Obesity is a disease that has become an epidemic in economically developed countries,and manifests itself at increasing rates in economically developing countries.Obesity is associated with a variety of comorbidities,such as metabolic disease,diabetes,cardiovascular diseases,and musculoskeletal disorders,all resulting in tremendous costs to health care systems around the world,a reduced capacity for work,and reduced quality of life for people with obesity,coupled with physical inactivity,thereby producing a vicious circle of inactivity-induced diseases that enhances obesity. 相似文献
Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also obese.In recent years,a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage(both with and without the superimposition of trauma),which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory mediators.Of note,there is a disparity between whether the dietary challenges commence at weaning,representing a weanling onset,or at skeletal maturity,representing an adult onset of obesity.We wished to evaluate the effect ofthe dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose(HFS) diet to determine whether these factors may result in disparate outcomes,as there is evidence suggesting that these factors result in differential metabolic disturbances.Based on dietary exposure time,we hypothesized that rats fed an HFS diet for 14 weeks from weaning(HFS Weanling) would demonstrate an increase in knee joint damage scores,whereas rats exposed to the HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult) and rats exposed to a standard chow diet(Chow)would not display an increase in knee joint damage scores.Methods:Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning(HFS Weanling) or an HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult).At sacrifice,joints were scored using the modified Mankin Criteria,and serum was analyzed for a defined subset of inflammatory markers(Interleukin-6,leptin,monocyte chemoattractant protein-1,and tumor necrosis factorα).Results:When the HFS Weanling and HFS Adult groups were compared,both groups had a similar percent of body fat,although the HFS Weanling group had a significantly greater body mass than the HFS Adult group.The HFS Weanling and HFS Adult animals had a significant increase in body mass and percentage of body fat when compared to the Chow group.Although knee joint damage scores were low in all 3 groups,we found,contrary to our hypothesis,that the HFS Adult group had statistically significant greater knee joint damage scores than the Chow and HFS Weanling groups.Furthermore,we observed that the HFS Weanling group did not have significant differences in knee joint damage scores relative to the Chow group.Conclusion:These findings indicate that the HFS Weanling animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group.Interestingly,when assessing various serum proinflammatory markers,no significant differences were detected between the HTS Adult and HFS Weanling groups.Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated,these findings indicate that dietary exposure time maybe less important than the age at which an HFS diet is introduced.Moreover,increases in serum proinflammatory mediators do not appear to be directly linked to knee joint damage scores in the HFS Weanling group animals but may be partially responsible for the observed knee joint damage in the adults over the very short time of exposure to the HFS diet. 相似文献
In two independent studies of questionnaire administration, respondents completed multidimensional self-concept inventories within four randomized research conditions that mirrored the most common administration formats used in practice: paper booklets with and without answer sheets and computer questionnaires with single versus multiple items per screen. Strong differences among conditions emerged for completion time, but not for psychometric properties of scores (means, variances, reliability coefficients, concurrent validity coefficients). Answer sheets increased completion time by 24% to 34%, single-item displays by 20% to 25%, and computerization by 13% to 17%. Completion time was longer for multiple-alternative than for rating-scale items, but relative effects of answer sheets, single-item displays, and computerization remained consistent. We discuss implications for questionnaire construction and administration. 相似文献
The purpose of this paper is to provide an estimate of the elasticity and cros-selasticities of demand for higher education facing an individual institution. The utility which a high school graduate derives from each educational option open to him is assumed to be a stochastic function of the attributes of that option. For certain types of utility functions the maximization of utility results in the logit probability model. This model is used to analyze the choices made by a sample of high school graduates in Hawaii. Estimates of the price elasticity and the cross-price elasticities of demand for enrollment at the University of Hawaii are obtained. It is found that the demand is quite inelastic with respect to both tuition and total cost of education. These estimates imply that changes in tuition will not affect enrollment appreciably.The authors wish to express their appreciation to Arthur S. Goldberger, H. Laurence Miller, and Pan A. Yotopoulos for their comments on earlier drafts of the paper. 相似文献
Throughout the history of art more attention has been given to pictorial balance than to any other principle of visual composition.
When examining pictorial balance, the visual weights of significant elements within a given field must be taken into consideration.
This study, by means of ocular photography and the analysis of eye fixations, examined factors that have an effect upon visual
weight. Confirming earlier studies, the upper half of a visual field was found to have inherently greater visual weight than
the lower half. While several researchers have attributed greater visual weight to the left side of a field, others have favored
the right. Data from this study were not sufficiently reliable to indicate a preference for either side. Results were insufficient
to support the hypothesis that the upper left quadrant has greater inherent visual weight than the upper right quadrant. While
it was shown that the interrelationships between tone and size have an effect on visual weight, the exact nature of these
relationships must await future investigation. 相似文献
Ethene/norbornene copolymerization by the catalyst system [Me2Si(3-tertBuCp)(NtertBu)]TiCl2/MAO was investigated in detail at 30 °C, 60 °C, and 90 °C. A mass flow controller was used in this work to obtain kinetic
data and investigate temperature's effects on activity, norbornene incorporation, copolymerization parameter, microstructure,
glass transition temperature, and molar masses were described. High copolymerization valuesrξ and high alternation are determined. The number of isotactic alternating sequences is much higher than that of the syndiotactic
alternating sequences. 相似文献
This paper suggests a particular value to treating the teaching of poetry in school comparatively. It argues that the justification for this claim derives from the ways in which peculiar symbiotic dependencies between poetry, languages, cultures and uniquely individual consciousness‐‐and between poetry, childhood learning and children's achievement of literacy‐‐can be represented in a teaching methodology. It refers to a unique teaching and research project, directed by the author at Goldsmiths’ College, University of London, which has developed principles and strategies for building a new pedagogy with children and in teacher education.相似文献
Statt eines Abstracts Der gro?e "Philosoph aus Wien", Paul Feyerabend, lehrte in den 1970er Jahren auf dem H?hepunkt seiner akademischen Karriere
stehend in Berkeley. In seinen Kurs waren jedes Semester Hunderte von Studenten eingeschrieben, seltsamerweise waren darunter
auch viele Sportstudenten und Fu?ballspieler, denen an den amerikanischen Universit?ten bekanntlich eine nicht geringe Bedeutung
zukommt. Was war der Grund für diese Anziehungskraft einer nicht leicht zu verstehenden Philosophie? Feyerabend versprach
jedem Studenten schon in der ersten Vorlesungsstunde eine Eins für seinen Kurs – und fügte noch hinzu, dass es bei ihm natürlich
keinerlei Prüfung oder Hausarbeiten g?be. Man bekam seine Eins selbst dann, wenn man niemals in die Vorlesung kam, was Feyerabend
mit seinem tiefen Vertrauen in das alte Humboldtsche Erziehungsziel der akademischen Freiheit rechtfertigte. Als die Universit?tsverwaltung
von dieser Sache Wind bekam, wurde Feyerabend gezwungen, zumindest eine Abschlussprüfung für seinen Kurs abzuhalten. Im n?chsten
Semester h?ndigte der Professor zu Beginn der Prüfungsstunde ein Blatt aus, auf dem in gro?en Buchstaben feierlich das Wort
"Abschlussprüfung" stand, und darunter hie? es einfach: "Erz?hle mir deinen Lieblingswitz!" Jeder Witz, auch der dümmste,
wurde dann mit der Note Eins belohnt. Der Chronist dieser Anekdote berichtet, dass das Universit?tsmanagement auch diesem
Verfahren bald ein Ende gemacht hatte – ohne zu sagen, mit welchen Methoden, und wie Feyerabend auf diesen Eingriff in seine
akademische Lehrfreiheit reagiert hat. 相似文献
This article gives an overview of current provisions for environmental education in the context of distance education programmes in a sample of European countries. The methodology, that was employed by means of a postal survey aimed at identifying current trends in environmental education in relation to distance teaching, is described. The sample surveyed consisted of approximately 500 higher education institutions, members of the Association of European Universities (CRE), over 200 of which had signed the CRE‐Copernicus Universities Charter on Sustainable Development. The article presents a regional summary of the research findings that formed part of a larger enquiry into the status of environmental education in European countries, Commonwealth countries, and individual countries such as the United Kingdom and Pakistan. 相似文献