IJCB》2000,15(2):148-154

We investigated the effect of cholesterol and the metalloporphyrins cobalt mesoporphyrin (CoMP) and chromium protoporphyrin (CrPP) on phospholipase A₂ (PLA₂) activity and the consequent hepatic mitochondrial stability as well as on lipid concentrations. Our studies revealed that on administration of cholesterol, CrPP, CoMP as well as simultaneous adminstration of cholesterol and CrPP, there was an inhibition of PLA₂ activity. These moieties may therefore, be agents for preventing destabilisation of the mitochondrial membrane and the consequent pathological conditions which may arise due to membrane lysis. Our results revealed that cholesterol administration increased phospholipid concentration, albeit by modest amounts. Although the independent administration of metalloporphyrins led only to minor elevations in phospholipid concentration, the simultaneous administration of cholesterol and CrPP generated a steep elevation in the concentration of total phospholipid. Since cholesterol inhibits PLA₂ activity it has the potential of being therapeutic agent for preventing the pathological conditions which may arise due to membrane lysis.  相似文献