Impact of age on host responses to diet-induced obesity:Development of joint damage and metabolic set points     

Kelsey H.Collins  Graham Z.MacDonald  David A.Hart  Ruth A.Seerattan  Jaqueline L.Rios  Raylene A.Reimer  Walter Herzog 《运动与健康科学(英文)》2020,9(2):132-139,197

Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also obese.In recent years,a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage(both with and without the superimposition of trauma),which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory mediators.Of note,there is a disparity between whether the dietary challenges commence at weaning,representing a weanling onset,or at skeletal maturity,representing an adult onset of obesity.We wished to evaluate the effect ofthe dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose(HFS) diet to determine whether these factors may result in disparate outcomes,as there is evidence suggesting that these factors result in differential metabolic disturbances.Based on dietary exposure time,we hypothesized that rats fed an HFS diet for 14 weeks from weaning(HFS Weanling) would demonstrate an increase in knee joint damage scores,whereas rats exposed to the HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult) and rats exposed to a standard chow diet(Chow)would not display an increase in knee joint damage scores.Methods:Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning(HFS Weanling) or an HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult).At sacrifice,joints were scored using the modified Mankin Criteria,and serum was analyzed for a defined subset of inflammatory markers(Interleukin-6,leptin,monocyte chemoattractant protein-1,and tumor necrosis factorα).Results:When the HFS Weanling and HFS Adult groups were compared,both groups had a similar percent of body fat,although the HFS Weanling group had a significantly greater body mass than the HFS Adult group.The HFS Weanling and HFS Adult animals had a significant increase in body mass and percentage of body fat when compared to the Chow group.Although knee joint damage scores were low in all 3 groups,we found,contrary to our hypothesis,that the HFS Adult group had statistically significant greater knee joint damage scores than the Chow and HFS Weanling groups.Furthermore,we observed that the HFS Weanling group did not have significant differences in knee joint damage scores relative to the Chow group.Conclusion:These findings indicate that the HFS Weanling animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group.Interestingly,when assessing various serum proinflammatory markers,no significant differences were detected between the HTS Adult and HFS Weanling groups.Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated,these findings indicate that dietary exposure time maybe less important than the age at which an HFS diet is introduced.Moreover,increases in serum proinflammatory mediators do not appear to be directly linked to knee joint damage scores in the HFS Weanling group animals but may be partially responsible for the observed knee joint damage in the adults over the very short time of exposure to the HFS diet.  相似文献   

The Reverend Gershom Bulkeley of Connecticut,an Eminent Clerical Physician     

Walter R. Steiner 《Journal of the Medical Library Association》1904,2(2):91-103

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On the Boundaries of Framing Terrorism: Guilt,Victimization, and the 2016 Orlando Shooting     

Nathan Walter  Thomas J. Billard  Sheila T. Murphy 《Mass Communication and Society》2017,20(6):849-868

The 2016 Orlando shooting offers an intriguing lens through which to evaluate the boundaries of media frames in the interpretation of terrorism. Using an experimental design (N = 243), the current study investigated the effects of two dominant frames—the homophobic hate crime and the Islamic terrorist frame—on collective guilt, collective victimization, and pro–lesbian, gay, bisexual, transgender, and queer (LGBTQ) political action. In addition, political partisanship and social network diversity were evaluated as potential moderators. Compared to the Islamic terrorist frame, exposure to the homophobic hate crime frame increased collective guilt and decreased collective victimization, subsequently enhancing support for the LGBTQ community. Moreover, social network diversity was shown to override the framing effect, as individuals who reported high diversity were more likely to sign a petition in solidarity with the LGBTQ community, irrespective of frame condition.  相似文献   

Video tutorials revisited: The relationship between their use and library assessment quiz scores     

Walter M. Fontane 《College & Undergraduate Libraries》2017,24(1):90-102

There is considerable literature evaluating video tutorials. By the first decade of the twenty-first century, research established that online video tutorials performed as well as traditional face-to-face instruction. However, there is little evidence that students actually viewed the tutorials. This study compares postinstruction assessment quiz scores from one class over four semesters with usage statistics for five video tutorials during the same time frame. The data indicate that students do view the tutorials. However, the results also show that usage statistics, together with quiz scores, declined as students progressed through the five tutorials. Additionally, the study determined that there was no positive correlation between the number of viewings and postviewing assessment scores.  相似文献   

Discourse,Justification, and Education: Jürgen Habermas on Moral Epistemology and Dialogical Conditions of Moral Justification and Rightness     

Walter C. Okshevsky 《Educational theory》2016,66(6):691-718

In this essay Walter Okshevsky addresses the question of whether a certain form of dialogically derived agreement can function as an epistemic (universal and necessary) criterion of moral judgment and ground of moral authority. Okshevsky examines arguments for and against in the literature of educational philosophy and develops Jürgen Habermas's affirmative answer as presented in his discourse theory of morality. Habermas's position is articulated as a moral epistemology (“strong dialogicality”) and is developed through his critique of the “monologism” of certain aspects of Immanuel Kant's moral theory. Okshevsky concludes with a consideration of some educational implications of Habermas's position.  相似文献   

Accreditation—what’s that?     

Walter Hanclosky  Rodney Earle 《TechTrends》1992,37(4):14-19

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The Minicourse—A Milestone on the Road to Better Teaching     

Walter R. Borg 《British journal of educational technology : journal of the Council for Educational Technology》1971,2(1):14-23

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Science achievement of english language learners in urban elementary schools: Results of a first‐year professional development intervention     

Okhee Lee  Jaime Maerten‐Rivera  Randall D. Penfield  Kathryn LeRoy  Walter G. Secada 《科学教学研究杂志》2008,45(1):31-52

This study is part of a 5‐year professional development intervention aimed at improving science and literacy achievement of English language learners (or ELL students) in urban elementary schools within an environment increasingly driven by high‐stakes testing and accountability. Specifically, the study examined science achievement at the end of the first‐year implementation of the professional development intervention that consisted of curriculum units and teacher workshops. The study involved 1,134 third‐grade students at seven treatment schools and 966 third‐grade students at eight comparison schools. The results led to three main findings. First, treatment students displayed a statistically significant increase in science achievement. Second, there was no statistically significant difference in achievement gains between students at English to Speakers of Other Language (ESOL) levels 1 to 4 and students who had exited from ESOL or never been in ESOL. Similarly, there was no significant difference in achievement gains between students who had been retained on the basis of statewide reading test scores and students who had never been retained. Third, treatment students showed a higher score on a statewide mathematics test, particularly on the measurement strand emphasized in the intervention, than comparison students. The results indicate that through our professional development intervention, ELL students and others in the intervention learned to think and reason scientifically while also performing well on high‐stakes testing. © 2007 Wiley Periodicals, Inc. J Res Sci Teach 45: 31–52, 2008  相似文献   

PILOT STUDY: SITUATIONAL EVALUATION AND BASE‐LINE TECHNIQUES IN ARTICULATION THERAPY     

Walter J. Peach  Charlotte Cordry 《International Journal of Disability, Development & Education》1969,16(2):108-111

The problem of this study was to consider how a speech therapist can adequately evaluate the effectiveness of therapy. The unique feature of this pilot study was the use of a pre‐ and post‐test administration at the beginning and end of each therapy session. An error sound of the subject was selected on the basis of maturity and stimulability. Ten correct or incorrect responses to this error sound were tabulated for each session, establishing a base‐line on the initial performance and enabling progress checks. The number of correct responses during each therapy session increased as the number of sessions progressed. Increased efficiency could have been attributed to the effectiveness of previous sessions.  相似文献   

Toward preparing students for change: A critical discussion of the contribution of the history of physics in physics teaching   总被引：1，自引：0，他引：1  

Walter Jung 《Science & Education》1994,3(2):99-130

In this paper I place physics teaching, and the inclusion of the history of physics into teaching, within a wide context. I start from the conviction that there are considerable changes ahead in the life circumstances of people in western industrial societies. This expectation should influence our aims of education generally, and in particular the aims of physics teaching. The paper does not offer final solutions, but analyses the situation and thereby argues for a change in perspective in physics teaching. The main idea is that physics teaching has to solve the problem of balancing seemingly incompatible needs, for example, conveying a stock of stable, dependable physics knowledge to students, and on the other hand to train them to see their physics knowledge within varying contexts of change. It is argued that the history of physics can be of high value in solving this problem.This article was originally published in: F. Bevilacqua and P.J. Kennedy (eds.): 1983, Proceedings of the Conference on Using History of Physics in Innovatory Physics Education, Pavia University.  相似文献