Additive Effect of Lipid Lowering Drug (Simvastatin) in Combination with Antidiabetic Drug (Glibenclamide) on Alloxan Induced Diabetic Rats with Long Term Dyslipidemia     

Mst. Marium Begum  Zakia Sultana  Md. Ershad Ali  Md. Safkath Ibne Jami  Proma Khondkar  Md. Masuduzzaman Khan  Md. Mominul Haque 《Indian journal of clinical biochemistry : IJCB》2014,29(4):452-461

High blood glucose level, elevated level of liver enzyme, necrosis and shrinkage of islets of Langerhans has been implicated in the pathogenesis of type 2 diabetes. High blood glucose cause oxidative stress, production of free radical as well as elevated SGPT and SGOT level. Both glibenclamide and simvastatin in fixed dose used as antihyperglycemic antidyslipidemic and antioxidative agents for type 2 diabetes treatment. This study therefore aimed to evaluate the antihyperglycemic, antidyslipidemic and antioxidative effect of fixed dose combination of glibenclamide (0.6 mg/70 kg body weight) and simvastatin (5 mg/70 kg body weight) on long term alloxan induced diabetic rats with cardiovascular disease using various diagnostic kits as a parameter of phamacotherapeutic and pharmacological effect. The study was carried out using 96 Swiss Albino male rats weighing about 200–220 g. Combination therapy induced a significant decrease in blood glucose level in alloxan induced diabetic rats, from 33.75 ± 1.65 to 5.80 ± 0.07 mmol/l 2 h after last dose administration, after 4 weeks treatment. In case of dyslipidemic effect, combination therapy reduced total cholesterol (45 %), triglyceride (36 %) and low density lipoprotein-cholesterol (32 %) levels significantly and increased high density lipoprotein-cholesterol level (57 %) in comparison with their respective diabetic control groups. Results of this study showed that combination therapy effectively decreased SGPT (ALAT) (55 %) and SGOT (ASAT) (51 %) in comparison with diabetic control group. It was also observed that catalase and superoxide dismutase enzyme activity was increased by 58 and 91 % respectively in comparison with diabetic control group after 4 weeks treatment with combination of both drugs. In conclusion, these findings of combination therapy (glibenclamide and simvastatin) on alloxan induced diabetes in rats are significantly better than monotherapy using single drug. The results of the present study suggest that, combination of the fixed dose of glibenclamide and simvastatin might be efficacious in patients with diabetic dyslipidemia and increased oxidative stress. Furthermore, this combination therapy offer dosage convenience to the patients and by virtue of its dual mode of action might be a useful addition to the therapeutic armamentarium for patients with diabetic dyslipidemia and oxidative stress.  相似文献   

Determinants of students’ outcome: a full-fledged structural equation modelling approach     

Mohammed Borhandden Musah  Hairuddin Bin Mohd Ali  Shafeeq Hussain Vazhathodi Al-Hudawi  Lokman Mohd Tahir  Khadijah Binti Daud  Abdul Rahim Hamdan 《Asia Pacific Education Review》2015,16(4):579-589

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The effects of scientific representations on primary students’ development of scientific discourse and conceptual understandings during cooperative contemporary inquiry-science     

Robyn M. Gillies  Kim Nichols  Asaduzzaman Khan 《Cambridge Journal of Education》2015,45(4):427-449

Teaching students to use and interpret representations in science is critically important if they are to become scientifically literate and learn how to communicate their understandings and learning in science. This study involved 248 students (119 boys and 129 girls) from 26 grade 6 teachers’ classes in nine primary schools in Brisbane, Australia. Teachers were randomly allocated by school to one of three conditions: the contemporary science + representations condition (Experimental^a), the contemporary condition (Experimental^b), or the comparison condition as they participated in an eight-week inquiry-science unit on Natural Disasters. Data on students’ discourse were collected at two time points during the implementation of the unit and data on the concept maps were collected pre- and post-intervention while data on the reasoning and problem-solving (RP-S) task were collected following the intervention. The results show that when students participate in an inquiry-based science unit that is augmented with a variety of multimedia resources presenting a range of current contemporary events (Experimental^a and Experimental^b conditions), they demonstrate significantly more social language and basic scientific language and marked increases in moderate scientific language than their peers in the comparison condition. Interestingly, although there were no significant differences on the Personal Concept Map scores between the conditions at Times 1 and 2, the students’ scores in all conditions improved decidedly across time. It appears that as the children had more time to engage with the material, participate in cooperative peer discussions, and receive encouragement from their teachers to provide elaborated feedback to each other, their conceptual understandings of earthquakes were enhanced. However, although the children in the experimental conditions demonstrated significantly more social and scientific language than their peers in the comparison condition, these oral language skills did not transfer to the RP-S task, possibly because they may not have had enough time to consolidate their application in a novel context where they had to work independently.  相似文献   

Minimization of students’ cognitive load in a virtual chemistry laboratory via contents optimization and arrow-textual aids     

Ali  Numan  Ullah  Sehat  Khan  Dawar 《Education and Information Technologies》2022,27(6):7629-7652

Education and Information Technologies - Virtual Chemistry Laboratories (VCLs) are used as an alternative to the physical laboratories, where users can enhance their performance for hands-on...  相似文献   

Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios     

Haslinda Abdul HAMID  Vahid Hosseinpour SARMADI  Vivek PRASAD  Rajesh RAMASAMY  Azizi MISKON 《Journal of Zhejiang University. Science. B》2022,23(1):42-57

Mesenchymal stem/stromal cell(MSC)-based therapy has been regarded as one of the most revolutionary breakthroughs in the history of modern medicine owing to its myriad of immunoregulatory and regenerative properties.With the rapid progress in the fields of osteo-and musculoskeletal therapies,the demand for MSC-based treatment modalities is becoming increasingly prominent.In this endeavor,researchers around the world have devised new and innovative techniques to support the proliferation of MSCs while minimizing the loss of hallmark features of stem cells.One such example is electromagnetic field(EMF)exposure,which is an alternative approach with promising potential.In this review,we present a critical discourse on the efficiency,practicability,and limitations of some of the relevant methods,with insurmountable evidence backing the implementation of EMF as a feasible strategy for the clinically relevant expansion of MSCs.  相似文献   

Mathematics Achievement as a Function of Within- and Between-School Differences     

Ebrahim Mohammadpour  Mohamed Najib Abdul Ghafar 《Scandinavian Journal of Educational Research》2014,58(2):189-221

Achievement in mathematics of eighth-grade students is modeled as a function of within-school, between-school and cross-country differences. The data were obtained from 217,728 students, within 7,216 secondary schools, in 48 countries, who participated in the 2007 Trends in International Mathematics and Science Study. Multilevel analysis showed that out of the total variance in mathematics achievement, 40.39%, 20.61%, and 38.99% were accounted for within-school, between-school-within-country, and cross-country differences, respectively. Mathematics self-concept followed by socioeconomic status was the strongest predictor of achievement at the student level. At the school level, school location yielded the strongest link to achievement, while at the country level socioeconomic status was the main predictor of national mathematics average.  相似文献   

IV. THE COGNITIVE IMPLICATIONS OF OBESITY AND NUTRITION IN CHILDHOOD     

Naiman A. Khan  Lauren B. Raine  Sharon M. Donovan  Charles H. Hillman 《Monographs of the Society for Research in Child Development》2014,79(4):51-71

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How to survive your first year in teaching     

Khalid Khan 《Studies in Continuing Education》2014,36(2):236-237

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Dendritic cell therapy with improved outcome in glioma multiforme-a case report     

Khan JA  Yaqin S 《Journal of Zhejiang University. Science. B》2006,7(2):114-117

Malignant gliomas are the most devastating tumors in clinical practice and nave poorest survival, Immunological treatment of such patients may likely increase the survival and quality of life. Dendritic cells （DCs）, most potent antigen presenting cells in combination with oral chemotherapeutic agents may be tried for patients giving consent to such treatment. We have successfully combined the two therapies in an adult male patient who was on downhill course after being operated on once with post operation chemotherapy and radiotherapy for glioma in the left parietal area. He received five dendritic cell therapy vaccines in combination with oral chemotherapy and responded dramatically having near normal quality of life for an additional five months with this regime, increasing the survival after operation to 11 months. This therapy is continuing with radiological betterment of the lesion. The DCs are matured with antigen extracted from wax embedded tissue at 6th day of culture. We feel that the treatment can be given to more number of patients to establish its efficacy for the dreaded cancer glioblastoma multiforme.  相似文献   

致力于发展的开放远程教育     

阿卜杜拉·汉  徐辉富 《开放教育研究》2007,13(5):37-41

本文从促进人类发展的角度探讨了农村和落后地区推广远程教育的意义。文章首先分析了人类发展面临的种种挑战、促进社会发展的原因,接着分析了教育与发展的关系,指出开放远程教育是促进发展的一个重要选择。文章最后阐述了开放远程教育在促进发展过程中存在一些问题,取得成功的实践(如社区多媒体中心和空中学校项目等),以及为取得成功需考虑的一些因素。  相似文献