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21.
The present study was carried out to evaluate the hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus (A indicus) in alloxan inducd diabetic rats. Oral administration of ethanol extract of root (500mg/ kg body weight) for 21 days resulted in significant decrease in the levels of blood glucose, triglycerides, total cholesterol, phospholipid and free fatty acids. Furthermore, the root extract (100–400μg) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The result of the present study demonstrated hypoglycemic, lipid lowering and antioxidant activities in root extract of A indicus, which could help in prevention of diabetic dyslipidemia and related diseases.  相似文献   
22.
This study is qualitative in nature and aims at assessing the information needs and seeking behavior of educational administrators and finding related problems. Interviews of a purposive sample and review of related literature are among the major research methods. The study is based on interviews of 13 educational administrators and 32 information professionals from Punjab province and Islamabad Capital Territory (ICT) of Pakistan. The results correspond with the previous studies conducted in other countries. The educational administrators' information needs and seeking behavior reflect a kinship with their work settings and information environment that highlights a need to understand problem situations as an ancestor to understanding how they seek and use information. The study has identified a gap in the provision of needed information which hinders the realistic planning and decision making process. It has also highlighted the need of a National Information System for educational administrators in Pakistan. As this is the first study on this topic in Pakistan, the results can be useful to design information services and facilities for educational administrators in Pakistan and other developing regions of the globe with similar conditions.  相似文献   
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Abstract

STEM outreach programmes in secondary schools are mediated by STEM teachers who are responsible for organising, implementing and evaluating the activities with a view to promoting STEM subjects. However, research investigating teachers’ STEM roles and professional development through participation in outreach activities is limited. This paper explores teachers’ views of STEM activities, how they understand their role as primary facilitators and the impact of their STEM engagement on their professional development. STEM outreach provides distinct opportunities for situated and dialogic learning. STEM teachers’ effectiveness in engaging students by demonstrating the importance and relevance of STEM subjects in the real world and engaging captivating STEM outreach partners not only supports students learning but also enhances their opportunities to develop their knowledge and skills. Semi structured interviews were conducted with eleven teachers from six different schools in the West Midlands, United Kingdom. The data reveals STEM facilitators become the ‘face’ of STEM to their pupils. The expertise, knowledge and partnerships STEM facilitators develop, broadens their capacity to deliver teaching imbued with real world applications and improve students’ understanding of the range of new and upcoming careers available. Most importantly, participating in STEM outreach activities help teachers maintain and reinforce their own sense of identity as STEM professionals. Outreach activities provide opportunities for teachers to interact with leading scientists and obtain exposure to cutting-edge research.  相似文献   
25.
Early child development has been influenced directly and indirectly by the COVID-19 pandemic, and these effects are exacerbated in contexts of poverty. This study estimates effects of the pandemic and subsequent population lockdowns on mental health, caregiving practices, and freedom of movement among female caregivers of children 6–27 months (50% female), in rural Bangladesh. A cohort (N = 517) was assessed before and during the pandemic (May–June, 2019 and July–September, 2020). Caregivers who experienced more food insecurity and financial loss during the pandemic reported larger increases in depressive symptoms (0.26 SD, 95% CI 0.08–0.44; 0.21 SD, 0.04–0.40) compared to less affected caregivers. Stimulating caregiving and freedom of movement results were inconsistent. Increases in depressive symptoms during the pandemic may have consequences for child development.  相似文献   
26.
To probe the glutathione peroxidase (GPx) activity coupled to ROS and TNF-α levels in younger versus elderly primigravidas. Monocytes were isolated from blood of young and elderly primigravidas after 12 hrs, 24 hrs and 14 days postpartum. Age-matched healthy female donors served as controls. Thereafter, the above monocytes were subjected to evaluation of GPx activity, levels of pro-inflammatory cytokine TNF-α and reactivity/specificity towards anti-TNF-α antibody. Suppression in GPx activity with simultaneous enhancement of TNF-α levels in monocytes was observed after 12 hrs and 24 hrs of spontaneous labor pain-induced maternal delivery through normal vaginal route. Conversely, an enhancement of GPx activity and decrease in TNF-α levels were observed on day 14 of postpartum, thereby indicating reversal of the impaired neutralizing mechanisms. The antioxidant network combating ROS was stronger in younger primigravidas. Capability of TNF-α and ROS suppression was somewhat lesser in elderly primigravidas even 14 days of postpartum via normal vaginal route. The capability of GPx activity enhancement with simultaneous suppression in ROS and TNF-α, decreases in elderly primigravidas. This may act as one of the important parameters leading to a variety of complications encountered by elderly primigravidas.  相似文献   
27.
The present studies with aluminium chloride given in drinking water showed marked inhibition in the activities of intestinal brush border membrane marker enzymes, namely alkaline phosphatase, acetyl cholinesterase, γ-glutamyl transpeptidase and sucrase. Moreover, a significant depression in the levels of membrane constituents, viz phospholipids, cholesterol, hexoses and sialic acid following aluminium chloride treatment was also observed. On the basis of these studies it may be concluded that if aluminium is taken in high quantities it may alter the structure and functioning of the intestinal brush border membrane, which in turn may lead to the improper digestion and reduced nutrient uptake from the small intestine.  相似文献   
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